histamine

Research Excerpts

Overview

Histamine is a multifunctional hormone that regulates smooth muscle contraction in the airways, acid secretion in the gut, and neurotransmitter release in the central nervous system. The histamine H(4) receptor is a G protein-coupled receptor that has attracted much interest for its role in inflammatory and immunomodulatory functions.

Excerpt	Reference	Relevance
"Histamine is a multifunctional hormone that regulates smooth muscle contraction in the airways, acid secretion in the gut, and neurotransmitter release in the central nervous system through three well characterized receptor subtypes, H(1), H(2), H(3), respectively. "	( Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Blevitt, J; Carruthers, N; Chai, W; Hofstra, CL; Jiang, X; Li, X; Liu, C; Lovenberg, TW; Ma, X; Pyati, J; Wilson, SJ, 2001)	2
"The histamine H(4) receptor is a G protein-coupled receptor that has attracted much interest for its role in inflammatory and immunomodulatory functions. "	( Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics. Bessembinder, K; de Esch, IJ; Kuhne, S; Leurs, R; Lim, HD; Smits, RA; van der Meer, T; Wijtmans, M; Zuiderveld, OP, 2012)	1.23
"Histamine is an important endogenous signaling molecule that is involved in a number of physiological processes including allergic reactions, gastric acid secretion, neurotransmitter release, and inflammation. "	( Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators. Savall, BM; Thurmond, RL; Tichenor, MS; Venable, JD, 2015)	2.12
"Histamine is a natural amine derived from L-histidine. "	( Food Intolerance: The Role of Histamine. Deeva, TA; Ivashkin, VT; Kaysheva, AL; Kopylov, AT; Malsagova, KA; Nechaev, VM; Popova, IR; Shulpekova, YO, 2021)	2.35
"Histamine is a small monoamine signaling molecule that plays a role in many peripheral and central physiological processes, including the regulation of wakefulness. "	( The Role of the Central Histaminergic System in Behavioral State Control. Arrigoni, E; Fuller, PM, 2022)	2.47
"Histamine is a mediator produced by mast cells in the conjunctiva during the allergic response."	( Resolvin D2 and Resolvin D1 Differentially Activate Protein Kinases to Counter-Regulate Histamine-Induced [Ca Bair, J; Botten, N; Dartt, DA; Hodges, R; Serhan, CN; Utheim, TP; Yang, M, 2021)	1.56
"Histamine is an interesting biomarker released in scalp affected by dandruff and SD even though the mechanism is not well understood yet."	( Relationship between scalp histamine levels and dandruff within an Indian population: A confirmation study using LC/MS/MS method. Bourokba, N; Choudhury, RP; Eilstein, J; Jourdain, R; Ngo, T; Roy, N; Vedula, SK; Vijayaraghavan, S, 2022)	1.74
"Histamine is a biogenic amine significantly formed in fish sauce leading to a major concern in consumers. "	( The functional starter and its genomic insight for histamine degradation in fish sauce. Abhisingha, M; Booncharoen, A; Chantarasakha, K; Mhuantong, W; Pitaksutheepong, C; Santiyanont, P; Tepaamorndech, S; Tepkasikul, P; Visessanguan, W, 2022)	2.42
"Histamine (HA) is an indicator of food freshness and quality. "	( Rapid and Wash-Free Time-Gated FRET Histamine Assays Using Antibodies and Aptamers. Chen, ZJ; Fu, HJ; Hildebrandt, N; Luo, L; Su, R; Sørensen, TJ; Xu, ZL, 2022)	2.44
"Histamine is a fermented food product that exerts adverse health effects on animals when consumed in high amounts. "	( Histamine avoidance through three gustatory receptors in Drosophila melanogaster. Aryal, B; Lee, Y, 2022)	3.61
"Histamine is a biogenic amine with four types of receptors."	( Therapeutic Potential of Histamine H3 Receptors in Substance Use Disorders. Di Ciano, P; Hendershot, CS; Le Foll, B, 2022)	1.75
"Histamine is a biogenic amine produced in fish by the action of certain groups of bacteria which are capable of producing an exogenous enzyme called histidine decarboxylase (HDC)."	( Influence of polyamine production and proteolytic activities of co-cultivated bacteria on histamine production by Morganiella morganii. Dam Roy, S; Devivilla, S; Kumar H, S; Lekshmi, M; Nayak, BB; Salam, F; Valappil, RK, 2023)	1.85
"Histamine is an organic nitrogenous compound that mediates a plethora of cell processes via different receptors."	( Mycobacterium tuberculosis Utilizes Host Histamine Receptor H1 to Modulate Reactive Oxygen Species Production and Phagosome Maturation via the p38MAPK-NOX2 Axis. Cai, Y; Chen, X; Dai, Y; Deng, G; Guo, J; Long, X; Mo, S; Peng, B; Xiao, W; Xu, D; Xu, Y; Ye, T; Zeng, J; Zhang, P; Zhang, X, 2022)	1.71
"Histamine is a pivotal mammalian immune modulator, and recently it was shown to be present in high concentrations in household dust from homes infested with bed bugs."	( Histamine Excretion by the Common Bed Bug (Hemiptera: Cimicidae). DeVries, ZC; Gaire, S; Principato, S; Schal, C, 2022)	2.89
"Histamine is a major neurotransmitter and alleviates neuronal damage after ischemic injury via H"	( Selective histamine H Awane, H; Ezaki, M; Hishinuma, S; Inazuki, N; Michinaga, S; Mizuguchi, H; Shimizu, K; Sonoda, K, 2022)	2.57
"Histamine is a major mediator released by mast cells in allergic inflammation and response."	( Histamine induced high mobility group box-1 release from vascular endothelial cells through H Gao, S; Ku, W; Liu, K; Nishibori, M; Qiao, H; Teshigawara, K; Wake, H; Wang, D, 2022)	2.89
"Histamine is an important monoamine neurotransmitter that regulates multiple physiological activities in both vertebrates and invertebrates. "	( Han, Y; Liang, Y; Peng, L; Wang, T; Xie, J, 2022)	2.16
"Histamine (HIS) is a potent vasodilator that contributes to anaphylactic reactions. "	( The potential mechanism of histamine-inducing cardiopulmonary inflammation and apoptosis in a novel oral model of rat intoxication. Hassanen, EI; Kamel, S; Mahmoud, MA; Mansour, HA; Mohamed, WA, 2023)	2.65
"Histamine is a critical mediator of anaphylaxis, a neurotransmitter, and a regulator of gastric acid secretion. "	( The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis. Finkelman, FD; Gao, J; Guan, X; Huang, H; Li, Y; Morris, SC; Zhao, D, 2023)	2.6
"Histamine (HA) is a key biogenic monoamine involved in a wide range of physiological and pathological processes in both the central and peripheral nervous systems. "	( Genetically encoded sensors for measuring histamine release both in vitro and in vivo. Dong, H; Leurs, R; Li, G; Li, M; Li, Y; Lin, Y; Liu, C; Ma, X; Qian, T; Vischer, HF; Wang, H; Yan, Y, 2023)	2.62
"Histamine is a well-known inflammatory mediator, but how histamine induces angiogenesis remains poorly understood. "	( Histamine promotes angiogenesis through a histamine H1 receptor-PKC-VEGF-mediated pathway in human endothelial cells. Hatipoglu, OF; Mori, S; Nishibori, M; Nishinaka, T; Takahashi, H; Toyomura, T; Wake, H; Watanabe, M; Yaykasli, KO, 2023)	3.8
"Histamine is a conserved neuromodulator in mammalian brains and critically involved in many physiological functions. "	( Whole-brain mapping of histaminergic projections in mouse brain. An, S; Chen, Z; Dong, H; Gong, H; Hu, W; Li, A; Li, M; Li, Y; Lin, W; Luo, Q; Pan, G; Wang, Y; Xu, L; Zhao, M; Zheng, Y, 2023)	2.66
"Histamine is a component of the bed bug aggregation pheromone. "	( Spatial distribution of histamine in bed bug-infested homes. DeVries, ZC; González-Morales, MA; Gordon, JM; Menechella, M; Santangelo, RG; Schal, C, 2023)	2.66
"Histamine is a biologically active molecule that serves as a reliable predictor of the quality of fish. "	( Humanoid shaped optical fiber plasmon biosensor functionalized with graphene oxide/multi-walled carbon nanotubes for histamine detection. Jha, R; Kumar, S; Li, G; Marques, C; Singh, R; Wang, Z; Xie, Y; Zhang, B; Zhang, W, 2023)	2.56
"Histamine is a biogenic amine implicated in various biological and pathological processes. "	( P19-derived neuronal cells express H Annabi, B; Lafortune, C; Marcocci, L; Mateescu, MA; Neree, AT; Paquin, J; Perez, MG; Pietrangeli, P; Suarez, NG; Tanasie, G, 2023)	2.35
"Histamine is a biogenic amine that regulates multiple physiological functions in diverse organisms, specifically playing a central role in the mammalian immune response. "	( Histamine excretion in common indoor and hematophagous arthropods. Campbell, K; Choe, DH; DeVries, Z; Lee, CY; Principato, S; Romero, A; Schal, C, 2023)	3.8
"Histamine is a biogenic amine that participates in allergic and inflammatory processes by stimulating histamine receptors. "	( Structural insights into the agonists binding and receptor selectivity of human histamine H Asada, H; Fujita-Fujiharu, Y; Hisano, H; Im, D; Ito, A; Iwata, S; Kato, T; Kishikawa, JI; Noda, T; Shiimura, Y; Sugita, Y, 2023)	2.58
"Histamine is a neuromodulator that affects gut motility and visceral sensitivity through intrinsic and extrinsic neural pathways, yet the mechanisms regulating histamine availability in these pathways remain poorly understood. "	( Sexually Dimorphic Effects of Histamine Degradation by Enteric Glial Histamine Demireva, EY; Gonzales, J; Gulbransen, BD; McClain, JL; Morales-Soto, W; Parmar, V, 2023)	2.64
"XC8 (histamine glutarimide) is a novel agent which targets eosinophilic migration and mast cell degranulation and has shown anti-asthmatic effects in animal studies."	( Safety, pharmacokinetics and pharmacodynamics of a novel anti-asthmatic drug, XC8, in healthy probands. Badorrek, P; Ferko, B; Marth, K; Müller, M; Nebolsin, V; Pohl, W; Renner, A; Romanova, J; Schmutz, H, 2019)	1.03
"Histamine is a key molecule required for the functioning of the photoreceptor as well as mechanoreceptors."	( An infection of Enterobacter ludwigii affects development and causes age-dependent neurodegeneration in Drosophila melanogaster. Jayabalan, R; Mishra, M; Priyadarsini, S; Sahoo, M; Sahu, S, 2019)	1.24
"Histamine is a biogenic amine that is chiefly produced in mast cells and basophils and elicits an allergic response upon stimulation. "	( Lipopolysaccharide-induced expansion of histidine decarboxylase-expressing Ly6G Fujimura, T; Moriguchi, T; Ohtsu, H; Sato, A; Takai, J; Uemura, S; Yamamoto, M, 2019)	1.96
"Histamine is a major peripheral inflammatory mediator and a neurotransmitter in the central nervous system. "	( Histamine Induces Microglia Activation and the Release of Proinflammatory Mediators in Rat Brain Via H Qu, C; Zhang, S; Zhang, W; Zhang, X; Zhang, Y; Zhou, X, 2020)	3.44
"Histamine is a key inflammatory mediator known to trigger vasodilation and vessel hyperpermeability upon binding to its receptors and evoking intracellular Ca"	( Ca Meininger, CJ; Peng, X; Si, H; Wang, J; Zawieja, DC; Zhang, SL, 2020)	1.28
"Histamine is a biogenic amine, produced in spoiled fish and some fermented products, which causes a foodborne disease similar to an allergic reaction. "	( Modified Enzymatic Assays for the Determination of Histamine in Fermented Foods. Bakke, M; Isono, E; Shimoji, K, 2020)	2.25
"Histamine is a biogenic amine, produced in spoiled fish and some fermented products, which causes a foodborne disease similar to an allergic reaction. "	( Modified Enzymatic Assays for the Determination of Histamine in Fermented Foods. Bakke, M; Isono, E; Shimoji, K, 2020)	2.25
"Histamine is a bioactive monoamine that is synthesized by the enzymatic activity of histidine decarboxylase (HDC) in basophils, mast cells, gastric enterochromaffin-like (ECL) cells and histaminergic neuronal cells. "	( Histamine and histidine decarboxylase: Immunomodulatory functions and regulatory mechanisms. Moriguchi, T; Takai, J, 2020)	3.44
"Histamine (HA) is a major molecular mediator of inflammation, and mast cells residing in the gut are a primary source of histamine."	( Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation. Ahnstedt, H; Ayyaswamy, S; Blasco, MP; Blixt, F; Bryan, R; Chauhan, A; d'Aigle, J; Durgan, D; Ganesan, A; Ganesh, BP; Haag, A; Honarpisheh, P; Kofler, J; Major, A; McCullough, LD; Venable, S, 2020)	1.54
"Histamine is a chemical mediator, released predominantly by tissue mast cells, circulating basophils, and neurons, which are activated in response to various immunological and non-immunological stimuli. "	( Antihistamines in children and adolescents: A practical update. Ciprandi, G; Corsico, A; Leonardi, S; Licari, A; Marseglia, GL; Miraglia Del Giudice, M; Parisi, GF; Peroni, D; Salpietro, C, )	2.13
"Histamine acts as a neurotransmitter to regulate various physiological processes. "	( Chronic brain histamine depletion in adult mice induced depression-like behaviours and impaired sleep-wake cycle. Kikkawa, T; Naganuma, F; Osumi, N; Yamada, Y; Yanai, K; Yoshikawa, T, 2020)	2.36
"Histamine, which is a naturally occurring chemical in seafood, is known to cause undesirable inflammatory response when consumed in large amounts. "	( Portable molecularly imprinted polymer-based platform for detection of histamine in aqueous solutions. Lam, MHW; Lau, SC; Li, JH; Li, LY; Li, T; Roy, VAL; Sun, QJ; Venkatesh, S; Yeung, CC, 2021)	2.3
"Histamine is a key mediator in allergic and inflammatory processes in the small intestines; however, it is a challenge to determine histamine levels at the duodenal mucosa, and classical bioreceptors are unsuitable for use in the digestive medium of bowel fluid."	( Electropolymerized Receptor Coatings for the Quantitative Detection of Histamine with a Catheter-Based, Diagnostic Sensor. Cornelis, P; Doll, T; Peeters, M; Putzeys, T; Tack, J; Troost, F; Verhaert, N; Wackers, G; Wagner, P, 2021)	1.58
"Histamine poisoning is a significant public health and safety concern. "	( Histamine accumulation in dairy products: Microbial causes, techniques for the detection of histamine-producing microbiota, and potential solutions. Botello-Morte, L; García-Gonzalo, D; Moniente, M; Ontañón, I; Pagán, R, 2021)	3.51
"Histamine acts as a neurotransmitter in the central nervous system and is involved in numerous physiological functions. "	( Organic Cation Transporters in Brain Histamine Clearance: Physiological and Psychiatric Implications. Naganuma, F; Yoshikawa, T, 2021)	2.34
"Histamine is a critical inflammatory mediator in allergic diseases. "	( Targeted inhibition of allergen-induced histamine production by neutrophils. Alcañiz, L; Bellido, V; Chacón, P; Cornejo-García, JA; Del Valle Rodríguez, A; Doukkali, B; Monteseirín, J; Palacios, R; Puente, Y; Rivas-Pérez, D; Rodríguez, D; Vega-Rioja, A, 2021)	2.33
"Histamine is a highly pleiotropic biogenic amine involved in key physiological processes including neurotransmission, immune response, nutrition, and cell growth and differentiation. "	( Histamine, Metabolic Remodelling and Angiogenesis: A Systems Level Approach. Medina, MÁ; Moya-García, AA; Pino-Ángeles, A; Sánchez-Jiménez, F; Urdiales, JL, 2021)	3.51
"Histamine is a biogenic amine and a food safety hazard, and it is the only biogenic amine regulated by statute or hazard analysis and critical control point guidance. "	( Histamine Limits by Country: A Survey and Review. Arcieri, J; Bell, JW; Correa, G; DeBEER, J; Nolte, F, 2021)	3.51
"Histamine is a monoaminergic neurotransmitter which is released within the entire brain from ascending axons originating in the tuberomammillary nucleus in a sleep state-dependent fashion. "	( Histamine triggers microglial responses indirectly via astrocytes and purinergic signaling. Huang, Y; Kettenmann, H; Logiacco, F; Semtner, M; Xia, P, 2021)	3.51
"Histamine is a pleiotropic mediator involved in a broad spectrum of (patho)-physiological processes, one of which is the regulation of inflammation. "	( The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut. Neumann, D; Schirmer, B, 2021)	2.39
"Histamine is a key signal molecule in humans, with multiple functions, such as being a neurotransmitter or modulator of immune responses."	( Histamine: A Bacterial Signal Molecule. Fernández, M; Gavira, JA; Krell, T; Matilla, MA; Monteagudo-Cascales, E; Roca, A; Velando, F, 2021)	2.79
"Histamine is a biogenic amine playing a central role in allergy and peripheral inflammatory reactions and acts as a neurotransmitter and neuromodulator in the brain. "	( Histamine in the Crosstalk Between Innate Immune Cells and Neurons: Relevance for Brain Homeostasis and Disease. Bernardino, L, 2022)	3.61
"Histamine is a well-characterized neuromodulator that follows a circadian rhythm, regulates IOP and modulates retinal circuits and vision."	( Novel Insight of Histamine and Its Receptor Ligands in Glaucoma and Retina Neuroprotection. Lanzi, C; Lucarini, L; Masini, E; Sgambellone, S, 2021)	1.68
"Histamine is an important mediator of allergic reactions, and mucus hypersecretion is a major allergic symptom. "	( Synergistic mucus secretion by histamine and IL-4 through TMEM16A in airway epithelium. Cho, HJ; Choi, JY; Kang, JW; Kang, MJ; Kim, CH; Lee, HJ; Lee, SN; Lee, YH; Min, HJ; Namkung, W; Oh, R; Yoon, JH, 2017)	2.18
"Histamine (HA) is a biogenic amine that can accumulate to high concentration levels in food as a result of microbial activity and can cause toxic effects in consumers. "	( Portable amperometric immunosensor for histamine detection using Prussian blue-chitosan-gold nanoparticle nanocomposite films. Beier, RC; Dong, XX; Lei, HT; Luo, L; Mao, C; Shen, YD; Sun, YM; Xu, ZL; Yang, JY; Zhang, YF, 2017)	2.17
"Histamine intolerance is a disorder in the homeostasis of histamine due to a reduced intestinal degradation of this amine, mainly caused by diamine oxidase (DAO) enzyme deficiency, which provokes its accumulation in plasma and the appearance of adverse health affects. "	( New approach for the diagnosis of histamine intolerance based on the determination of histamine and methylhistamine in urine. Bernacchia, R; Comas-Basté, O; Latorre-Moratalla, ML; Veciana-Nogués, MT; Vidal-Carou, MC, 2017)	2.18
"Histamine iontophoresis is a well-standardized in vivo model to quantitatively study the early stages of cutaneous inflammation with minimal impact on the skin barrier. "	( Histamine Iontophoresis as in vivo Model to Study Human Skin Inflammation with Minimal Barrier Impairment: Pilot Study Results of Application of the Model to a Sensitive Skin Panel. Falcone, D; Richters, R; Uzunbajakava, N; van de Kerkhof, PCM; van Erp, PEJ, 2017)	3.34
"Histamine is a toxic chemical and is the causative agent of food poisoning. "	( Degradation of Histamine by Lactobacillus plantarum Isolated from Miso Products. Huang, YL; Huang, YR; Kung, HF; Lee, YC; Su, YC; Tsai, YH, 2017)	2.25
"Histamine is a biogenic amine with extensive effects on many immune cell types. "	( Immune regulation by histamine and histamine-secreting bacteria. Akdis, CA; Barcik, W; O'Mahony, L; Wawrzyniak, M, 2017)	2.22
"Histamine is an important chemical mediator in the development of allergic rhinitis and plays a key role in eliciting the nasal symptoms of the disorder. "	( Expression and localization of histamine H Li, L; Tang, Y; Xia, Q; Yu, C, 2017)	2.18
"Histamine is a neurotransmitter that regulates diverse physiological functions including the sleep-wake cycle. "	( Histamine N-methyltransferase regulates aggression and the sleep-wake cycle. Iida, T; Kárpáti, A; Matsuzawa, T; Miura, Y; Mochizuki, T; Mogi, A; Naganuma, F; Nakamura, T; Okamura, N; Yanai, A; Yanai, K; Yoshikawa, T, 2017)	3.34
"Histamine is a widely distributed biogenic amine involved in the regulation of an array of biological processes. "	( Histamine deficiency aggravates cardiac injury through miR-206/216b-Atg13 axis-mediated autophagic-dependant apoptosis. Abudupataer, M; Chen, J; Ding, S; Ge, J; Hong, T; Li, H; Wang, TC; Xu, L; Yang, X; Zhang, S; Zhang, W; Zhou, Z; Zou, Y, 2018)	3.37
"Histamine acts as a neurotransmitter to regulate various physiological functions in CNS. "	( [Analysis of brain histamine clearance using genetically engineered mice]. Nakamura, T; Yanai, K; Yoshikawa, T, )	1.9
"Histamine is a well-known mediator involved in skin allergic responses through up-regulation of pro-inflammatory cytokines. "	( Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-κB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT). Abas, F; Ahmad, S; Lai, KS; Nazarudin, NA; Razali, NA, 2018)	2.12
"Histamine is a biogenic amine that influences many immune cells. "	( Histamine contributes to severe pneumonia in pigs infected with 2009 pandemic H1N1 influenza virus. Jang, Y; Jin, M; Seo, SH, 2018)	3.37
"Histamine is a key biological signaling molecule. "	( High-Affinity Chemotaxis to Histamine Mediated by the TlpQ Chemoreceptor of the Human Pathogen Pseudomonas aeruginosa. Conejero-Muriel, M; Corral-Lugo, A; Gavira, JA; Hida, A; Kato, J; Krell, T; Martín-Mora, D; Matilla, MA; Mesa Torres, N; Oku, S; Silva Jiménez, H, 2018)	2.22
"Histamine is a heterocyclic amine formed by decarboxylation of the amino acid l-histidine. "	( Current Trends in Detection of Histamine in Food and Beverages. Adam, V; Gagic, M; Jamroz, E; Kopel, P; Krizkova, S; Milosavljevic, V, 2019)	2.24
"Histamine is an important immunomodulator influencing both the innate and adaptive immune system. "	( Bacterial secretion of histamine within the gut influences immune responses within the lung. Akdis, CA; Altunbulakli, C; Barcik, W; Brescó, MS; Ferstl, R; Frei, R; Groeger, D; Krawczyk, K; O'Mahony, L; Pugin, B; Rinaldi, A; Sokolowska, M; Van Elst, D; Wawrzyniak, M; Westermann, P, 2019)	2.27
"Histamine is a well-known mediator of inflammation that is released from mast cells and basophils. "	( Expression of Histidine Decarboxylase and Its Roles in Inflammation. Hirasawa, N, 2019)	1.96
"Histamine is an inflammatory factor."	( An Herbal H2 Blocker in Melasma Treatment. Khoushabi, A; Mahjour, M, 2020)	1.28
"Histamine is known to be a principal causative agent associated with marine food poisoning outbreaks worldwide, which is typically formed in the contaminated food by decarboxylation of histidine by bacterial histidine decarboxylase. "	( Nanomaterials based optical and electrochemical sensing of histamine: Progress and perspectives. Nair, SS; Sai, VVR; Satija, J; Yadav, S, 2019)	2.2
"Histamine is a central mediator released from mast cells through allergic reactions."	( The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy. Ogasawara, M; Yamauchi, K, 2019)	1.61
"Histamine is an immune modulator, neuroprotective, and remyelinating agent, beneficially acting on skeletal muscles and promoting anti-inflammatory features in amyotrophic lateral sclerosis (ALS) microglia. "	( Histaminergic transmission slows progression of amyotrophic lateral sclerosis. Amadio, S; Apolloni, S; Cavallaro, S; Fabbrizio, P; Ferri, A; Latagliata, EC; Madaro, L; Morello, G; Proietti, D; Puglisi-Allegra, S; Salvatori, I; Spampinato, AG; Volonté, C, 2019)	3.4
"Histamine is a crucial mediator in the development of anaphylaxis. "	( Decreased intracellular histamine concentration and basophil activation in anaphylaxis. Hide, M; Ishii, K; Ohshimo, S; Shime, N; Yamaga, S; Yanase, Y, 2020)	2.31
"Histamine clearance is an essential process for avoiding excessive histaminergic neuronal activity. "	( Molecular mechanism of histamine clearance by primary human astrocytes. Harada, R; Iida, T; Kasajima, A; Mohsen, AS; Naganuma, F; Nakamura, T; Sasano, H; Yanai, K; Yoshikawa, T, 2013)	2.14
"Histamine is a potent biogenic amine that mediates numerous physiological processes throughout the body, including digestion, sleep, and immunity. "	( Characterization of gastric and neuronal histaminergic populations using a transgenic mouse model. Chuang, JC; Osborne-Lawrence, S; Park, WM; Perello, M; Sakata, I; Walker, AK; Zigman, JM, 2013)	2.1
"Histamine is an important mediator in the development of allergic reactions. "	( Histamine production by human neutrophils. Alcañiz, L; Aroca, R; Bergstralh, DT; Blanca, M; Chacón, P; El Bekay, R; Monteseirin, J; Vega, A; Ventura, I, 2013)	3.28
"Histamine is a biogenic monoamine that plays a role in several physiological functions, including induction of inflammatory reactions, wound healing, and regeneration."	( The neglected role of histamine in Alzheimer's disease. Mirshafiey, A; Naddafi, F, 2013)	1.43
"Histamine (HA) is a key regulator of experimental allergic encephalomyelitis (EAE), the autoimmune model of multiple sclerosis. "	( Systemic lack of canonical histamine receptor signaling results in increased resistance to autoimmune encephalomyelitis. Case, LK; del Rio, R; Noubade, R; Saligrama, N; Teuscher, C, 2013)	2.13
"Histamine acts as a modulatory neurotransmitter in the mammalian brain. "	( The histaminergic network in the brain: basic organization and role in disease. Nuutinen, S; Panula, P, 2013)	2.39
"histamine intolerance is a little known disease with a potentially relevant incidence. "	( Histamine intolerance as a cause of chronic digestive complaints in pediatric patients. Ferrés-Ramis, L; García-Teresa-García, E; Pérez-Esteban, G; Rosell-Camps, A; Vila-Vidal, M; Zibetti, S, 2013)	3.28
"Histamine is a major inflammatory mediator present in large quantities in asthmatic airways."	( Histamine stimulates hydrogen peroxide production by bronchial epithelial cells via histamine H1 receptor and dual oxidase. Boudreau, HE; Leto, TL; Park, JJ; Rada, B, 2014)	2.57
"Histamine is a regulator of the microcirculation and is supplied by release from its stores and/or by de novo production via the induction of histidine decarboxylase (HDC)."	( Roles played by histamine in strenuous or prolonged masseter muscle activity in mice. Endo, Y; Kumamoto, H; Niijima-Yaoita, F; Ohtsu, H; Sasaki, K; Sugawara, S; Tadano, T; Tsuchiya, M; Watanbe, M; Yanai, K; Yoneda, H, 2013)	1.46
"Histamine is an important mediator of allergic diseases. "	( Histamine downregulates the Th1-associated chemokine IP-10 in monocytes and myeloid dendritic cells. Glatzer, F; Gschwandtner, M; Gutzmer, R; Köther, B; Mommert, S; Stark, H; Werfel, T, 2014)	3.29
"Histamine is a biogenic amine with extensive effects on many cell types, mediated by the activation of its four receptors (H1R-H4R). "	( Histamine and gut mucosal immune regulation. Crameri, R; Jutel, M; O'Mahony, L; Smolinska, S, 2014)	3.29
"Histamine (HA) is a neurotransmitter synthesized in most mammalian tissues exclusively by histidine decarboxylase enzyme. "	( Histamine inhibits adrenocortical cell proliferation but does not affect steroidogenesis. Mondillo, C; Monzón, C; Pagotto, RM; Pereyra, EN; Pignataro, OP, 2014)	3.29
"Histamine is an inflammatory mediator that increases vascular permeability, and so we examined the effect of treating human umbilical vein endothelial cells (HUVECs) for 24 h with 1 μM simvastatin and 100 μM aspirin on histamine responsiveness."	( The inhibitory effect of simvastatin and aspirin on histamine responsiveness in human vascular endothelial cells. Absi, M; Bruce, JI; Ward, DT, 2014)	1.37
"Histamine is an important modulatory agent of the sympathetic neurotransmission, but its exact action on the testicular capsule or rat vas deferens is not fully understood. "	( A comparison of histamine effects on the sympathetic neurotransmission of testicular capsule and rat vas deferens. Caricati-Neto, A; da Silva Júnior, ED; de Souza, BP; Jurkiewicz, A; Jurkiewicz, NH; Rodrigues, JQ, 2014)	2.19
"Histamine is a potent mediator of inflammation and a regulator of innate and adaptive immune responses. "	( Histamine induces upregulated expression of histamine receptors and increases release of inflammatory mediators from microglia. Dong, H; He, S; Hu, G; Zeng, X; Zhang, H; Zhang, S; Zhang, W, 2014)	3.29
"Histamine is a potent mediator of allergic inflammation, substantially involved in asthmatic pathophysiology."	( Histamine induces human lung fibroblast-mediated collagen gel contraction via histamine H1 receptor. Horie, M; Jo, T; Kohyama, T; Mikami, Y; Nagase, T; Nakajima, J; Saito, A; Sakamoto, M; Takizawa, H; Yamauchi, Y, 2014)	2.57
"Histamine is an important immunomodulator involved in allergic reactions and inflammatory responses. "	( Stromal interaction molecule 1 (STIM1) and Orai1 mediate histamine-evoked calcium entry and nuclear factor of activated T-cells (NFAT) signaling in human umbilical vein endothelial cells. He, L; Jin, Y; Kuo, L; Muñoz-Garay, C; Peng, JM; Peng, X; Si, H; Zawieja, DC; Zhang, SL; Zheng, H; Zhou, MH; Zhou, Y, 2014)	2.09
"Histamine is a mast cell mediator released e.g. "	( Communication between mast cells and rat submucosal neurons. Althaus, M; Bell, A; Diener, M, 2015)	1.86
"Histamine is an important mediator of anaphylactic reactions. "	( Development of a UHPLC-MS/MS method for the determination of plasma histamine in various mammalian species. Chen, X; Hu, W; Liu, J; Wang, L; Zhong, D, 2014)	2.08
"Histamine is an important mediator in the pathophysiology of asthma. "	( Genetic variation within the histamine pathway among patients with asthma--a pilot study. Dai, H; Jones, BL; Raje, N; Vyhlidal, CA, 2015)	2.15
"Histamine is an important biogenic amine involved in regulating numerous physiological and pathophysiological processes in humans and animals. "	( Development and validation of a liquid-chromatography tandem mass spectrometry method to determine in vitro and in vivo histamine release. Boyne, MT; Chimalakonda, KC; Howard, KE; Pang, E; Patel, V; Weaver, JL, 2015)	2.07
"Histamine is a well-known mammalian acid secretagogue and it stimulates acid secretion through H2 receptors."	( Acute high blood glucose level attenuates histamine-stimulated acid secretion in male Wistar rats. Alada, AR; Olatunji, LA; Usman, TO, 2015)	1.4
"Histamine is a physiological amine which initiates a multitude of physiological responses by binding to four known G-protein coupled histamine receptor subtypes as follows: histamine H1 receptor (H1 R), H2 R, H3 R, and H4 R. "	( Histamine H3 receptor in primary mouse microglia inhibits chemotaxis, phagocytosis, and cytokine secretion. Harada, R; Iida, T; Iwata, R; Matsuzawa, T; Miura, Y; Mohsen, AS; Naganuma, F; Nakamura, T; Yanai, K; Yoshikawa, T, 2015)	3.3
"Histamine is an important mediator in the pathogenesis of asthma. "	( Genetic Variation along the Histamine Pathway in Children with Allergic versus Nonallergic Asthma. Anvari, S; Dai, H; Jones, BL; Vyhlidal, CA, 2015)	2.15
"Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues. "	( International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors. Chazot, PL; Cowart, M; Gutzmer, R; Haas, HL; Leurs, R; Liu, WL; Panula, P; Stark, H; Thurmond, RL, 2015)	2.1
"Histamine appears to be an important transmitter throughout the Animal Kingdom. "	( Histamine Immunoreactive Elements in the Central and Peripheral Nervous Systems of the Snail, Biomphalaria spp., Intermediate Host for Schistosoma mansoni. Croll, RP; Delgado, N; Habib, MR; Miller, MW; Mohamed, AH; Mossalem, HS; Osman, GY; Rolón-Martínez, S; Sharaf El-Din, AT; Torres, G, 2015)	3.3
"Histamine is a mediator of allergic inflammation released mainly from mast cells. "	( Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial Barrier Disruption In Vivo. Ashina, K; Hori, M; Kobayashi, K; Murata, T; Nakamura, T; Omori, K; Ozaki, H; Tsubosaka, Y, 2015)	3.3
"Histamine is a biogenic amine that is widely distributed and has multiple functions, but the role it plays in acute myocardial infarction (AMI) remains unclear. "	( Histamine deficiency exacerbates myocardial injury in acute myocardial infarction through impaired macrophage infiltration and increased cardiomyocyte apoptosis. Chen, J; Deng, L; Ding, S; Ge, J; Hong, T; Huang, Z; Jia, J; Lin, J; Wang, TC; Yang, X; Zou, Y, 2015)	3.3
"Histamine (HA) is a small amine playing an important role in anaphylactic reactions. "	( Histamine quantification in human plasma using high resolution accurate mass LC-MS technology. Amé-Thomas, P; Bendavid, C; Gicquel, T; Laurichesse, M; Moreau, C; Morel, I; Tarte, K; Tribut, O, 2016)	3.32
"Histamine is an endogenous nitrogenous compound with extensive effects on immunologic cells and involved in many physiological functions. "	( Histamine levels in embryonic chicken livers infected with very virulent infectious bursal disease virus. Cheng, X; He, L; Jia, Y; Li, J; Li, Y; Yang, D, 2015)	3.3
"Histamine is an important pleiotropic factor in neuroimmune regulation."	( Neuroimmune Crosstalk in CNS Disorders: The Histamine Connection. Aliev, G; Cacabelos, R; Fernández-Novoa, L; Torrellas, C, 2016)	1.42
"Histamine is an important chemical messenger that regulates multiple physiological processes in both vertebrate and invertebrate animals. "	( Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors. An, F; Borycz, J; Borycz, JA; Meinertzhagen, IA; Wang, T; Xu, Y, 2015)	3.3
"Histamine is a neurotransmitter crucial to the visual processing of Drosophila melanogaster. "	( Quantification of Histamine and Carcinine in Drosophila melanogaster Tissues. Borman, RP; Denno, ME; Privman, E; Venton, BJ; Wolin, DC, 2016)	2.21
"Histamine is an imidazolic compound performing a crucial function in the pathogenesis of inflammation. "	( Histamine and Histaminergic Receptors in Colorectal Cancer: From Basic Science to Evidence-based Medicine. Barone, M; Di Leo, A; Girardi, B; Ierardi, E; Losurdo, G; Pricci, M; Principi, M, 2018)	3.37
"Histamine is a primordial signalling molecule, capable of activating cells in an autocrine or paracrine fashion via specific cell surface receptors, in a variety of pathways that probably predate its more recent role in innate and adaptive immunity. "	( Evidence of a broad histamine footprint on the human exercise transcriptome. Dreyer, HC; Ely, MR; Halliwill, JR; Hocker, AD; Luttrell, MJ; Mangum, JE; Romero, SA; Sieck, DC; Struck, AJ; Turnbull, DW, 2016)	2.2
"Histamine is a primordial signalling molecule, capable of activating cells in an autocrine or paracrine fashion via specific cell surface receptors. "	( Evidence of a broad histamine footprint on the human exercise transcriptome. Dreyer, HC; Ely, MR; Halliwill, JR; Hocker, AD; Luttrell, MJ; Mangum, JE; Romero, SA; Sieck, DC; Struck, AJ; Turnbull, DW, 2016)	2.2
"Histamine is a biogenic molecule that plays a role in many physiological pathways via binding to a specific receptor. "	( Histamine Stimulates Ciliary Beat Frequency via the H2 Receptor in the Protochordate Botryllus schlosseri. Cima, F; Franchi, N, 2016)	3.32
"Histamine is an important neurotransmitter that exerts its physiological actions through H1-4 metabotropic receptors in mammals. "	( Mutagenesis and computational docking studies support the existence of a histamine binding site at the extracellular β3+β3- interface of homooligomeric β3 GABAA receptors. Ernst, M; Fleck, MW; Hoerbelt, P; Hough, LB; Ramerstorfer, J; Sieghart, W; Thomson, JL, 2016)	2.11
"Histamine (HA) is a pleiotropic monoamine involved in several neurophysiological functions, neuroimmune regulation, and CNS pathogenesis."	( Histamine and Immune Biomarkers in CNS Disorders. Cacabelos, R; Fernández-Novoa, L; López-Muñoz, F; Torrellas, C, 2016)	2.6
"Histamine is a potent vasodilator that has been found to increase during exercise. "	( Histamine H2 receptor blockade augments blood pressure responses to acute submaximal exercise in males. Choi, HM; Doh, HW; Kim, JK; Nho, H; Park, J; Stebbins, CL, 2016)	3.32
"Histamine is an amine widely known as a peripheral inflammatory mediator and as a neurotransmitter in the central nervous system. "	( Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation. Alves, G; Bernardino, L; Cortes, L; Cristóvão, AC; Esteves, M; Ferreira, R; Je, G; Kim, YS; Klibanov, A; Rocha, SM; Santos, T; Saraiva, C; Saraiva, T; Valero, J, 2016)	3.32
"Histamine is a key immunoregulatory mediator in immediate-type hypersensitivity reactions and chronic inflammatory responses, in particular histamine suppresses proinflammatory responses to bacterial ligands, through histamine receptor 2 (H2R). "	( Histamine Receptor 2 is Required to Suppress Innate Immune Responses to Bacterial Ligands in Patients with Inflammatory Bowel Disease. Akdis, CA; Ferstl, R; Frei, R; Groeger, D; Jutel, M; Konieczna, P; OʼMahony, L; Perez, NR; Schiavi, E; Smolinska, S, 2016)	3.32
"Low-histamine diet is a therapeutically useful, simple and cost-free tool to decrease symptoms and increase quality of life in CsU patients with gastrointestinal involvement. "	( A Popular myth - low-histamine diet improves chronic spontaneous urticaria - fact or fiction? Dirk, D; Mitzel, H; Peveling-Oberhag, A; Rady-Pizarro, U; Reese, I; Staubach, P; Wagner, N, 2017)	1.33
"Histamine is an aminergic neurotransmitter, which regulates wakefulness, arousal and attention in the central nervous system. "	( Histamine induces KCNQ channel-dependent gamma oscillations in rat hippocampus via activation of the H1 receptor. Andersson, R; Fisahn, A; Galter, D; Papadia, D, 2017)	3.34
"Histamine is a transmitter in the nervous system and a signaling molecule in the gut, the skin, and the immune system. "	( Histamine in the nervous system. Haas, HL; Selbach, O; Sergeeva, OA, 2008)	3.23
"Histamine (HA) is an important neuro-modulator, contributing to a variety of physiological responses in the mammalian central nervous system (CNS). "	( Histamine responses of large neostriatal interneurons in histamine H1 and H2 receptor knock-out mice. Akaike, H; Akaike, N; Ito, Y; Ogawa, S; Wang, ZM; Watanabe, T; Yanai, K, 2009)	3.24
"Histamine (HA) is a biogenic amine with multiple activities in the immune system. "	( Cutting edge: histamine receptor H4 activation positively regulates in vivo IL-4 and IFN-gamma production by invariant NKT cells. Diem, S; Dy, M; Leite-de-Moraes, MC; Michel, ML; Ohtsu, H; Schneider, E; Thurmond, RL, 2009)	2.16
"As histamine is a wake-promoting amine known to decrease during sleep, decreased histamine could either passively reflect or partially mediate daytime sleepiness in these pathologies."	( Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls. Mignot, E; Nevsimalova, S; Nishino, S; Sakurai, E; Watanabe, T; Yanai, K; Yoshida, Y, 2009)	1.23
"Histamine is a recognized growth factor in melanoma, and exogenous histamine produces a dual effect on proliferation. "	( Involvement of hydrogen peroxide in histamine-induced modulation of WM35 human malignant melanoma cell proliferation. Bergoc, RM; Cricco, GP; Martín, GA; Massari, NA; Medina, VA; Rivera, ES, 2009)	2.07
"Histamine is a typical chemical mediator involved in allergic conjunctivitis and induces hyperemia."	( Image analyses of the kinetic changes of conjunctival hyperemia in histamine-induced conjunctivitis in Guinea pigs. Fukushima, A; Tomita, T, 2009)	1.31
"Histamine is a biogenic amine that has been shown to contribute to several pathological conditions, such as allergic conditions, experimental encephalomyelitis, and malaria. "	( Histamine H(3) receptor-mediated signaling protects mice from cerebral malaria. Arrang, JM; Beghdadi, W; Dubayle, D; Dy, M; Louis, J; Mécheri, S; Morisset, S; Peronet, R; Porcherie, A; Schneider, BS, 2009)	3.24
"Histamine is a key inflammatory mediator derived from L: -histidine that governs vital cellular processes beyond inflammation, while recent evidence implies additional actions in both prokaryotes and eukaryotes."	( Histamine modulates the cellular stress response in yeast. Delitheos, B; Papamichael, K; Tiligada, E, 2010)	2.52
"Histamine is a central nervous system (CNS) neurotransmitter. "	( Histamine, antihistamines, and the central nervous system. Lieberman, P, )	3.02
"Histamine is a potent mediator in allergic inflammatory processes and is released by basophils and mast cells. "	( Histamine stimulates human lung fibroblast migration. Kamitani, S; Kawasaki, S; Kohyama, T; Nagase, T; Takizawa, H; Yamauchi, Y, 2010)	3.25
"Histamine intolerance is a clinically heterogeneous disease. "	( [Histamine intolerance mimics anorexia nervosa]. Herbst, RA; Peters, KP; Stolze, I, 2010)	2.71
"Histamine is a well known mediator of allergic skin diseases and, with the discovery of the histamine H(4) receptor, the role of histamine is re-evaluated. "	( The histamine H receptor as a new target for treatment of canine inflammatory skin diseases. Bäumer, W; Kietzmann, M; Leurs, R; Rossbach, K; Sander, K; Stark, H, 2009)	2.35
"Histamine is a powerful modulator that regulates blood vessels and blood flow. "	( Effect of histamine on regional cerebral blood flow of the parietal lobe in rats. Chen, XL; Liu, Y; Tian, YM; Yang, PB; Zhang, JF; Zhang, JS; Zhao, JJ, 2010)	2.21
"Histamine is an important biogenic amine, which acts with a group of four G-protein coupled receptors (GPCRs), namely H(1) to H(4) (H(1)R - H(4)R) receptors. "	( Molecular modeling and QSAR studies of a set of indole and benzimidazole derivatives as H₄ receptor antagonists. Brandt, CA; Fernandes, JP; Ferreira, EI; Pasqualoto, KF, 2011)	1.81
