Compounds > basic red 51
Page last updated: 2024-12-08

basic red 51

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Basic Red 51: a semi-permanent hair dye, cytotoxic to human skin cells; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID166491
SCHEMBL ID334242
SCHEMBL ID334243
MeSH IDM000595155

Synonyms (40)

Synonym
77061-58-6
12270-25-6
2-((4-(dimethylamino)phenyl)azo)-1,3-dimethyl-1h-imidazolium chloride
basic red 51
1h-imidazolium, 2-(2-(4-(dimethylamino)phenyl)diazenyl)-1,3-dimethyl-, chloride (1:1)
einecs 278-601-4
1h-imidazolium, 2-((4-(dimethylamino)phenyl)azo)-1,3-dimethyl-, chloride
unii-a7a946jj6i
a7a946jj6i ,
1h-imidazolium,2-[2-[4-(dimethylamino)phenyl]diazenyl]-1,3-dimethyl-, chloride (1:1)
ci basic red 51
ruby red
1h-imidazolium, 2-[2-[4-(dimethylamino)phenyl]diazenyl]-1,3-dimethyl-, chloride (1:1)
vibracolor ruby red
2-[2-[4-(dimethylamino)phenyl]diazenyl]-1,3-dimethyl-1h-imidazolium chloride (1:1)
1016649-33-4
2-(4-(dimethylamino-phenylazo)-1,3-dimethyl-1,3-dimethyl-3h-imidazol- 1-ium chloride
1h-imidazolium, 2-[(1e)-2-[4-(dimethylamino)phenyl]diazenyl]-1,3-dimethyl-, chloride (1:1)
basic red 51 [inci]
colorex br51
SCHEMBL334242
SCHEMBL334243
1h-imidazolium, 2-[[4-(dimethylamino)phenyl]azo]-1,3-dimethyl-, chloride
2-[[4-(dimethylamino)phenyl]azo]-1,3-dimethyl-1h-imidazolium chloride
c.i. basic red 51
J-004845
DTXSID80874049
2-[2-[4-(dimethylamino)phenyl]diazenyl]-1,3-dimethyl-1h-imidazolium chloride
AS-17151
Q27273724
basicred51
4-[(1,3-dimethylimidazol-1-ium-2-yl)diazenyl]-n,n-dimethylaniline;chloride
1h-imidazolium, 2-[[4-(dimethylamino)phenyl]azo]-1,3-dimethyl-, chloride (9ci); 2-[2-[4-(dimethylamino)phenyl]diazenyl]-1,3-dimethyl-1h-imidazolium chloride (1:1)
AKOS037643593
2-{2-[4-(dimethylamino)phenyl]diazen-1-yl}-1,3-dimethyl-1h-imidazol-3-ium chloride
mip red 2985
rosso di base 51
rojo basico 51
vermelho basico 51
rouge de base 51

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" In this study, we investigated the toxic effects of two hair dyes, Basic Red 51 (BR51) and Basic Brown 17 (BB17), which are temporary dyes of the azo group (R-N=N-R'), used in the composition of the black hair dye."( Cytotoxic and genotoxic effects of two hair dyes used in the formulation of black color.
Fernandes, TC; Marin-Morales, MA; Suares-Rocha, P; Tafurt-Cardona, Y, 2015)		0.65
" Degradation of ERY by light prevented all toxic effects previously observed, suggesting a cheap, fast and easy alternative treatment of effluents containing this natural dye."( Toxicity of dyes to zebrafish at the biochemical level: Cellular energy allocation and neurotoxicity.
Abe, FR; Gravato, C; Oliveira, DP; Soares, AMVM, 2018)		0.48
" The toxic mode of action of Basic Blue 99 seems to be the induction of cell death, without genotoxic effects, but while the necrotic pathway is observed in HaCaT monolayer cell culture, was apoptosis seen in the Equivalent Human Epidermis (EHE) model."( Immortalized equivalent human epidermis as a platform to evaluation hair dyes toxicity: Efficiency comparison between 3D and monolayer culture.
Dorta, DJ; Maria-Engler, SS; Mini, CA; Oliveira, DP, 2020)		0.56
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (77.78)24.3611
2020's2 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.25 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index42.09 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (33.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dinitrochlorobenzene
Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.. 1-chloro-2,4-dinitrobenzene : A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.		2.2510C-nitro compound;
monochlorobenzenes		allergen;
epitope;
sensitiser
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.		2.2510sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
hydroquinone
[no description available]		2.2510benzenediol;
hydroquinones		antioxidant;
carcinogenic agent;
cofactor;
Escherichia coli metabolite;
human xenobiotic metabolite;
mouse metabolite;
skin lightening agent
pyrogallol
benzenetriol : A triol in which three hydroxy groups are substituted onto a benzene ring.		2.2510benzenetriol;
phenolic donor		plant metabolite
kojic acid
[no description available]		2.17104-pyranones;
enol;
primary alcohol		Aspergillus metabolite;
EC 1.10.3.1 (catechol oxidase) inhibitor;
EC 1.10.3.2 (laccase) inhibitor;
EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 1.4.3.3 (D-amino-acid oxidase) inhibitor;
NF-kappaB inhibitor;
skin lightening agent
resorcinol
resorcinol: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7951. resorcinol : A benzenediol that is benzene dihydroxylated at positions 1 and 3.		2.2510benzenediol;
phenolic donor;
resorcinols		erythropoietin inhibitor;
sensitiser
triclosan
[no description available]		2.1710aromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols		antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
lawsone
lawsone: a molluscacide from leaves of Lawsonia inermis L. topical sunscreening agent; structure; powdered leaves of Lawsonia inermis(Lythraceae) used as brown hair dye. lawsone : 1,4-Naphthoquinone carrying a hydroxy function at C-2. It is obtained from the leaves of Lawsonia inermis.		2.2510
triclocarban
triclocarban: bacteriostat; antiseptic in soaps & other cleansing solns; germicide; structure. triclocarban : A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.		2.1710dichlorobenzene;
monochlorobenzenes;
phenylureas		antimicrobial agent;
antiseptic drug;
disinfectant;
environmental contaminant;
xenobiotic
4-phenylenediamine
4-phenylenediamine: agent hair dye responsible for contact dermatitis; RN given refers to parent cpd. 1,4-phenylenediamine : A phenylenediamine in which the amino functions are at positions 1 and 4 of the benzene nucleus.		2.2510phenylenediamineallergen;
dye;
hapten;
reagent
2-naphthol
2-naphthol: RN given refers to parent cpd. 2-naphthol : A naphthol carrying a hydroxy group at position 2.. naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent.		2.1710naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
alpha-aminopyridine
alpha-aminopyridine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #485. aminopyridine : Compounds containing a pyridine skeleton substituted by one or more amine groups.		2.2510
2,7-dihydroxynaphthalene
[no description available]		2.1710
4-amino-2-hydroxytoluene
4-amino-2-hydroxytoluene: an ingredient in oxidative hair coloring products; structure in first source		2.2510
2-amino-3-hydroxypyridine
[no description available]		2.2510aminopyridine;
monohydroxypyridine
1,4-diaminoanthraquinone
[no description available]		2.2510
basic blue 99
Basic Blue 99: causes contact dermatitis; structure given in first source		2.2510
sodium dodecyl sulfate
Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.		2.2510organic sodium saltdetergent;
protein denaturant
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.		2.6620
ConditionIndicatedRelationship StrengthStudiesTrials
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		02.5520
Cardiac Toxicity
[description not available]		02.1710
Cardiotoxicity
Damage to the HEART or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.		02.1710