km 2210 profile

bestrabucil: cpd from reaction of chlorambucil and estradiol; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	6917688
CHEMBL ID	2106381
SCHEMBL ID	8659
MeSH ID	M0111383

Synonym
atrimustine
kregan
busramustine
km-2210
bestrabucil
atrimustinum [inn-latin]
atrimustina [inn-spanish]
estra-1,3,5(10)-triene-3,17-diol, (17-beta)-, 3-benzoate, 17-((4-(4-(bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acetate)
km 2210
atrimustine [inn]
estradiol 3-benzoate 17-glycolate, 4-(p-(bis(2-chloroethyl)amino)phenyl)butyrate
[(8r,9s,13s,14s,17s)-17-[2-[4-[4-[bis(2-chloroethyl)amino]phenyl]butanoyloxy]acetyl]oxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] benzoate
75219-46-4
xc0k09b7k4 ,
unii-xc0k09b7k4
atrimustinum
atrimustina
estradiol benzoate butyrate [who-dd]
atrimustine [jan]
CHEMBL2106381
KM2210 ,
SCHEMBL8659
CS-6616
HY-101604
Q27293770
MS-31233
DTXSID501046416
AKOS040741179

Excerpt	Reference	Relevance
"KM 2210 was thought to be an effective drug for CLL."	( [KM 2210 therapy for chronic lymphocytic leukemia]. Fukayama, M; Ikebuchi, K; Kaise, M; Miwa, A; Mori, M; Murai, Y; Nakamura, N, 1983)	1.9

Excerpt	Relevance	Reference
" All of the compounds were effective against estrogen receptor-positive T-61 with a clear dose-response relationship, while estrogen receptor-negative MX-1 was sensitive to all of the agents except estradiol."	( Mode of action of estra-1,3,5(10)-triene-3,17 beta-diol 3-benzoate 17-[4-(4-bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acet ate) on human breast carcinoma xenografts in nude mice. Abe, O; Asano, K; Enomoto, K; Ishibiki, K; Koh, J; Kubota, T; Masui, O; Oka, S; Yamada, Y, 1988)	0.27

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	24 (66.67)	18.7374
1990's	12 (33.33)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	3 (7.69%)	5.53%
Reviews	2 (5.13%)	6.00%
Case Studies	12 (30.77%)	4.05%
Observational	0 (0.00%)	0.25%
Other	22 (56.41%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
chlorambucil Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed). chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.	14.36	36	2	aromatic amine; monocarboxylic acid; nitrogen mustard; organochlorine compound; tertiary amino compound	alkylating agent; antineoplastic agent; carcinogenic agent; drug allergen; immunosuppressive agent
mitomycin Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.	6.97	1	0	mitomycin	alkylating agent; antineoplastic agent
prednimustine Prednimustine: Ester of CHLORAMBUCIL and PREDNISOLONE used as a combination alkylating agent and synthetic steroid to treat various leukemias and other neoplasms. It causes gastrointestinal and bone marrow toxicity.	1.97	1	0	corticosteroid hormone
etoposide [no description available]	1.99	1	0	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
estramustine Estramustine: A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.. estramustine : A carbamate ester obtained by the formal condensation of the hydroxy group of 17beta-estradiol with the carboxy group of bis(2-chloroethyl)carbamic acid.	3.99	4	0	17beta-hydroxy steroid; carbamate ester; organochlorine compound	alkylating agent; antineoplastic agent; radiation protective agent
tacrolimus Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.. tacrolimus (anhydrous) : A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.	2.39	2	0	macrolide lactam	bacterial metabolite; immunosuppressive agent
transforming growth factor alpha Transforming Growth Factor alpha: An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.	1.98	1	0
cyclosporine Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).	2.39	2	0