"As histamine is an important regulator of allergic inflammation we investigated the role of histamine receptors, particularly the most recently identified histamine H(4) receptor (H(4) R), in modulating the pro-inflammatory function of slanDC."	( Histamine H(4) receptor activation on human slan-dendritic cells down-regulates their pro-inflammatory capacity. Gschwandtner, M; Gutzmer, R; Schäkel, K; Werfel, T, 2011)	2.33
"Histamine is an endogenous biogenic amine that is synthesized from the basic amino acid histidine. "	( Histamine induces the neuronal hypertrophy and increases the mast cell density in gastrointestinal tract. Coskun, M; Elpek, GO; Keles, N; Yavuz Arican, R, 2012)	3.26
"Histamine is a biological amine that plays an important role in allergic responses. "	( Histamine differentially regulates the production of Th1 and Th2 chemokines by keratinocytes through histamine H1 receptor. Fujimoto, S; Kagami, S; Karakawa, M; Komine, M; Ohtsuki, M; Saeki, H; Tada, Y; Tamaki, K; Uratsuji, H, 2011)	3.25
"Histamine is an important inflammatory mediator in allergic conjunctivitis. "	( Niflumic Acid Reduces Histamine-Induced MUC5AC Expression in Human Conjunctival Epithelial Cells. Choi, SH; Chung, SH; Jeon, S; Seo, KY, 2011)	2.13
"Histamine is a neurotransmitter and inflammation mediator, which at physiological pH conditions is present mainly in monocationic form."	( Hydrogen bond dynamics of histamine monocation in aqueous solution: Car-Parrinello molecular dynamics and vibrational spectroscopy study. Grdadolnik, J; Maksić, ZB; Mavri, J; Stare, J; Vianello, R; Zidar, J, 2011)	1.39
"Histamine is a ubiquitous inflammatory mediator intimately associated with the pathology of allergy. "	( The role of histamine in asthma. Dunford, PJ; Holgate, ST, 2010)	2.18
"Histamine is a biogenic amine widely distributed throughout the body. "	( Histamine in normal and malignant cell proliferation. Darvas, Z; Falus, A; Pós, Z, 2010)	3.25
"Histamine is an important wake-promoting neurotransmitter that activates seven-transmembrane G-protein coupled histamine receptors. "	( The wake-promoting transmitter histamine preferentially enhances α-4 subunit-containing GABAA receptors. Bianchi, MT; Clark, AG; Fisher, JL, 2011)	2.1
"Histamine is a biogenic amine with extensive effects on many cell types, including important immunologic cells, such as antigen-presenting cells, natural killer cells, epithelial cells, and T and B lymphocytes. "	( Regulation of the immune response and inflammation by histamine and histamine receptors. Akdis, CA; Akdis, M; O'Mahony, L, 2011)	2.06
"Histamine is a bioactive amine that exerts immunomodulatory functions, including many allergic symptoms. "	( TLR-induced activation of neutrophils promotes histamine production via a PI3 kinase dependent mechanism. Bryce, PJ; Smuda, C; Wechsler, JB, 2011)	2.07
"Histamine is an important allergic mediator, and studies have defined roles for both histamine 1 and 4 receptors in allergic airway inflammation. "	( Cutting edge: histamine is required for IL-4-driven eosinophilic allergic responses. Bryce, PJ; Byrne, AJ; Swartzendruber, JA, 2012)	2.18
"Histamine is a key mediator governing vital cellular processes in mammals beyond its decisive role in inflammation. "	( Histamine in two component system-mediated bacterial signaling. Kyriakidis, DA; Theodorou, MC; Tiligada, E, 2012)	3.26
"Histamine is a regulator of the microcirculation (which performs these exchanges), suggesting a possible involvement of histamine in exercise."	( Roles of histamine in exercise-induced fatigue: favouring endurance and protecting against exhaustion. Endo, Y; Niijima-Yaoita, F; Ohtsu, H; Sugawara, S; Tadano, T; Tsuchiya, M; Yanai, K, 2012)	1.52
"Histamine is an established growth factor for gastrointestinal malignancies. "	( Deletion and down-regulation of HRH4 gene in gastric carcinomas: a potential correlation with tumor progression. Fang, Z; Li, J; Li, M; Liu, L; Wang, L; Wang, W; Xiong, Y; Yang, Y; Zhang, C, 2012)	1.82
"Histamine is a potent mediator in allergic inflammation with immunomodulatory properties. "	( Histamine down-regulates IL-27 production in antigen-presenting cells. Bäumer, W; Bunk, H; Gschwandtner, M; Gutzmer, R; Kietzmann, M; Köther, B; Thurmond, RL; Werfel, T, 2012)	3.26
"Histamine is a biogenic amine performing pleiotropic effects in humans, involving tasks within the immune and neuroendocrine systems, neurotransmission, gastric secretion, cell life and death, and development. "	( Histamine: an undercover agent in multiple rare diseases? Melgarejo, E; Pino-Ángeles, A; Reyes-Palomares, A; Sánchez-Jiménez, F, 2012)	3.26
"Histamine is a mediator of inflammation in allergic disease and asthma. "	( Involvement of histamine receptors in SAPK/JNK phosphorylation. Dandekar, RD; Khan, MM, 2012)	2.17
"Histamine is an essential factor in the ascending arousal system (AAS) during motivated behaviors. "	( Organization of the histaminergic system in adult zebrafish (Danio rerio) brain: neuron number, location, and cotransmitters. Panula, P; Sundvik, M, 2012)	2.15
"Histamine is an important inflammatory mediator during the early phase of allergic response and antihistamine is known to have an ability to reduce mucus secretion in inflamed airways. "	( Histamine regulates mucin expression through H1 receptor in airway epithelial cells. Kim, HM; Lee, CH; Rhee, CS, 2012)	3.26
"Histamine is a biogenic amine with fundamental roles in circulatory and immune systems. "	( Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride. Chang, YT; Kielland, N; Lavilla, R; Vendrell, M, 2012)	2.26
"Histamine contamination is a food safety issue with this product that is manufactured from tuna fish that has been temperature abused."	( Histamine stability in Rihaakuru at -80, 4 and 30°C. Bremer, PJ; Fletcher, GC; Flint, S; Meerdink, G; Naila, A, 2012)	2.54
"Histamine is a biogenic amine that forms in a variety of foods and can cause food poisoning at high concentrations (>500 ppm). "	( Prediction of the amount and rate of histamine degradation by diamine oxidase (DAO). Bremer, PJ; Fletcher, GC; Flint, S; Meerdink, G; Morton, RH; Naila, A, 2012)	2.09
"Histamine is an important non-neural mediator of asthma from mast cells."	( Histamine-induced changes in rat tracheal goblet cell mucin store and mucosal edema. Fu, YS; Guo, JJ; Huang, HT; Huang, YH, 2013)	2.55
"Histamine is a biogenic amine that exerts its biological effects as a neurotransmitter and local mediator via four histamine receptor (HR) subtypes (H(x)Rs) - H(1)R, H(2)R, H(3)R, and H(4)R - belonging to the superfamily of G-protein-coupled receptors (GPCRs). "	( Species-dependent activities of G-protein-coupled receptor ligands: lessons from histamine receptor orthologs. Buschauer, A; Schneider, EH; Seifert, R; Strasser, A; Wittmann, HJ, 2013)	2.06
"Histamine is a biogenic amine that is indispensable in the efficient functioning of various physiological systems. "	( Impedimetric detection of histamine in bowel fluids using synthetic receptors with pH-optimized binding characteristics. Cleij, TJ; Ingebrandt, S; Mingels, RH; Peeters, M; Thoelen, R; Troost, FJ; van Grinsven, B; Vranken, T; Wagner, P; Welsch, T, 2013)	2.13
"Histamine is a potent vasoactive agent, bronchial smooth muscle constrictor, and stimulant of nociceptive itch nerves. "	( Histamine in health and disease. Baraniuk, JN; Repka-Ramirez, MS, 2002)	3.2
"Histamine is a primary mediator of anaphylaxis and signs and symptoms of anaphylaxis can be reproduced by histamine infusion."	( Histamine and antihistamines in anaphylaxis. Lieberman, PL; Winbery, SL, 2002)	2.48
"Histamine is a potent bioamine with multiple activities in various pathological and physiological conditions. "	( Immune regulation by histamine. Akdis, CA; Akdis, M; Blaser, K; Jutel, M; Watanabe, T, 2002)	2.08
"Histamine is an aminergic neurotransmitter that is localized in the CNS and in peripheral tissues. "	( Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype. Ishikawa, T; Kotani, H; Suwa, H; Takahashi, K, 2002)	2
"Histamine (HA), which acts as a neurotransmitter in the central nervous system, has also been shown to be involved in feeding and exerts an inhibitory effect through activation of H(1) receptors."	( The role of hypothalamic histamine in leptin-induced suppression of short-term food intake in fasted rats. Kjaer, A; Knigge, U; Toftegaard, CL; Warberg, J, 2003)	1.34
"Histamine acts as a neurotransmitter in the brain and regulates e.g. "	( Subcellular distribution of histamine, GABA and galanin in tuberomamillary neurons in vitro. Kukko-Lukjanov, TK; Panula, P, 2003)	2.06
"Histamine is an important mediator released from activated mast cells provoked by allergen and has a substantial role in the pathophysiology of asthma. "	( Histamine deficiency in gene-targeted mice strongly reduces antigen-induced airway hyper-responsiveness, eosinophilia and allergen-specific IgE. Appel, J; Buzás, E; Falus, A; Keszei, M; Komlósi, Z; Kozma, GT; Losonczy, G; Magyar, P; Pállinger, E; Szabó, T; Szalai, C, 2003)	3.2
"Histamine release is a well known side effect of polygeline and - to a lesser extent - also of albumin, but was a novel finding for hydroxyethyl starch."	( Early and late histamine release induced by albumin, hetastarch and polygeline: some unexpected findings. Celik, I; Duda, D; Gajek, H; Kimura, K; Lorenz, W; Stinner, B, 2003)	1.39
"Histamine signaling is a principal regulator in a variety of pathophysiological processes including inflammation, gastric acid secretion, neurotransmission, and tumor growth. "	( Activation of the canonical beta-catenin pathway by histamine. Diab, RM; Diks, SH; Hardwick, JC; Peppelenbosch, MP; Richel, DJ; van Deventer, SJ; van Santen, MM; Versteeg, HH, 2003)	2.01
"Histamine is a biogenic amine with multiple physiological functions. "	( Upregulation of CYP2e1 and CYP3a activities in histamine-deficient histidine decarboxylase gene targeted mice. Falus, A; Fülöp, AK; Hegyi, K; Monostory, K; Tamási, V, 2003)	2.02
"Histamine is a biogenic amine synthesized by the enzymatic decarboxylation of histidine. "	( Homogeneous time resolved fluorescence assay to measure histamine release. Claret, EJ; Ouled-Diaf, J; Seguin, P, 2003)	2.01
"Histamine is a neurotransmitter with actions throughout the nervous system of vertebrates and invertebrates. "	( Actions of a histaminergic/peptidergic projection neuron on rhythmic motor patterns in the stomatogastric nervous system of the crab Cancer borealis. Beenhakker, MP; Christie, AE; Marder, E; Nusbaum, MP; Quinlan, JE; Stein, W, 2004)	2.14
"Histamine is an important mast cell- and basophil-derived mediator that has been implicated in the pathogenesis of asthma, resulting in smooth muscle contraction, mucus hypersecretion, and increased vascular permeability leading to mucosal edema."	( Second-generation antihistamines in asthma therapy: is there a protective effect? Walsh, GM, 2002)	1.35
"Histamine is a potent activator of human colon mast cells, which represents a novel and pivotal self-amplification mechanism of mast cell degranulation."	( Modulation of tryptase secretion from human colon mast cells by histamine. He, SH; Xie, H, 2004)	2
"Histamine is a versatile mediator that, according to in vitro studies, affects the synthesis of inflammatory cytokines and acute-phase proteins. "	( Hepatic acute-phase reaction in histamine-deficient gene targeted mice. Donászi-Ivanov, A; Falus, A; Fülöp, AK; Scharek, P, 2004)	2.05
"Histamine is a degradation product of the bacterial decarboxylation of the amino acid histidine, which is present in large amounts in fish tissues of the Clupeidae and Scombridae families and its presence is an indicator of good manufacturing practices and of the state of preservation of some food. "	( Validation and comparison of analytical methods for the determination of histamine in tuna fish samples. Baccelliere, R; Calì, A; Cinquina, AL; Cozzani, R; De Santis, L; Longo, F, 2004)	2
"Histamine is a downstream effector of leptin as its release, metabolism is enhanced by leptin and hypothalamic histamine reduces food intake."	( High leptin level is accompanied with decreased long leptin receptor transcript in histamine deficient transgenic mice. Falus, A; Fülöp, KA; Hegyi, K; Kovács, KJ; Tóth, S, 2004)	1.27
"Histamine is an important agent of innate immunity, transiently increasing the flux of immune-competent molecules from the vascular space to the tissues and then allowing rapid restoration of the integrity of the endothelial barrier. "	( Histamine selectively interrupts VE-cadherin adhesion independently of capacitive calcium entry. Ries, DR; Shasby, DM; Shasby, SS; Winter, MC, 2004)	3.21
"Histamine is a potent stimulator of arginine vasopressin (AVP) release and therefore, the role of AVP was studied in the reversal of critical haemorrhagic hypotension induced by endogenous central histamine after inhibition of histamine N-methyltransferase (HNMT) activity in rats."	( Involvement of arginine vasopressin in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats. Jochem, J, 2004)	2.01
"Histamine is a major inflammatory molecule released from the mast cell, and is known to activate endothelial cells. "	( Histamine induces Toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to Gram-positive and Gram-negative bacterial cell wall components. B Filla, M; Dileepan, KN; Kabir, MH; Stechschulte, DJ; Talreja, J, 2004)	3.21
"Histamine is an inflammatory agent that contributes to bovine laminitis. "	( Nutritional requirements of Allisonella histaminiformans, a ruminal bacterium that decarboxylates histidine and produces histamine. Garner, MR; Gronquist, MR; Russell, JB, 2004)	1.97
"Histamine (HA) is a potent stimulator of cAMP synthesis in various structures of chick brain, including the pineal gland. "	( Pertussis toxin-sensitive G protein modulates the ability of histamine to stimulate cAMP production in the chick pineal gland. Nowak, JZ; Rosiak, J; Zawilska, JB, )	1.82
"Histamine acts as a neurotransmitter of photoreceptors in insects and other arthropods, where it directly activates a chloride channel and mediates rapid inhibitory responses. "	( Unusual functional properties of homo- and heteromultimeric histamine-gated chloride channels of Drosophila melanogaster: spontaneous currents and dual gating by GABA and histamine. Gisselmann, G; Hatt, H; Plonka, J; Pusch, H, 2004)	2.01
"Histamine is a multifunctional biogenic amine with relevant roles in intercellular communication, inflammatory processes and highly prevalent pathologies. "	( Mammalian histidine decarboxylase: from structure to function. Medina, MA; Moya-Garcia, AA; Sánchez-Jiménez, F, 2005)	1.77
"Histamine is a key mediator of the allergic immediate reaction. "	( [Oral second generation antihistamines in allergic rhinitis]. Riechelmann, H, 2005)	2.07
"Histamine is a central neurotransmitter, it increases arousal via H1 receptors. "	( Histamine at high dilution reduces spectral density in delta band in sleeping rats. Pérez-Ordaz, L; Poitevin, B; Ruiz-Vega, G, 2005)	3.21
"Histamine is an important mediator contributing to oedema formation after thermal injury. "	( Microdialysis for detection of dynamic changes in tissue histamine levels in experimental thermal injury. Alhava, E; Härmä, M; Harvima, R; Lahtinen, T; Papp, A; Uusaro, A, 2005)	2.02
"Histamine is a major mediator in allergic diseases, and has multiple effects that are mediated by specific surface receptors on target cells."	( Roles of histamine and its receptors in allergic and inflammatory bowel diseases. He, SH; Xie, H, 2005)	1.47
"Histamine is an inflammation mediator that is fundamental for the development of some allergic reactions and is also implied in several common dermatological affections. "	( [Anti-H1 in dermatological practice]. Gaudy-Marqueste, C; Grob, JJ; Richard, MA, 2005)	1.77
"Histamine is an important mediator in airway inflammation. "	( The role of antihistamines in asthma management. Wilson, AM, 2006)	2.12
"Histamine is an essential mediator and marker of basophils and is highly up-regulated in CML."	( The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells. Agis, H; Aichberger, KJ; Bilban, M; Derdak, S; Esterbauer, H; Falus, A; Florian, S; Gleixner, KV; Krauth, MT; Mayerhofer, M; Pickl, WF; Sillaber, C; Sonneck, K; Valent, P; Vales, A, 2006)	1.27
"Histamine is a potent stimulator of nerve growth factor (NGF) production in the central nerve system and in the periphery as well. "	( Multiple role of histamine H1-receptor-PKC-MAPK signalling pathway in histamine-stimulated nerve growth factor synthesis and secretion. Lipnik-Stangelj, M, 2006)	2.12
"Histamine is a well-known mediator of allergic, inflammatory, and neurological responses. "	( Development of a high-throughput assay to measure histidine decarboxylase activity. August, EM; Brown, M; Gautschi, E; Hopkins, J; Kabcenell, A; Kronkaitis, A; Patnaude, L; Rajotte, D; Shrutkowski, A; Studts, J, 2006)	1.78
"Histamine is a biogenic amine responsible for multiple biological actions including regulation of physiological functions of mammary gland. "	( Histamine-mediated signaling processes in human malignant mammary cells. Bergoc, R; Correa-Fiz, F; Cricco, G; Martín, G; Medina, V; Mohamad, N; Nuñez, M; Rivera, ES; Sanchez-Jimenez, F, 2006)	3.22
"Histamine is a well-known mediator eliciting a broad range of responses in different cell types. "	( Functional characterization of histamine receptor subtypes in a human bronchial epithelial cell line. Bayer, H; Idzko, M; Müller, T; Myrtek, D; Norgauer, J; Schneider, K; Sorichter, S; Zissel, G, 2006)	2.06
"Histamine is a low-molecular-weight amine, synthesized from l-histidine by histidine decarboxylase. "	( Histamine network in atherosclerosis. Ohtsu, H; Sasaguri, Y; Tanimoto, A, 2006)	3.22
"Histamine is a well-known inflammatory mediator exerting various immunomodulatory effects and affecting the development of antigen-specific immune responses. "	( Increased antigen presentation and T(h)1 polarization in genetically histamine-free mice. Buzás, E; Falus, A; Hangya, B; Horváth, Z; Jelinek, I; László, V; Pállinger, E, 2007)	2.02
"Histamine is a potent mediator of itch in humans, yet histamine H(1) receptor antagonists have been shown to be of limited use in the treatment of certain chronic pruritic diseases. "	( Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. Desai, PJ; Dunford, PJ; Karlsson, L; McQueen, D; Thurmond, RL; Williams, KN, 2007)	3.23
"Histamine is a bioactive amine acting as a neurotransmitter as well as a chemical mediator."	( Food components inhibiting recombinant human histidine decarboxylase activity. Kikuzaki, H; Nitta, Y; Ueno, H, 2007)	1.06
"Histamine is an important mediator of inflammatory and allergic responses."	( Histamine prevents apoptosis in human monocytes. Katoh, N; Kishimoto, S; Soga, F, 2007)	2.5
"Histamine is a major mediator in allergy acting mainly through the histamine H(1) receptor (H1R). "	( Stimulation of histamine H1 receptor up-regulates histamine H1 receptor itself through activation of receptor gene transcription. Das, AK; Dev, S; Fujimoto, K; Fukui, H; Horio, S; Kitamura, Y; Mishima, R; Mizuguchi, H; Takeda, N; Wakayama, Y; Yoshimura, S, 2007)	2.14
"As histamine is a key mediator of allergic reactions, we investigated whether histamine is involved in airway remodeling."	( Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential role of histamine in airway remodeling. Akdis, CA; Azzi, A; Blaser, K; Kramer, BW; Kunzmann, S; Schmidt-Weber, C; Speer, CP; Zingg, JM, 2007)	1.2
"Histamine is a primary mediator of the inflammatory response in mammals. "	( Effect of mast cell degranulation on chicken ileal ion transport in vitro. Baird, AW; Campion, DP; Collins, CB; McGrath, J, 2007)	1.78
"Histamine is a biogenic amine that occurs to various degrees in many foods."	( Histamine and histamine intolerance. Maintz, L; Novak, N, 2007)	2.5
"The histamine H(3) receptor is a constitutively active G protein-coupled receptor for the neurotransmitter histamine that serves a negative feedback function. "	( Reduced histamine levels and H3 receptor antagonist-induced histamine release in the amygdala of Apoe-/- mice. Pfankuch, T; Raber, J; van Meer, P, 2007)	1.33
"Histamine is an important inflammatory mediator and associated with early phase allergic response. "	( Histamine induces MUC5AC expression via a hCLCA1 pathway. Kim, SW; Kim, YM; Lee, CH; Min, YG; Rhee, CS; Won, TB, 2007)	3.23
"Histamine is a major mast cell mediator of immunoneural signalling in the gut and mast cells play a role in the pathophysiology of functional and inflammatory bowel diseases. "	( Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors. Breunig, E; Michel, K; Schemann, M; Seidl, S; Weyhern, CW; Zeller, F, 2007)	3.23
"Histamine is a known inducer of cAMP-responsive element binding protein (CREB), which plays a key role in initiation of adipogenesis. "	( Elevated CREB activity in embryonic fibroblasts of gene-targeted histamine deficient mice. Falus, A; Hegyi, K; Toth, S, 2007)	2.02
"Histamine is a neurotransmitter and neuromodulator within the central nervous system that affects the regulation of food intake and obesity. "	( Neuronal histamine and histamine receptors in food intake and obesity. Masaki, T; Yoshimatsu, H, 2007)	2.2
"Histamine is a major autacoid released during allergic reactions. "	( Insights into the mechanisms of histamine-induced inflammation in the nasal mucosa. Taylor-Clark, TE, 2008)	2.07
"Histamine is an important mediator in immune responses, but it is unclear whether periodontal tissues express histamine receptors and are able to respond to histamine. "	( Histamine amplifies immune response of gingival fibroblasts. Endo, Y; Kuroishi, T; Minami, T; Ozawa, A; Shimauchi, H; Sugawara, S, 2007)	3.23
"Histamine is a key regulator of the immune system. "	( Nitric oxide mediates T cell cytokine production and signal transduction in histidine decarboxylase knockout mice. Buzas, E; Falus, A; Fazakas, F; Koncz, A; Mazan, M; Nagy, G; Pasztoi, M, 2007)	1.78
"Histamine is proved to be an important substance that controls body temperature and respiration in systemic anaphylaxis but its role in controlling blood pressure is minor."	( Progress in allergy signal research on mast cells: the role of histamine in immunological and cardiovascular disease and the transporting system of histamine in the cell. Ohtsu, H, 2008)	1.31
"Histamine is a putative neurotransmitter in mammals and molluscs, but its role in the nervous systems of other animals is not known. "	( Histamine as a neurotransmitter in the stomatogastric nervous system of the spiny lobster. Claiborne, BJ; Selverston, AI, 1984)	3.15
"Histamine is a potent mediator of immediate hypersensitivity reactions, and is stored primarily in mast cells and basophils. "	( Histamine. Marquardt, DL, 1983)	3.15
"Histamine challenge is a satisfactory method of assessing the proective effect of a drug in asthmatic children."	( Protective effect of inhaled salbutamol powder in children assessed by histamine challenge. Martin, AJ; Pullan, CR, 1980)	1.22
"Histamine is an important amine within the lung. "	( Factors influencing lung histamine content. Aroyave, CM; Newman, JH; Reeves, JT; Voelkel, NF, 1981)	2.01
"histamine infusion test is a useful model for the study of experimental vascular headache."	( Headache provocation by continuous intravenous infusion of histamine. Clinical results and receptor mechanisms. Krabbe, AA; Olesen, J, 1980)	1.23
"The histamine H2 receptor is a member of the family of G-protein-coupled receptors, and has three extracellular potential sites for N-glycosylation (Asn-4, Asn-162 and Asn-168)."	( Structural and functional analysis of the canine histamine H2 receptor by site-directed mutagenesis: N-glycosylation is not vital for its action. Asano, T; Fukushima, Y; Katagiri, H; Matsuhashi, N; Oka, Y; Saitoh, T; Sugano, K; Takata, K; van Breda, E; Yazaki, Y, 1995)	1.03
"Histamine is a known chromaffin cell secretagogue that induces Ca(2+) -dependent release of catecholamines. "	( Histamine-evoked chromaffin cell scinderin redistribution, F-actin disassembly, and secretion: in the absence of cortical F-actin disassembly, an increase in intracellular Ca2+ fails to trigger exocytosis. Rodríguez Del Castillo, A; Trifaró, JM; Zhang, L, 1995)	3.18
"Histamine (HA) acts as a neurotransmitter and/or neuromodulator in mammalian brain. "	( Effects of neurotoxic lesions in the posterior hypothalamic region on psychomotor activity and learning. Alvarez, XA; Cacabelos, R; Fernández-Novoa, L; Franco, A, 1994)	1.73
"Histamine is an accepted neurotransmitter and/or neuromodulator in the central nervous system (CNS). "	( Histamine in the central nervous system: its role in circadian rhythmicity. Nowak, JZ, 1994)	3.17
"Histamine is a paracrine messenger in the communication network."	( Neuroimmune communication in the submucous plexus of guinea pig colon after sensitization to milk antigen. Cooke, HJ; Frieling, T; Wood, JD, 1994)	1.01
"Histamine is a vasoactive amine which is endogenously produced in many organs including the penis."	( Characterization and function of histamine receptors in corpus cavernosum. Carson, CC; Davies, MG; Hagen, PO; Kim, YC; Lee, TH, 1995)	1.29
"Histamine (HA) is a biogenic amine involved in the regulation of neurovegetative, cognitive, neuroendocrine and neuroimmune functions in the central nervous system (CNS). "	( Effects of neurotoxic lesions in histaminergic neurons on brain tumor necrosis factor levels. Alvarez, XA; Cacabelos, R; Fernández-Novoa, L; Franco, A, 1994)	2.01
"Histamine (HA) is a known neurotransmitter with a wide spectrum of biological actions at the central and peripheral levels. "	( CDP-choline-induced blood histamine changes in Alzheimer's disease. Alvarez, XA; Caamaño, J; Cacabelos, R; Fernández-Novoa, L; Franco-Maside, A, 1994)	2.03
"Histamine is a major mediator of the mast cells that are present between epithelial cells in asthma. "	( Activation by histamine of bronchial epithelial cells from nonasthmatic subjects. Bousquet, J; Campbell, AM; Chanez, P; Godard, P; Lacoste, P; Michel, FB; Vignola, AM, 1993)	2.09
"Histamine is a potent vasodilatory substance released during anaphylaxis. "	( Histamine-induced venodilation in human beings involves both H1 and H2 receptor subtypes. Bedarida, G; Blaschke, TF; Dachman, WD; Hoffman, BB, 1994)	3.17
"Histamine is an important mediator of allergic inflammation and bronchial hyperresponsiveness (BHR), a hallmark of asthma. "	( Plasma histamine and bronchial reactivity in allergic asthma. Bury, T; Corhay, JL; Louis, R; Radermecker, MF, 1993)	2.18
"Histamine is a neuromodulator in the brain, and the hippocampus is one of the regions of the brain that is innervated by histaminergic neurons. "	( Enhancement by histamine of NMDA-mediated synaptic transmission in the hippocampus. Bekkers, JM, 1993)	2.08
"Histamine poisoning is a foodborne chemical intoxication resulting from the ingestion of food products containing high levels of histamine. "	( [Level of histamine and tyramine in ripening cheeses]. Fonberg-Broczek, M; Sawilska-Rautenstrauch, D, 1995)	2.14
"Histamine is considered to be an activator of cells with suppressive capacity. "	( Dual control of human interleukin-2 and interferon-gamma gene expression by histamine: activation and suppression. Arad, G; Kaempfer, R; Na'amad, M; Nussinovich, R, 1996)	1.97
"Histamine is an established growth factor for gastric and colorectal cancer. "	( In vitro effect of histamine and histamine H1 and H2 receptor antagonists on cellular proliferation of human malignant melanoma cell lines. Akhter, J; Morris, DL; Reynolds, JL, 1996)	2.07
"Histamine is a major mediator of the allergic reaction, and histamine H1-receptor antagonists have a long history of clinical efficacy in a variety of allergic disorders. "	( Antiallergic properties of antihistamines. Funes, E; García Cánovas, A; García-Sellés, FJ; Hernández, J; López-Sánchez, JD; Negro-Alvarez, JM; Pagán, JA, )	1.86
"The histamine H2 receptor is a member of the family of G-protein-coupled receptors and is linked to the activation of adenylate cyclase phospholipase C (PLC). "	( Interaction between the two signal transduction systems of the histamine H2 receptor: desensitizing and sensitizing effects of histamine stimulation on histamine-dependent cAMP production in Chinese hamster ovary cells. Aihara, M; Anai, M; Asano, T; Fukushima, Y; Funaki, M; Inukai, K; Katagiri, H; Matsuhashi, N; Ogihara, T; Oka, Y; Saitoh, T; Sugano, K; Yazaki, Y, 1996)	1.09
"Histamine is a forceful stimulus for inducing ETIA. "	( Histamine induced bronchoconstriction and end tidal inspiratory activity in man. Folgering, HT; Luijendijk, SC; Meessen, NE; van der Grinten, CP, 1996)	3.18
"Histamine is a biogenic amine, which is involved in a variety of biologic processes comprising inflammation, allergic responses, neurotransmission and regulation of gastric acid secretion. "	( The regulation of histidine decarboxylase gene expression. Höcker, M; Koh, TJ; Wang, TC; Zhang, Z, )	1.57
"Histamine serves as a neurotransmitter and neuromodulator in the brain."	( Oral famotidine: a potential treatment for children with autism. Linday, LA, 1997)	1.02
"Histamine is a mediator in allergic respiratory diseases."	( Effect of histamine on lecithin content in broncho-alveolar lavage fluid of rat. Janardhana Rao, G, 1997)	1.42
"Histamine is a potent activator of endothelial cells (EC): it induces the expression of P-selectin on the surface of endothelium and the secretion of IL-6 and IL-8."	( Inhibitory activity of loratadine and descarboxyethoxyloratadine on histamine-induced activation of endothelial cells. Czarlewski, W; Gosset, P; Lassalle, P; Molet, S; Tonnel, AB, 1997)	1.25
"Histamine is known to be a neurotransmitter in the brain, but it has not been clearly implicated in major diseases. "	( Neuronal histamine deficit in Alzheimer's disease. Eriksson, KS; Kalimo, H; Kuokkanen, K; Panula, P; Relja, M; Rinne, J; Sallmen, T, 1998)	2.16
"Histamine is a critical mediator of immediate hypersensitivity reactions. "	( A role for histamine and substance P in immediate allergic responses in guinea pig airways: characterization of MDL 108,207DA, a dual H1/NK-1 receptor antagonist. Esteve, H; Hsieh, L; Knippenberg, R; Kudlacz, E; Logan, D; Maynard, G; Olsen, K; Shatzer, S, 1998)	2.13
"Histamine is an important mediator in allergic reactions, gastric acid secretions, and neurotransmission in the central nervous system. "	( Induction of L-histidine decarboxylase in a human mast cell line, HMC-1. Butterfield, JH; Maeda, K; Ohno, I; Ohtsu, H; Sakurai, E; Shirato, K; Taniguchi, H; Tanno, Y; Watanabe, T; Yamauchi, K, 1998)	1.74
"Histamine is a general dilator of rat blood vessels. "	( Histamine receptor subtypes mediating hyperpolarization in the isolated, perfused rat mesenteric pre-arteriolar bed. Adeagbo, AS; Oriowo, MA, 1998)	3.19
"Histamine is an important mediator released from activated mast cells in acute bronchoconstriction provoked by allergen, exercise, hypertonic stimuli and inhaled adenosine. "	( Experimental models in asthma. Holgate, ST, 1999)	1.75
"Histamine is a key factor in the regulation of gastric acid secretion."	( Physiological significance of ECL-cell histamine. Andersson, K; Chen, D; Håkanson, R; Mattsson, H; Sundler, F, )	1.12
"Histamine is an inflammatory mediator produced by mast cells that reside close to blood vessels. "	( Nitric oxide: role in venular permeability recovery after histamine challenge. Al-Naemi, H; Baldwin, AL, 1999)	1.99
"Histamine is a known secretagogue in adrenal chromaffin cells. "	( Voltage-dependent, pertussis toxin insensitive inhibition of calcium currents by histamine in bovine adrenal chromaffin cells. Currie, KP; Fox, AP, 2000)	1.98
"Histamine is a potent facilitating agent."	( Dexamethasone pharmacokinetics in the inner ear: comparison of route of administration and use of facilitating agents. Baredes, S; Chandrasekhar, SS; Connelly, PE; Gatz, M; Huang, E; Kwartler, JA; Rubinstein, RY, 2000)	1.03
"Thus histamine is a very important modulator of Th1 cytokine production in PBMCs and is quite unique in triggering IL-18-initiating cytokine cascade without inducing IL-12 production."	( Histamine is a potent inducer of IL-18 and IFN-gamma in human peripheral blood mononuclear cells. Akagi, T; Iwagaki, H; Kobashi, K; Kohka, H; Nakaya, N; Nishibori, M; Saeki, K; Tanaka, N; Yoshino, T, 2000)	2.2
"Histamine is an important mediator and regulator of inflammation. "	( Update on histamine as a mediator of inflammation. Weltman, JK, )	1.98
"Histamine is a central nervous system (CNS) neurotransmitter that has been implicated in the pathophysiology of schizophrenia. "	( Histamine N-methyltransferase functional polymorphism: lack of association with schizophrenia. Lachman, HM; Rice, SR; Sobell, JL; Szumlanski, CL; Weinshilboum, RM; Yan, L, 2000)	3.19
"Histamine is an inflammatory mediator present in mast cells, which are abundant in the wall of the gallbladder. "	( Actions of histamine on muscle and ganglia of the guinea pig gallbladder. Firth, TA; Guarraci, FA; Hemming, JM; Jennings, LJ; Mawe, GM; Nelson, MT, 2000)	2.14
"Histamine is a cation at neutral pH, but chlorination eliminated the charge on the amino group and shifted the pKa of the imidazole ring, resulting in formation of neutral histamine-chloramines."	( Myeloperoxidase-catalyzed chlorination of histamine by stimulated neutrophils. Dabbous, MK; Jefferson, MM; King, CC; Learn, DB; Thomas, EL, 2000)	1.29
"Histamine is a neurotransmitter at arthropod photoreceptors. "	( The determination of histamine in the Drosophila head. Borycz, J; Meinertzhagen, IA; Tokarczyk, G; Vohra, M, 2000)	2.07
"Histamine is an important mediator in the pathogenesis of nasal allergy."	( Regulatory effect of histamine H1 receptor antagonist on the expression of messenger RNA encoding CC chemokines in the human nasal mucosa. Fujikura, T; Shimosawa, T; Yakuo, I, 2001)	1.35
"Histamine is a well known mediator of inflammation including the allergic reaction. "	( [Regulation of cytokine production by histamine through H2-receptor stimulation]. Kohka-Takahashi, H; Mori, S; Nishibori, M, 2001)	2.02
"Histamine is a classical, but still interesting inflammatory mediator. "	( [Induction of histidine decarboxylase in inflammation and immune responses]. Endo, Y, 2001)	1.75
"As histamine is a key inflammatory mediator in cattle, while serotonin takes on this role in rodents, the diversification of these tick proteins may reflect host adaptation."	( A high affinity serotonin- and histamine-binding lipocalin from tick saliva. Nuttall, PA; Paesen, GC; Sangamnatdej, S; Slovak, M, 2002)	1.11
"Histamine is a well-known mediator of inflammatory and allergic reactions and has immunomodulatory capacities. "	( Expression and function of histamine receptors 1 and 2 on human monocyte-derived dendritic cells. Gutzmer, R; Kapp, A; Langer, K; Lisewski, M; Mommert, S; Rieckborn, D; Werfel, T, 2002)	2.05
"Histamine also functions as a bioprotection system against various noxious and unfavorable stimuli (for examples, convulsion, nociception, drug sensitization, ischemic lesions, and stress)."	( Studies on functional roles of the histaminergic neuron system by using pharmacological agents, knockout mice and positron emission tomography. Watanabe, T; Yanai, K, 2001)	1.31
"Histamine is a well-known mediator eliciting different responses in immune and nonimmune cells, but its role in modulating dendritic cell (DC) functions has been marginally investigated."	( Expression and function of histamine receptors in human monocyte-derived dendritic cells. Di Virgilio, F; Dichmann, S; Ferrari, D; Girolomoni, G; Herouy, Y; Idzko, M; la Sala, A; Mockenhaupt, M; Norgauer, J; Panther, E, 2002)	2.05
"The histamine H4 receptor is a novel G-protein-coupled receptor with a unique pharmacological profile. "	( Molecular modeling and site-specific mutagenesis of the histamine-binding site of the histamine H4 receptor. Bayne, M; Coates, E; Monsma, FJ; Morse, KL; Murgolo, NJ; Shin, N; Strader, CD, 2002)	1.12
"Histamine is a ubiquitous biogenic amine involved in the regulation of numerous basic physiological and pathophysiological processes. "	( Histamine genomics in silico: polymorphisms of the human genes involved in the synthesis, action and degradation of histamine. Falus, A; Fitzimons, CP; Igaz, P; Szalai, C, 2002)	3.2
"A histaminergic pathway is an attractive possibility to explain the excitatory response, because both pyrilamine and cimetidine inhibit the thyrotropin-releasing hormone induced response and the peptide has no further influence on antral motility after the tissue is exposed to a supramaximal concentration of histamine."	( Histaminergic involvement in thyrotropin-releasing hormone stimulation of antral tissue in the rat. Behsudi, FM; Bruce, LA; Fawcett, CP, 1979)	2.26
"Histamine is an important mediator of asthma. "	( Antihistamines in the treatment of asthma. Bousquet, J; Godard, P; Michel, FB, 1992)	2.28
"Histamine was found to be a potent stimulus for acid secretion in 1920. "	( Histamine and gastric acid secretion. A review. Obrink, KJ, 1991)	3.17
"Histamine is thought to be a neuroactive substance in the brain and have various physiological functions such as biological rhythms and autonomic regulation. "	( Synaptic inputs to histaminergic neurons in the rat posterior hypothalamus. Tamiya, R, 1991)	2.05
"Histamine is known to be a classical inducer of pruritus. "	( Histamine, antihistamines and atopic eczema. Behrendt, H; Ring, J, 1990)	3.16
"Histamine is known to be a mediator of inflammation. "	( Histamine-stimulated and GTP-binding proteins-mediated phospholipase A2 activation in rabbit platelets. Kajiyama, Y; Murayama, T; Nomura, Y, 1990)	3.16
"Histamine was found to be a potent activator of phospholipase C, leading to polyphosphoinositide hydrolysis and subsequent intracellular Ca2+ mobilization."	( Histamine as a growth factor and chemoattractant for human carcinoma and melanoma cells: action through Ca2(+)-mobilizing H1 receptors. de Laat, SW; Ladoux, A; Moolenaar, WH; Remorie, R; Tertoolen, LG; Tilly, BC; Verlaan, I, 1990)	2.44
"Histamine (HA), which acts as a neurotransmitter in the central nervous system, participates in the neuroendocrine regulation of prolactin (PRL) secretion. "	( Histaminergic regulation of prolactin secretion. Knigge, UP, 1990)	3.16
"Histamine release is a frequent event in the perioperative period. "	( [Histamine liberation induced by anesthetics or their solvents: specific or non-specific?]. Doenicke, A; Lorenz, W, 1985)	2.62
"Histamine is an important pro-inflammatory molecule mediating leukocyte margination, plasma extravasation and vasodilation, but its precise mode of action on vascular endothelium is unclear. "	( Release of prostacyclin from cultured human endothelial cells following prolonged exposure to histamine. Bull, HA; Dowd, PM; Rustin, MH, 1989)	1.94
"Histamine (HA) is a neurotransmitter present in the brain. "	( delta 9-Tetrahydrocannabinol decreases turnover of brain histamine. Itoh, Y; Nishibori, M; Oishi, R; Saeki, K, 1985)	1.96
"As histamine is a potent inducer of pruritus."	( Plasma histamine levels and kinetics in chronic hemodialysis patients. Bonete, R; Callebert, J; Chauveau, P; Delons, S; Launay, JM; Man, NK; Poignet, J; Tabuteau, F, )	1.1
"Histamine is a 4-substituted imidazole and a preliminary study has shown it to be an inhibitor of rat liver microsomal drug oxidation."	( Histamine inhibition of mixed function oxidase activity in rat and human liver microsomes and in the isolated perfused rat liver. Crewe, HK; Harlow, JR; Lennard, MS; Morris, CQ; Tucker, GT; Woods, HF, 1989)	2.44
"Histamine is a major mediator of the allergic reactions. "	( [The H1 and H2 histamine receptors]. Ruff, F; Santais, MC, 1988)	2.07
"Histamine is an impressive modulator of immune functions at least via its effects on lymphoid cells. "	( The effects of derivatives of histamine on natural suppressor cells. Bristow, MR; Goodman, M; Khan, MM; Marr-Leisy, D; Melmon, KL; Strober, S; Verlander, MS, 1986)	2
"Histamine is alleged to be a potential inducing factor for degrading enzymes."	( The response of histamine degrading enzymes to nematode infection. Dastych, J; Fogel, WA; Maśliński, C, 1988)	1.34
"Histamine is a widely distributed amine with many functions, both physiological and pathological. "	( Relevance of histamine to the anaesthetist. Withington, DE, 1988)	2.09
"Histamine is a potent secretagogue for opioid pentapeptides (Met- and Leu-enkephalin) in adrenal chromaffin cells in vitro. "	( Histamine affects release and biosynthesis of opioid peptides primarily via H1-receptors in bovine chromaffin cells. Bommer, M; Herz, A; Kley, N; Liebisch, D; Noble, E, 1987)	3.16

