antipyrine has been researched along with Necrosis in 28 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was designed to evaluate the protective effect of edaravone, a free radical scavenger, on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma." | 9.19 | Effect of edaravone on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma after radiotherapy: a randomized controlled trial. ( Hu, W; Li, G; Luo, J; Rong, X; Tang, Y; Xu, P; Yang, J; Yang, X, 2014) |
| " This study was designed to evaluate the protective effect of edaravone, a free radical scavenger, on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma." | 5.19 | Effect of edaravone on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma after radiotherapy: a randomized controlled trial. ( Hu, W; Li, G; Luo, J; Rong, X; Tang, Y; Xu, P; Yang, J; Yang, X, 2014) |
| "Edaravone mainly showed a prophylactic effect on neurons against glutamate neurotoxicity, possibly through the inhibition of necrosis via the suppression of ROS production." | 3.75 | Protective effects of the free radical scavenger edaravone against glutamate neurotoxicity in nearly pure neuronal culture. ( Hisano, K; Morimoto, Y; Watanabe, M, 2009) |
| "Fatty degeneration and necrosis with marked elevation of serum alanine aminotransferase and lactate dehydrogenase levels developed after CCl4 administration were significantly reduced by edaravone." | 3.72 | A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury. ( Ishii, H; Kameyama, K; Kitamura, K; Kurita, S; Nakamoto, N; Saito, H; Saito, Y; Tada, S, 2003) |
| " The objective of the present investigation was to study some of the possible mechanisms involved in the protective effect of sucrose ingestion against liver necrosis induced by acetaminophen." | 3.68 | Cytochrome P450 and glutathione in the liver of rats under exclusive sucrose ingestion. ( Martinelli, AL; Meneghelli, UG; Zucoloto, S, 1993) |
| "Iodo(14C-)antipyrine autoradiography and imaging bioluminescence have been combined to obtain pixel-to-pixel correlations between absolute values for local blood flow and ATP concentrations at a microscopical level within designated areas in hamster melanomas." | 3.68 | Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours. ( Dellian, M; Goetz, AE; Kuhnle, GE; Mueller-Klieser, W; Walenta, S, 1992) |
| " Parallel studies were performed to measure relative changes in tumor blood perfusion using [14C]iodo-antipyrine and changes in % tumor necrosis using Chalkley's method." | 3.67 | Phosphorus-31 magnetic resonance spectroscopy and blood perfusion of the RIF-1 tumor following X-irradiation. ( Bhujwalla, ZM; Griffiths, JR; Maxwell, RJ; Tozer, GM, 1989) |
| "Drug-metabolizing capacity has been assessed by serial measurements of the plasma antipyrine half life in 11 patients with severe barbiturate intoxication and in 17 patients with acute hepatic necrosis due to paracetamol overdosage." | 3.65 | Abnormal drug metabolism after barbiturate and paracetamol overdose. ( Forrest, JA; Prescott, LF; Roscoe, P; Stevenson, IH, 1974) |
| " Hepatic pharmacokinetic modelling was performed with a two-phase physiologically-based organ pharmacokinetic model with the vascular space and dispersion evaluated with the MID technique." | 1.38 | Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage. ( Crawford, DH; Fletcher, LM; Li, P; Roberts, MS; Robertson, TA; Weiss, M; Zhang, Q, 2012) |
| "However, its effect on myocardial reperfusion injury after prolonged ischemia has not yet been demonstrated." | 1.29 | Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart. ( Koide, S; Minhaz, U; Nakazawa, H; Shohtsu, A; Tanaka, M; Tsukamoto, H; Watanabe, K, 1996) |
| "Four caffeine-treated rats had histologic evidence of acute myocardial infarction which was not found in any of the other rats." | 1.26 | Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine. ( Johansson, S, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (46.43) | 18.7374 |
| 1990's | 7 (25.00) | 18.2507 |
| 2000's | 5 (17.86) | 29.6817 |
