P2Y purinoceptor 12

A P2Y purinoceptor 12 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H244]

Synonyms

P2Y12;
ADP-glucose receptor;
ADPG-R;
P2T(AC);
P2Y(AC);
P2Y(cyc);
P2Y12 platelet ADP receptor;
P2Y(ADP);
SP1999

Research

Bioassay Publications (21)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (4.76)	18.2507
2000's	6 (28.57)	29.6817
2010's	9 (42.86)	24.3611
2020's	5 (23.81)	2.80

Compounds (29)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
emodin	Homo sapiens (human)	Ki	10.0000	1	1
mitoxantrone	Homo sapiens (human)	Ki	10.0000	1	1
benzotriazole	Homo sapiens (human)	IC50	7,430.0000	1	1
aloe emodin	Homo sapiens (human)	Ki	10.0000	1	1
chrysophanic acid	Homo sapiens (human)	Ki	10.0000	1	1
physcione	Homo sapiens (human)	Ki	10.0000	1	1
diadenosine tetraphosphate	Homo sapiens (human)	IC50	250.0000	1	1
clopidogrel	Homo sapiens (human)	IC50	2.4000	1	1
spiroglumide	Homo sapiens (human)	IC50	1.2230	1	1
methylthio-adp	Homo sapiens (human)	Ki	0.0321	1	1
emodin anthrone	Homo sapiens (human)	Ki	10.0000	1	1
frangulin b	Homo sapiens (human)	Ki	10.0000	1	1
phosphoramidon	Homo sapiens (human)	IC50	0.0170	1	1
ar c67085mx	Homo sapiens (human)	IC50	0.0025	1	1
lofepramine hydrochloride	Homo sapiens (human)	IC50	0.3500	1	1
salvianolic acid B	Homo sapiens (human)	Ki	36.4000	1	1
prasugrel	Homo sapiens (human)	IC50	1.8000	1	1
cangrelor	Homo sapiens (human)	IC50	0.0043	5	5
alloin	Homo sapiens (human)	Ki	10.0000	1	1
ticagrelor	Homo sapiens (human)	IC50	1.1028	5	5
ticagrelor	Homo sapiens (human)	Ki	0.0080	2	2
salvianolic acid c	Homo sapiens (human)	Ki	15.6000	1	1
elinogrel	Homo sapiens (human)	IC50	3.3533	3	3
elinogrel	Homo sapiens (human)	Ki	0.0230	2	2
azd1283	Homo sapiens (human)	IC50	0.6959	10	10
acid blue 40	Homo sapiens (human)	Ki	10.0000	1	1
acid blue 25	Homo sapiens (human)	IC50	3.1200	1	1
acid blue 25	Homo sapiens (human)	Ki	9.8300	2	2
acid blue 129	Homo sapiens (human)	Ki	10.0000	1	1
tetracycline	Homo sapiens (human)	Ki	10.0000	1	1
chlortetracycline	Homo sapiens (human)	Ki	10.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
leukotriene e4	Homo sapiens (human)	EC50	0.0013	1	1
ar c67085mx	Homo sapiens (human)	EC50	0.0013	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
G protein-coupled adenosine receptor activity	molecular function	Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:mah, PMID:9755289]
G protein-coupled ADP receptor activity	molecular function	Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah, GOC:signaling, PMID:11196645]
guanyl-nucleotide exchange factor activity	molecular function	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]
G protein-coupled purinergic nucleotide receptor activity	molecular function	Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah, PMID:9755289]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
cell projection membrane	cellular component	The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. [GOC:krc, GOC:mah]
cell body membrane	cellular component	The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections. [GOC:ecd]

Involved In

This protein is involved in 27 target(s):

Target	Category	Definition
G protein-coupled adenosine receptor signaling pathway	biological process	The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. [GOC:dph]
monoatomic ion transport	biological process	The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
substrate-dependent cell migration, cell extension	biological process	The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell. [ISBN:0815316194, PMID:11944043, PMID:14657486]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
phospholipase C-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
hemostasis	biological process	The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. [ISBN:0198506732]
calcium-mediated signaling	biological process	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling]
cerebral cortex radial glia-guided migration	biological process	The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
cell projection organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
lamellipodium assembly	biological process	Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. [GOC:mah, ISBN:0815316194]
platelet activation	biological process	A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. [http://www.graylab.ac.uk/omd/]
positive regulation of integrin activation by cell surface receptor linked signal transduction	biological process	Any process that activates or increases the frequency, rate, or extent of integrin activation by cell surface receptor linked signal transduction. This can occur by increased affinity of an integrin for its extracellular ligands. [GOC:add, PMID:12213832, PMID:14754902]
positive regulation of cell adhesion mediated by integrin	biological process	Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin. [GOC:add]
G protein-coupled purinergic nucleotide receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:BHF, PMID:9755289]
positive regulation of monoatomic ion transport	biological process	Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:jl]
response to axon injury	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
regulation of chemotaxis	biological process	Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. [GOC:ai]
positive regulation of chemotaxis	biological process	Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. [GOC:ai]
establishment of localization in cell	biological process	Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. [GOC:ai, GOC:dos, GOC:dph, GOC:tb]
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
platelet aggregation	biological process	The adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:BHF, GOC:vk]
cellular response to ATP	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. [GOC:mah]
visual system development	biological process	The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways. [GOC:aruk, GOC:bc, GOC:krc, PMID:15004427, PMID:20647017, PMID:22632727]
positive regulation of ruffle assembly	biological process	Any process that activates or increases the frequency, rate or extent of ruffle assembly. [GOC:TermGenie, GOC:yaf]
regulation of microglial cell migration	biological process	Any process that modulates the frequency, rate or extent of microglial cell migration. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
positive regulation of microglial cell migration	biological process	Any process that activates or increases the frequency, rate or extent of microglial cell migration. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]

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