Effects

Histamine has a long history of therapeutic use in many diseases, including multiple sclerosis (MS) Histamine has an antinociceptive effect in the brain and may be involved in opioid-induced analgesia. Histamine causes an increase in serotonin immediately after treatment, which then returns to the control level after 24 h.

Histamine antagonists have been in clinical use since 1942. Histamine has been determined by bioassay, chemically by different modification of a fluorometric method, by radioenzymatic methods and, recently, by immunoassays.

Excerpt	Reference	Relevance
"Histamine has an impact on the gene expression profile of macrophages during compressive strain in vitro, most likely having an impairing effect on orthodontic tooth movement by upregulation of osteoprotegerin expression."	( Effects of histamine and various histamine receptor antagonists on gene expression profiles of macrophages during compressive strain. Damanaki, A; Jantsch, J; Kirschneck, C; Petring, C; Proff, P; Schröder, A, 2022)	2.55
"The histaminergic system has a role in the treatment of brain disorders by the development of histamine receptor agonists, antagonists."	( The neglected role of histamine in Alzheimer's disease. Mirshafiey, A; Naddafi, F, 2013)	1.19
"Histamine has a selective affinity for H3 receptors and it may specifically inhibit the neurogenic edema response involved in migraine pathophysiology."	( Subcutaneous histamine versus botulinum toxin type A in migraine prophylaxis: a randomized, double-blind study. Barreto-Vizcaíno, S; Isais-Millán, S; Millán-Guerrero, RO; Rios-Madariaga, C; Rivera-Castaño, L, 2009)	2.16
"Histamine has a direct suppressive effect on IEL-derived cytokines via H(2)R, which would have a crucial role in the suppression of local immunoregulation in the intestinal epithelium."	( Cytokine responses of intraepithelial lymphocytes are regulated by histamine H(2) receptor. Furuta, T; Hamaya, Y; Hishida, A; Horio, Y; Ikuma, M; Osawa, S; Takagaki, K; Takayanagi, Y; Yamada, T, 2009)	2.03
"Histamine has a positive inotropic effect on ventricular myocardium and stimulation of histamine H₂ receptors increases the intracellular cAMP level via Gs protein, as dose stimulation of β-adrenergic receptors, and worsens heart failure. "	( A histamine H₂ receptor blocker ameliorates development of heart failure in dogs independently of β-adrenergic receptor blockade. Asakura, M; Asanuma, H; Fujita, M; Kim, J; Kitakaze, M; Komamura, K; Minamino, T; Sanada, S; Sasaki, H; Sugimachi, M; Takahama, H; Takashima, S; Wakeno, M, 2010)	2.52
"CSF histamine has a robust daily rhythm, with a mean of 24.9 ± 3.29 pg mL(-1) , amplitude of 31.7 ± 6.46 pg mL(-1) and a peak at 17:49 ± 70.3 min (lights on 07:00-19:00 hours)."	( Time-course of cerebrospinal fluid histamine in the wake-consolidated squirrel monkey. Buckmaster, CL; Honda, Y; Kodama, T; Lyons, DM; Mignot, E; Nishino, S; Zeitzer, JM, 2012)	1.14
"Histamine has a variety of airway actions and is considered to be an important mediator in asthma. "	( Disruption of L-histidine decarboxylase reduces airway eosinophilia but not hyperresponsiveness. Hattori, T; Ichinose, M; Ishigaki-Suzuki, S; Koarai, A; Kuramasu, A; Makabe-Kobayashi, Y; Ohtsu, H; Sakurai, E; Shirato, K; Sugiura, H; Watanabe, T; Yamagata, S, 2003)	1.76
"Histamine has a short-term, transient, stimulating effect on endothelial nitric oxide synthase (eNOS) activity; however, long-term effects on eNOS have not been described yet. "	( Histamine upregulates gene expression of endothelial nitric oxide synthase in human vascular endothelial cells. Brausch, I; Burkhardt, C; Förstermann, U; Heinrich, UR; Li, H; Xia, N, 2003)	3.2
"Histamine has an important role in the development of gastric ulcers and mast cell derived histamine might be essential in this process."	( Effects of the vasoactive intestinal peptide on stress-induced mucosal ulcers and modulation of methylation of histamine in gastric tissue of the rats. Aboul-Enein, HY; Tunçel, M; Tunçel, N, 2003)	1.25
"Histamine has a recognised role in allergic and inflammatory reactions, and is reported to affect several aspects of chondrocyte behaviour."	( Histamine, histamine receptors (H1 and H2), and histidine decarboxylase expression by chondrocytes of osteoarthritic cartilage: an immunohistochemical study. Tetlow, LC; Woolley, DE, 2005)	2.49
"Histamine has an important role in regulation of immune response which is mediated by differential expression of four distinct receptors, H1R-H4R. "	( Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. Center, DM; Cross, L; Cruikshank, WW; Green, DS; Kornfeld, H; McAllister, B; Morgan, RK, 2007)	3.23
"Histamine has a selective affinity for H3-receptors and it may specifically inhibit the neurogenic edema response involved in migraine pathophysiology. "	( Subcutaneous histamine versus sodium valproate in migraine prophylaxis: a randomized, controlled, double-blind study. Barreto-Vizcaíno, S; Garcia-Solorzano, A; Isais-Millán, R; López-Blanca, C; Membrila-Maldonado, M; Millán-Guerrero, RO; Muñoz-Solis, R; Rivera-Castaño, L, 2007)	2.15
"Histamine has a key role in allergic inflammatory conditions. "	( The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Dunford, PJ; Gelfand, EW; Thurmond, RL, 2008)	2.17
"Histamine has a selective affinity for H3 receptors and it may specifically inhibit the neurogenic edema response involved in migraine pathophysiology."	( Subcutaneous histamine versus topiramate in migraine prophylaxis: a double-blind study. Baltazar, LM; Barreto-Vizcaíno, S; Gutiérrez, I; Isais-Millán, R; Millán-Guerrero, RO; Rivera-Castaño, L; Trujillo-Hernández, B, 2008)	2.16
"Histamine has a greater relaxant effect on mesenteric artery strips at 22 degrees than at 38 degrees, normally."	( Dibenamine enhancement of histamine-induced relaxation of the rabbit mesenteric artery. Christiansen, VJ; Horst, MA; Robinson, C, 1983)	1.29
"Histamine has a trophic effect on at least two colorectal cancer cell lines in vivo and in vitro."	( Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth. Adams, WJ; Lawson, JA; Morris, DL, 1994)	1.24
"Histamine has a different effect causing an increase in serotonin immediately after treatment, which then returns to the control level after 24 h."	( Effect of hormones and hormone-induced imprinting on the serotonin level in Tetrahymena: immunocytochemical studies. Csaba, G; Kovács, P, 1994)	1.01
"Histamine has a marked secretagogue effect in the exocrine pancreas of several animal species but in many cases the secretory effect is gender-related."	( The physiological role of histamine in the exocrine pancreas. Pariente, JA; Salido, GM; Singh, J, 1997)	1.32
"Histamine has a long history of therapeutic use in many diseases, including multiple sclerosis (MS). "	( Transdermal histamine in multiple sclerosis: part one -- clinical experience. Ballasiotes, G; DeLack, E; Gillson, G; Wright, JV, 1999)	2.13
"Histamine has an antinociceptive effect in the brain and may be involved in opioid-induced analgesia."	( Opposite modulation of histaminergic neurons by nociceptin and morphine. Eriksson, KS; Haas, HL; Stevens, DR, 2000)	1.34
"Histamine has a dual action on the isolated perfused ear preparation of the rabbit. "	( Histamine receptors in the vasculature of the rabbit ear. Ercan, ZS; Türker, RK, 1975)	3.14
"1 Histamine has a dual action on the in situ gall bladder of the guinea-pig: a spasmogenic and a relaxant effect mediated through H1- and H2-receptor stimulation respectively. "	( Occurrence of H1- and H2-histamine receptors in the guinea-pig gall bladder in situ. Impicciatore, M, 1978)	1.28
"Histamine has a positive inotropic action in humans. "	( Influence of histamine receptors on basal left ventricular contractile tone in humans: assessment using the H2 receptor antagonist famotidine and the beta-adrenoceptor antagonist esmolol as pharmacologic probes. Berlin, R; Borow, KM; Ehler, D; Neumann, A, 1992)	2.1
"Histamine has a similar, although less notable effect than histidine."	( Receptor-level interrelationships of amino acids and the adequate amino acid type hormones in Tetrahymena: a receptor evolution model. Csaba, G; Darvas, Z, 1986)	0.99
"Histamine has multiple effects on cardiac physiology, mainly via the histamine 1 and 2 receptors, which on a simplified level have opposing effects on heart rate, force of contraction, and coronary vasculature function."	( Histamine receptors in heart failure. Levick, SP, 2022)	2.89
"Histamine has long been accepted as an anorexigenic agent. "	( Targeting Histamine and Histamine Receptors for the Precise Regulation of Feeding. Chen, Z; Zheng, Y, 2022)	2.57
"Histamine has been implicated in urinary bladder dysfunction as an inflammatory mediator driving sensory nerve hypersensitivity. "	( Histamine receptors rapidly desensitize without altering nerve-evoked contractions in murine urinary bladder smooth muscle. Jones, BM; Mingin, GC; Tykocki, NR, 2022)	3.61
"Histamine has shown a possible role in the etiopathogenesis of migraine. "	( Increased serum diamine oxidase activity in nonallergic patients with migraine. Agúndez, JAG; Alonso-Navarro, H; Amo, G; Calleja, M; García-Albea, E; García-Martín, E; García-Ruiz, R; Jiménez-Jiménez, FJ; Millán-Pascual, J; Navacerrada, F; Navarro-Muñoz, S; Plaza-Nieto, JF; Recio-Bermejo, M; Rodriguez, C; Serrador, M; Turpín-Fenoll, L, 2022)	2.16
"Histamine poisoning has been reported worldwide. "	( [Literature Review on the Type of Fish and Histamine-producing Bacteria Associated with Histamine Poisonings in Japan]. Hara-Kudo, Y; Toda, M; Tomaru, A, 2022)	2.43
"Histamine has been postulated to play a role in atopic dermatitis via histamine receptor 4, mediating pruritic and inflammatory effects. "	( Adriforant is a functional antagonist of histamine receptor 4 and attenuates itch and skin inflammation in mice. Bäumer, W; Bruno, S; Delucis-Bronn, C; Fehlmann, D; Goetschy, JF; Hauchard, A; Kaupmann, K; Kempf, D; Raulf, F; Röhn, TA; Roussel, E; Stark, H; Uluckan, Ö; Urban, B; Wack, N; Wang, Y; Wilzopolski, J; Zerwes, HG, 2023)	2.62
"Once histamine has formed, freezing or cooking the fish will not remove the histamine content."	( Scombroid Poisoning: An Overview for the Emergency Nurse Practitioner. Crenshaw, N; Gonzalez, JM; McGhee, S; Nadeau, C; Ortega, J, )	0.59
"Histamine has been shown to play a series of pathophysiological roles by modulating immune and inflammatory responses in a number of disease conditions, whereas the mechanistic aspects underlying induced HDC expression remain elusive."	( Histamine and histidine decarboxylase: Immunomodulatory functions and regulatory mechanisms. Moriguchi, T; Takai, J, 2020)	2.72
"Histamine has to bind to specific receptors to exert its physiological and pathophysiological functions."	( Antihistamines in children and adolescents: A practical update. Ciprandi, G; Corsico, A; Leonardi, S; Licari, A; Marseglia, GL; Miraglia Del Giudice, M; Parisi, GF; Peroni, D; Salpietro, C, )	1.41
"Antihistamine medications have been suggested to elicit clinical features of restless legs syndrome. "	( Tibialis anterior electromyographic bursts during sleep in histamine-deficient mice. Alvente, S; Bastianini, S; Berteotti, C; Lin, JS; Lo Martire, V; Matteoli, G; Ohtsu, H; Silvani, A; Zoccoli, G, 2021)	1.42
"Histamine has an impact on the gene expression profile of macrophages during compressive strain in vitro, most likely having an impairing effect on orthodontic tooth movement by upregulation of osteoprotegerin expression."	( Effects of histamine and various histamine receptor antagonists on gene expression profiles of macrophages during compressive strain. Damanaki, A; Jantsch, J; Kirschneck, C; Petring, C; Proff, P; Schröder, A, 2022)	2.55
"Histamine has been shown to modulate visual system and photic behavior in arthropods. "	( External Influences on Invertebrate Brain Histamine and Related Compounds via an Automated Derivatization Method for Capillary Electrophoresis. Denoroy, L; Parrot, S; Pavón Vergés, M; Perrot-Minnot, MJ, 2017)	2.16
"Histamine has been shown to regulate NF-κB activity, though not in hepatocytes."	( Regulation of apolipoprotein A-I gene expression by the histamine H1 receptor: Requirement for NF-κB. Haas, MJ; Hammoud, R; Jurado-Flores, M; Mooradian, AD; Onstead-Haas, L; Plazarte, G; Wong, NCW, 2018)	1.45
"Histamine has generally excitatory effects on target neurons, but paradoxically, histamine neurons may also release the inhibitory neurotransmitter GABA."	( Histamine: neural circuits and new medications. Dauvilliers, Y; Franks, NP; Jackson, AC; Scammell, TE; Wisden, W, 2019)	2.68
"The histaminergic system has a role in the treatment of brain disorders by the development of histamine receptor agonists, antagonists."	( The neglected role of histamine in Alzheimer's disease. Mirshafiey, A; Naddafi, F, 2013)	1.19
"Anti-histaminergic drugs have been widely used in the clinical treatment of vestibular disorders and most studies concentrate on their presynaptic actions. "	( Postsynaptic mechanisms underlying the excitatory action of histamine on medial vestibular nucleus neurons in rats. Peng, SY; Wang, JJ; Yu, L; Zhang, XY; Zhu, JN; Zhuang, QX, 2013)	1.15
"The histamine field has moved on rapidly in the last four years, with expansion in roles and clinical development, particularly in the newest two of four histamine receptors. "	( Histamine pharmacology: four years on. Chazot, PL, 2013)	2.39
"Histamine synthesis has been demonstrated in osteoclast precursors."	( [Histamine in regulation of bone remodeling processes]. Folwarczna, J; Wiercigroch, M, 2013)	2.02
"Histamine has been suggested to participate in seizure control."	( Effect of hyperthermia on histamine blood level and convulsive behavior in infant rats. Fereidoni, J; Gholipoor, P; Roshan-Milani, S; Saboory, E, 2013)	1.41
"Histamine has been studied in both health and disease since the initial description a century ago. "	( Histamine in migraine and brain. Alstadhaug, KB, 2014)	3.29
"Histamine antagonism has been in common use to block its adverse effects."	( Histamine: metabolism, physiology, and pathophysiology with applications in veterinary medicine. Kovacic, JP; Peters, LJ, 2009)	2.52
"Histamine has been implicated in the pathogenesis of migraine. "	( Diamine oxidase rs10156191 and rs2052129 variants are associated with the risk for migraine. Agúndez, JA; Alonso-Navarro, H; Ayuso, P; García-Martín, E; Jiménez-Jiménez, FJ; Martínez, C; Navacerrada, F; Serrador, M, 2015)	1.86
"Histamine has previously been studied with FSCV; however, the lack of a robust Faradaic electrochemical signal makes it difficult to selectively identify histamine in complex media, as found in vivo."	( In vivo histamine voltammetry in the mouse premammillary nucleus. Abdalla, A; Hashemi, P; Robke, R; Samaranayake, S; Wood, KM; Zeqja, A, 2015)	1.57
"Low histamine metabolism has been suggested to play a role in the pathogenesis of allergy and migraine. "	( Association of diamine oxidase and histamine N-methyltransferase polymorphisms with presence of migraine in a group of Mexican mothers of children with allergies. Ávila-Hernández, J; Espinosa-Padilla, S; López-Márquez, F; Meza-Velázquez, R; Rivera-Guillen, M; Rosales-González, M, 2017)	1.29
"Histamine has been reported to decrease the ultrafiltration coefficient, which inversely correlates with glomerular permselectivity, however the mechanism(s) underling this effect have never been investigated. "	( Histamine type 1-receptor activation by low dose of histamine undermines human glomerular slit diaphragm integrity. Chazot, PL; Fantozzi, R; Grange, C; Miglio, G; Moggio, A; Pini, A; Premoselli, F; Rosa, AC; Tiligada, K; Veglia, E, 2016)	3.32
"Histamine receptors have been the target of efforts to develop pro-cognitive drugs to treat disorders such as Alzheimer's disease and schizophrenia."	( Histamine induces KCNQ channel-dependent gamma oscillations in rat hippocampus via activation of the H1 receptor. Andersson, R; Fisahn, A; Galter, D; Papadia, D, 2017)	2.62
"Histamine has been proposed to be an excitatory transmitter between the carotid body (CB) chemoreceptor (glomus) cells and petrosal ganglion (PG) neurons. "	( Modulatory effects of histamine on cat carotid body chemoreception. Alcayaga, J; Del Rio, R; Fujiwara, K; Iturriaga, R; Koenig, CS; Moya, EA, 2008)	2.1
"Histamine has a selective affinity for H3 receptors and it may specifically inhibit the neurogenic edema response involved in migraine pathophysiology."	( Subcutaneous histamine versus botulinum toxin type A in migraine prophylaxis: a randomized, double-blind study. Barreto-Vizcaíno, S; Isais-Millán, S; Millán-Guerrero, RO; Rios-Madariaga, C; Rivera-Castaño, L, 2009)	2.16
"Histamine has various effects in physiological and pathological reactions, such as inflammation, cell growth, and neuro-transmission."	( Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression. Hong, SH; Jeong, HJ; Kang, IC; Kang, TH; Kim, HM; Kim, JJ; Kim, SJ; Moon, PD; Seo, JU; Um, JY, 2009)	1.07
"Histamine has a direct suppressive effect on IEL-derived cytokines via H(2)R, which would have a crucial role in the suppression of local immunoregulation in the intestinal epithelium."	( Cytokine responses of intraepithelial lymphocytes are regulated by histamine H(2) receptor. Furuta, T; Hamaya, Y; Hishida, A; Horio, Y; Ikuma, M; Osawa, S; Takagaki, K; Takayanagi, Y; Yamada, T, 2009)	2.03
"Histamine and tyramine have been affected by pyrogallol, catechol, starch, ascorbic and chlorogenic acids at different levels with different conditions."	( High performance liquid chromatography, thin layer chromatography and spectrophotometric studies on the removal of biogenic amines from some Egyptian foods using organic, inorganic and natural compounds. El-Din, AM; El-Din, LA; El-Hameed, AK; Mohamed, GG, 2010)	1.08
"Histamine has been proposed to be an important regulator of energy intake and expenditure. "	( Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice. Ding, Y; Guo, X; Hirano, K; Kohno, K; Sasaguri, Y; Tanimoto, A; Tsukada, H; Wang, KY; Watanabe, T; Yamada, S, 2010)	3.25
"Histamine has been demonstrated to be involved in cell proliferation, embryonic development, and tumour growth. "	( Histamine and histamine receptor antagonists in cancer biology. Alonso-Tejerina, E; Asumendi, A; Blaya, B; Boyano, MD; Burgos-Bretones, J; Jangi, SM; Nicolau-Galmés, F; Ortega-Martínez, I; Pérez-Yarza, G, 2010)	3.25
"Histamine has a positive inotropic effect on ventricular myocardium and stimulation of histamine H₂ receptors increases the intracellular cAMP level via Gs protein, as dose stimulation of β-adrenergic receptors, and worsens heart failure. "	( A histamine H₂ receptor blocker ameliorates development of heart failure in dogs independently of β-adrenergic receptor blockade. Asakura, M; Asanuma, H; Fujita, M; Kim, J; Kitakaze, M; Komamura, K; Minamino, T; Sanada, S; Sasaki, H; Sugimachi, M; Takahama, H; Takashima, S; Wakeno, M, 2010)	2.52
"Histamine has been shown to promote Th2 polarization by dendritic cells."	( Histamine H(4) receptor antagonism inhibits allergen-specific T-cell responses mediated by human dendritic cells. Borrebaeck, CA; Broos, S; Greiff, L; Lindstedt, M; Lundberg, K, 2011)	2.53
"Histamine has been reported to play an important role in pathogenesis of bronchial asthma. "	( [Roles of histamine in the pathogenesis of bronchial asthma and reevaluation of the clinical usefulness of antihistamines]. Kobayashi, H; Maeyama, K; Nakamura, Y; Ogasawara, M; Shikanai, T; Yamauchi, K, 2011)	2.21
"Histamine has been detected after controlled challenges with allergen and, when administered into the nasal cavity, elicits signs and symptoms similar to those elicited by allergen."	( Histamine in allergic rhinitis. Taylor-Clark, T, 2010)	2.52
"CSF histamine has a robust daily rhythm, with a mean of 24.9 ± 3.29 pg mL(-1) , amplitude of 31.7 ± 6.46 pg mL(-1) and a peak at 17:49 ± 70.3 min (lights on 07:00-19:00 hours)."	( Time-course of cerebrospinal fluid histamine in the wake-consolidated squirrel monkey. Buckmaster, CL; Honda, Y; Kodama, T; Lyons, DM; Mignot, E; Nishino, S; Zeitzer, JM, 2012)	1.14
"Antihistamines have been classifed as first or second generation drugs, according to their pharmacokinetic properties, chemical structure and adverse effects. "	( Bilastine and the central nervous system. Bartra, J; Dávila, I; del Cuvillo, A; Ferrer, M; Jáuregui, I; Montoro, J; Mullol, J; Sastre, J; Valero, A, 2011)	0.93
"Histamine has been recognized as a NANC factor in the early postprandial period in pythons, but the mechanism of its release has not been identified."	( Humoral regulation of heart rate during digestion in pythons (Python molurus and Python regius). Enok, S; Pedersen, SV; Simonsen, LS; Skovgaard, N; Wang, T, 2012)	1.1
"Histamine has been shown to induce melanogenesis via histamine receptor 2, suggesting the possibility of histamine as a repigmenting agent for the treatment of vitiligo."	( Histamine receptor 2-mediated growth-differentiation factor-15 expression is involved in histamine-induced melanogenesis. Kang, JH; Kim, HJ; Kim, HM; Kim, YL; Lee, AY; Lee, CH; Lee, EJ; Lee, HJ; Park, MK, 2012)	2.54
"Histamine has the ability to influence the activity of immune cells including neutrophils and plays a pivotal role in inflammatory processes, which are a complex network of cellular and humoral events. "	( Modulation of neutrophil oxidative burst via histamine receptors. Cíž, M; Lojek, A, 2013)	2.09
"Histamine has a variety of airway actions and is considered to be an important mediator in asthma. "	( Disruption of L-histidine decarboxylase reduces airway eosinophilia but not hyperresponsiveness. Hattori, T; Ichinose, M; Ishigaki-Suzuki, S; Koarai, A; Kuramasu, A; Makabe-Kobayashi, Y; Ohtsu, H; Sakurai, E; Shirato, K; Sugiura, H; Watanabe, T; Yamagata, S, 2003)	1.76
"Histamine has pro-inflammatory effects on conjunctival fibroblasts, inducing the production of cytokines and the expression of ICAM-1. "	( Histamine-induced cytokine production and ICAM-1 expression in human conjunctival fibroblasts. De Paoli, M; DeFranchis, G; Fregona, I; Leonardi, A; Plebani, M; Secchi, A, 2002)	3.2
"Histamine has a short-term, transient, stimulating effect on endothelial nitric oxide synthase (eNOS) activity; however, long-term effects on eNOS have not been described yet. "	( Histamine upregulates gene expression of endothelial nitric oxide synthase in human vascular endothelial cells. Brausch, I; Burkhardt, C; Förstermann, U; Heinrich, UR; Li, H; Xia, N, 2003)	3.2
"Histamine has an important role in the development of gastric ulcers and mast cell derived histamine might be essential in this process."	( Effects of the vasoactive intestinal peptide on stress-induced mucosal ulcers and modulation of methylation of histamine in gastric tissue of the rats. Aboul-Enein, HY; Tunçel, M; Tunçel, N, 2003)	1.25
"Histamine has been suggested to have roles as a neurotransmitter or a neuromodulator. "	( Signal transduction by histamine in the cerebellum and its modulation by N-methyltransferase. Kitanaka, J; Kitanaka, N; Takemura, M, 2003)	2.07
"Histamine (HA) has been shown to stimulate ACTH secretion in rats, an effect in part mediated by CRH and arginine vasopressin (AVP)."	( Effect of interleukin 1beta on the HPA axis in H1-receptor knockout mice. Friis-Hansen, L; Kjaer, A; Knigge, U; Toftegaard, CL; Warberg, J; Watanabe, T, )	0.85
"Histamine has been referred to as an anorexic factor that decreases appetite and fat accumulation and affects feeding behavior. "	( Hyperleptinemia, visceral adiposity, and decreased glucose tolerance in mice with a targeted disruption of the histidine decarboxylase gene. Buzás, E; Falus, A; Földes, A; Fülöp, AK; Hegyi, K; Kleiber, M; Kovács, KJ; Miklós, IH; Nagy, A; Romics, L, 2003)	1.76
"Histamine has been shown to depress transmission through the perfused superior cervical ganglion of the cat when doses of 150 mug. "	( Effect of histamine on ganglionic transmission. GERTNER, SB; KOHN, R, 1959)	2.08
"Histamine has been proposed to be an important modulator of developing neurons, but its mechanism of action remains unclear. "	( Histamine activates a background, arachidonic acid-sensitive K channel in embryonic chick dorsal root ganglion neurons. Catacuzzeno, L; Fioretti, B; Franciolini, F; Tata, AM, 2004)	3.21
"Histaminergic neurons have been strongly implicated in the regulation of wakefulness by activating cortical neurons. "	( Extracellular histamine level in the frontal cortex is positively correlated with the amount of wakefulness in rats. Chu, M; Eguchi, N; Huang, ZL; Qu, WM; Urade, Y; Yao, MH, 2004)	2.13
"Histamine has many regulatory activities and is well recognised for its importance in allergic and inflammatory disorders. "	( Effect of histamine on the production of matrix metalloproteinases-1, -3, -8 and -13, and TNFalpha and PGE(2) by human articular chondrocytes and synovial fibroblasts in vitro: a comparative study. Tetlow, LC; Woolley, DE, 2004)	2.17
"Histamine has been proven to be a major regulator of the immune system's T-helper cell subset balance and major shifts in this balance towards TH2 cytokines have contributed to diseases such as asthma, lupus and cancer."	( Site specific therapy: an integrative approach to treating melanoma. Kavekos, M, 2005)	1.05
"Histamine has a recognised role in allergic and inflammatory reactions, and is reported to affect several aspects of chondrocyte behaviour."	( Histamine, histamine receptors (H1 and H2), and histidine decarboxylase expression by chondrocytes of osteoarthritic cartilage: an immunohistochemical study. Tetlow, LC; Woolley, DE, 2005)	2.49
"Histamine has been shown to have a key physiological role in the control of gastric acid secretion and a pathophysiological role in a range of allergic disorders."	( Histamine and its receptors. Ganellin, CR; Parsons, ME, 2006)	2.5
"Histamine has multiple functions in the process of pregnancy, different studies have shown the direct and/or indirect presence of histamine action in the placenta as well."	( Histamine regulates placental cytokine expression--in vivo study on HDC knockout mice. Borck, H; Diel, F; Falus, A; Mihályi, D; Pállinger, E; Pap, E, )	2.3