| 2010's | 3 (10.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tang, Y | 1 |
| Rong, X | 1 |
| Hu, W | 1 |
| Li, G | 1 |
| Yang, X | 1 |
| Yang, J | 1 |
| Xu, P | 1 |
| Luo, J | 1 |
| Hisano, K | 1 |
| Watanabe, M | 3 |
| Morimoto, Y | 2 |
| Kikuchi, K | 1 |
| Uchikado, H | 1 |
| Miyagi, N | 1 |
| Ito, T | 1 |
| Tancharoen, S | 1 |
| Miura, N | 1 |
| Miyata, K | 1 |
| Sakamoto, R | 1 |
| Kikuchi, C | 1 |
| Iida, N | 1 |
| Shiomi, N | 1 |
| Kuramoto, T | 1 |
| Kawahara, K | 1 |
| Li, P | 1 |
| Robertson, TA | 1 |
| Zhang, Q | 1 |
| Fletcher, LM | 1 |
| Crawford, DH | 1 |
| Weiss, M | 1 |
| Roberts, MS | 1 |
| Wu, TW | 1 |
| Zeng, LH | 1 |
| Wu, J | 1 |
| Fung, KP | 1 |
| GORDH, T | 1 |
| Nakamoto, N | 1 |
| Tada, S | 1 |
| Kameyama, K | 1 |
| Kitamura, K | 1 |
| Kurita, S | 1 |
| Saito, Y | 1 |
| Saito, H | 1 |
| Ishii, H | 1 |
| Zhu, C | 1 |
| Wang, X | 1 |
| Huang, Z | 1 |
| Qiu, L | 1 |
| Xu, F | 1 |
| Vahsen, N | 1 |
| Nilsson, M | 1 |
| Eriksson, PS | 1 |
| Hagberg, H | 1 |
| Culmsee, C | 1 |
| Plesnila, N | 1 |
| Kroemer, G | 1 |
| Blomgren, K | 1 |
| Ikegami, E | 1 |
| Fukazawa, R | 1 |
| Kanbe, M | 1 |
| Abe, M | 1 |
| Kamisago, M | 1 |
| Hajikano, M | 1 |
| Katsube, Y | 1 |
| Ogawa, S | 1 |
| Johansson, S | 1 |
| Chan, HL | 1 |
| Knights, KM | 1 |
| Gourlay, GK | 1 |
| Hall, P | 1 |
| Cousins, MJ | 1 |
| Martinelli, AL | 1 |
| Meneghelli, UG | 1 |
| Zucoloto, S | 1 |
| Minhaz, U | 1 |
| Tanaka, M | 1 |
| Tsukamoto, H | 1 |
| Watanabe, K | 1 |
| Koide, S | 1 |
| Shohtsu, A | 1 |
| Nakazawa, H | 1 |
| Tatsumi, M | 1 |
| Yutani, K | 1 |
| Kusuoka, H | 1 |
| Nishimura, T | 1 |
| Bingham, WG | 1 |
| Goldman, H | 1 |
| Friedman, SJ | 1 |
| Murphy, S | 1 |
| Yashon, D | 1 |
| Hunt, WE | 1 |
| Bradley, WG | 1 |
| O'Brien, MD | 1 |
| Walder, DN | 1 |
| Murchison, D | 1 |
| Johnson, M | 1 |
| Newell, DJ | 1 |
| Walenta, S | 1 |
| Dellian, M | 1 |
| Goetz, AE | 1 |
| Kuhnle, GE | 1 |
| Mueller-Klieser, W | 1 |
| Van Hillegersberg, R | 1 |
| Kort, WJ | 1 |
| ten Kate, FJ | 1 |
| Terpstra, OT | 1 |
| Nagahiro, S | 1 |
| Yamamoto, YL | 1 |
| Diksic, M | 1 |
| Mitsuka, S | 1 |
| Sugimoto, S | 1 |
| Feindel, W | 1 |
| Torrelo, A | 1 |
| Soria, C | 1 |
| Rocamora, A | 1 |
| Ledo, A | 1 |
| Tozer, GM | 1 |
| Bhujwalla, ZM | 1 |
| Griffiths, JR | 1 |
| Maxwell, RJ | 1 |
| Altmann, HW | 1 |
| Forrest, JA | 1 |
| Roscoe, P | 1 |
| Prescott, LF | 1 |
| Stevenson, IH | 1 |
| Lassen, NA | 1 |
| Holstein, P | 1 |
| Eegholm, A | 1 |
| Brown, DM | 1 |
| Hardy, TL | 1 |
| Rogers, W | 1 |
| Edlich, RF | 1 |
| Aust, JB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Edaravone on Radiation-induced Temporal Lobe Necrosis in Patients With Nasopharyngeal Carcinoma After Radiotherapy[NCT01865201] | Phase 2 | 154 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for antipyrine and Necrosis
| Article | Year |
|---|---|
Beyond neurological disease: new targets for edaravone (Review).
Topics: Animals; Antipyrine; Apoptosis; Cardiovascular Diseases; Edaravone; Free Radical Scavengers; Free Ra | 2011 |
1 trial available for antipyrine and Necrosis
| Article | Year |
|---|---|
Effect of edaravone on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma after radiotherapy: a randomized controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Antipyrine; Brain Injuries; Carcinoma; Case-Control Studies; Edaravo | 2014 |
26 other studies available for antipyrine and Necrosis
| Article | Year |
|---|---|
Protective effects of the free radical scavenger edaravone against glutamate neurotoxicity in nearly pure neuronal culture.
Topics: Animals; Antipyrine; Apoptosis; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Ed | 2009 |
Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage.
Topics: Adrenergic Antagonists; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti | 2012 |
Myocardial protection of MCI-186 in rabbit ischemia-reperfusion.
Topics: Animals; Antipyrine; Blood Pressure; Disease Models, Animal; Edaravone; Electrocardiography; Free Ra | 2002 |
[LOCAL COMPLICATIONS OF INTRAVENOUS ANESTHESIA].