Condition	Relationship Strength	Studies	Trials
Cancer of Prostate [description not available]	3.98	5	0
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	3.98	5	0
Breast Cancer [description not available]	3.36	7	0
Benign Neoplasms [description not available]	2.66	3	0
Breast Neoplasms Tumors or cancer of the human BREAST.	3.36	7	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.66	3	0
Leukemia, Lymphocytic [description not available]	4.04	3	1
Leukemia, Lymphoid Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.	4.04	3	1
Hand-Schu00FCller-Christian Disease [description not available]	1.96	1	0
Chylopericardium [description not available]	1.96	1	0
Histiocytosis, Langerhans-Cell A group of disorders resulting from the abnormal proliferation of and tissue infiltration by LANGERHANS CELLS which can be detected by their characteristic Birbeck granules (X bodies), or by monoclonal antibody staining for their surface CD1 ANTIGENS. Langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder.	1.96	1	0
Pericardial Effusion Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of THORACIC DUCT. Severe cases can lead to CARDIAC TAMPONADE.	6.96	1	0
Carcinoma, Anaplastic [description not available]	1.98	1	0
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	1.98	1	0
B-Cell Chronic Lymphocytic Leukemia [description not available]	2.38	2	0
Cancer, Second Primary [description not available]	1.99	1	0
Leukemia, Myeloid, Acute, M4 [description not available]	1.99	1	0
Leukemia, Lymphocytic, Chronic, B-Cell A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.	2.38	2	0
Leukemia, Myelomonocytic, Acute A pediatric acute myeloid leukemia involving both myeloid and monocytoid precursors. At least 20% of non-erythroid cells are of monocytic origin.	1.99	1	0
ATLL [description not available]	3.77	2	1
Leukemia-Lymphoma, Adult T-Cell Aggressive T-Cell malignancy with adult onset, caused by HUMAN T-LYMPHOTROPIC VIRUS 1. It is endemic in Japan, the Caribbean basin, Southeastern United States, Hawaii, and parts of Central and South America and sub-Saharan Africa.	3.77	2	1
Hormone-Dependent Neoplasms [description not available]	1.97	1	0
Experimental Hepatoma [description not available]	2.89	1	0
Carcinosarcoma A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)	1.97	1	0
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	1.97	1	0
Cytomegalic Inclusion Disease [description not available]	2.88	1	0
Graft-Versus-Host Disease [description not available]	2.88	1	0
Complication, Postoperative [description not available]	2.88	1	0
Alveolitis, Fibrosing [description not available]	2.88	1	0
Acute Hemolytic Transfusion Reaction [description not available]	2.88	1	0
Cytomegalovirus Infections Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.	2.88	1	0
Graft vs Host Disease The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.	2.88	1	0
Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	2.88	1	0
Pulmonary Fibrosis A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.	2.88	1	0
Transfusion Reaction Complications of BLOOD TRANSFUSION. Included adverse reactions are common allergic and febrile reactions; hemolytic (delayed and acute) reactions; and other non-hemolytic adverse reactions such as infections and adverse immune reactions related to immunocompatibility.	2.88	1	0
BLV Infections [description not available]	2.37	2	0
Germinoblastoma [description not available]	4.04	3	1
Kahler Disease [description not available]	3.76	2	1
Thrombocythemia [description not available]	1.96	1	0
Lymphoma A general term for various neoplastic diseases of the lymphoid tissue.	4.04	3	1
Multiple Myeloma A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.	3.76	2	1
Experimental Mammary Neoplasms [description not available]	1.97	1	0
Carcinoma 256, Walker A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)	3.29	2	0
Foreign-Body Reaction Chronic inflammation and granuloma formation around irritating foreign bodies.	1.97	1	0
Granulocytic Leukemia [description not available]	3.76	2	1
Leukocytopenia [description not available]	2.37	2	0
Thrombopenia [description not available]	1.96	1	0
Leukemia, Myeloid Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.	3.76	2	1
Leukopenia A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).	2.37	2	0
Thrombocytopenia A subnormal level of BLOOD PLATELETS.	1.96	1	0
Brill-Symmers Disease [description not available]	1.96	1	0
Lymphoma, Follicular Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.	1.96	1	0
Bladder Cancer [description not available]	2.37	2	0
Cancer of Kidney [description not available]	1.97	1	0
Cancer of Testis [description not available]	1.97	1	0
Genito-urinary Cancer [description not available]	1.97	1	0
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	2.37	2	0
Kidney Neoplasms Tumors or cancers of the KIDNEY.	1.97	1	0
Testicular Neoplasms Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.	1.97	1	0
Urogenital Neoplasms Tumors or cancer of the UROGENITAL SYSTEM in either the male or the female.	1.97	1	0
Adenocarcinoma, Basal Cell [description not available]	2.37	2	0
Cancer of Lung [description not available]	1.97	1	0
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.37	2	0
Lung Neoplasms Tumors or cancer of the LUNG.	1.97	1	0
Carcinoma, Papillary A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)	1.97	1	0
Local Neoplasm Recurrence [description not available]	2.37	2	0
Cancer of Pelvis [description not available]	1.97	1	0
Carcinoma, Transitional Cell A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.	1.97	1	0
Retroperitoneal Neoplasms New abnormal growth of tissue in the RETROPERITONEAL SPACE.	1.97	1	0
Recrudescence [description not available]	1.97	1	0
Ache [description not available]	1.96	1	0
Anorexia The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.	1.96	1	0
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	1.96	1	0
Experimental Neoplasms [description not available]	1.96	1	0

km 2210

Description

Cross-References

Synonyms (28)

Research Excerpts

Overview

Dosage Studied

Research

Studies (36)

Market Indicators

Research Demand Index: 10.59

Study Types

km 2210

Description

Cross-References

Synonyms (28)

Research Excerpts

Overview

Dosage Studied

Research

Studies (36)

Market Indicators

Research Demand Index: 10.59

Study Types

Related Drugs (8)

Related Conditions (74)