"Antihistamines have been shown to have bronchodilatory effects, effects on allergen-, exercise-, and adenosine-monophosphate-challenge testing, and also to prevent allergen-induced nonspecific airways hyperresponsiveness."	( The role of antihistamines in asthma management. Wilson, AM, 2006)	1.16
"Histamine and carnosine have been proposed as protective agents against such damage."	( Evidence for rapid inter- and intramolecular chlorine transfer reactions of histamine and carnosine chloramines: implications for the prevention of hypochlorous-acid-mediated damage. Davies, MJ; Pattison, DI, 2006)	1.28
"Histamine has many physiological roles in the brain and periphery. "	( Evidence for the presence of histamine uptake into the synaptosomes of rat brain. Kato, M; Nishiyama, S; Oreland, L; Sakurai, E; Watanabe, T; Yanai, K, 2006)	2.07
"Histamine has an important role in regulation of immune response which is mediated by differential expression of four distinct receptors, H1R-H4R. "	( Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. Center, DM; Cross, L; Cruikshank, WW; Green, DS; Kornfeld, H; McAllister, B; Morgan, RK, 2007)	3.23
"Histamine has a selective affinity for H3-receptors and it may specifically inhibit the neurogenic edema response involved in migraine pathophysiology. "	( Subcutaneous histamine versus sodium valproate in migraine prophylaxis: a randomized, controlled, double-blind study. Barreto-Vizcaíno, S; Garcia-Solorzano, A; Isais-Millán, R; López-Blanca, C; Membrila-Maldonado, M; Millán-Guerrero, RO; Muñoz-Solis, R; Rivera-Castaño, L, 2007)	2.15
"Histamine has a key role in allergic inflammatory conditions. "	( The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Dunford, PJ; Gelfand, EW; Thurmond, RL, 2008)	2.17
"Histamine has a selective affinity for H3 receptors and it may specifically inhibit the neurogenic edema response involved in migraine pathophysiology."	( Subcutaneous histamine versus topiramate in migraine prophylaxis: a double-blind study. Baltazar, LM; Barreto-Vizcaíno, S; Gutiérrez, I; Isais-Millán, R; Millán-Guerrero, RO; Rivera-Castaño, L; Trujillo-Hernández, B, 2008)	2.16
"Histamine has the potential to optimize cytokine-induced activation of T cells and natural killer cells; therefore, the addition of histamine to cytokine treatment may improve treatment efficacy."	( Histamine dihydrochloride for the treatment of acute myeloid leukemia, malignant melanoma and renal cell carcinoma. Ho, AD; Perz, JB, 2008)	2.51
"Histamine has neurotransmitter/neuromodulator functions in the adult brain, but its role during CNS development has been elusive. "	( Histamine induces neural stem cell proliferation and neuronal differentiation by activation of distinct histamine receptors. Molina-Hernández, A; Velasco, I, 2008)	3.23
"Histamine has been assumed to contribute to embryo-uterine interactions due to its vasoactive, differentiation and growth-promoting properties. "	( Effects of histamine and diamine oxidase activities on pregnancy: a critical review. Bieber, T; Maintz, L; Novak, N; Schwarzer, V; van der Ven, K, )	1.96
"Histamine has been shown to increase renal blood flow via H1- and H2-receptors. "	( Evaluation of presynaptic histamine receptors in the canine renal vascular bed. Barker, LA; Robie, NW, 1983)	2.01
"Histamine release has been detected biologically after exposure of human right atrial biopsy samples to compound 48/80. "	( Histamine release from human right atrium. Gristwood, RW; Lincoln, JC; Owen, DA; Smith, IR, 1981)	3.15
"Histamine has been reported to attenuate adrenergic responses in cardiovascular tissues. "	( Release of histamine by sympathetic nerve stimulation in the guinea pig heart and modulation of adrenergic responses. A physiological role for cardiac histamine? Bailey, WH; Chenouda, AA; Gross, SS; Guo, ZG; Levi, R, 1984)	2.1
"Histamine has a greater relaxant effect on mesenteric artery strips at 22 degrees than at 38 degrees, normally."	( Dibenamine enhancement of histamine-induced relaxation of the rabbit mesenteric artery. Christiansen, VJ; Horst, MA; Robinson, C, 1983)	1.29
"Histamine has been shown to activate cyclic AMP synthesis in brain slices and homogenates of certain species, although less is known about species differences in brain homogenates. "	( Histamine-activated adenylate cyclase in brain homogenates of several species. Green, JP; Hough, LB, 1981)	3.15
"Histamine has been known as a cardiac stimulant for over 70 years. "	( Histamine and the heart. McNeill, JH, 1984)	3.15
"Histamine receptors have been demonstrated on lymphocyte membranes by a variety of techniques. "	( A technique for the flow cytometric analysis of lymphocytes bearing histamine receptors. Cohen, EB; McCaffrey, RP; Osband, ME; Shapiro, HM, 1980)	1.94
"Histamine has been shown to possess many neurotransmitter-like properties, and a variety of studies indicate that central histamine may function in modulating behavioral arousal. "	( Histamine-induced arousal in the conscious and pentobarbital-pretreated rat. Kalivas, PW, 1982)	3.15
"Histamine has been measured by an isotopic enzyme conversion assay in guinea pig bone marrow cultures under conditions which stimulate basophilopoiesis. "	( Basophil production III: relation of histamine to guinea pig basophil growth in vitro. Befus, AD; Bienenstock, J; Denburg, JA; Goodacre, R, 1981)	1.98
"Histamine has been implicated in the pathogenesis of gastroduodenal ulcers. "	( Spontaneous stomach ulcer in genetically mast-cell depleted W/Wv mice. Kitamura, Y; Maeyama, K; Miyano, Y; Shimada, M; Takahashi, Y; Tatsuta, M; Yamatodani, A; Yokoyama, M, 1980)	1.7
"Histamine has been investigated for its effect on gastric acid secretion and mucosal blood flow in man. "	( The effect of histamine and histamine antagonists on gastric acid secretion and mucosal blood flow in man. Knight, SE; McIsaac, RL; Rennie, CD, 1980)	2.06
"Histamine transport has been characterized in cultured astroglial cells of rat brain. "	( [3H]histamine uptake and release by astrocytes from rat brain: effects of sodium deprivation, high potassium, and potassium channel blockers. Huszti, Z; Imrik, P; Madarász, E, 1994)	2.29
"Histamine has a trophic effect on at least two colorectal cancer cell lines in vivo and in vitro."	( Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth. Adams, WJ; Lawson, JA; Morris, DL, 1994)	1.24
"Histamine has a different effect causing an increase in serotonin immediately after treatment, which then returns to the control level after 24 h."	( Effect of hormones and hormone-induced imprinting on the serotonin level in Tetrahymena: immunocytochemical studies. Csaba, G; Kovács, P, 1994)	1.01
"Histamine has numerous functions in the brain and has recently been shown to modulate responses of N-methyl-D-aspartate (NMDA) receptors on hippocampal neurons by a mechanism that does not involve classical histamine receptors. "	( Subunit-specific potentiation of recombinant N-methyl-D-aspartate receptors by histamine. Williams, K, 1994)	1.96
"Histamine has potent effects on cerebral blood vessels which include increased permeability and dilatation. "	( Effects of antihistaminics on experimental brain edema. Schilling, L; Wahl, M, 1994)	1.73
"Histamine tachyphylaxis has been demonstrated after repeated challenges in mild asthmatics not using inhaled corticosteroid."	( Effect of magnitude of airway responsiveness and therapy with inhaled corticosteroid on histamine tachyphylaxis in asthma. Manning, PJ; O'Byrne, PM; Strban, M; Watson, RM, 1994)	1.23
"Histamine has previously been described as a possible substrate for the semicarbazide-sensitive amine oxidase activity (SSAO) of rat white adipose tissue (WAT). "	( Histamine lipolytic activity and semicarbazide-sensitive amine oxidase (SSAO) of rat white adipose tissue (WAT). Banchelli, G; Buffoni, F; Conforti, L; Ignesti, G; Pirisino, R; Raimondi, L, 1993)	3.17
"Histamine and IL-1 have been implicated in the pathogenesis of chronic inflammatory diseases, such as pulmonary allergic reactions and rheumatoid arthritis. "	( Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Comparison with IL-1 receptor antagonist. Dinarello, CA; Vannier, E, 1993)	3.17
"Histamine has arrhythmogenic, chronotropic, inotropic and vasoactive effects."	( Toxic oxygen metabolites and ischemia-reperfusion increase histamine synthesis and release in the isolated rat heart. Kaszaki, J; Nagy, S; Szabó, I; Vaage, J; Valen, G, 1993)	1.25
"Histamine has been implicated as a neuromodulator of secretion of gonadotropins in several species. "	( Effects of season and estradiol on concentrations of histamine within discrete brain regions of ovariectomized ewes. Alexander, BM; Moss, GE; Murdoch, WJ; Rose, JD; Van Kirk, EA, 1993)	1.98
"Histamine has recently been shown to be a growth factor for some gastric and colorectal cancer cells. "	( Ranitidine and cimetidine differ in their in vitro and in vivo effects on human colonic cancer growth. Adams, WJ; Lawson, JA; Morris, DL, 1996)	1.74
"The histamine H3 receptor has been shown to inhibit pentagastrin-induced gastric acid secretion in dogs. "	( Modulation of pentagastrin-induced histamine release by histamine H3 receptors in the dog. Bertini, S; Garbarg, M; Intorre, L; Rouleau, A; Schwartz, JC; Soldani, G, 1996)	1.13
"Antihistamines have been compared on the basis of their ability to block the histamine-induced wheal and flare in the skin."	( Appraisal of the validity of histamine-induced wheal and flare to predict the clinical efficacy of antihistamines. Daly, AF; Monroe, EW; Shalhoub, RF, 1997)	1.07
"Histamine has been shown to be involved in atherosclerosis and coronary heart disease. "	( Novel effects of histamine on lipoprotein metabolism: suppression of hepatic low density lipoprotein receptor expression and reduction of plasma high density lipoprotein cholesterol in the rat. Angelin, B; Liao, W; Rudling, M, 1997)	2.08
"Histamine has been widely used experimentally to induce headache in healthy subjects and migraine in migraineurs. "	( Nitric oxide synthase inhibition in the histamine headache model. Eichler, HG; Findl, O; Graselli, U; Kastner, J; Schmetterer, L; Simak, S; Singer, EA; Strenn, K; Wolzt, M, 1997)	2.01
"Histamine has important neuromodulatory influences on the central electrophysiology which underlies normal thalamocortical function."	( Role of the central histaminergic neuronal system in the CNS toxicity of the first generation H1-antagonists. Sangalli, BC, 1997)	1.34
"Histamine has a marked secretagogue effect in the exocrine pancreas of several animal species but in many cases the secretory effect is gender-related."	( The physiological role of histamine in the exocrine pancreas. Pariente, JA; Salido, GM; Singh, J, 1997)	1.32
"Histamine has been found to stimulate growth of colorectal cancer in vitro and in vivo. "	( Histamine content in colorectal cancer. Are there sufficient levels of histamine to affect lymphocyte function? Adams, WJ; Akhter, J; Morris, DL; Reynolds, JL, 1997)	3.18
"Histamine has been well tolerated, and 21/22 CR patients have treated themselves at home throughout the trial."	( Histamine and interleukin-2 in acute myelogenous leukemia. Brune, M; Carneskog, J; Celsing, F; Hellstrand, K; Kimby, E; Mellqvist, UH; Wallhult, E, 1997)	2.46
"Histamine has not been proved responsible for signs."	( [Mechanism of severe, immediate reactions to iodinated contrast material]. Laroche, D, 1998)	1.02
"Histamine has been shown to affect circadian rhythms both in vivo and in vitro."	( Histamine phase shifts the hamster circadian pacemaker via an NMDA dependent mechanism. Hall, AC; Harrington, ME; Meyer, JL, 1998)	2.46
"Histamine has long been suspected as one of the factors that is involved in implantation."	( Histidine decarboxylase gene in the mouse uterus is regulated by progesterone and correlates with uterine differentiation for blastocyst implantation. Das, N; Das, SK; Dey, SK; Dileepan, KN; Paria, BC; Zhao, X, 1998)	1.02
"Histamine has been converted into a non-imidazole H3-receptor histamine antagonist by addition of a 4-phenylbutyl group at the N alpha-position followed by removal of the imidazole ring. "	( Synthesis of potent non-imidazole histamine H3-receptor antagonists. Arrang, JM; Ganellin, CR; Garbarg, M; Leurquin, F; Ligneau, X; Piripitsi, A; Schunack, W; Schwartz, JC, 1998)	2.02
"Histamine has been shown to increase the adhesion of leucocytes to the endothelium and to stimulate production of IL-6 and IL-8 by endothelial cells."	( Histamine--a major role in allergy? Bachert, C, 1998)	2.46
"Histamine has been incriminated as having a responsibility for intolerance reaction to wines. "	( Histamine content does not influence the tolerance of wine in normal subjects. Bauza, T; Blaise, A; Cabanis, JC; Daumas, F; Frémont, S; Guillemin, F; Kanny, G; Moneret-Vautrin, DA; Nicolas, JP, 1999)	3.19
"Histamine has been proposed to play an important role in early inflammatory responses, based on studies documenting the effects of histamine on vasodilation and permeability of microvascular endothelium, as well as histamine-stimulated neutrophil adhesion to endothelial cells. "	( Histamine induced homologous and heterologous regulation of histamine receptor subtype mRNA expression in cultured endothelial cells. Neugebauer, E; Schaefer, U; Schmitz, V; Schneider, A, 1999)	3.19
"Histamine has direct effects on keratinocytes as well."	( H2 histamine receptor-mediated increase in intracellular Ca2+ in cultured human keratinocytes. Koizumi, H; Ohkawara, A, 1999)	1.65
"Histamine has a long history of therapeutic use in many diseases, including multiple sclerosis (MS). "	( Transdermal histamine in multiple sclerosis: part one -- clinical experience. Ballasiotes, G; DeLack, E; Gillson, G; Wright, JV, 1999)	2.13
"Histamine has an antinociceptive effect in the brain and may be involved in opioid-induced analgesia."	( Opposite modulation of histaminergic neurons by nociceptin and morphine. Eriksson, KS; Haas, HL; Stevens, DR, 2000)	1.34
"Histamine has been reported to potentiate NMDA receptor-mediated events under a variety of conditions."	( Potentiation by histamine of synaptically mediated excitotoxicity in cultured hippocampal neurones: a possible role for mast cells. Facci, L; Kee, WJ; Skaper, SD; Strijbos, PJ, 2001)	1.38
"Histamine has been suggested to be a immunomodulator."	( [Regulation of cytokine production by histamine through H2-receptor stimulation]. Kohka-Takahashi, H; Mori, S; Nishibori, M, 2001)	1.3
"Histamine has been shown to play a role in arthropod vision; it is the major neurotransmitter of arthropod photoreceptors. "	( Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye. Cully, DF; Hirschberg, B; Hunt, DC; Ludmerer, SW; Schmatz, DM; Wang, AP; Yuan, J; Zheng, Y, 2002)	2.01
"Histamine has also been shown to play a role in the regulation of sleep and feeding."	( Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus. Brown, RE; Eriksson, KS; Haas, HL; Sergeeva, O, 2001)	1.32
"Histamine has been shown to inhibit ROS formation and possibly synergize with cytokines to permit activation of natural killer cells and T cells."	( Results from a randomized phase III study comparing combined treatment with histamine dihydrochloride plus interleukin-2 versus interleukin-2 alone in patients with metastatic melanoma. Agarwala, SS; Belt, R; Feun, L; Gehlsen, KR; Glaspy, J; Gonzalez, R; Gutheil, J; Hellstrand, K; Hersh, E; Kirkwood, JM; Meyskens, F; Mitchell, M; Naredi, P; O'Day, SJ; Whitman, E; Wood, D, 2002)	1.27
"Histamine has a dual action on the isolated perfused ear preparation of the rabbit. "	( Histamine receptors in the vasculature of the rabbit ear. Ercan, ZS; Türker, RK, 1975)	3.14
"1 Histamine has a dual action on the in situ gall bladder of the guinea-pig: a spasmogenic and a relaxant effect mediated through H1- and H2-receptor stimulation respectively. "	( Occurrence of H1- and H2-histamine receptors in the guinea-pig gall bladder in situ. Impicciatore, M, 1978)	1.28
"Histamine may have been released close to airway receptors, inducing bronchoconstriction, but in amounts undetectable in arterial plasma."	( Histamine release during antigen inhalation in experimental asthma in dogs. Chiesa, A; Dain, D; Gold, WM; Kessler, GF; Meyers, GL, 1975)	2.42
"Histamine has been shown to inhibit a variety of immune responses including the antigen-induced, IgE mediated, release of histamine from sensitized human leucocytes and from sensitized monkey and dog mast cells. "	( The effects of H2-receptor antagonists on anaphylaxis in the guinea-pig. Dulabh, R; Vickers, MR, 1978)	1.7
"Histamine has been measured in whole blood and in the plasma of twenty-three subjects following exercise testing of seventeen asthmatics and six normal controls. "	( Blood histamine levels after exercise testing. Burge, PS; Cromwell, O; Harries, MG; O'Brien, I; Pepys, J, 1979)	2.18
"Histamine has been found biochemically in the mammalian vascular wall. "	( Evidence for non-mast cell histamine in the vascular wall. Brody, MJ; El-Ackad, TM, 1975)	1.99
"Histamine has been alleged to have a role in the vasoconstrictor response with generalized alveolar and thus systemic hypoxia, but the role for histamine is not clear in localized alveolar hypoxia."	( Role of histamine in the hypoxic vascular response of the lung. Hales, CA; Kazemi, H, 1975)	1.41
"Histamine release have been demonstrated in haemorrhagic shock. "	( Histamine release and SOD, allopurinol and ranitidine pretreatment in haemorrhagic shock in the rat. Asakawa, H; Karácsonyi, S; Zöllei, I, 1992)	3.17
"Histamine has a positive inotropic action in humans. "	( Influence of histamine receptors on basal left ventricular contractile tone in humans: assessment using the H2 receptor antagonist famotidine and the beta-adrenoceptor antagonist esmolol as pharmacologic probes. Berlin, R; Borow, KM; Ehler, D; Neumann, A, 1992)	2.1
"Antihistamines have been reported to have antitussive actions in allergic rhinitis which may be due to an effect of the drug on the cough reflex. "	( The effect of oral terfenadine on the sensitivity of the cough reflex in normal volunteers. Fuller, RW; Studham, J, 1992)	0.84
"Histamine has been reported to cause endothelium-dependent relaxation of vascular smooth muscle and vasodilation. "	( Histamine H1-receptors mediate endothelium-dependent relaxation of rat isolated pulmonary arteries. Bailly, DA; Gruetter, CA; Stewart, NL; Szarek, JL, 1992)	3.17
"Histamine has been shown to mediate features of pulmonary allergic reactions including increased tracheobronchial blood flow. "	( Bronchial vasodilation by histamine in sheep: characterization of receptor subtype. Brock, JM; Chung, KF; Colbert, SR; Howard, RS; Nichol, GM; Parsons, GH; Villablanca, AC, 1992)	2.03
"Histamine, which has long been implicated as a mediator of allergic airway disease, has multiple effects on airways which are mediated by at least three histamine receptors. "	( Histamine receptors in the lung. Barnes, PJ, 1991)	3.17
"Histamine has been proposed as a photoreceptor neurotransmitter in two major groups of arthropods, the insects and the crustacea. "	( Histamine: a putative afferent neurotransmitter in Limulus eyes. Andrews, AW; Battelle, BA; Callaway, JC; Calman, BG; Grieco, FD; Mleziva, MB; Stuart, AE, 1991)	3.17
"Histamine, which has been found in middle ear effusions, is a potent pharmacological mediator released at an early stage of allergic reactions or general inflammatory process, increasing permeability of small blood vessels. "	( Histamine-induced mucociliary dysfunction and otitis media with effusion. Esaki, Y; Furuya, H; Nakai, Y; Ohashi, Y; Ohno, Y; Okamoto, H; Sugiura, Y, 1991)	3.17
"Histamine antagonists have been in clinical use since 1942."	( H1- and H2-antagonists in allergic and pseudoallergic diseases. Behrendt, H; Ring, J, 1990)	1
"Histamine has been determined by bioassay, chemically by different modification of a fluorometric method, by radioenzymatic methods, and, recently, by immunoassays."	( Radioimmunoassay of histamine. Brenna, E; Sandvik, AK; Schulze Søgnen, B; Waldum, HL, 1991)	1.33
"Histamine has been involved in the first minutes of the anaphylactic reaction and new-formed compounds in the subsequent response."	( Pharmacological characterization of mediators and vagal influence in the acute allergic bronchoconstriction in guinea pigs. Montaño, LM; Segura, P; Selman, M; Vanda, B; Vargas, MH, 1990)	1
"Histamine has remained a putative neurotransmitter for many years, partially because some of the criteria necessary to define it as a central nervous system neurotransmitter have not been established. "	( Release of histamine in rat hypothalamus and corpus striatum in vivo. Clemens, JA; Henry, DP; Phebus, LA; Russell, WL, 1990)	2.11
"Histamine has been shown previously to cause dose-dependent systemic hypotension and concurrent alterations in the permeability of the blood-brain barrier of rats. "	( Blockade of histamine-stimulated alterations in cerebrovascular permeability by the H2-receptor antagonist cimetidine. Boertje, SB; Le Beau, D; Williams, C, 1989)	2.1
"Histamine has generally been accepted to be an important mediator of immediate-type-allergic reactions. "	( [Significance of histamine in immediate allergic reactions]. Behrendt, H, 1985)	2.05
"Histamine H1 receptors have been demonstrated on adherent rheumatoid synovial cells using biochemical and radioligand binding assays in vitro. "	( Histamine H1 receptors on adherent rheumatoid synovial cells in culture: demonstration by radioligand binding and inhibition of histamine-stimulated prostaglandin E production by histamine H1 antagonists. Taylor, DJ; Woolley, DE, 1987)	3.16
"Histamine has been suggested as an important mediator of the cardiovascular abnormalities during septic shock. "	( Blood histamine concentrations are not elevated in humans with septic shock. Jacobs, R; Kaliner, M; Parrillo, JE; Shelhamer, JH, 1989)	2.2
"Histamine has a similar, although less notable effect than histidine."	( Receptor-level interrelationships of amino acids and the adequate amino acid type hormones in Tetrahymena: a receptor evolution model. Csaba, G; Darvas, Z, 1986)	0.99
"Histamine has been shown to have both positive inotropic and chronotropic effects. "	( The effects of histamine on contraction frequency, sodium influx, and cyclic AMP in cultured rat heart cells. Lui, CY; McCall, D, 1986)	2.07
"Histamine has been compared with methacholine inhalation challenge in two samples of adults from a small town to determine which is the better agent for use in community studies."	( Comparison of histamine and methacholine for use in bronchial challenge tests in community studies. Britton, JR; Burney, PG; Chinn, S; Higgins, BG; Jones, TD; Tattersfield, AE; Vathenen, AS, 1988)	1.36
"Histamine has been found to activate three subtypes of receptors: the H1 subtype, which mediates a number of cellular events resulting in airway obstruction; the H2 subtype, which plays an unclear and perhaps variable role in mediating airway caliber changes; and the newly described H3 subtype, which has not yet been studied in relation to airway caliber."	( Histamine and airway caliber. Casale, TB; Joad, J, 1988)	2.44
"Histamine (H) levels have been reported during various types of shock, but there is a paucity of such data during hemorrhagic shock. "	( Histamine level changes in the plasma and tissues in hemorrhagic shock. Adamicza, A; Nagy, A; Nagy, S; Szabó, I; Tárnoky, K; Traub, A, 1986)	3.16
"Histamine has been claimed to be the final common chemical mediator of acid secretion."	( Effects of cimetidine, atropine and pirenzepine on basal and stimulated gastric acid secretion in the rat. Ekelund, M; Håkanson, R; Vallgren, S, 1987)	0.99
"Histamine levels have been measured in plasma and synovial fluid (SF) obtained from patients with various arthritides, using a radioenzymatic assay procedure. "	( Histamine levels in human synovial fluid. Cleland, LG; Frewin, DB; Jonsson, JR; Robertson, PW, 1986)	3.16
"Histamine levels have been measured using an HPLC procedure involving fluorimetric detection after fluorescamine derivatization."	( A rapid HPLC technique for determining levels of histamine in tears from normal and inflamed human eyes. Angi, MR; Benassi, CA; Bettero, A; Galiano, F, 1985)	1.24
"Histamine, which has been associated with food poisoning in concentrations of 185 mg/100 g in Swiss cheese and 180 to 500 mg/100 g in fish, was found in concentrations above 500 mg/100 g in Swiss cheese."	( Analysis of cheese for histamine, tyramine, tryptamine, histidine, tyrosine, and tryptophane. Ayres, JW; Chang, SF; Sandine, WE, 1985)	1.3
"Histamine levels have been determined in nine tissues of four kinds (W/Wv, Wv/+, W/+, +/+) of WBB6F1 male and female mice, and mast cells have been counted in the skin and the fundus of W/Wv and +/+ mice. "	( Tissue histamine levels in male and female mast cell deficient mice (W/Wv) and in their littermates (Wv/+, W/+ and +/+). Burtin, C; Canu, P; Galoppin, L; Ponvert, C; Scheinmann, P, 1985)	2.17
"Histamine, which has recently been shown to increase leukocyte cyclic AMP, had a pronounced inhibitory effect on lysate-induced histamine release, producing 50% inhibition at a concentration of only 2.5 x 10(-12) M.Leukocytes, incubated with leukocyte lysates, were sampled at various times and assayed for free histamine released into the incubation mixture supernates, and for bound histamine associated with the leukocyte buttons after centrifugation."	( Histamine release induced by human leukocyte lysates. Reabsorption of previously released histamine after exposure to cyclic amp-active agents. Kelly, MT; White, A, 1973)	2.42
"Histamine has positive inotropic and chronotropic effects on the heart which are not abolished by beta adrenergic-blocking agents. "	( Activation of myocardial adenyl cyclase by histamine in guinea pig, cat, and human heart. Klein, I; Levey, GS, 1971)	1.95

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Histamine plays an important part in the cutaneous weal and flare response which underlies many allergic skin conditions. Histaminergic system is involved in the regulation of neuropeptides and gastric acid secretion. As histamine plays a central role in allergic diseases, it is possible that SST affects the allergy-related histamine signaling.