Topics: Anesthesia; Anesthesia, Intravenous; Anesthetics; Antipyrine; Glycerol; Hexobarbital; Humans; Inject | 1964 |
A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acute Disease; Alanine Transaminase; Aldehydes; Animals; Antipyrine; Ap | 2003 |
Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia.
Topics: Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Antipyrine; Apoptosis; Apoptosis Inducin | 2007 |
Edaravone, a potent free radical scavenger, prevents anthracycline-induced myocardial cell death.
Topics: Animals; Anthracyclines; Antipyrine; Apoptosis; Caspase 3; Cell Survival; Cells, Cultured; Daunorubi | 2007 |
Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine.
Topics: Acetaminophen; Animals; Antipyrine; Caffeine; Cardiovascular Diseases; Heart; Male; Myocardial Infar | 1981 |
Observations on drug-induced toxic epidermal necrolysis in Singapore.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antipyrine; Barbiturates; Burns; Child; Diagnosis, Differenti | 1984 |
The predictive value of changes in antipyrine pharmacokinetics in halothane and paracetamol induced hepatic necrosis in rats.
Topics: Acetaminophen; Animals; Antipyrine; Chemical and Drug Induced Liver Injury; Half-Life; Halothane; Ki | 1983 |
Cytochrome P450 and glutathione in the liver of rats under exclusive sucrose ingestion.
Topics: Acetaminophen; Animals; Antipyrine; Body Weight; Cholesterol Side-Chain Cleavage Enzyme; Fasting; Gl | 1993 |
Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart.
Topics: Animals; Antioxidants; Antipyrine; Creatine Kinase; Edaravone; Free Radical Scavengers; Humans; In V | 1996 |
Technetium-99m HL91 uptake as a tumour hypoxia marker: relationship to tumour blood flow.
Topics: Animals; Antipyrine; Autoradiography; Blood Volume; Carbon Radioisotopes; Carcinoma 256, Walker; Cel | 1999 |
Blood flow in normal and injured monkey spinal cord.
Topics: Animals; Antipyrine; Autoradiography; Carbon Dioxide; Carbon Radioisotopes; Cardiac Output; Cats; Ch | 1975 |
Failure to confirm a vascular cause of muscular dystrophy.
Topics: Adult; Animals; Antipyrine; Autoradiography; Blood Circulation; Child; Humans; Iodine Radioisotopes; | 1975 |
Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours.
Topics: Adenosine Triphosphate; Animals; Antipyrine; Autoradiography; Cricetinae; Luminescent Measurements; | 1992 |
Water-jet-cooled Nd:YAG laser coagulation: selective destruction of rat liver metastases.
Topics: Adenocarcinoma; Alanine Transaminase; Aluminum Silicates; Animals; Antipyrine; Aspartate Aminotransf | 1991 |
Neurotoxicity after intracarotid 1,3-bis(2-chloroethyl)-1-nitrosourea administration in the rat: hemodynamic changes studied by double-tracer autoradiography.
Topics: Aminobutyrates; Amygdala; Animals; Antipyrine; Autoradiography; Blood-Brain Barrier; Carbon Radioiso | 1991 |
Propyphenazone-induced serum sickness.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Female; Humans; Middle Aged; Necrosis; Predniso | 1990 |
Phosphorus-31 magnetic resonance spectroscopy and blood perfusion of the RIF-1 tumor following X-irradiation.
Topics: Adenosine Triphosphate; Animals; Antipyrine; Energy Metabolism; Magnetic Resonance Spectroscopy; Mal | 1989 |
Morphological changes in the liver due to phenazone and its derivatives.
Topics: Antipyrine; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Fatty Liver; Granulom | 1986 |
Abnormal drug metabolism after barbiturate and paracetamol overdose.
Topics: Acetaminophen; Adult; Aged; Alanine Transaminase; Amobarbital; Antipyrine; Barbiturates; Bilirubin; | 1974 |
Use of radioisotopes in assessment of distal blood flow and distal blood pressure in arterial insufficiency.
Topics: Aged; Amputation, Surgical; Antipyrine; Arterial Occlusive Diseases; Blood Flow Velocity; Blood Pres | 1974 |
Vascularization of the femoral head following fracture of the neck of the femur.
Topics: Adult; Age Factors; Aged; Antipyrine; Female; Femoral Neck Fractures; Femur Head; Fractures, Bone; H | 1970 |
Short-term study of the effect of phenacetin, phenazone and amidopyrine on the rat kidney.
Topics: Albuminuria; Aminopyrine; Animals; Antipyrine; Blood Urea Nitrogen; Body Weight; Carbohydrates; Crea | 1968 |
Tumor blood flow. II. Distribution of blood flow in experimental tumors.
Topics: Animals; Antipyrine; Chromium Isotopes; Coloring Agents; Cricetinae; Iodine Isotopes; Liver Circulat | 1969 |