Excerpt	Reference	Relevance
"The histaminergic system plays a significant role in the maintenance of wakefulness, appetite regulation, cognition and arousal, which are severely affected in neuropsychiatric disorders."	( The Histaminergic System in Neuropsychiatric Disorders. Chen, Z; Cheng, L; Liu, J, 2021)	1.66
"Histamine promotes cell transformation through redox-mediated alterations in the cell cycle, DNA repair, and immunological response."	( Examining the Role of Histaminergic, Orexinergic, and Cannabinergic Systems in Redox Regulation in Gastric Adenocarcinoma. Aschner, M; Guijosa, A; Hernández-Mora, VM; Molina, A; Morales-Mulia, M; Ortega-Gómez, A; Prospero-García, O; Rodríguez-Flores, KL; Ruiz-García, E; Santamaría, A; Torres-Román, AL, 2023)	1.95
"Histamine plays pivotal role in normal physiology and dysregulated production of histamine or signaling through histamine receptors (HRH) can promote pathology. "	( A genetic locus complements resistance to Bordetella pertussis-induced histamine sensitization. Ball, RL; Blankenhorn, EP; Case, LK; Chen, Y; Chesler, EJ; Diehl, SA; Huang, R; Kost, J; Krementsov, DN; Li, D; Ma, R; Mahoney, JM; Philip, VM; Raza, A; Teuscher, C; Tyler, AL, 2023)	2.59
"Histamine plays a central role in its creation."	( [Perioperative aspects of anaphylaxis]. Domokos, K; Sütő, B, 2023)	1.63
"Histamine plays a complex role and stands out as a promising drug for TNBC treatment, which deserves to be tested in clinical settings. "	( Study of the antitumour effects and the modulation of immune response by histamine in breast cancer. Cremaschi, GA; Formoso, K; Herrero Ducloux, MV; Martinel Lamas, D; Massari, NA; Medina, VA; Nicoud, MB; Sterle, HA; Táquez Delgado, MA, 2020)	2.23
"Histamine can cause foodborne intoxication."	( Relationship between Salinity and Histamine Accumulation in Padaek, a Salt-Fermented Freshwater Fish Paste from Laos. Boulom, S; Giavang, Y; Marui, J; Phouphasouk, S; Yialee, Y, 2021)	1.62
"Histamine can cause foodborne intoxication."	( Relationship between Salinity and Histamine Accumulation in Padaek, a Salt-Fermented Freshwater Fish Paste from Laos. Boulom, S; Giavang, Y; Marui, J; Phouphasouk, S; Yialee, Y, 2021)	1.62
"Histamine plays a central role in various allergic diseases, such as allergic asthma and allergic rhinitis. "	( Histamine triggers the formation of neutrophil extracellular traps via NADPH oxidase, ERK and p38 pathways. Li, P; Wang, J; Wu, Z; Yang, Z; Zhou, E; Zhu, X, 2021)	3.51
"Histamine was found to activate S-type sensilla, which harbor bitter-sensing gustatory receptor neurons."	( Histamine gustatory aversion in Drosophila melanogaster. Aryal, B; Lee, Y, 2021)	2.79
"The histamine-mediated increase of theta phase-locking of spikes and high gamma power is consistent with successful spatial recognition."	( Histamine Enhances Theta-Coupled Spiking and Gamma Oscillations in the Medial Entorhinal Cortex Consistent With Successful Spatial Recognition. Chen, Q; Gao, D; He, C; Hu, B; Hu, Z; Jiang, J; Liao, X; Luo, F; Xia, J; Xiao, Q; Yue, F; Zhang, J, 2018)	2.4
"Histamine plays an important role in physiology and pathophysiology of cardiovascular system."	( Experimental autoimmune myocarditis in rats and therapeutic histamine H1 - H4 receptor inhibition. Fogel, WA; Gola, J; Kobos, J; Kraszewska, K; Mazurek, U; Mussur, M; Stark, H; Stasiak, A, 2018)	1.44
"Histamine plays a role in airway obstruction via smooth muscle contraction, bronchial secretion, and airway mucosal edema."	( The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy. Ogasawara, M; Yamauchi, K, 2019)	1.61
"Histamine plays an important role in neuromodulation and the biological immune response. "	( Mechanism of Histamine Oxidation and Electropolymerization at Carbon Electrodes. Lee, ST; Puthongkham, P; Venton, BJ, 2019)	2.33
"Histamine is known to increase vascular permeability and induce apoptosis, and these effects are closely associated with endothelial and mitochondrial dysfunction, respectively."	( Histamine H2 receptor activation exacerbates myocardial ischemia/reperfusion injury by disturbing mitochondrial and endothelial function. Bin, J; Chen, B; Dai, M; Fukushima, Y; He, N; Huang, Q; Kitakaze, M; Liao, Y; Luo, T; Wu, B; Xu, D; Zeng, Z; Zhao, Z, 2013)	2.55
"Histamine plays an important role in the development of symptoms in allergic, infectious, neoplastic and other diseases. "	( Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non-allergic diseases. Dauth, W; Hagel, AF; Hagel, E; Hagel, HJ; Hagel, WH; Kressel, J; Layritz, CM; Molderings, GJ; Neurath, MF; Raithel, M; Regnet, T; Rosenberg, A, 2013)	2.08
"Histamine is the main cause of sneezing and hypersecretion, while other mediators probably also play a role in nasal blockage."	( Allergic rhinitis. Mygind, N, 2014)	1.12
"Histamine plays a critical role in cancer cell proliferation, migration, and invasion."	( Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line. Ikeda, J; Jiang, Y; Morii, E; Ohtsu, H; Sato, A; Tian, T; Wang, Y, 2014)	1.54
"Histamine plays a key role in the morbidity and mortality associated with allergy, asthma, gastric ulcers, anaphylaxis, sepsis, hemorrhagic shock, anesthesia, surgery, cardiovascular disease, cancer, CNS disorders, and immune-mediated disease. "	( Histamine: metabolism, physiology, and pathophysiology with applications in veterinary medicine. Kovacic, JP; Peters, LJ, 2009)	3.24
"Histamine plays a major role in the mediation of allergic reactions such as peripheral inflammation. "	( In vivo histamine voltammetry in the mouse premammillary nucleus. Abdalla, A; Hashemi, P; Robke, R; Samaranayake, S; Wood, KM; Zeqja, A, 2015)	2.29
"Histamine can cause histaminergic angioedema."	( Oral medicine case book 64: Some aspects of the pathophysiology of angioedema with special reference to the upper aerodigestive tract. Bouckaert, M; Feller, L; Khammissa, R; Lemmer, J; Wood, NH, 2014)	1.12
"Antihistamines inhibit histamine signaling by blocking histamine H1 receptor (H1R) or suppressing H1R signaling as inverse agonists. "	( Antihistamines suppress upregulation of histidine decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene 2,4-diisocyanate-sensitized rats. Das, AK; Dev, S; Fukui, H; Kitamura, Y; Maeyama, K; Mizuguchi, H; Shahriar, M; Takeda, N, 2016)	1.55
"Histamine plays an important role as a neurotransmitter in diverse brain functions, and clearance of histamine is essential to avoid excessive histaminergic neuronal activity. "	( Histamine Clearance Through Polyspecific Transporters in the Brain. Yanai, K; Yoshikawa, T, 2017)	3.34
"Histamine promotes the development of eczematous lesions, elevates IgE serum levels, and induces scratching behavior in CACD."	( Histamine and Histamine Receptors in Allergic Dermatitis. Ohtsu, H; Seike, M, 2017)	2.62
"The histamine plays a decisive role in acute and chronic inflammatory responses and is regulated through its four types of distinct receptors designated from H1 to H4. "	( Effect of H4R antagonist N-(2-aminoethyl)-5-chloro-1H-indol-2-carboxamides and 5-chloro-2-(piperazin-1-ylmethyl)-1H-benzimidazole on histamine and 4-methylhistamine-induced mast cell response. Elden, BT; Kaliappan, I; Mariappanadar, V; Nagarajan, G; Tamizh, M, 2017)	1.22
"Histamine plays significant roles in the early-phase swelling via H1 receptors, and the late-phase swelling via H3/H4 receptors in this TPA-modified allergic dermatitis model."	( Modification of the picryl chloride-induced allergic dermatitis model in mouse ear lobes by 12-O-tetradecanoylphorbol 13-acetate, and analysis of the role of histamine in the modified model. Hirasawa, N; Hong, J; Ishihara, K; Katoh, G; Ohsawa, Y; Ohuchi, K; Seyama, T; Shibata, K; Tamura, S, 2009)	1.27
"Histamine plays an important role in many physiological functions; and a change in cytosolic Ca(2+) ([Ca(2+)](i)) may be an early signal in these processes. "	( Stimulation of histamine H2 receptors activates TRPC3 channels through both phospholipase C and phospholipase D. Chen, ZY; Dominic Chan, TW; Huang, Y; Kwan, HY; Wong, CO; Yao, X, 2009)	2.15
"As histamine plays a central role in allergic diseases, it is possible that SST affects the allergy-related histamine signaling."	( Sho-seiryu-to suppresses histamine signaling at the transcriptional level in TDI-sensitized nasal allergy model rats. Das, AK; Dev, S; Fukui, H; Kitamura, Y; Kodama, M; Matsushita, C; Mizuguchi, H; Takeda, N; Umehara, H, 2009)	1.17
"Histamine was shown to increase the number of osteoclasts and osteoclast precursors whereas antagonists of histamine receptor-1 and -2 decreased both osteoclast recruitment and resorption."	( Histamine promotes osteoclastogenesis through the differential expression of histamine receptors on osteoclasts and osteoblasts. Baroukh, B; Biosse-Duplan, M; de Vernejoul, MC; Dy, M; Saffar, JL, 2009)	2.52
"Histamine plays important roles in eliciting AR symptoms."	( Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine decarboxylase and IL-4 gene transcriptions. Fukui, H; Hattori, M; Horio, S; Kitamura, Y; Maeyama, K; Mizuguchi, H; Orimoto, N; Shahriar, M; Takeda, N; Umehara, H, 2009)	1.37
"Histamine plays an important role in allergy mainly through histamine H1 receptor (H1R). "	( Interleukin-4 up-regulates histamine H1 receptors by activation of H1 receptor gene transcription. Fujimoto, K; Fukui, H; Horio, S; Mizuguchi, H, 2010)	2.1
"Histamine is known to increase vascular permeability."	( Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins. Akhmedov, A; Becher, B; Borén, J; Hofmann, J; Johansen, P; Lüscher, TF; Mocharla, P; Rohrer, L; Rozenberg, I; Sluka, SH; Soliz, J; Steffel, J; Tanner, FC; Watanabe, T, 2010)	2.52
"Histamine promotes immune complex-induced vascular leakage in vivo, a critical and early event that leads to joint-specific autoimmune damage. "	( Histamine modulation of peripheral CRH receptor type 1alpha expression is dependent on Ca(2+) signalling and NF-kappaB/p65 transcriptional activity. McMorrow, JP; Murphy, EP; Zocco, D, 2010)	3.25
"Histaminergic neurons enhance cognition and memory, suggesting that their degeneration may contribute to the cognitive decline of AD."	( CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer's disease. Arrang, JM; Callebert, J; Motawaj, M; Peoc'h, K, 2010)	1.42
"Histamine plays an important role in morphine addiction and memory-dependent behavior. "	( Ameliorating effect of histamine on impairment of cued fear extinction induced by morphine withdrawal in histidine decarboxylase gene knockout mice. Chen, Z; Feng, B; Gong, YX; Ohtsu, H; Shou, WT; Wang, HJ; Zhang, WP, 2010)	2.11
"The histaminergic system plays a major role in cognition and H(3) receptor inverse agonists are expected to be a potential therapeutics for cognitive deficits of Alzheimer's disease (AD)."	( [The histaminergic system: a target for innovative treatments of cognitive deficits]. Arrang, JM; Burban, A; Davenas, E; Faucard, R; Gbahou, F; Morisset, S; Motawaj, M, )	1.13
"Histamine plays significant roles in early-phase swelling via H₁ receptors and in late-phase swelling via H₃/H₄ receptors in this TPA-modified allergic dermatitis model."	( [Roles of histamine in the exacerbated allergic dermatitis]. Hirasawa, N; Ohuchi, K, 2011)	1.49
"Histamine plays a major role in allergic rhinitis. "	( Histamine in allergic rhinitis. Taylor-Clark, T, 2010)	3.25
"Histamine plays major roles in allergic diseases and its action is mediated mainly by histamine H(1) receptor (H1R). "	( Albizia lebbeck suppresses histamine signaling by the inhibition of histamine H1 receptor and histidine decarboxylase gene transcriptions. Choudhuri, MS; Fukui, H; Hattori, M; Maeyama, K; Mizuguchi, H; Mukherjee, PK; Nurul, IM; Shahriar, M; Takeda, N; Venkatesh, P, 2011)	2.11
"Histamine plays a role in several (patho) physiological processes that are commonly studied in mouse models. "	( Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains: C57Bl/6 and Balb/c. Burhenne, H; Kaever, V; Neumann, D; Seifert, R; Zimmermann, AS, 2011)	2.12
"The histaminergic system plays an important role in memory and learning. "	( The central histamine level in rat model of vascular dementia. Fogel, WA; Kiec-Kononowicz, K; Lazewska, D; Mussur, M; Stasiak, A; Unzeta, M, 2011)	1.31
"Histamine increase in [Ca(2+)](i) was desensitized by repeated addition of agonist and blocked by a phospholipase C antagonist."	( Effect of histamine on Ca(2+)-dependent signaling pathways in rat conjunctival goblet cells. Carozza, RB; Dartt, DA; Hodges, RR; Li, D; Shatos, MA, 2012)	1.5
"Histamine induced the increase of IP1 formation, but failed to cause an increase in extracellularly releasing of [3H]choline metabolites, or intracellular accumulation of [³H]phosphscholine."	( Differential inhibitory effects of 2-azafluorenones on PI-PLC activation but not on PC-PLC- or PC-PLD-activation induced by histamine, PAF, PMA or A23187 in C6 glioma cells. Wang, HL; Wang, LC; Wei, JW, 2013)	1.32
"Histamine produce a contractile response in isolated myometrial strips, in the majority of mammals, via H1 histamine receptors activation, but in some species e.g."	( [Histamine receptors in the female reproductive system. Part II. The role of histamine in the placenta, histamine receptors and the uterus contractility]. Merwid-Lad, A; Szelag, A; Trocha, M, 2002)	1.95
"Histamine plays the role of neurotransmitter in the central nervous system, and histaminergic fibers are widely distributed in the brain."	( [Cerebral ischemia and histamine]. Adachi, N, 2002)	1.35
"Histamine plays an important role in modulating acquisition and retention in learning and memory process in experimental animals."	( Ameliorative effects of histamine on 7-chlorokynurenic acid-induced spatial memory deficits in rats. Kamei, C; Nishiga, M, 2003)	2.07
"The histamine-induced increase in ICAM-1 expression was inhibited by emedastine but not by azelastine and levocabastine."	( Histamine-induced cytokine production and ICAM-1 expression in human conjunctival fibroblasts. De Paoli, M; DeFranchis, G; Fregona, I; Leonardi, A; Plebani, M; Secchi, A, 2002)	2.24
"Histamine induced an increase in serosal-to-mucosal chloride flux leading to a decrease of chloride net absorption."	( Histamine-induced chloride secretion is mediated via H2-receptors in the pig proximal colon. Ahrens, F; Aschenbach, JR; Gäbel, G; Garz, B, 2003)	2.48
"Thus histamine can increase as well as decrease muscle blood flow, according to local concentration."	( Abolition of arteriolar dilation but not constriction to histamine in cremaster muscle of eNOS-/- mice. Madri, JA; Payne, GW; Segal, SS; Sessa, WC, 2003)	1.02
"Histamine plays an important role in the pathogenesis of atopic asthma through differential regulation of T helper lymphocytes."	( Effects of histamine on Th1/Th2 cytokine balance. Khan, MM; Packard, KA, 2003)	1.43
"of histamine all produce contractions, giving tracings about 4 cm."	( A sensitive method for the assay of 5-hydroxytryptamine. VANE, JR, 1957)	0.75
"Histamine and serotonin cause the endothelial cells of certain vessels to separate, and thus to create discrete intercellular gaps."	( Studies on inflammation. II. The site of action of histamine and serotonin along the vascular tree: a topographic study. MAJNO, G; PALADE, GE; SCHOEFL, GI, 1961)	1.21
"Histamine plays an important role in upper and lower airway inflammation."	( Mechanisms of specific immunotherapy: current knowledge. Akdis, CA; Blaser, K, 2003)	1.04
"Histamine plays an important role in the regulation of gastric acid secretion; however, its role in maintenance of gastric morphology remains unclear. "	( Lack of histamine alters gastric mucosal morphology: comparison of histidine decarboxylase-deficient and mast cell-deficient mice. Aihara, T; Furutani, K; Ichikawa, A; Jimbo, K; Kataoka, T; Nakamura, E; Ohtsu, H; Okabe, S; Tanaka, S, 2004)	2.2
"Histamine further promotes the immune response and stimulates gastric acid secretion."	( Effects of Helicobacter pylori infection on gastric inflammation and local cytokine production in histamine-deficient (histidine decarboxylase knock-out) mice. Buzás, E; Falus, A; Fülöp, AK; Gyulai, Z; Klausz, G; Mándi, Y; Scharek, P; Tiszlavicz, L, 2004)	1.26
"Histamine and thrombin cause phosphorylation and activation of endothelial NO-synthase (eNOS) on Ser1177. "	( Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-Akt. Halldórsson, H; Thorgeirsson, G; Thors, B, 2004)	2.14
"Histamine release may cause anaphylactoid reactions. "	( Classification of perioperative histamine-related reactions. Duda, D; Sattler, J; Sitter, H; Torossian, A, 2004)	2.05
"More histamine was needed to produce a wheal in Poland than in Libya: a 20-mm2 wheal required an injected histamine concentration of about 8.8 mg/ml in Libya, 29.5 mg/ml in Italy and 102.1 mg/ml in Poland."	( Skin reactivity to histamine and codeine in unselected 9-year-old children from Italy, Poland and Libya. Al-Bousafy, A; Al-Tubuly, A; Barreto, M; Bohmerova, Z; Falasca, C; Haluszka, J; Lesiak-Bednarek, A; Martella, S; Ronchetti, R; Villa, MP; Zakrzewski, J, 2004)	1.11
"Histamine plays an initial central role in airway inflammation, further release of histamine by circulating basophils, and peripheral thrombotic events."	( Pharmacological stabilization of mast cells abrogates late thrombotic events induced by diesel exhaust particles in hamsters. Hoet, PH; Hoylaerts, MF; Nemery, B; Nemmar, A; Vermylen, J, 2004)	1.04
"Histamine plays an important role in the regulation of various immunological functions. "	( Negative regulatory effect of histamine in DNFB-induced contact hypersensitivity. Buzás, E; Dobozy, A; Falus, A; Garaczi, E; Jánossy, T; Kemény, L; Koreck, A; Pivarcsi, A; Pos, Z; Széll, M, 2004)	2.05
"Histamine evoked an increase in mucin release to 3.9 +/- 0.4 microg/cm2/min (p < 0.01), protein output to 24.1 +/- 3.3 microg/cm2/min (p < 0.01) and viscosity to 12.8 +/- 1.1 (p < 0.05)."	( Secretory function of the esophageal mucosa in opossum: the role of cholinergic, peptidergic and histaminergic pathways. McCallum, RW; Namiot, Z; Sarosiek, J, 2004)	1.26
"Histamine plays an important role in the allergic inflammation. "	( No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations. Deichmann, K; Deindl, P; Heinzmann, A; Lau, S; Müller, S; Nickel, R; Niggemann, B; Peri-Jerkan, S; Sengler, C; Sommerfeld, C; Wahn, U, 2005)	2.1
"The histamine-induced increase in excitability was unaffected by K+ channel inhibitors; however, it was reduced by either blockage of voltage-gated Ca2+ channels with 200 microM Cd2+ or replacement of extracellular Ca2+ with Mg2+."	( Ionic mechanisms of histamine-induced responses in guinea pig intracardiac neurons. Hardwick, JC; Kotarski, AF; Powers, MJ, 2006)	1.14
"Histamine plays a role as a neurotransmitter in the mammalian brain, and histamine release from nerve endings is enhanced in ischemia by facilitation of histaminergic activity."	( Cerebral ischemia and brain histamine. Adachi, N, 2005)	1.34
"The histamine-induced increase in I(sc) was blocked by the histamine H(1) antagonist, pyrilamine, but was resistant against the histamine H(2) antagonist, cimetidine."	( Histamine-induced ion secretion across rat distal colon: involvement of histamine H1 and H2 receptors. Diener, M; Hennig, B; Prinz, G; Schultheiss, G; Schunack, W, 2006)	2.26
"This histamine-induced increase in the number of citric acid-induced coughs was dose dependently and significantly reduced when animals were pretreated with fexofenadine, a histamine H1 receptor antagonist."	( Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs. Kamei, J; Takahashi, Y, 2006)	1.04
"Histamine plays an important role in vascular disease. "	( Histamine differentially interacts with tumor necrosis factor-alpha and thrombin in endothelial tissue factor induction: the role of c-Jun NH2-terminal kinase. Akhmedov, A; Arnet, C; Iseli, SM; Lüscher, TF; Steffel, J; Tanner, FC, 2006)	3.22
"If histamine actually plays an inhibitory role in reward, then it would be expected that mice lacking histamine would be more sensitive to the behavioral effects of cocaine."	( The psychostimulant and rewarding effects of cocaine in histidine decarboxylase knockout mice do not support the hypothesis of an inhibitory function of histamine on reward. Anaclet, C; Brabant, C; Lin, JS; Ohtsu, H; Quertemont, E; Tirelli, E, 2007)	1.05
"Histamine plays a central role in allergic responses. "	( Inhibition of the histamine-induced weal and flare response: a valid surrogate measure for antihistamine clinical efficacy? Bousquet, J; Devillier, P, 2007)	2.12
"Histamine can inhibit the metastasis of melanoma B16 cells in C57BL/6 mice either through lymphatic or hemal route, and this partly because of its inhibitory effect on tumor growth."	( [Effect of histamine on metastasis of melanoma B16 cell xenograft in C57BL/6 mice]. Li, L; Qin, YS; Yu, HL; Zhang, X, 2007)	2.17
"Histamine induced increase in histamine H(1) receptor gene expression in vitro, and the protein kinase C-delta isoform was suggested to mediate the gene expression."	( Progress in allergy signal research on mast cells: up-regulation of histamine signal-related gene expression in allergy model rats. Fukui, H, 2008)	1.3
"Histamine also plays a role in inducing atherosclerosis in the mouse model."	( Progress in allergy signal research on mast cells: the role of histamine in immunological and cardiovascular disease and the transporting system of histamine in the cell. Ohtsu, H, 2008)	1.31
"Histamine is known to enhance the contractility of the human myocardium in vitro. "	( Inotropic effects of histamine in human myocardium: differentiation between positive and negative components. Gay, WA; Graver, LM; Guo, ZG; Levi, R; Robertson, DA, )	1.89
"Histamine tended to increase the released amount of radioactive arachidonic acid."	( Histamine-induced release of arachidonic acid and of prostaglandins in the peripheral vascular bed: mode of action. Juan, H; Sametz, W, 1980)	2.43
"Histamine was able to suppress not only spontaneous GH secretion but also the antiserum-stimulated GH release."	( Failure of somatostatin antiserum to reverse histamine-induced inhibition of pulsatile growth hormone secretion. Guidobono, F; Netti, C; Olgiati, VR; Pagani, F; Pecile, A; Sibilia, V, 1984)	1.25
"The histamine-induced increase in nasal airway resistance was 52% inhibited by combined use of the two antihistamine sprays (p less than 0.05), 22% by chlorpheniramine alone (p less than 0.05), and 29% by ranitidine."	( Significance of H1 and H2 receptors in the human nose: rationale for topical use of combined antihistamine preparations. Borum, P; Kirkegaard, J; Maansson, A; Mygind, N; Osterhammel, P; Secher, C, 1982)	0.96
"Histamine increase was blocked by alpha-fluoromethyl histidine (alpha FMH), acting after a significant lag period."	( Stimulation by epinephrine of histamine synthesis by rat peritoneal fluid mast cells in vitro. Gomes, EL; Rothschild, AM, 1984)	1.28
"Histamine and VIP produce an elevation of cAMP production in gastric glands isolated from the human fetal stomach at 15 weeks gestation. "	( Action of histamine and vasoactive intestinal peptide (VIP) on cyclic AMP in gastric glands isolated from human fetal stomach. Dupont, C; Gespach, C; Rosselin, G, 1981)	2.11
"Histamine was shown to cause vascular leakage via an H1 receptor."	( Production and antagonism of cutaneous vascular permeability in the guinea pig in response to histamine, leukotrienes and A23187. Bemis, KG; Fleisch, JH; Rinkema, LE, 1984)	1.21
"Histamine appears to cause its effect on secretion of gastric mucus via the activating influence on production of hydrochloric acid."	( [Biochemical mechanisms of the regulation of gastric mucus secretion in the rat: the role of prostaglandin E2 and histamine]. Argutinskaia, SV; Bersimbaev, RI; Deribas, VI; Kiseleva, EV; Tairov, MM, )	1.06
"The histamine-induced increase in serum corticosterone levels of stressed rats was considerably antagonized by prazosin, phenoxybenzamine, phentolamine and yohimbine, alpha 1 and alpha 2-adrenergic antagonists."	( The effect of adrenergic and cholinergic antagonists on central histaminergic stimulation of pituitary-adrenocortical response under stress in rats. Bugajski, J; Gadek, A, 1984)	0.99
"Histamine might increase either of these determinants of transport in the sheep lung."	( Histamine decreases selectivity of sheep lung blood-lymph barrier. McNamee, JE, 1983)	2.43
"Histamine caused an increase in pulmonary resistance and a decrease in compliance: these effects were partially vagally mediated and partially due to a direct stimulation of smooth muscles by the drug."	( Respiratory modulation by vagal afferents in pigs. Aguggini, G; Clement, MG; Miserocchi, G, 1981)	0.98
"Histamine caused an increase in gastric blood flow and oxygen uptake."	( Oxygen uptake as a determinant of gastric blood flow autoregulation. Granger, DN; Murphree, D; Perry, MA, 1982)	0.99
"Histamine plays no major role in AGBM-induced immune injury in the rat and does not prevent a reduction in nephron filtration rate."	( Glomerular immune injury in the rat: effect of antagonists of histamine activity. Blantz, RC; Gushwa, LC; Peterson, OW; Tucker, BJ; Wilson, CB, 1981)	1.22
"Histamine plays an important role in the control of gastric acid secretion by activating H2 receptors located on parietal cells. "	( Autoregulation of histamine synthesis through H3 receptors in isolated fundic mucosal cells. Bali, JP; Hollande, F; Magous, R, 1993)	2.06
"The histamine-induced increase in rG-CSF binding appeared to be definitely through H2 receptors."	( Reinforcement effect of histamine on the differentiation of murine myeloblasts and promyelocytes: externalization of granulocyte colony-stimulating factor receptors induced by histamine. Doi, M; Mio, M; Nakaya, N; Tasaka, K, 1994)	1.08
"Histamine is known to cause edema and excitation of small-diameter primary afferent neurons. "	( Histamine-induced edema in the rat paw--effect of capsaicin denervation and a CGRP receptor antagonist. Amann, R; Donnerer, J; Lanz, I; Schuligoi, R, 1995)	3.18
"Histamine did not increase after antigen challenge."	( Contralateral differences among biomarkers determined by a modified nasal lavage technique after unilateral antigen challenge. Baumgarten, CR; Petersson, G; Wihl, JA, 1995)	1.01
"Histamine plays an important role in the control of gastric acid secretion. "	( Histamine chloramines have a persistent stimulating effect on histamine H2 receptors and gastric acid secretion. Asagoe, K; Kita, T; Murakami, M, 1995)	3.18
"Histamine is known to activate vasopressin neurons via a histamine receptor subtype 1 and to increase release of vasopressin, but effects on oxytocin neurons have been previously unexplored."	( Histamine mediates fast synaptic inhibition of rat supraoptic oxytocin neurons via chloride conductance activation. Hatton, GI; Yang, QZ, 1994)	2.45
"Histamine can produce vasodilation of submucosal arterioles by two distinct mechanisms: activation of vascular H1 receptors resulting in release of nitric oxide from endothelium and activation of H3 receptors on sympathetic nerve terminals resulting in presynaptic inhibition of vasoconstrictor tone."	( Histamine H1 and H3 vasodilator mechanisms in the guinea pig ileum. Beyak, M; Vanner, S, 1995)	3.18
"Histamine induced increase in IL-5 production was inhibited by histamine H2-receptor antagonists, but remained unaffected by H1- or H3-receptor antagonists."	( Histamine increases anti-CD3 induced IL-5 production of TH2-type T cells via histamine H2-receptors. Fleissner, S; Heimann-Weitschat, I; Lindstaedt, R; Schmidt, J; Szelenyi, I, 1994)	2.45
"Histamine was chosen because it is one of the naturally occurring inflammatory mediators."	( Middle ear mucosal inflammation: an in vivo model. Chan, KH; Swarts, JD; Tan, L, 1994)	1.01
"Histamine elicited an increase in cAMP content in bone marrow stromal cells."	( Histamine-induced production of interleukin-1 alpha from murine bone marrow stromal cells and its inhibition by H2 blockers. Mio, M; Nakaya, N; Shimazawa, M; Tasaka, K, 1993)	2.45
"Histamine plays a major part in food and wine intolerance."	( [The histamine-free diet]. Götz, M; Jarisch, R; Wantke, F, 1993)	1.52
"Histamine did not increase isometric tension."	( Histamine and thrombin modulate endothelial focal adhesion through centripetal and centrifugal forces. Bodmer, J; Giaever, I; Kamath, J; Keese, C; Moy, AB; Shasby, DM; Shasby, S; Van Engelenhoven, J, 1996)	2.46
"Histamine did not cause any major effects on testicular blood flow."	( 5-Hydroxytryptamine--a local regulator of testicular blood flow and vasomotion in rats. Bergh, A; Collin, O; Damber, JE, 1996)	1.02
"Histamine was shown to increase afferent impulse activity of the small intestine's mesenteric nerves in a dose-dependent manner, the effect being reduced by antagonists of the H1 and H2 histamine receptors. "	( [The effect of the mast-cell mediators histamine and prostaglandins on the afferent nerve fibers of the small intestine in the cat]. Akoev, GN; Filippova, LV; Sherman, NO, 1996)	2.01
"The histamine-induced increase in [Ca2+]i was attenuated completely by chlorpheniramine, an H1 antagonist, but not by cimetidine, an H2 antagonist."	( Histamine H1 receptor-induced Ca2+ mobilization and prostaglandin E2 release in human gingival fibroblasts. Possible role of receptor-operated Ca2+ influx. Furuyama, S; Niisato, N; Ogata, Y; Sugiya, H, 1996)	2.22
"Histamine plays a critical role in the pathogenesis of bronchial asthma. "	( [Regulation of gene expression of L-histidine decarboxylase and histamine N-methyl-transferase, and its relevance to the pathogenesis of bronchial asthma]. Yamauchi, K, 1996)	1.98
"Histamine did not increase eosinophil transendothelial migration."	( [The effect of histamine on the adhesion of endothelial cells to eosinophils]. Hamano, N; Hiruma, K; Isikawa, K; Konno, A; Sirotori, K; Terada, N; Togawa, K, 1996)	1.37
"Histamine caused RL to increase at all ages."	( Maturational changes in responses of tissue and airway resistance to histamine. Agani, FH; Dreshaj, IA; Haxhiu, MA; Martin, RJ; Potter, CF, 1996)	1.25
"A histamine-induced increase in short-circuit current was also significantly reduced by inhibitors of the cyclooxygenase pathway indicating the involvement of prostaglandin E2 in its action."	( Regulation of ion transport by histamine in mouse cecum. Burakoff, R; Homaidan, FR; Tripodi, J; Zhao, L, 1997)	1.14
"Histamine did not cause superoxide anion production by equine neutrophils."	( Differential superoxide anion generation by equine eosinophils and neutrophils. Cunningham, FM; Foster, AP, 1997)	1.02
"Histamine plays an important role in gastric function, and the histaminergic system is involved in the regulation of neuropeptides and gastric acid secretion."	( Effect of histamine on thyrotropin-releasing hormone and somatostatin secretion in rat stomach. Kaneko, H; Konagaya, T; Kusugami, K; Mitsuma, T; Nagai, H; Yamamoto, H, )	1.98
"Histamine plays an important part in the cutaneous weal and flare response which underlies many allergic skin conditions. "	( Effects of H1 antagonists on the cutaneous vascular response to histamine and bradykinin: a study using scanning laser Doppler imaging. Bennett, AR; Church, MK; Clough, GF, 1998)	1.98
"The histamine-induced increase in [Ca2+]i transient was significantly inhibited by chlorpheniramine, but not by cimetidine."	( Histamine H1-receptor-mediated increase in the Ca2+ transient without a change in the Ca2+ current in electrically stimulated guinea-pig atrial myocytes. Hattori, Y; Houzen, H; Kanno, M; Yasuda, K; Yoshimoto, K, 1998)	2.22
"The histamine-evoked increase was prevented by the H1-receptor antagonist, mepyramine (2 microM)."	( Histamine causes Ca2+ entry via both a store-operated and a store-independent pathway in bovine adrenal chromaffin cells. Bunn, SJ; Powis, DA; Zerbes, M, 1998)	2.22
"Histamine was found to produce less response in mice to PCl."	( Effects of several drugs on the liver injury induced by delayed-type hypersensitivity to picryl chloride by regulating suppressor or helper T cells. Cao, J; Cheng, X; Lu, J; Wu, F; Xu, Q, 1999)	1.02
"Histamine may also activate additional pathways for Ca2+ entry."	( Different contributions of voltage-sensitive Ca2+ channels to histamine-induced catecholamine release and tyrosine hydroxylase activation in bovine adrenal chromaffin cells. Marley, PD; O'Farrell, M, 1999)	1.27
"Histamine did not increase myosin light chain phosphorylation of control or transfected ECV304 cells."	( Histamine alters cadherin-mediated sites of endothelial adhesion. Chen, YT; Kamath, AM; Ries, DR; Shasby, DM; Shasby, SS; Winter, MC, 1999)	2.47
"Histamine plays a key role in the pathogenesis of chronic urticaria (CU). "	( Abnormalities in histamine pharmacodynamics in chronic urticaria. Feldman, L; Gueant, JL; Kanny, G; Mallie, JP; Moneret-Vautrin, DA; Schohn, H, 1993)	2.07
"Histamine induced an increase in c-jun mRNA in human embryonic kidney cells stably transfected with the hH(2)R (maximal effect: 554.6 +/- 86.8% of control)."	( The human histamine H(2) receptor regulates c-jun and c-fos in a differential manner. del Valle, J; Grand, E; Todisco, A; Wang, LD; Wang, M, 2000)	1.43
"Histamine induced an increase in tyrosine phosphorylation in four main clusters of proteins with apparent molecular weights of 25, 35, 65 and 150 kDa."	( Involvement of tyrosine phosphorylation in the positive inotropic effect produced by H(1)-receptors with histamine in guinea-pig left atrium. Akaishi, Y; Hattori, Y; Kanno, M; Kitabatake, A; Yasuda, K; Yoshimoto, K, 2000)	1.24
"The histamine induced increase of acid output in the Heidenhain pouch dog was blocked by 71% 150 min after oral administration of enteric-coated IY-81149 at a dose of 3 mg/kg, and omeprazole showed similar effects."	( Effects of IY-81149, a newly developed proton pump inhibitor, on gastric acid secretion in vitro and in vivo. Chae, JB; Cho, KD; Huh, IH; Kim, DY; Kim, EJ; Kim, YS; Kwon, D; Lee, SM; Park, CW, 2001)	0.79
"Histamine plays a role in various cellular functions, including cell differentiation."	( Inhibition of effects of endogenously synthesized histamine disturbs in vitro human dendritic cell differentiation. Falus, A; László, V; Orsó, E; Pállinger, E; Pós, Z; Rothe, G; Schmitz, G; Szeberényi, JB; Szeberényi, S; Zsinkó, M, 2001)	1.29
"Histamine plays a central role in the pathogenesis of allergic and inflammatory diseases by modulating vascular and airway responses. "	( Histamine-induced activation of human lung macrophages. De Rosa, N; Gentile, M; Marone, G; Petraroli, A; Triggiani, M, )	3.02
"Histamine plays fundamental roles in numerous immune reactions. "	( Bidirectional communication between histamine and cytokines. Falus, A; Héninger, E; Horváth, B; Igaz, P; Lázaár, E; Novák, I, 2001)	2.03
"Histamine failed to increase ([Ca2+](i)) in Ca2+-free medium after cells were pretreated with thapsigargin (an endoplasmic reticulum Ca2+ pump inhibitor)."	( Mechanisms of histamine-induced intracellular Ca2+ release and extracellular Ca2+ entry in MG63 human osteosarcoma cells. Chen, YC; Cheng, JS; Jan, CR; Lee, KC; Lo, YK; Lu, CH; Tseng, LL; Wang, JL; Wang, JW, 2001)	1.39
"Histamine plays important biological roles in cell-to-cell communication; it is a mediator in allergic responses, a regulator of gastric acid secretion, a messenger in bronchial asthma, and a neurotransmitter in the central nervous system. "	( Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons. Cheng, X; Horton, JR; Nishibori, M; Sawada, K; Zhang, X, 2001)	2.04
"Histamine also plays important roles in bioprotection against various noxious or unfavorable stimuli (convulsion, nociception, drug sensitization, ischemic lesions, stress and so on)."	( [Studies on histamine with L-histidine decarboxylase, a histamine-forming enzyme, as a probe: from purification to gene knockout]. Watanabe, T, 2001)	1.41
"The histamine-induced increase in the content of VEGF protein in the conditioned medium was inhibited by the cyclic AMP antagonist Rp-cAMP (IC(50) 6.8 microM), and the protein kinase A inhibitor H-89 (IC(50) 12.5 microM), but not by the protein kinase C inhibitors Ro 31-8425 and calphostin C or the tyrosine kinase inhibitor genistein."	( Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H(2) receptors. Ghosh, AK; Hirasawa, N; Ohuchi, K, 2001)	1.14
"Histamine can cause a severe constriction of the central as well as peripheral airways in cotton dust-exposed workers, enabling a paradoxical effect for a differential diagnosis of byssinosis."	( Differential diagnosis of byssinosis by blood histamine and pulmonary function test: a review and an appraisal. Mohan-Rao, N; Panchal, GM; Venkatakrishna-Bhatt, H, )	1.11
"The histamine-induced increase in intranasal pressure was significantly augmented after repeated antigen challenge, indicating that nasal hyperresponsiveness was achieved. "	( Elevated nasal mucosal G protein levels and histamine receptor affinity in a guinea pig model of nasal hyperresponsiveness. Chiba, Y; Matsuo, K; Misawa, M; Saitoh, N, 2002)	1.13
"The histamine-induced increase in cGMP appeared to be mediated through calcium: the increase in cGMP required the presence of calcium in the extracellular medium, and the calcium ionophore A23187 caused a calcium-dependent increase in cGMP."	( Regulation by histamine of cyclic nucleotide levels in sympathetic ganglia. Greengard, P; Study, RE, 1978)	1.1
"Histamine was found to inhibit cytolysis reversibly and to increase lymphoid cell cyclic AMP levels."	( Properties of a subpopulation of T cells bearing histamine receptors. Henney, CS; Lichtenstein, LM; Plaut, M, 1975)	1.23
"The histamine-induced increase in respiration was inhibited when the atropine concentration was raised to 10 (-4) M."	( Effects of common inhibitors of gastric acid secretion on secretagogue-induced respiration and aminopyrine accumulation in isolated gastric glands. Berglindh, T, 1977)	0.74
"histamine-induced increase of intractracheal pressure and the effect was longer-lasting."	( Bronchodilator activity in vivo and in vitro of four 13,14-didehydro-PGE2 analogues. Bianco, S; Ceserani, R; Gandolfi, C; Marotta, F; Orlando, N; Usardi, MM, 1979)	0.98
"Histamine is known to enhance left ventricular contractility in the guinea-pig heart by interacting with H2-receptors. "	( Histamine-induced negative inotropism: mediation by H1-receptors. Levi, R; Zavecz, JH, 1978)	3.14
"Histamine is known to cause a substantial increase in the permeability of venules to both water and proteins. "	( Possible mechanism(s) for permeability recovery of venules during histamine application. Baldwin, AL; Wu, NZ, 1992)	1.96
"No histamine increase was seen following saline SPT."	( Histamine release in immediate-type hypersensitivity reactions in intact human skin measured by microdialysis. A preliminary study. Bindslev-Jensen, C; Petersen, LJ; Skov, PS; Søndergaard, J, 1992)	2.24
"Histamine can cause the release of catecholamines from bovine adrenal medullary chromaffin cells by a mechanism distinct from that of the depolarizing agents nicotine or high K+ buffer. "	( Protein phosphorylation in bovine adrenal medullary chromaffin cells: histamine-stimulated phosphorylation of tyrosine hydroxylase. Bunn, SJ; Dunkley, PR; Harrison, SM, 1992)	1.96
"Histamine is known to increase permeability of venules and to cause formation of gaps between endothelial cells. "	( Transient venular permeability increase and endothelial gap formation induced by histamine. Baldwin, AL; Wu, NZ, 1992)	1.95
"The histamine-induced increase in intracellular calcium was not blocked by the H1 or H2 antagonists pyrilamine or cimetidine (10(-4) M), respectively; however, the response to 10(-6) M histamine was completely blocked by the specific H3 antagonist thioperamide (10(-6) M)."	( Mast cell mediators prostaglandin-D2 and histamine activate human eosinophils. Cardillo, R; DiMuzio, J; Post, TJ; Raible, DG; Schulman, ES, 1992)	1.03
"Histamine did not inhibit the release of marker proteins from specific or gelatinase containing granules by neutrophils in suspension."	( Histamine inhibits cell spreading and C3bi receptor clustering and diminishes hydrogen peroxide production by adherent human neutrophils. Boxer, LA; Francis, JW; Petty, HR; Todd, RF, 1991)	2.45
"Histamine did not increase adenosine 3',5'-cyclic monophosphate at any doses tested but induced a rapid increase in the cytoplasmic free calcium concentration ([Ca2+]c)."	( Mechanism of glycogenolytic action of histamine in rat hepatocytes. Kojima, I; Mine, T; Ogata, E, 1991)	1.27
"The histamine-induced increase in Isc was dose-dependent with the maximal increase from the baseline value and EC50 being 4.4 +/- 0.5 microA/cm2 and 10(-6) M, respectively."	( [Effect of histamine on electrical properties in canine tracheal epithelium]. Isono, K; Kanemura, T; Sakai, N; Takeuchi, S; Takeyama, K; Takizawa, T; Tamaoki, J, 1991)	1.15
"Histamine was shown to suppress the in vitro generation of secondary syngeneic tumour-specific Ly-2+, L3T4- cytotoxic T cells from Ly-2+, L3T4- precursor cells. "	( Immune response against P815X2 mastocytoma growing in syngeneic DBA/2 mice. VI. Histamine-induced suppression of in vitro generation of tumour-specific cytotoxic T cells. Laatikainen, A, 1989)	1.95
"Histamine caused an increase of respiratory resistance (Rrs) at lower frequencies and a frequency dependence of Rrs."	( Response localization of the pharmacological agents histamine and salbutamol along the respiratory system by forced oscillations in asthmatic subjects. Polko, AH; Visser, BF; Wouters, EF, 1989)	1.25
"The histamine increase in the postanaphylactic phase was accompanied by the increase of histidine decarboxylase activity in inflammatory tissues."	( Role of endogenous histamine in postanaphylactic phase of allergic inflammation in rats. Hirasawa, N; Ohuchi, K; Tsurufuji, S; Watanabe, M, 1987)	1.08
"Histamine at lower concentrations between about 5 x 10(-8) and 10(-6) M caused a dose-dependent deceleration of the rhythm of spontaneous contractions."	( Dual effects of histamine on spontaneous activity in isolated bovine mesenteric lymphatics. Kawai, Y; Ohhashi, T; Watanabe, N, 1988)	1.34
"Histamine was shown to suppress to a similar extent the production of interleukin 2 (IL-2) and gamma interferon (IFN-gamma) by Leu 3+, Leu 3+8+, and Leu 3+8- cell subsets."	( Inhibitory effects of histamine on interleukin 2 and gamma interferon production of different human T helper cell subsets. Carlsson, R; Dohlsten, M; Hedlund, G; Sjögren, HO, 1988)	1.31
"(Histamine levels were lower in one subject and were only 50% higher in another subject than the corresponding baseline value.) Histamine levels and symptom scores were maximal at the same dose of allergen in only four of seven clinical responders."	( Tryptase levels in nasal-lavage fluid as an indicator of the immediate allergic response. Castells, M; Schwartz, LB, 1988)	0.9
"The histamine-induced increase in [Ca2+]i was not markedly diminished when the extracellular calcium was bound by excess ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA)."	( Influence of vasoactive agents on cytoplasmic free calcium in vascular endothelial cells. Avdonin, PV; Danilov, SM; Popov, EG; Posin, EY; Ryan, US; Tkachuk, VA, 1988)	0.76
"Histamine was found to produce a marked release of both amines from rat cerebral cortex at concentrations between 0.1 and 1 mM."	( Studies on the mechanism of histamine-induced release of noradrenaline and 5-hydroxytryptamine from slices of rat cerebral cortex. Hill, SJ; Mason, R; Young, CS, 1988)	1.29
"Histamine did not produce any marked changes of the duration of a TEA-broadened somatic action potential of B18."	( An identified histaminergic neuron can modulate the outputs of buccal-cerebral interneurons in Aplysia via presynaptic inhibition. Chiel, HJ; Kupfermann, I; Weiss, KR, 1988)	1.36
"Histamine was found to suppress the myocardial contractile function, to decrease systemic arterial blood pressure and to exert a positive chronotropic effect in unanesthetized dogs. "	( [Cardiovascular effects of histamine mediated by H1- and H2-receptors]. Mokhort, NA; Seredinskaia, NN, )	1.87
"The histamine-induced increase in myocardial oxygen extraction was accompanied by a significant increase in MVO2 in the presence of diphenhydramine."	( Histamine-induced changes in coronary circulation and myocardial oxygen consumption: influences of histamine receptor antagonists. Fisher, H; Kang, YH; Merrill, GF; Wei, HM, 1987)	2.2
"Histamine stimulated an increase in [Ca2+]i from a resting level of 111 +/- 4 nM (mean +/- SEM, n = 10) to micromolar levels; maximal and half-maximal responses were elicited by 10(-4) M and 5 X 10(-6) M histamine, respectively."	( Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin, and promotes albumin diffusion across cultured endothelial monolayers. Gallin, JI; Rotrosen, D, 1986)	2.44
"The histamine content was lower in all parts of the upper gastrointestinal tract in duodenal ulcer patients than in controls and was raised again in all regions after selective proximal vagotomy."	( Sample taking problems in measuring actual histamine levels of human gastroduodenal mucosa: specific and general relevance in clinical trials on peptic ulcer pathogenesis and selective proximal vagotomy. Lorenz, W; Ohmann, C; Rohde, H; Röher, HD; Thon, KP; Weber, D, 1985)	1.01
"The histamine-induced increase in RL was blocked by pretreatment with the histamine H1 receptor antagonist, chlorpheniramine, whereas the histamine-induced elevation in Qbr was prevented by the H2 antagonist, metiamide."	( Effects of histamine on bronchial artery blood flow and bronchomotor tone. Abraham, WM; el Fawal, H; Eyre, P; Long, WM; Sprung, CL; Wanner, A; Yerger, LD, 1985)	1.14
"Histamine failed to enhance responses of the muscle to electrical stimulation of either the muscle, directly, or its motor nerve.7."	( The influence of histamine and other vasoactive substances on contractile responses of cat skeletal muscle to acetylcholine. Block, AJ; Reit, E, 1973)	1.31

Treatment

Histamine treatment upregulated VEGF and IL-6 and downregulated PEDF expression in ARPE-19 cells cultivated under hyperglycemic conditions. Histamine treatment failed to produce gastric lesions, but when it was combined with ischemia, the widespread gastric lesions in the corpus mucosa were observed.

Excerpt	Reference	Relevance
"Histamine treatment (5 mg kg"	( Study of the antitumour effects and the modulation of immune response by histamine in breast cancer. Cremaschi, GA; Formoso, K; Herrero Ducloux, MV; Martinel Lamas, D; Massari, NA; Medina, VA; Nicoud, MB; Sterle, HA; Táquez Delgado, MA, 2020)	1.51
"Histamine treatment upregulated VEGF and IL-6 and downregulated PEDF expression in ARPE-19 cells cultivated under hyperglycemic conditions."	( Histamine causes an imbalance between pro-angiogenic and anti-angiogenic factors in the retinal pigment epithelium of diabetic retina via H4 receptor/p38 MAPK axis. Byeon, HE; Che, JH; Cho, CS; Kim, JH; Kim, YH; Kwon, JW; Lee, BJ; Lee, K; Seok, SH, 2020)	2.72
"Histamine levels of HPP-treated loins were in the range of 3.08 to 3.35 μg/g, identical to that of steam-treated loin."	( Physicochemical, Microstructural, and Microbiological Properties of Skipjack Tuna (Katsuwonus pelamis) After High-Pressure Processing. Berends, P; Devahastin, S; Jiranuntakul, W; Kasemsuwan, T; Nakwiang, N; Saetung, T, 2018)	1.2
"Histamine treatment decreased the extracellular glutamate content and alleviated neuronal cell death induced by exogenous glutamate challenge."	( Histamine up-regulates astrocytic glutamate transporter 1 and protects neurons against ischemic injury. Chen, Z; Fang, Q; Hu, WW; Jin, MM; Lou, GD; Shen, Y; Wang, XF; Xu, TL; Yan, HJ; Yang, Y; Zeng, WZ; Zhang, SH, 2014)	2.57
"Histamine treatment had extensive effects on keratinocytes, including effects on proinflammatory responses and cellular functions promoting wound healing. "	( Histamine enhances keratinocyte-mediated resolution of inflammation by promoting wound healing and response to infection. Gutowska-Owsiak, D; Ogg, GS; Salimi, M; Selvakumar, TA; Taylor, S, 2014)	3.29
"Histamine treatment failed to produce gastric lesions, but when it was combined with ischemia, the widespread gastric lesions in the corpus mucosa, but not in the antrum, were observed. "	( Acute gastric lesions induced by the administration of histamine to rats with partial vascular occlusion: evidence for the gastroprotective effect of prostaglandin. Brzozowski, T; Konturek, PC; Konturek, SJ; Neurath, MF; Raithel, M; Sliwowski, Z, 2010)	2.05
"Histamine treatment substantially reduced the grade of aplasia, the oedema and vascular damage induced by ionising radiation on bone marrow of mice and rats. "	( Histamine protects bone marrow against cellular damage induced by ionising radiation. Bergoc, RM; Carabajal, E; Croci, M; Medina, VA; Rivera, ES, 2010)	3.25
"Histamine treatment inhibited significantly exploration of the lesser fear-inducing arms of the labyrinth but its effect was more pronounced when histamine microinjection was in the left BLA."	( Functional lateralization of the baso-lateral amygdala neural circuits modulating the motivated exploratory behaviour in rats: role of histamine. Alvarez, EO; Banzan, AM, 2011)	1.29
"Histamine-5 Gy and untreated-5 Gy groups were irradiated with a single dose of whole-body Cesium-137 irradiation."	( Histamine prevents functional and morphological alterations of submandibular glands induced by ionising radiation. Bergoc, RM; Carabajal, E; Croci, M; Elverdin, JC; Medina, VA; Prestifilippo, JP; Rivera, ES, 2011)	2.53
"Histamine treatment partially reversed the methacholine-induced salivation reduction produced by EP while preventing SMG histological damage. "	( Histamine modulates salivary secretion and diminishes the progression of periodontal disease in rat experimental periodontitis. Carabajal, E; Croci, M; Elverdin, JC; Fernández-Solari, J; Medina, VA; Prestifilippo, JP; Rivera, ES, 2012)	3.26
"Histamine-5Gy and untreated-5Gy groups were irradiated with a dose of whole-body Cesium-137 irradiation."	( Radioprotective potential of histamine on rat small intestine and uterus. Bergoc, RM; Carabajal, E; Croci, M; Martinel Lamas, DJ; Massari, N; Medina, VA; Prestifilippo, JP; Rivera, ES, 2012)	1.39
"Histamine treatment also decreased mRNA expression of ob gene in epididymal white adipose tissue and up-regulated uncoupling protein 1 mRNA expression in brown adipose tissue."	( Neuronal histamine regulates food intake, adiposity, and uncoupling protein expression in agouti yellow (A(y)/a) obese mice. Chiba, S; Kakuma, T; Masaki, T; Noguchi, H; Sakata, T; Yasuda, T; Yoshimatsu, H; Yoshimichi, G, 2003)	1.46
"Histamine treatment of iDC significantly increased the IL-12 p40 mRNA and protein levels compared to histamine untreated iDC."	( Effects of histamine on functional maturation of dendritic cells. Iwabuchi, K; Kikuchi, K; Onoé, K; Pavlinkova, G; Yanagawa, Y, 2003)	1.43
"Histamine treatment (0.5 or 5.0 mg/kg, twice daily) protected against this liver injury as evident by normal serum transaminase levels and significantly reduced liver pathology scores."	( Histamine dihydrochloride protects against early alcohol-induced liver injury in a rat model. Gehlsen, KR; Haaparanta, T; Hornyak, SC, 2003)	2.48
"Antihistamine treatment inhibited but did not prevent leucocyte recruitment in the skin flaps post-surgery in +/+ and Wistar rats."	( Increased tissue survival in experimental skin flaps in mast cell-deficient rats. Guo, Y; Hedqvist, P; Raud, J; Törkvist, L, 2003)	0.8
"Histamine treatment for 30 min resulted in an approx."	( Trafficking and phosphorylation dynamics of AQP4 in histamine-treated human gastric cells. Carmosino, M; Mannucci, R; Procino, G; Svelto, M; Tamma, G; Valenti, G, 2007)	1.31
"The histamine-treated cells showed increased cytoplasmic staining for MUC5AC compared to cells treated with media alone, and cells pretreated with chlorpheniramine or NFA before histamine treatment."	( Histamine induces MUC5AC expression via a hCLCA1 pathway. Kim, SW; Kim, YM; Lee, CH; Min, YG; Rhee, CS; Won, TB, 2007)	2.26
"Histamine-10 Gy and untreated-10 Gy groups were irradiated with a single dose on whole-body using Cesium-137 source (7 Gy/min) and were sacrificed 3 days after irradiation."	( Mechanisms underlying the radioprotective effect of histamine on small intestine. Bergoc, RM; Crescenti, EJ; Cricco, GP; Croci, M; Garbarino, G; Martín, GA; Massari, N; Medina, VA; Mohamad, NA; Núñez, MA; Rivera, ES, 2007)	1.31
"Histamine treatment reduced mucosal atrophy, edema and preserved villi, crypts and nuclear and cytoplasmic characteristics of small intestine after radiation exposure. "	( Mechanisms underlying the radioprotective effect of histamine on small intestine. Bergoc, RM; Crescenti, EJ; Cricco, GP; Croci, M; Garbarino, G; Martín, GA; Massari, N; Medina, VA; Mohamad, NA; Núñez, MA; Rivera, ES, 2007)	2.03
"Histamine treatment resulted in loss of response of the adenylate cyclase to histamine in purified plasma membranes, but had no effect on basal, vasoactive intestinal peptide (VIP)- or NaF-stimulated enzyme activities."	( Desensitization by histamine of H2 receptor-mediated adenylate cyclase activation in the human gastric cancer cell line HGT-1. Emami, S; Gespach, C; Prost, A, 1984)	1.32
"Histamine treatment accelerated tumor growth, but only in normal animals and had little effect on tumor growth in immunocompromised hosts."	( The effect of histamine, antihistamines, and a mast cell stabilizer on the growth of cloudman melanoma cells in DBA/2 mice. Askenase, PW; Nordlund, JJ, 1983)	1.35
"In histamine-treated and in serotonin-treated mice, histological studies of the tumours showed large and numerous foci of haemorrhagic necrosis."	( Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: influence of H1 and H2 histamine receptors. Burtin, C; Canu, P; Lespinats, G; Salomon, JC; Scheinmann, P, 1982)	1.04
"Histamine pretreatment significantly inhibited 5-HT and insulin-derived growth factor-1-induced MAP kinase activation."	( Histamine antagonizes serotonin and growth factor-induced mitogen-activated protein kinase activation in bovine tracheal smooth muscle cells. Abe, MK; Chao, TS; Gomes, I; Hershenson, MB; Kelleher, MD; Rosner, MR; Solway, J, 1995)	2.46
"Histamine pretreatment (0.1 mM, 10-120 min) failed to modify the inositol phosphate response to a subsequent NaF or thrombin challenge."	( Agonist-induced desensitization of histamine H1 receptor-mediated inositol phospholipid hydrolysis in human umbilical vein endothelial cells. Hall, IP; Hill, SJ; McCreath, G, 1994)	1.29
"Two histamine-treated patients showed complete resolution of extensive liver metastasis."	( Histamine in immunotherapy of advanced melanoma: a pilot study. Asztély, M; Hafström, L; Hellstrand, K; Hermodsson, S; Lindner, P; Lundholm, K; Naredi, P; Rudenstam, CM, 1994)	2.21
"Antihistamine pretreatment increased mean baseline measurements of forced expiratory volume in 1 second (FEV1) between 2.58% and 9.28% compared with placebo, which was significant for all drugs except brompheniramine and clemastine. "	( The comparative actions and adverse effect profile of single doses of H1-receptor antihistamines in the airways and skin of subjects with asthma. Holgate, ST; Wood-Baker, R, 1993)	1.07
"Histamine pretreatment did not affect cell surface high affinity TNF-alpha receptors, as determined by ligand binding and immunodetection, and did not induce KC TNF-alpha production."	( Histamine and cis-urocanic acid augment tumor necrosis factor-alpha mediated induction of keratinocyte intercellular adhesion molecule-1 expression. Mitra, RS; Nickoloff, BJ; Shimizu, Y, 1993)	2.45
"2. Histamine pretreatment desensitized guinea-pig cortex slices to a subsequent challenge with histamine, which was observed as a reduction in the best-fit maximum response to 182 +/- 32% over basal accumulation."	( Desensitization of histamine H1 receptor-mediated inositol phosphate accumulation in guinea pig cerebral cortex slices. Bajusz, I; Banford, PC; Bristow, DR; Vedat, A; Young, JM, 1993)	1.13
"3. Histamine (10(-4) M) pretreatment of HeLa cells for 30 min desensitized the subsequent histamine-induced IPn accumulation."	( Desensitization of histamine H1 receptor-mediated inositol phosphate production in HeLa cells. Bristow, DR; Zamani, MR, 1993)	1.13
"With histamine in seven BDP-treated and in five placebo-treated patients, decrease in FEV1 > or = 20 percent from saline solution was paralleled by a significant decrease in tidal volume (VT), inspiratory time (Ti), and expiratory time (Te), and increase in respiratory frequency (RF)."	( Preventive effects of beclomethasone on histamine-induced changes in breathing pattern in asthma. Duranti, R; Fanelli, A; Gorini, M; Maggi, E; Scano, G; Stendardi, L, 1993)	1.01
"4. Histamine pretreatment in nominal (zero calcium + 0.2 mM EGTA) or in low (0.3 mM) extracellular calcium did not induce histamine receptor desensitization, supporting a role for extracellular calcium in the homologous H1 receptor desensitization process."	( The histamine H1 receptor in GT1-7 neuronal cells is regulated by calcium influx and KN-62, a putative inhibitor of calcium/calmodulin protein kinase II. Bristow, DR; Zamani, MR, 1996)	1.37
"Antihistamine treatment significantly reduced the increase in plasma histamine levels after the first histamine injection but did not alter the levels after subsequent histamine injections."	( Administration of H1 and H2 antagonists for chemoprophylaxis: a double-blind, placebo-controlled study in healthy volunteers. Doenicke, A; Hoernecke, R; Lorenz, W; Moss, J; Ostwald, P; Toledano, A, 1997)	0.78
"Histamine treatment did not result in iNOS mRNA expression or detectable NO synthesis."	( Expression and activity of nitric oxide synthases in human airway epithelium. Basclain, KA; Garlepp, MJ; Peroni, DJ; Thompson, PJ; Watkins, DN, 1997)	1.02
"Histamine pretreatment of non-IBD control tissues reduced anti-IgE responses to levels seen in IBD colon but had no effect in small intestine."	( Mast cell mediated ion transport in intestine from patients with and without inflammatory bowel disease. Crowe, SE; Luthra, GK; Perdue, MH, 1997)	1.02
"Antihistamine pretreatment significantly decreased the incidence and severity of the reactions."	( Tryptase levels are not increased during vancomycin-induced anaphylactoid reactions. Finn, HA; Laroche, D; Lynch, JP; Moss, J; Renz, CL; Thisted, R; Thurn, JD, 1998)	0.78
"Histamine or thrombin treatment also caused IL-8-containing granules to rapidly disappear from HIMEC."	( Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells. Bakka, A; Brandtzaeg, P; Haraldsen, G; Jahnsen, FL; Utgaard, JO, 1998)	1.02
"Histamine treatment (10-5 M) increased the release of IL-10 from unstimulated (2.2-fold) and LPS-stimulated (1."	( Importance of histamine in the cytokine network in the lung through H2 and H3 receptors: stimulation of IL-10 production. Bissonnette, EY; Ménard, G; Moses, AS; Sirois, J, 2000)	1.39
"Histamine treatment induced a similar adhesion phenomenon."	( Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins. André, P; Denis, CV; Hynes, RO; Ruggeri, ZM; Saffaripour, S; Wagner, DD; Ware, J, 2000)	1.03
"Histamine treatment reduced body fat weight, ob gene expression, and serum leptin concentration more in the model mice than in pair-fed controls."	( Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice. Chiba, S; Masaki, T; Sakata, T; Watanabe, T; Yoshimatsu, H, 2001)	1.36
"Histamine or serotonin treatment of HFL-1 augmented the expression of eotaxin mRNA."	( Histamine and serotonin stimulate eotaxin production by a human lung fibroblast cell line. Haniuda, M; Koyama, S; Numanami, H; Okubo, Y; Sato, E; Takashi, S; Tsukadaira, A; Ushiyama, T, 2002)	2.48
"histamine, whereas pretreatment with p-chlorophenylalanine, a selective depletor of serotonin stores, had no effect."	( Further investigations on the antipropulsive effect of centrally administered histamine and its relation with morphine. Donin, L; Gori, E; Massi, P; Parolaro, D; Patrini, G; Rubino, T, 1992)	1.23
"Histamine treatment restored the dopamine response of desensitized tracheal muscle with resensitization of the adrenoceptors."	( Effect of histamine treatment on dopamine tachyphylaxis of canine tracheal smooth muscle. Chen, CJ; Shue, CH, 1992)	1.41
"Histamine-treated cells showed marked increases in expressions of steady-state c-fos mRNA, with a time course of mRNA induction similar to cells exposed to platelet-derived growth factor or serum, known smooth muscle and fibroblast cell mitogens."	( Histamine stimulates proliferation of airway smooth muscle and induces c-fos expression. Kelly, AM; Kotlikoff, MI; Panettieri, RA; Rubinstein, NA; Yadvish, PA, 1990)	2.44
"Antihistamine pretreatment ablates the histamine but not the effect of thermal injury or bradykinin."	( Hageman factor-dependent kinin activation in burns and its theoretical relationship to postburn immunosuppression syndrome and infection. Holder, IA; Neely, AN, )	0.61
"Histamine treatment significantly reduced both the large vessel and middle compartment compliances before and during low venous pressure elevation."	( Effect of pulmonary venous pressure elevation on vascular resistance and compliance. Barman, SA; Taylor, AE, 1990)	1
"Histamine treatment increased free cytosolic calcium levels, but not those of adenosine 3',5'-cyclic monophosphate (cAMP) or guanosine 3',5'-cyclic monophosphate (cGMP)."	( Immune-related intestinal Cl- secretion. I. Effect of histamine on the T84 cell line. Barrett, KE; Beuerlein, G; Dharmsathaphorn, K; Huott, PA; Kagnoff, MF; Wasserman, SI, 1988)	1.24
"Treatment with histamine (100 µM) in U&LP of juvenile animals caused increases in baseline tension by 47.84 ± 6.52 mN/g (p < 0.001, n = 51) and by 50.76 ± 4.10 mN/g (p < 0.001, n = 55) in adult animals."	( Alterations in histamine responses between juvenile and adult urinary bladder urothelium, lamina propria and detrusor tissues. Chess-Williams, R; Moro, C; Stromberga, Z, 2020)	1.25
"Pretreatment with histamine receptor-1 antagonist, azelastine prevented the early effect of nasal secretions of AR patients on epithelial integrity."	( Histamine and T helper cytokine-driven epithelial barrier dysfunction in allergic rhinitis. Akdis, CA; Boeckxstaens, G; Boon, L; Bullens, DM; Ceuppens, JL; Farré, R; Hellings, PW; Kortekaas Krohn, I; Raap, U; Seys, SF; Steelant, B; Talavera, K; Van Gerven, L; Van Woensel, M; Wawrzyniak, P, 2018)	2.25
"Pretreatment with histamine significantly prevented the cell damage and rescued the expression of GS in a concentration-dependent manner."	( Modulation of astrocytic glutamine synthetase expression and cell viability by histamine in cultured cortical astrocytes exposed to OGD insults. Chen, Z; Gao, JQ; Hou, WW; Hu, WW; Li, J; Shen, Y; Shi, XJ; Tan, L; Tian, YY; Wang, XF; Yan, HJ, 2013)	0.94
"pre-treatment with histamine H1 receptor antagonist chlorpheniramine (50 nmol)."	( Involvement of the histaminergic system in the resuscitating effect of centrally acting leptin in haemorrhagic shock in rats. Altinbas, B; Giuliani, D; Guarini, S; Jochem, J; Kasperska-Zajac, A; Ottani, A; Savci, V; Yalcin, M, 2016)	1.08
"treatment with histamine increased the phosphorylation of the NR1 subunit of N-methyl-D-aspartate (NMDA) receptors."	( Involvement of glial cells in the nociceptive behaviors induced by a high-dose of histamine administered intrathecally. Iwata, Y; Katsuyama, S; Komatsu, T; Mizoguchi, H; Onodera, K; Orito, T; Sakurada, S; Sakurada, T; Watanabe, C; Watanabe, H; Yonezawa, A, 2011)	0.93
"Co-treatment with histamine and the histamine receptor-1 agonist trifluoromethyl toluidide did not inhibit the vacuolation."	( H1-antihistamines induce vacuolation in astrocytes through macroautophagy. Chen, Z; Hu, WW; Shen, Z; Wang, GH; Wang, Z; Yang, Y; Zhang, XN, 2012)	1.16
"Pretreatment with histamine at a concentration of 1 mM induced MUC2 mRNAand protein production, which was equivalent to that caused by 10 µg/ml LPS, but less than that of 0.5 µM PMA."	( Histamine regulates mucin expression through H1 receptor in airway epithelial cells. Kim, HM; Lee, CH; Rhee, CS, 2012)	2.15
"Pre-treatment with histamine resulted in significant mitigation of each of these end-points."	( Histamine protects against the acute phase of experimentally-induced hepatic ischemia/re-perfusion. Dewidar, BI; El-Desouky, KI; El-Mahdy, NA; El-Sisi, AE, )	1.89
"Pretreatment with histamine ameliorated the GalN/LPS-induced necrotic and apoptotic changes in the hepatocytes and inhibited the elevation of serum AST and ALT levels."	( The role of histamine H1 receptor and H2 receptor in LPS-induced liver injury. Chiba, S; Endo, M; Kakuma, T; Masaki, T; Noguchi, H; Seike, M; Tatsukawa, H; Watanabe, T; Yoshimatsu, H, 2005)	1.03
"Treatment with histamine led to significant dose-dependent reductions in proteinuria compared to the control antibody-injected group and markedly decreased the number of crescentic glomeruli and macrophage infiltration of the glomeruli."	( Histamine ameliorates anti-glomerular basement membrane antibody-induced glomerulonephritis in rats. Adachi, N; Hatta, T; Kameyama, H; Kimura, T; Kishimoto, N; Kusaba, T; Matsubara, H; Mori, Y; Okigaki, M; Sado, Y; Sasaki, S; Sonomura, K; Takeda, K; Tamagaki, K; Tanda, S, 2007)	2.12
"Treatment with histamine stimulated the phagocytotic activity of the Tetrahymena to a measurable degree, which was still demonstrable after a week (about 40 generations). "	( A functional study of concanavalin A-histamine binding site overlap in Tetrahymena phagocytosis test. Csaba, G; Darvas, Z; László, V, 1983)	0.89
"Pigs treated with histamine (2 micrograms/kg/minute for 60 minutes) had significantly higher blood flow to the gastric mucosa (P less than 0.025), particularly to the region of the proper gastric (fundic) glands (P less than 0.01), than did the saline-treated pigs."	( Effect of histamine and prostaglandin E2 on gastric blood flow in swine. Gallagher, L; Johnson, P; Reddy, VK; Zamora, CS, 1981)	0.99
"Pretreatment with histamine significantly potentiated the increases in RL caused by vagal stimulation but the potentiation of the increases in RL produced by histamine and acetylcholine were not significant."	( The effects of 5-hydroxytryptamine, histamine and acetylcholine on the reactivity of the lung of the anaesthetized dog. Dixon, M; Jackson, DM; Richards, IM, 1980)	0.86
"Treatment with histamine increased P1CP production in keloid fibroblasts, although it did not change that in the controls."	( Effects of various growth factors and histamine on cultured keloid fibroblasts. Kadono, T; Kikuchi, K; Takehara, K, 1995)	0.9
"Treatment with histamine (0.1, 0.2, 0.4 mumol/rat, i.c.v.) 150 min after intraplantar carrageenin (0.1 ml of 1% solution) caused a significant increase of paw pressure thresholds in inflamed (but not in non-inflamed) paws."	( Evidence for an inhibitory role of central histamine on carrageenin-induced hyperalgesia. Braga, PC; Guidobono, F; Netti, C; Pecile, A; Sibilia, V; Villani, P, 1994)	0.89
"Pretreatment with histamine inhibited IL-2 mRNA expression and secretion in cells activated with anti-CD3 or PMA, but not in cells activated with PMA + ionomycin."	( Involvement of protein kinase A in histamine-mediated inhibition of IL-2 mRNA expression in mouse splenocytes. Huggler, GK; Khan, MM; Patterson, EB; Poluektova, LY, 1999)	0.9
"Pretreatment by histamine perfusion (10(-5) M final concentration) increased this value to 30 +/- 9% (p < 0.001), and pretreatment by Ca2+-free buffer perfusion increased it to 67 +/- 8% (p < 0.001)."	( Highly efficient adenovirus-mediated gene transfer to cardiac myocytes after single-pass coronary delivery. Chossat, N; Haddada, H; Hatem, SN; Heimburger, M; Logeart, D; Mercadier, JJ; Névo, N; Perricaudet, M; Rücker-Martin, C, 2000)	0.64
"treatment with histamine thus makes it possible to partially restore the distorted energy intake and expenditure in leptin-resistant mice."	( Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice. Chiba, S; Masaki, T; Sakata, T; Watanabe, T; Yoshimatsu, H, 2001)	0.97
"Also treatment with histamine markedly reduced ulcer area evoked by WRS."	( Histamine in stress ulcer prophylaxis in rats. Brzozowski, T; Ceranowicz, P; Dembiński, A; Dembiński, M; Konturek, SJ; Stachura, J; Warzecha, Z, 2001)	2.07
"1 Treatment with histamine H2-receptor antagonists, which inhibit basal acid secretion was found to activate rat stomach histidine decarboxylase. "	( Activation of histidine decarboxylase by H2-receptor blockade: mechanism of action. Häkanson, R; Hedenbro, J; Liedberg, G; Rehfeld, JF; Stadil, F, 1975)	0.59
"Pretreatment with histamine had no effect on rat gastric tissue or gastric secretion, under identical conditions of stimulation."	( Gastric secretory response to cholinergic stimulation in rats chronically pretreated with pentagastrin or histamine in depot form. Kowalewski, K, 1976)	0.79
"Treatment with histamine (10(-4) M) of cultured non-pigmented human ciliary epithelial cells led to a biphasic elevation of free intracellular calcium mediated by H1-receptors. "	( Elevation of cytosolic free calcium in cultured ciliary epithelial cells by histamine: effects of verapamil and staurosporine. Stahl, F; Strauss, O; Wiederholt, M, 1992)	0.87
"Treatment with histamine only did not affect the level of specific IgE antibody."	( Effect of histamine antagonists and agonists on IgE production in mice. Nakazawa, T; Umegae, Y, 1992)	1.03
"Pretreatment with histamine H2 receptor antagonist cimetidine significantly reduced the extravasation of both the tracers and thwarted the increase of brain water content as compared to the untreated group."	( Role of histamine in pathophysiology of heat stress in rats. Cervós-Navarro, J; Sharma, HS, 1991)	1.04
"The treatment of histamine type 2 (H2) agonist showed decreased PFC responses in the mouse as well as histamine did."	( The suppressive effect of histamine on anti-DNP antibody production in mice. Abe, T; Furusawa, S; Okitsu-Negishi, S; Yoshino, K, 1988)	0.9

Toxicity

Tyramine and histamine, the most toxic biogenic amines (BA), are often found in high concentrations in certain foods. In a screening programme with reliable animal tests, such as a modified mouse-weight-gain assay, mouse leukocytosis test, histamine sensitization in mice, allergic encephalitis in rats, and the limulus test it could be demonstrated that the vaccine with whole inactivated bacteria was more toxic.

Excerpt	Reference	Relevance
"The oral LD50'S of clioquinol, histamine and chloroform and the intravenous LD50 of histamine were determined separately in male and female mice of the Tif : MAGf (SPF), Tif : MF2f (SPF), C3H/Tif Bomf, DBA2/J Bomf, C57Bl/6J/Bomf and A/J Bomf strains."	( Comparison of the acute toxicity of clioquinol, histamine, and chloroform in different strains of mice. Pericin, C; Thomann, P, 1979)	0.8
" In the subchronic study, all doses of Nal-Glu were well tolerated and there were no apparent systemic toxic effects."	( A 90-day subcutaneous toxicity and fertility study of a LHRH antagonist in rats. Bardin, CW; DeJesus, W; Didolkar, AK; Keizer-Zucker, A; Rivier, J; Sundaram, K; Vale, W, 1990)	0.28
" The formaldehyde treatment of acellular preparations affected the potency and did not destroy the toxic effects of PT completely."	( Production of a safe, potent and immunogenic partially purified acellular pertussis vaccine using simple indigenous techniques. Ahuja, S; Gupta, RK; Saxena, SN; Sharma, SB, 1991)	0.28
"5 mg/kg showed any toxic reactions and different patterns of the body weight growth from these in the control group."	( Immunological safety assessments of anti-IgE antibody which is detached from therapeutic immunoadsorbents for removing IgE. Kidaka, T; Sato, H, 1989)	0.28
"The optimal conditions for inactivation of Bordetella pertussis organisms with glutaraldehyde for the production of a safe and potent whole cell pertussis vaccine were investigated."	( Studies on the optimal conditions for inactivation of Bordetella pertussis organisms with glutaraldehyde for preparation of a safe and potent pertussis vaccine. Ahuja, S; Gupta, RK; Saxena, SN; Sharma, SB, 1988)	0.27
" The inhibition cannot be explained either by a direct toxic effect on effector cells or by blocking of Fc receptors."	( Effect of histamine receptor blocking on human antibody-dependent cell-mediated cytotoxicity. Gergely, P; Láng, I; Nékám, K; Petrányi, G; Török, K, 1981)	0.67
" In a screening programme with reliable animal tests, such as a modified mouse-weight-gain assay, mouse leukocytosis test, histamine sensitization in mice, allergic encephalitis in rats, and the limulus test it could be demonstrated that the vaccine with whole inactivated bacteria was more toxic than that with extracted antigens."	( Pertussis antigens--screening models on toxicity. Blackkolb, F; Guthöhrlein, G; Ronneberger, H, 1982)	0.47
" Our studies on the evaluation of some histidine decarboxylase inhibitors show that these compounds have a promising potential for developing an effective and safe anti-ulcer drug."	( Histidine decarboxylase inhibition: a novel approach towards the development of an effective and safe gastric anti-ulcer drug. Gulati, OP; Hennings, G; Parmar, NS, 1984)	0.27
"The development of potent H1-receptor antagonists that are free of adverse effects has renewed interest in their use in the treatment of asthma."	( The comparative actions and adverse effect profile of single doses of H1-receptor antihistamines in the airways and skin of subjects with asthma. Holgate, ST; Wood-Baker, R, 1993)	0.51
" The tolerance of the trial medication was registered by means of global assessment, rhinoscopy, recording of adverse events and with the aid of vital and laboratory parameters."	( A randomized equivalence trial comparing the efficacy and safety of Luffa comp.-Heel nasal spray with cromolyn sodium spray in the treatment of seasonal allergic rhinitis. Gegenheimer, LH; Klein, P; Weiser, M, 1999)	0.3
" Adverse systemic effects did not occur."	( A randomized equivalence trial comparing the efficacy and safety of Luffa comp.-Heel nasal spray with cromolyn sodium spray in the treatment of seasonal allergic rhinitis. Gegenheimer, LH; Klein, P; Weiser, M, 1999)	0.3
"The extensive use of selective histamine H2 receptor antagonists provides a unique opportunity to describe very rare adverse drug reactions."	( Nephrotoxicity and hepatotoxicity of histamine H2 receptor antagonists. Fisher, AA; Le Couteur, DG, 2001)	0.87
" This study also examined possible adverse reactions associated with methylsulfonylmethane supplementation."	( A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. Barrager, E; Schauss, AG; Schiller, RN; Veltmann, JR, 2002)	0.31
" All reported adverse events were included in the analysis."	( Treatment with histamine dihydrochloride and interleukin-2 in patients with advanced metastatic malignant melanoma: a detailed safety analysis. Agarwala, SS; Gehlsen, KR; Glaspy, J; Kass, CL; Naredi, P; O'Day, SJ, 2003)	0.67
" Histamine was applied at 10(-9),10(-8), 10(-7),10(-6), and 10(-5) M for 16 h into the cultures and the highest dose was found to be the most toxic one."	( Contribution of the histaminergic receptor subtypes to histamine-induced cerebellar granular neurotoxicity. Buyukokuroglu, ME; Gepdiremen, A; Hacimuftuoglu, A; Suleyman, H, )	1.37
"05) adverse experiences or side effects developed in either group."	( Nalpha-methyl histamine safety and efficacy in migraine prophylaxis: phase III study. Benjamín, TH; Isais-Millán, R; Millán-Guerrero, RO; Tene, CE, 2006)	0.69
" In the validation study, these new equations accurately predicted PC(20) allergen following inhalation of HDM allergen allowing a safe starting concentration of allergen of three doubling concentrations below predicted PC(20) allergen in all cases."	( Validated safety predictions of airway responses to house dust mite in asthma. de Kluijver, J; Diamant, Z; Grootendorst, DC; Ravensberg, AJ; Ricciardolo, FL; Sterk, PJ; van Rensen, EL, 2007)	0.34
" Four patients receiving HDC/IL-2/IFN and nine receiving DTIC experienced at least one grade 4 adverse event."	( Results of a multicenter randomized study to evaluate the safety and efficacy of combined immunotherapy with interleukin-2, interferon-{alpha}2b and histamine dihydrochloride versus dacarbazine in patients with stage IV melanoma. Anderson, R; Burdette-Radoux, S; Gehlsen, K; Hauschild, A; Hellstrand, K; Middleton, M; Naredi, P; Thomson, D, 2007)	0.54
" Searches were also conducted to identify articles on the pharmacokinetics, pharmacodynamics, and adverse effects of the intranasal corticosteroids discussed in this article."	( Pharmacokinetic/pharmacodynamic profile of mometasone furoate nasal spray: potential effects on clinical safety and efficacy. Hochhaus, G, 2008)	0.35
"The data reviewed indicate that MFNS has a number of qualities that are important in achieving nasal selectivity with minimal systemic adverse effects."	( Pharmacokinetic/pharmacodynamic profile of mometasone furoate nasal spray: potential effects on clinical safety and efficacy. Hochhaus, G, 2008)	0.35
"MFNS is an intranasal corticosteroid with a low potential for systemic adverse effects."	( Pharmacokinetic/pharmacodynamic profile of mometasone furoate nasal spray: potential effects on clinical safety and efficacy. Hochhaus, G, 2008)	0.35
"Increased BDNF concentrations may underly the adverse effects of salmeterol monotherapy on airway responsiveness in asthma."	( Adverse effects of salmeterol in asthma: a neuronal perspective. Bratke, K; Edner, A; Kuepper, M; Lindner, Y; Lommatzsch, M; Virchow, JC, 2009)	0.35
" Therefore, the GM mustard may be as safe as its native counterpart with reference to allergenic responses."	( Safety evaluation of genetically modified mustard (V4) seeds in terms of allergenicity: comparison with native crop. Chanana, NP; Das, M; Dhawan, V; Dwivedi, PD; Kumar, S; Misra, A; Verma, AK, )	0.13
" According to risk assessment data published by EFSA in 2011, histamine and tyramine are the most toxic biogenic amines and the ones that most affect food safety."	( Melatonin is formed during winemaking at safe levels of biogenic amines. Callejón, RM; Cantos-Villar, E; Garcia-Parrilla, MC; Ordóñez, JL; Rodriguez-Naranjo, MI, 2013)	0.63
"There is currently an urgent need to develop safe and effective adjuvants for enhancing vaccine-induced antigen-specific immune responses."	( Polymyxins as novel and safe mucosal adjuvants to induce humoral immune responses in mice. Endo, M; Kanno, H; Matsukawa, N; Sato, S; Takeshita, R; Tsutsumi, R; Yoshino, N, 2013)	0.39
" Adverse events and evaluation of clinical laboratory tests were used to assess the safety profile."	( Pharmacokinetic properties and safety profile of histamine dihydrochloride injection in Chinese healthy volunteers: a phase I, single-center, open-label, randomized study. Fang, Y; Feng, W; Huang, X; Jiang, H; Jing, S; Li, J; Liu, Y; Wang, Q; Wei, Z; Zang, Y; Zhao, L, 2015)	0.67
"Tyramine and histamine, the most toxic biogenic amines (BA), are often found in high concentrations in certain foods."	( Comparative analysis of the in vitro cytotoxicity of the dietary biogenic amines tyramine and histamine. Alvarez, MA; del Rio, B; Fernandez, M; Ladero, V; Linares, DM; Martin, MC; Redruello, B; Ruas-Madiedo, P, 2016)	1.02
" tragacantha exhibited anti-inflammatory and analgesic properties and they are also safe for medicinal use."	( Phytochemical screening, safety evaluation, anti-inflammatory and analgesic studies of the leaf extracts of Sterculia tragacantha. Abatan, MO; Adedapo, AA; Mogbojuri, OM, 2016)	0.43
"5 mg/day with most common treatment related adverse events being headache and insomnia."	( Pharmacokinetics, pharmacodynamics and safety of CEP-26401, a high-affinity histamine-3 receptor antagonist, following single and multiple dosing in healthy subjects. Hellriegel, E; Mayleben, DW; Maynard, JP; Nathan, PJ; Spiegelstein, O; Stevens, J; Van Gerven, J; Yang, R, 2016)	0.66
" The incidence of adverse events did not differ significantly between the groups, nor were there any serious adverse events."	( Efficacy and safety of Ergoferon versus oseltamivir in adult outpatients with seasonal influenza virus infection: a multicenter, open-label, randomized trial. Andrianova, E; Averyanov, A; Bart, B; Epstein, O; Minina, E; Putilovskiy, M; Rafalsky, V, 2016)	0.43
"Ergoferon and oseltamivir were equally effective and safe in adult outpatients with seasonal influenza A or B virus infection."	( Efficacy and safety of Ergoferon versus oseltamivir in adult outpatients with seasonal influenza virus infection: a multicenter, open-label, randomized trial. Andrianova, E; Averyanov, A; Bart, B; Epstein, O; Minina, E; Putilovskiy, M; Rafalsky, V, 2016)	0.43
"Tyramine and histamine are the biogenic amines (BA) most commonly found at high concentrations in food; they may even appear together at toxic concentrations."	( The dietary biogenic amines tyramine and histamine show synergistic toxicity towards intestinal cells in culture. Alvarez, MA; Del Rio, B; Fernandez, M; Ladero, V; Linares, DM; Martin, MC; Redruello, B; Ruas-Madiedo, P, 2017)	1.09
"No severe adverse events occurred."	( Safety, pharmacokinetics and pharmacodynamics of a novel anti-asthmatic drug, XC8, in healthy probands. Badorrek, P; Ferko, B; Marth, K; Müller, M; Nebolsin, V; Pohl, W; Renner, A; Romanova, J; Schmutz, H, 2019)	0.51
"XC8 was safe and well tolerated."	( Safety, pharmacokinetics and pharmacodynamics of a novel anti-asthmatic drug, XC8, in healthy probands. Badorrek, P; Ferko, B; Marth, K; Müller, M; Nebolsin, V; Pohl, W; Renner, A; Romanova, J; Schmutz, H, 2019)	0.51
" Inhibiting SSAO activity by natural agents might reduce the potential adverse effects of creatine metabolism in population of T2DM."	( Beneficial Impact of Semicarbazide-Sensitive Amine Oxidase Inhibition on the Potential Cytotoxicity of Creatine Supplementation in Type 2 Diabetes Mellitus. Deng, Y; Papukashvili, D; Rcheulishvili, N, 2020)	0.56
"Single doses of SUVN-G3031 up to 20 mg and multiple doses up to 6 mg once daily were found to be safe and well tolerated in healthy young adults."	( Safety, Tolerability, and Pharmacokinetics of SUVN-G3031, a Novel Histamine-3 Receptor Inverse Agonist for the Treatment of Narcolepsy, in Healthy Human Subjects Following Single and Multiple Oral Doses. Bhyrapuneni, G; Goyal, VK; Jetta, S; Mohammed, AR; Muddana, NR; Mudigonda, K; Nirogi, R; Palacharla, VRC; Pandey, SK; Ravula, J; Shinde, A, 2020)	0.8
"SUVN-G3031 was found to be safe and well tolerated in healthy human subjects without any effect of age, gender, and food on the pharmacokinetics and safety profile."	( Safety, Tolerability, and Pharmacokinetics of SUVN-G3031, a Novel Histamine-3 Receptor Inverse Agonist for the Treatment of Narcolepsy, in Healthy Human Subjects Following Single and Multiple Oral Doses. Bhyrapuneni, G; Goyal, VK; Jetta, S; Mohammed, AR; Muddana, NR; Mudigonda, K; Nirogi, R; Palacharla, VRC; Pandey, SK; Ravula, J; Shinde, A, 2020)	0.8
" The purpose of this review is to examine the existing literature regarding the benefits of histidine intake, the adverse effects of excess histidine, and the upper tolerance level for histidine."	( Benefits and Adverse Effects of Histidine Supplementation. Gheller, ME; Thalacker-Mercer, AE, 2020)	0.56
" Endotoxins were discussed as the cause for the adverse effects and sisomicin was identified as the lead impurity; batches containing sisomicin were contaminated with more impurities and were responsible for the fatalities."	( Analysis of histamine and sisomicin in gentamicin: Search for the causative agents of adverse effects. Holzgrabe, U; Wohlfart, J, 2021)	1
" Antihistamines are generally safe, but some patients experience adverse reactions, such as cardiotoxicity, central inhibition and anticholinergic effects."	( Pharmacogenomics for the efficacy and side effects of antihistamines. Chen, X; Li, J; Li, L; Liu, R; Peng, C, 2022)	1.48
" However, the histamine component in bee venom can cause adverse events; therefore, attention is required for BVP use."	( Investigation of the Adverse Events Associated with Bee Venom Pharmacopuncture in Patients Hospitalized in a Korean Hospital: A Retrospective Chart Review Study. Bae, IH; Cho, KH; Cho, SY; Jung, WS; Ko, CN; Kwon, S; Lee, HG; Moon, SK; Park, JM; Park, SU, 2022)	1.08
" The clinical safety evaluation showed that the doses administered are safe for human consumption."	( Genomic, phenotypic, and clinical safety of Limosilactobacillus reuteri ATCC PTA 4659. Axelsson, J; Liu, P; Roos, S; Sendelius, M, 2023)	0.91

Pharmacokinetics

The aim of this work was to model the pharmacokinetic and pharmacodynamic relationship of mizolastine, a new H1-receptor antagonist. The pharmacodynamic effect of the chosen preparation was tested on the shaved back of histamine sensitized rabbits.

Excerpt	Reference	Relevance
" The increase in potency appears to be related in part to a decrease in the metabolic clearance rate in vivo (6-fold) and, in vitro, to an increase in half-life (3-fold) when incubated with rat liver plasma membranes."	( N-acetyl oxyntomodulin30-37: pharmacokinetics and activity on gastric acid secretion. Bataille, D; Carles-Bonnet, C; Jarrousse, C; Martinez, J; Niel, H; Rolland, M, 1992)	0.28
" Blood samples were collected and assayed for MP by HPLC for pharmacokinetic analysis."	( Two-compartment basophil cell trafficking model for methylprednisolone pharmacodynamics. Chen, HY; Jusko, WJ; Salazar, DE; Wald, JA, 1991)	0.28
" Pharmacodynamic models were applied for these immediate effects of methylprednisolone based on the premise that receptor interactions of steroids are followed by rapid suppression of the circadian rhythm of cortisol and recirculation of basophils and helper T cells, which persist until inhibitory concentrations (IC50) of methylprednisolone disappear."	( Pharmacokinetics and pharmacodynamics of methylprednisolone in obesity. Camara, DS; Dunn, TE; Jusko, WJ; Ludwig, EA; Slaughter, RL, 1991)	0.28
" The 50% inhibitory concentration values derived from pharmacodynamic models developed to describe the direct suppressive effects of corticosteroids indicated no alteration in intrinsic sensitivity in the presence of ketoconazole."	( Lack of pharmacokinetic and pharmacodynamic interactions between ketoconazole and prednisolone. Jusko, WJ; Ludwig, EA; Middleton, E; Yamashita, SK, 1991)	0.28
" A pharmacodynamic model for basophil cell distribution to and from an extravascular compartment describes the effects of MP after both regimens."	( Steroid dose sparing: pharmacodynamic responses to single versus divided doses of methylprednisolone in man. Jusko, WJ; Ludwig, EA; Middleton, E; Reiss, WG; Slaughter, RL, 1990)	0.28
" The half-life in seconds for xenon clearance on the day when CDA was inhaled was 56 +/- 6, 41 +/- 5, and 110 +/- 31, before, during, and 10 minutes after challenge, respectively."	( Decrease in xenon clearance during response to cold, dry air: problems of interpretation. Bartenfelder, D; Civelek, CA; Fisher, C; Koller, D; La France, ND; Naclerio, RM, 1990)	0.28
" The mean serum elimination half-life of hydroxyzine was 36."	( The pharmacokinetics and pharmacodynamics of hydroxyzine in patients with primary biliary cirrhosis. Chen, XY; Minuk, GY; Simons, FE; Simons, KJ; Watson, WT, 1989)	0.28
" Pharmacodynamic parameters measured were plasma cortisol, whole blood histamine (reflecting basophils), and blood helper T lymphocytes."	( Oral contraceptive effects on methylprednisolone pharmacokinetics and pharmacodynamics. Ferry, JJ; Jusko, WJ; Lew, KH; Ludwig, EA; Middleton, E; Slayter, KL, 1996)	0.53
"447 L/hr/kg), resulting in a longer elimination half-life (2."	( Oral contraceptive effects on methylprednisolone pharmacokinetics and pharmacodynamics. Ferry, JJ; Jusko, WJ; Lew, KH; Ludwig, EA; Middleton, E; Slayter, KL, 1996)	0.29
" This slower clearance rate contributed to a longer elimination half-life for methylprednisolone (2."	( Oral contraceptive effects on methylprednisolone pharmacokinetics and pharmacodynamics. Ferry, JJ; Jusko, WJ; Lew, KH; Ludwig, EA; Middleton, E; Slayter, KL, 1996)	0.29
" The pharmacokinetic study included 11 plasma and 9 blister fluid samples and blister epidermal-roof specimens."	( Plasma and skin suction-blister-fluid pharmacokinetics and time course of the effects of oral mizolastine. Bianchetti, G; Chosidow, O; Danjou, P; Dubruc, C; Espagne, E; Fuseau, E; Herson, S; Revuz, J; Rosenzweig, P; Thenot, JP, 1996)	0.29
"Mizolastine mean Cmax (SD) and median tmax were, respectively, 380 ng."	( Plasma and skin suction-blister-fluid pharmacokinetics and time course of the effects of oral mizolastine. Bianchetti, G; Chosidow, O; Danjou, P; Dubruc, C; Espagne, E; Fuseau, E; Herson, S; Revuz, J; Rosenzweig, P; Thenot, JP, 1996)	0.29
"The pharmacokinetic and pharmacodynamic properties of FK613, a novel indolyl piperidine derivative, were investigated after oral administrations of 5, 10 and 20 mg in hard gelatin capsules to healthy male volunteers."	( Design of a suitable formulation of FK613, a novel antiallergic agent, based on its pharmacokinetic and pharmacodynamic properties in healthy subjects. Inaba, H; Kageyama, H; Kajiho, T; Nagashima, S; Nakashima, M; Sugiyama, A; Uematsu, T, 1996)	0.29
"The aim of this study was to establish whether pharmacokinetic differences between two pro-drugs of methylprednisolone (MP) are likely to be of clinical significance."	( Pharmacokinetic and pharmacodynamic assessment of bioavailability for two prodrugs of methylprednisolone. Brooks, CD; Daley-Yates, PT; Gregory, AJ, 1997)	0.3
" Bioequivalence was assessed by conventional pharmacokinetic analysis, by measuring pharmacodynamic responses plus a novel approach using pharmacokinetic/pharmacodynamic modeling."	( Pharmacokinetic and pharmacodynamic assessment of bioavailability for two prodrugs of methylprednisolone. Brooks, CD; Daley-Yates, PT; Gregory, AJ, 1997)	0.3
"The MP Cmax was less for MP suleptanate due to a longer absorption halflife of the prodrug from the intramuscular injection site."	( Pharmacokinetic and pharmacodynamic assessment of bioavailability for two prodrugs of methylprednisolone. Brooks, CD; Daley-Yates, PT; Gregory, AJ, 1997)	0.3
" The use of both pharmacokinetic and pharmacodynamic response data together gives greater confidence in the conclusions compared with those based only on conventional pharmacokinetic bioequivalence analysis."	( Pharmacokinetic and pharmacodynamic assessment of bioavailability for two prodrugs of methylprednisolone. Brooks, CD; Daley-Yates, PT; Gregory, AJ, 1997)	0.3
"Emedastine displays pharmacodynamic properties comparable with cetirizine and therefore qualifies as a safe and alternative compound with H1-receptor antagonist properties."	( Pharmacokinetics and pharmacodynamics of the novel H1-receptor antagonist emedastine in healthy volunteers. Assandri, A; Dallinger, S; Graselli, U; Jansen, B; Kiss, B; Müller, M; Schlagbauer-Wadl, H; Wacheck, V, )	0.13
"The aim of this work was to model the pharmacokinetic and pharmacodynamic relationship of mizolastine, a new H1-receptor antagonist obtained from histamine-induced wheal and flare inhibition test."	( Pharmacokinetic and pharmacodynamic modeling of mizolastine in healthy volunteers with an indirect response model. Deschamps, C; Dubruc, C; Mentre, F; Rosenzweig, P, 2000)	0.51
" Pharmacokinetic and pharmacodynamic modeling were performed subject by subject for the 4 doses altogether by nonlinear regression."	( Pharmacokinetic and pharmacodynamic modeling of mizolastine in healthy volunteers with an indirect response model. Deschamps, C; Dubruc, C; Mentre, F; Rosenzweig, P, 2000)	0.31
" The mean values of the pharmacodynamic parameters of apparent zero-order rate constant for the flare or wheal spontaneous appearance (k(in)), the first-order rate constant for the flare or wheal disappearance, the mizolastine concentration that produced 50% suppression of the maximum attainable inhibition of k(in), and the maximum attainable inhibition of the effect production were 14."	( Pharmacokinetic and pharmacodynamic modeling of mizolastine in healthy volunteers with an indirect response model. Deschamps, C; Dubruc, C; Mentre, F; Rosenzweig, P, 2000)	0.31
"Pharmacokinetic and pharmacodynamic relationships of mizolastine were reliably described with the use of an indirect pharmacodynamic model; this led to an accurate prediction of the pharmacodynamic activity of mizolastine."	( Pharmacokinetic and pharmacodynamic modeling of mizolastine in healthy volunteers with an indirect response model. Deschamps, C; Dubruc, C; Mentre, F; Rosenzweig, P, 2000)	0.31
"To summarize the physicochemical characterization, pharmacokinetic behavior, and biological evaluation of P792, a new monogadolinated MRI blood-pool agent."	( Physicochemical and biological evaluation of P792, a rapid-clearance blood-pool agent for magnetic resonance imaging. Bonnemain, B; Corot, C; Dencausse, A; Idee, JM; Lancelot, E; Lautrou, J; Meyer, D; Port, M; Raynal, I, 2001)	0.31
" The pharmacokinetic and biodistribution profiles were studied in rabbits."	( Physicochemical and biological evaluation of P792, a rapid-clearance blood-pool agent for magnetic resonance imaging. Bonnemain, B; Corot, C; Dencausse, A; Idee, JM; Lancelot, E; Lautrou, J; Meyer, D; Port, M; Raynal, I, 2001)	0.31
" The pharmacokinetic and biodistribution profiles are consistent with that of a rapid-clearance blood-pool agent: P792 is mainly excreted by glomerular filtration, and its diffusion across normal endothelium is limited."	( Physicochemical and biological evaluation of P792, a rapid-clearance blood-pool agent for magnetic resonance imaging. Bonnemain, B; Corot, C; Dencausse, A; Idee, JM; Lancelot, E; Lautrou, J; Meyer, D; Port, M; Raynal, I, 2001)	0.31
" The pharmacokinetic and biodistribution profiles are consistent with those of a rapid-clearance blood-pool agent."	( Physicochemical and biological evaluation of P792, a rapid-clearance blood-pool agent for magnetic resonance imaging. Bonnemain, B; Corot, C; Dencausse, A; Idee, JM; Lancelot, E; Lautrou, J; Meyer, D; Port, M; Raynal, I, 2001)	0.31
"A mechanism-based pharmacodynamic model was used to describe the inhibitory effect by omeprazole on gastric acid secretion measured after histamine stimulation in the dog."	( Gastric acid secretion in the dog: a mechanism-based pharmacodynamic model for histamine stimulation and irreversible inhibition by omeprazole. Abelö, A; Eriksson, UG; Gabrielsson, J; Holstein, B; Karlsson, MO, 2002)	0.74
"A nonlinear mixed-effects modelling approach was used to analyse pharmacokinetic and pharmacodynamic data from two Phase I studies of a platelet activating factor (PAF) antagonist under development for the treatment of seasonal allergic rhinitis."	( A pharmacokinetic/pharmacodynamic model for a platelet activating factor antagonist based on data arising from Phase I studies. Aarons, L; Brearley, C; Evans, L, 2005)	0.33
" Pharmacokinetic and pharmacodynamic parameter values were similar on 2 occasions during the consumption of a low-carbohydrate diet and a Weight Watchers diet, indicating that the decreased clearance was unlikely attributable to a change in diet composition."	( Reduced methylprednisolone clearance causing prolonged pharmacodynamics in a healthy subject was not associated with CYP3A5*3 allele or a change in diet composition. Calis, KA; Goldstein, JA; Hon, YY; Jann, MW; Jusko, WJ; Lee, SJ; Salaita, CG; Spratlin, VE, 2006)	0.33
"This article reviews the pharmacokinetic and pharmacodynamic properties of MFNS, highlighting the potential clinical relevance of data concerning its glucocorticoid receptor binding, bioavailability, and metabolism, and its role in activating and suppressing transcription of steroid-dependent genes."	( Pharmacokinetic/pharmacodynamic profile of mometasone furoate nasal spray: potential effects on clinical safety and efficacy. Hochhaus, G, 2008)	0.35
" The efficacy and safety profiles of MFNS seen in clinical use are consistent with its pharmacokinetic and pharmacodynamic properties."	( Pharmacokinetic/pharmacodynamic profile of mometasone furoate nasal spray: potential effects on clinical safety and efficacy. Hochhaus, G, 2008)	0.35
" Our data suggest that thioperamide, at least at 10 mg/kg, increases cocaine-induced locomotion through the combination of pharmacokinetic effects and the blockade of H3 receptors located on non-histaminergic neurons."	( Effects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions. Alleva, L; Brabant, C; Grisar, T; Jatlow, P; Lakaye, B; Lin, JS; Ohtsu, H; Picciotto, MR; Quertemont, E; Tirelli, E, 2009)	0.76
" The pharmacodynamic effect of the chosen preparation was tested on the shaved back of histamine sensitized rabbits."	( Microencapsulation of hydroxyzine HCl by thermal phase separation: in vitro release enhancement and in vivo pharmacodynamic evaluation. Ibrahim Soliman, I; latif Aziz, R; Zaki Rizkalla, CM, 2013)	0.61
" Despite years of clinical applications of HDC in Europe, no data are available on its tolerability and pharmacokinetic properties in Chinese patients."	( Pharmacokinetic properties and safety profile of histamine dihydrochloride injection in Chinese healthy volunteers: a phase I, single-center, open-label, randomized study. Fang, Y; Feng, W; Huang, X; Jiang, H; Jing, S; Li, J; Liu, Y; Wang, Q; Wei, Z; Zang, Y; Zhao, L, 2015)	0.67
" Pharmacokinetic parameters were estimated through noncompartmental procedures based on concentration-time data."	( Pharmacokinetic properties and safety profile of histamine dihydrochloride injection in Chinese healthy volunteers: a phase I, single-center, open-label, randomized study. Fang, Y; Feng, W; Huang, X; Jiang, H; Jing, S; Li, J; Liu, Y; Wang, Q; Wei, Z; Zang, Y; Zhao, L, 2015)	0.67
"0 mg HDC were well tolerated in Chinese HVs, and the pharmacokinetic profile of HDC in Chinese HVs was characterized in this study."	( Pharmacokinetic properties and safety profile of histamine dihydrochloride injection in Chinese healthy volunteers: a phase I, single-center, open-label, randomized study. Fang, Y; Feng, W; Huang, X; Jiang, H; Jing, S; Li, J; Liu, Y; Wang, Q; Wei, Z; Zang, Y; Zhao, L, 2015)	0.67
" Pharmacodynamic endpoints included a subset of tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB) and nocturnal polysomnography."	( Pharmacokinetics, pharmacodynamics and safety of CEP-26401, a high-affinity histamine-3 receptor antagonist, following single and multiple dosing in healthy subjects. Hellriegel, E; Mayleben, DW; Maynard, JP; Nathan, PJ; Spiegelstein, O; Stevens, J; Van Gerven, J; Yang, R, 2016)	0.66
" However, the EH method is limited in providing an objective and qualitative assessment of histamine pharmacodynamic response."	( Population pharmacokinetic/pharmacodynamic modeling of histamine response measured by histamine iontophoresis laser Doppler. Jones, BL; Liu, X; Roberts, JK; Sherwin, CM, 2016)	0.9
" In order to quantitatively characterize the potential risk and/or support regulatory decision-making, chronic and acute BA exposure scenarios were developed and simulated with a physiologically based pharmacokinetic model."	( Profiling wines in China for the biogenic amines: A nationwide survey and pharmacokinetic fate modelling. Bogdal, C; Göktaş, RK; Ke, R; Wei, Z; Xiao, R, 2018)	0.48
"To determine the pharmacokinetic and pharmacodynamic properties of diphenhydramine in dogs after intravenous (1 mg/kg) and oral (5 mg/kg) administration, and when given orally as dimenhydrinate at a dose of 10 mg/kg (≈5 mg/kg diphenhydramine)."	( Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study. Bäumer, W; Ehling, S; Papich, MG, 2019)	0.71
"Blood samples were collected for pharmacokinetic analysis of diphenhydramine and chlorotheophylline at defined intervals."	( Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study. Bäumer, W; Ehling, S; Papich, MG, 2019)	0.71
"Oral absorption of diphenhydramine was approximately three times greater with a longer half-life when it was administered as the combination product dimenhydrinate."	( Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study. Bäumer, W; Ehling, S; Papich, MG, 2019)	0.71
"The objective of this placebo-controlled phase 1 study was to assess the safety of oral XC8 and to evaluate its pharmacokinetic and pharmacodynamic properties."	( Safety, pharmacokinetics and pharmacodynamics of a novel anti-asthmatic drug, XC8, in healthy probands. Badorrek, P; Ferko, B; Marth, K; Müller, M; Nebolsin, V; Pohl, W; Renner, A; Romanova, J; Schmutz, H, 2019)	0.51
" The pharmacokinetic data showed similar dose and time dependent mean plasma XC8 concentrations after single (Day 1) and multiple (Day 21) dosing."	( Safety, pharmacokinetics and pharmacodynamics of a novel anti-asthmatic drug, XC8, in healthy probands. Badorrek, P; Ferko, B; Marth, K; Müller, M; Nebolsin, V; Pohl, W; Renner, A; Romanova, J; Schmutz, H, 2019)	0.51
" Full processing of all glycoforms is critical for preserving the improved in vivo half-life characteristics of the rhDAO heparin-binding motif mutants."	( Glycosylation site Asn168 is important for slow in vivo clearance of recombinant human diamine oxidase heparin-binding motif mutants. Boehm, T; Borth, N; Gludovacz, E; Hofbauer, S; Jilma, B; Maresch, D; Petroczi, K; Resch, M; Schuetzenberger, K, 2022)	0.72

Compound-Compound Interactions

Histamine combined with melphalan had a promising effect in the ILP. Future studies should explore the mechanism of action as well as its potential use in organ perfusion.

Excerpt	Reference	Relevance
"The projections from the subiculum to histaminergic cells in the posterior hypothalamic region of the rat were studied by means of anterograde neuroanatomical tracing with Phaseolus vulgaris-leucoagglutinin (PHA-L) combined with histidine decarboxylase (HDC)-immunohistochemistry."	( Subicular efferents to histaminergic neurons in the posterior hypothalamic region of the rat studied with PHA-L tracing combined with histidine decarboxylase immunocytochemistry. Tuinhof, R; Wouterlood, FG, 1992)	0.87
"By means of anterograde neuroanatomical tracing with Phaseolus vulgaris leucoagglutinin (PHA-L) combined with immunohistochemistry of histidine decarboxylase (HDC), we studied in the rat whether the histaminergic neurons in the posterior hypothalamic region are innervated by fibers arising from neurons in the medial preoptic region (MPO)."	( Innervation of histaminergic neurons in the posterior hypothalamic region by medial preoptic neurons. Anterograde tracing with Phaseolus vulgaris leucoagglutinin combined with immunocytochemistry of histidine decarboxylase in the rat. Gaykema, RP; Wouterlood, FG, 1988)	0.82
" In the present study, we have investigated the effect of oral terfenadine 180 mg, flurbiprofen 100 mg, and the drug combination on AMP-induced bronchoconstriction in eight nonatopic asthmatic subjects with a mean age of 53."	( The effect of oral terfenadine alone and in combination with flurbiprofen on the bronchoconstrictor response to inhaled adenosine 5'-monophosphate in nonatopic asthma. Holgate, ST; Phillips, GD, 1989)	0.28
"The connections between nuclei of the septum-diagonal band complex and the clusters of histaminergic neurons in the posterior hypothalamic region were studied with a dual-labeling procedure in which anterograde neuroanatomical tracing with Phaseolus vulgaris-leucoagglutinin was combined with immunohistochemistry of histidine decarboxylase."	( The connections between the septum-diagonal band complex and histaminergic neurons in the posterior hypothalamus of the rat. Anterograde tracing with Phaseolus vulgaris-leucoagglutinin combined with immunocytochemistry of histidine decarboxylase. Gaykema, RP; Steinbusch, HW; Wada, H; Watanabe, T; Wouterlood, FG, 1988)	0.74
"We investigated immediate and late changes in airway responsiveness to histamine, after bronchoconstriction due to exercise combined with inhalation of cold air, in ten asthmatic subjects who came on six days."	( Bronchoconstriction due to exercise combined with cold air inhalation does not generally influence bronchial responsiveness to inhaled histamine in asthmatic subjects. Cartier, A; Ghezzo, H; Malo, JL; Martin, RR; Tessier, P, 1988)	0.71
" The magnitude of the inhibitory effect of ranitidine, both administered alone and in combination with clemastine, suggests that in the production of histamine induced cutaneous weal and flare reactions, the contribution afforded by stimulation of cutaneous H2-histamine receptors is only small."	( The influence of ranitidine, alone and in combination with clemastine, on histamine-mediated cutaneous weal and flare reactions in human skin. Browne, PD; Kirby, JD; Thomas, RH, 1985)	0.7
" Within the frames of synergoantagonism interplay, the drug combination produced on some of the reactions an effect which was similar to that exerted by one of the components."	( [Characteristics of the effect of drug combinations on the development of immediate hypersensitivity]. Chetverikov, GN, )	0.13
" Studies revealed that tripelennamine (Tp) alone produced antinociception (ANTI) in mice and also caused potentiation when combined with morphine (M) or nalbuphene (NB)."	( The effect of tripelennamine alone and in combination with opiates to produce antinociception in mice. Hanig, JP; Hui, FW; Sun, CJ; Tocus, EC, 1983)	0.27
" Efficacy and safety of histamine, when given in combination with interleukin-2 (IL-2) and interferon-alpha (IFN-alpha), were evaluated in patients with metastatic renal cell carcinoma (mRCC)."	( Outpatient treatment with subcutaneous histamine dihydrochloride in combination with interleukin-2 and interferon-alpha in patients with metastatic renal cell carcinoma: results of an open single-armed multicentre phase II study. Donskov, F; Engman, K; Hellstrand, K; Henriksson, R; Naredi, P; Nellemann, H; Stiemer, U; von der Maase, H; Wersäll, P, 2002)	0.89
" After immunization with ovalbumin (OVA), a common dietary constituent, we evaluated the efficacy of pretreatment with histamine-receptor or serotonin-receptor blockers administered alone or in combination with a nitric oxide synthase inhibitor (L-NAME) on OVA-induced anaphylactic shock in Brown Norway rats."	( Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock. Bellou, A; Gerard, P; Gillois, P; Guéant, JL; Lambert, H; Longrois, D; Mallié, JP; Montémont, C; Sainte-Laudy, J; Vauthier, E, 2003)	0.77
" As ciproxifan and thioperamide are inhibitors of cytochrome P450 enzymes, responsible for metabolizing risperidone and haloperidol, the possibility that the augmentation of antipsychotics by imidazoles resulted from drug-drug interactions was tested."	( Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug-drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs. Ballard, ME; Cowart, M; Decker, MW; Esbenshade, TA; Faghih, R; Fox, GB; Hancock, AA; Pan, L; Roberts, S; Rueter, LE; Zhang, M, 2005)	0.33
"To evaluate the potential benefit of histamine combined with melphalan in the isolated limb perfusion (ILP) as an alternative to TNF-alfa and melphalan combination, for the treatment of irresectable soft tissue sarcomas of the limbs in Brown Norway (BN) rats."	( Histamine combined with melphalan in isolated limb perfusion for the treatment of locally advanced soft tissue sarcomas: preclinical studies in rats. Brunstein, F; Eggermont, AM; Ferreira, LM; Santos, ID; Ten Hagen, TL; van Tiel, ST, )	1.85
"Histamine combined with melphalan had a promising effect in the ILP warranting future studies to better explore the mechanism of action as well as its potential use in organ perfusion."	( Histamine combined with melphalan in isolated limb perfusion for the treatment of locally advanced soft tissue sarcomas: preclinical studies in rats. Brunstein, F; Eggermont, AM; Ferreira, LM; Santos, ID; Ten Hagen, TL; van Tiel, ST, )	3.02
"Agonists of the Gq/11-activated G-protein-coupled receptors (GPCRs) combined with strong membrane depolarization (high KCl) induce a synergistic amplification of transmitter release."	( Membrane depolarization combined with Gq-activated G-protein-coupled receptors induce transient receptor potential channel 1 (TRPC1)- dependent potentiation of catecholamine release. Atlas, D; Birnbaumer, L; Marom, M, 2011)	0.37
"55% when the Maillard reaction was combined with pressure treatment (MPT)."	( Reduction of the histamine content and immunoreactivity of parvalbumin in Decapterus maruadsi by a Maillard reaction combined with pressure treatment. Cao, MJ; Han, XY; Hu, JW; Li, XY; Liu, GM; Liu, H; Min, J; Yang, H, 2018)	0.82
"To examine the clinical typing and individualized treatment approach for allergic rhinitis and to determine the optimal treatment method for this disease using various drug combination therapies."	( Individualized treatment for allergic rhinitis based on key nasal clinical manifestations combined with histamine and leukotriene D4 levels. Chen, F; Li, G; Shen, C; Wang, H; Wen, Z; Zhang, X, )	0.35
"Clinical symptom evaluation combined with experimental detection of histamine and leukotriene levels can be an objective and accurate method to clinically classify the allergic rhinitis types."	( Individualized treatment for allergic rhinitis based on key nasal clinical manifestations combined with histamine and leukotriene D4 levels. Chen, F; Li, G; Shen, C; Wang, H; Wen, Z; Zhang, X, )	0.58
"The study did not provide any evidence of clinical efficacy for AZD5213 when combined with pregabalin in the treatment of painful diabetic neuropathy."	( A 3-way Cross-over Study of Pregabalin, Placebo, and the Histamine 3 Receptor Inverse Agonist AZD5213 in Combination With Pregabalin in Patients With Painful Diabetic Neuropathy and Good Pain-reporting Ability. Alexander, RC; Katz, N; Raudibaugh, K; Spierings, ELH, 2021)	0.87
" Carbon spheres QuEChERS mixed dispersion solid phase extraction combined with HPLC was used for the classification and analysis of batch samples."	( Pollution, Exposure and Risk of Biogenic Amines in Canned Sea Fish: Classification of Analytical Methods Based on Carbon Spheres QuEChERS Extraction Combined with HPLC. Dai, Z; Guo, X; Zhang, W, 2022)	0.72

Bioavailability

N1-Aryl(heteroaryl)alkyl-N2-[3-(1H-imidazol-4-yl)propyl]guanidines are potent histamine H2-receptor (H2R) agonists. Their applicability is compromised by the lack of oral bioavailability and CNS penetration.

Excerpt	Reference	Relevance
"Antagonistic effect against histamine-induced wheals was used to evaluate the bioavailability of terfenadine in monkeys."	( The objective and timing of drug disposition studies, appendix V. A comparison of the bioavailability of three dosage forms of terfenadine. Kinsolving, CR; Munro, NL, 1975)	0.55
" 3 Cimetidine was well absorbed by mouth and had a blood half-life of 2 hours."	( Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man. Burland, WL; Duncan, WA; Haggie, SJ; Hesselbo, T; Mills, JG; Sharpe, PC; Wyllie, JH, 1975)	0.51
" Although it is poorly absorbed after administration by mouth, disodium cromoglycate is of clinical benefit to patients with systemic mastocytosis."	( Oral disodium cromoglycate in the treatment of systemic mastocytosis. Austen, KF; Soter, NA; Wasserman, SI, 1979)	0.26
"The low ocular bioavailability of topically applied pilocarpine is attributed to extensive precorneal drug loss in conjection with the resistance to corneal penetration."	( Mechanistic and quantitative evaluation of precorneal pilocarpine disposition in albino rabbits. Lee, VH; Robinson, JR, 1979)	0.26
" The drug seems to display a very low animal toxicity, and, in humans, is well absorbed orally and metabolized via ring methylation before urinary excretion."	( The histamine H3-receptor: pharmacology, roles and clinical implications studied with agonists. Arrang, JM; Garbarg, M; Lecomte, JM; Lipp, R; Schunack, W; Schwartz, JC; Stark, H, 1991)	0.84
" N-Nitro-L-arginine (NOLA) (5 x 10(-5) to 10(-4) M), an inhibitor of NO synthase, and haemoglobin (10(-5) M), which reduces bioavailability of NO, both reduced the amplitude of nerve-mediated relaxations to less than 50%, without affecting the ability of the muscle to relax."	( Evidence that nitric oxide participates in non-adrenergic inhibitory transmission to intestinal muscle in the guinea-pig. Furness, JB; Murphy, R; Shuttleworth, CW, 1991)	0.28
" An albumin concentration of 30 mg ml-1 markedly increased the rate of absorption of [131I]albumin."	( Effects of airway luminal concentration of albumin on histamine-induced mucosal exudation of radio-iodine labelled albumin. Erjefält, I; Greiff, L; Persson, CG; Pipkorn, U, 1991)	0.53
"), total pepsin output, and is well absorbed from the gastrointestinal tract."	( Pharmacological profile of etintidine, a new histamine H2-receptor antagonist. Katz, LB; Scott, CK; Shriver, DA, 1986)	0.53
" Present interest focuses on the development of new agents with sufficiently high oral bioavailability and long duration of action."	( Pharmacological actions of various inotropic agents. Scholz, H, 1983)	0.27
" No influence can be expected from cimetidine on the bioavailability of these metal ions, the opposite being also true."	( An assessment of the physiological significance of cimetidine interactions with copper and zinc in biofluids as based on the computer-simulated distribution of the involved complexes at therapeutic levels of the drug. Akrivos, F; Berthon, G; Blais, MJ; Hoffelt, J, 1984)	0.27
" Comparison of the parenteral and enteral potencies indicated that FRG-8813 has a lower bioavailability than famotidine and cimetidine in rats and dogs."	( Gastric antisecretory effect of FRG-8813, a new histamine H2 receptor antagonist, in rats and dogs. Chida, Y; Inaba, N; Ohnishi, H; Onodera, S; Shibata, M; Yamaura, T, 1993)	0.54
" The bioavailability of MP was equivalent when based on AUC with a MP suleptanate median 108% of the MP succinate value (90% CI: 102-114%)."	( Pharmacokinetic and pharmacodynamic assessment of bioavailability for two prodrugs of methylprednisolone. Brooks, CD; Daley-Yates, PT; Gregory, AJ, 1997)	0.3
" However, when purified cells were preincubated with SNP in the presence of 5 mM N-acetylcysteine (NAC), increasing the bioavailability of NO, the downregulation was recovered."	( Exogenous nitric oxide regulates the degranulation of human basophils and rat peritoneal mast cells. Hirai, K; Iida, M; Iikura, M; Koshino, T; Morita, Y; Takaishi, T; Yamada, H, 1998)	0.3
"The bioavailability of endothelial nitric oxide (NO) is regulated by transition metals but their mechanisms of action on NO synthesis and degradation are not clearly understood."	( [Transition metals and nitric oxide production in human endothelial cells]. Brunet, A; David-Dufilho, M; Devynck, J; Devynck, MA; Privat, C; Richard, MJ, 2001)	0.31
" After oral administration, the bioavailability was only 3%."	( Clinical pharmacology of clemastine in healthy dogs. Bergvall, K; Bondesson, U; Hansson, H; Hedeland, M; Törneke, K, 2004)	0.32
" Pharmacokinetic data in the rat demonstrated approximately 100% bioavailability of the agent."	( Pharmacological profile of CR3465, a new leukotriene CysLT1 receptor antagonist with broad anti-inflammatory activity. Caselli, G; Ferrari, F; Makovec, F; Mennuni, L; Zanelli, T, 2004)	0.32
" The bioavailability after percutaneous exposure was equivalent to 15."	( Formulation and evaluation of ethylene-vinyl acetate copolymer matrix patches containing formoterol fumarate. Kakubari, I; Kawakami, J; Shinkai, N; Takayama, K; Takayama, S; Takayasu, T; Uruno, A; Yamauchi, H, 2006)	0.33
" Its systemic bioavailability (0."	( Pharmacokinetic/pharmacodynamic profile of mometasone furoate nasal spray: potential effects on clinical safety and efficacy. Hochhaus, G, 2008)	0.35
"N1-Aryl(heteroaryl)alkyl-N2-[3-(1H-imidazol-4-yl)propyl]guanidines are potent histamine H2-receptor (H2R) agonists, but their applicability is compromised by the lack of oral bioavailability and CNS penetration."	( Acylguanidines as bioisosteres of guanidines: NG-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists. Bernhardt, G; Buschauer, A; Dove, S; Elz, S; Ghorai, P; Götte, C; Igel, P; Keller, M; Kraus, A; Schneider, E; Schnell, D; Seifert, R; Zabel, M, 2008)	0.79
" Finally, A-940894 has good pharmacokinetic properties, including half-life and oral bioavailability in rats and mice."	( In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. Adair, RM; Baranowski, JL; Bettencourt, BM; Brioni, JD; Brito, AA; Carr, TL; Cowart, MD; Cuff, CA; Esbenshade, TA; Liu, H; Manelli, AM; Marsh, KC; McPherson, MJ; Miller, TR; Rundell, L; Strakhova, MI; Vortherms, TA; Wetter, JM; Witte, DG; Yao, BB, 2009)	0.6
" A 9-month chronic study (0, 200, 500, and 1000 mg/kg/day) was done in fasted dogs to take advantage of the reported improved catechin bioavailability with fasting."	( Exposure and toxicity of green tea polyphenols in fasted and non-fasted dogs. Crowell, JA; Kapetanovic, IM; Krishnaraj, R; Lindeblad, M; Lyubimov, A; Zakharov, A, 2009)	0.35
"001), with an enormous reduction in the oral bioavailability of ebastine and significantly reduced histamine-induced skin reactions."	( Itraconazole and rifampin alter significantly the disposition and antihistamine effect of ebastine and its metabolites in healthy participants. Cha, IJ; Lee, SS; Liu, KH; Shin, JG; Shon, JH; Yeo, CW, 2010)	0.81
"The main objective of this study was to develop a novel aerosolized liposome formulation for pulmonary delivery of anti-asthmatic medication and to explore the relationship between the bioavailability and anti-asthmatic efficacy of such a formulation."	( Liposomes prolong the therapeutic effect of anti-asthmatic medication via pulmonary delivery. Chen, X; Huang, W; Wong, BC; Wong, YF; Xu, M; Yang, Z; Yin, L, 2012)	0.38
" Curcumin is known for its low systemic bioavailability and rapid metabolization through oral route and has limited its applications."	( Intranasal curcumin and its evaluation in murine model of asthma. Chauhan, PS; Chawla, R; Dash, D; Kumar, JP; Kumari, S; Singh, M; Singh, R, 2013)	0.39
" Because the strength of adsorption of PTx to the vaccine adjuvant could change over time, we also used both assays to examine the bioavailability of PTx in spiked vaccine samples that had been stored at 25 °C for 9 weeks, mimicking long term vaccine storage conditions."	( Towards replacement of the acellular pertussis vaccine safety test: Comparison of in vitro cytotoxic activity and in vivo activity in mice. Burns, DL; Corvette, LJ; Ngundi, MM; Wagner, LD, 2017)	0.46
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51
"Phloretin is a promising polyphenolic compound known for its anti-inflammatory properties, but its poor solubility and low bioavailability hinder its clinical applicability."	( Abu-Azzam, O; Nasr, M, 2020)	0.56

Dosage Studied

histamine was used at doses at the lower end of the dose-response scale in five dogs with gastric fistula. The dose- response curve of anti-IgE induced histamine release from bronchoalveolar cells of subjects with more than 20% of lymphocytes in the lavage cell population was significantly greater than that of controls.

Excerpt	Relevance	Reference
" A linear dose-response relationship was obtained for theophylline."	( Acid secretion by guinea-pig isolated stomach. Holton, P; Spencer, J, 1976)	0.26
" Metamide, at doses of 3 X 10(-6)M, and 3 X 10(-5)M, caused a parallel displacement of the histamine dose-response curve, indicating competitive antagonism."	( A quantitative study of metiamide, a histamine H2-antagonist, on the isolated whole rat stomach. Bunce, KT; Parsons, ME, 1976)	0.75
" (2) The dose-response curves for the relaxation by ISO shifted to the right in a parallel manner as the concentration of the spasmogen increased, and became stationary at high concentrations of the spasmogen."	( Studies on the mode of antagonism between adrenergic beta-mimetics and beta-blocking agents (III). Functional antagonism between beta-mimetics and spasmogens. Ohashi, M, 1976)	0.26
" From dose-response curves for adrenaline and 5-hydroxytryptamine (5-HT) obtained in strips of rat aorta before and after incubation with each of the three blocking agents, the fractions of receptors remaining active for adrenaline and 5-HT, respectively, were estimated."	( Selective alpha-adrenoceptor blocking actions of a new derivative of 2-halogenotheylamine: 6-(2-bromoethyl)-10,11-methylenedioxy-5,6,7,8-tetrahydrodibenz[c,e]azocine. Ishida, Y; Kihar, M; Kobayashi, S; Watanabe, K, 1976)	0.26
"Cumulative dose-response curves for histamine were determined on acid secretion from the isolated guinea pig gastric mucosa."	( Analysis of the actions of cimetidine and metiamide on gastric acid secretion in the isolated guinea pig gastric mucosa. Olbe, L; Ryberg, B; Sjöstrand, SE, 1977)	0.53
" Fentanyl also shifted the dose-response curve of the contractile response of aorta to norepinephrine to the right."	( Alpha-adrenergic blocking action of fentanyl on the isolated aorta of the rabbit. Hatano, Y; Toda, N, 1977)	0.26
" Dose-response data were obtained and ED50 values for pulmonary and cardiovascular blockade were compared."	( Differences in pulmonary and cardiovascular beta receptors in the guinea pig and rabbit. Alvarez, R; Bradshaw, J; Marian, J; Weissberg, RM, 1977)	0.26
" When the H2-receptor antagonists burimamide, metiamide and cimetidine were labelled with 35S, 14C or 3H and dosed to rats, whole body autoradiography showed that the stomach was predominantly labelled in the glandular mucosa from 5 to 120 min after administration."	( Localization of histamine and histamine H2-receptor antagonists in the gastric mucosa. Cross, SA, 1977)	0.6
"In aortic strips, the dose-response curves for phenylephrine were obtained before and after addition of droperidol."	( Droperidol, its alpha-adrenergic blocking action on the aortic strip and inhibitory action on norepinephrine uptake of the adrenergic terminal of the left atrial strip of rabbit. Kasama, A; Kaya, K; Satoh, M; Yamanaka, I; Yanagisawa, M, 1978)	0.26
" Isoprenaline evoked vasodilation and propranolol (beta-adrenoceptor antagonist) caused a parallel shift to the right of the isoprenaline log dose-response curve."	( Identification of beta-adrenoceptors and histamine receptors in the cat nasal vasculature. Hiley, CR; Wilson, H; Yates, MS, )	0.4
" Contractions to 5-hydroxytryptamine (5-HT) and histamine of longitudinal muscle from the isolated ileum of the tree shrew (Tupaia), guinea-pig and rat were investigated by constructing dose-response curves and studying the effects of various antagonists."	( The actions of 5-hydroxytryptamine and histamine on the isolated ileum of the tree shrew (Tupaia glis). Sakai, K; Shiraki, Y; Tatsumi, T; Tsuji, K, 1979)	0.78
"027 mug/ml within 3 min, which was not futher enhanced on increasing the dosage of L-3 to 1 mg/kg."	( Blood histamine levels and arteriovenous concentration differences after the intravenous administration of the basic compounds l-3 and 48/80 in the anaesthetized dog. Kolassa, N; Kraupp, O; Schütz, W, 1975)	0.74
" However, its part in human bronchial asthma remains discussed, because neither the dosage of histamine in blood, nor the use of antihistaminics have furnished any real evidence."	( [Study of histamine in asthma]. Mordelet, M; Parrot, JL; Ruff, F; Santais, MC, )	0.75
"We performed dose-response curves to inhaled histamine (H) and methacholine (MC) in a group of eight rhesus monkeys, with and without natural allergy to Ascaris suum antigen (AA)."	( Airway responses to histamine and methocholine in Ascaris suum-allergic rhesus monkeys. Boucher, R; Hogg, JC; Michoud, MC; Paré, PD, 1978)	0.84
" The provocation doses which produced a 20% fall in forced expiratory volume in 1 sec (FEV1) and the slopes of the dose-response curves were analyzed."	( Bronchial hyperreactivity to histamine and methacholine in asthmatic children after inhalation of SCH 1000 and chlorpheniramine maleate. Kattan, M; Levison, H; Orange, RP; Woenne, R, 1978)	0.55
" Intravenous pentagastrin in a dose of 0,5 mug per kg could thus achieve the same extent of discrimination between individuals with a 10-fold economy in dosage over subcutaneous pentagastrin."	( Intravenous pentagastrin as a partial agonist of gastric secretion in man: evidence in favor of the existence of hormonal inhibitory sites. Makhlouf, GM; Prugh, MF; Schorr, BA; Vlahcevic, ZR, 1975)	0.25
" In vitro dose-response curves to gastrin I, CCK, and the octapeptide of CCK (OP) demonstrated that both CCK and OP were partial agonists on the LES muscle."	( Mechanism of cholecystokinin inhibition of lower esophageal sphincter pressure. Cohen, S; DiMarino, AJ; Fisher, RS, 1975)	0.25
" Noncyclic nucleotides, adenosine, adenosine 5'-monophosphate (AMP), and guanosine 5'-monophosphate (GMP) showed clear, dose-response protection against histamine death of propranolol-treated mice when they were given 45 to 90 min before histamine."	( Hypersensitivity to histamine and systemic anaphylaxis in mice with pharmacologic beta adrenergic blockade: protection by nucleotides. Matsumura, Y; Tan, EM; Vaughan, JH, 1976)	0.78
" The dose-response curves were shifted to the right in a parallel fashion by promethazine (3 x 10(-6)M)+."	( Cardiac histamine receptors: differences between left and right atria and right ventricle. McNeill, JH; Verma, SC, 1977)	0.69
" The histamine respiratory dose-response curve was shifted to the left in the presence of the phosphodiesterase inhibitor aminophylline."	( Potentiation by carbachol and aminophylline of histamine- and db-cAMP-induced parietal cell activity in isolated gastric glands. Berglindh, T, 1977)	1.03
"The inotropic response induced by beta-adrenergic and H1 histaminergic receptor stimulation was characterized in guinea pig left atria by obtaining dose-response relationships for isoproterenol and histamine under various experimental conditions."	( Characterization of the inotropic response induced by stimulation of beta-adrenergic and H1 histaminergic receptors in guinea pig left atria. McNeill, JH; Tenner, TE, 1978)	0.72
" The dose-response relationships and kinetics of histamine and BK-A release from antigen-challenged peripheral leukocytes are similar."	( Anaphylactic relase of a basophil kallikrein-like activity. II. A mediator of immediate hypersensitivity reactions. Lichtenstein, LM; Newball, HH; Talamo, RC, 1979)	0.51
" Blood samples obtained prior to and at various times after PIC were used to measure complement and split products of complement and plasma histamine levels and to determine dose-response slopes of lymphocyte cyclic adenosine monophosphate (cAMP) following stimulation with agonists."	( Inhalation challenge and pharmacologic studies of toluene diisocyanate (TDI)-sensitive workers. Butcher, BT; Dharmarajan, V; Karr, RM; O'Neil, CE; Salvaggio, JE; Weill, H; Wilson, MR, 1979)	0.46
" In addition, dose-response curves obtained on the mesenteric artery demonstrated that the H2-receptor mediated depressor responses coincided with cyclic AMP increases."	( Relationship between histamine-induced changes of cyclic AMP and mechanical activity on smooth muscle preparations of the guinea-pig ileum and the rabbit mesenteric artery. Butzheinen, R; Reinhardt, D; Ritter, E; Schümann, HJ, 1979)	0.58
" Intradermal histamine dose-response thresholds of pruritus were obtained before and after pretreatment with the three antihistamines and placebo in each subject."	( Suppression of histamine-induced pruritus by three antihistaminic drugs. Cohan, R; Leifer, KN; Rhoades, RB; Wittig, HJ, 1975)	0.98
" A dose-response curve revealed that a 50-mg dose of metiamide was required to suppress food-stimulated acid secretion by 50%."	( The effect of an H2-receptor antagonist on food-stimulated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcers. Comparison with an anticholinergic drug. Bailey, BA; Fordtran, JS; Richardson, CT; Walsh, JH, 1975)	0.25
" Isoproterenol, isoetharine and N-t-butylnorepinephrine, individually, had similar dose-response curves and ED50 values when tested as antagonists of histamine and carbamylcholine-induced bronchoconstriction in dogs."	( The role of bronchoconstrictors in evaluating smooth muscle relaxant activity. Minatoya, H; Spilker, B, 1975)	0.45
" Each amine was given in 45-min incremental step doses to constitute full dose-response curves."	( Evidence for a histamine H2 receptor that inhibits pepsin secretion in the dog. Hirschowitz, BI; Hutchison, GA, 1977)	0.61
" The reduction in carcass lipid was not produced in normal mice that were dosed orally or were fed on a diet containing 55 per cent sucrose."	( Effects of acetylenedicarboxylate: relationship between decreased carcass lipid and increased liver size and lean body weight. Arch, JR; Cawthorne, MA; Cornish, S; Green, A, 1979)	0.26
"The ECF-A acidic tetrapeptides Val-Gly-Ser-Glu, Ala-Gly-Ser-Glu and the analogue Val-Gly-Asp-Glu were selectively chemotactic for human eosinophils over a narrow dose range although eosinophils from different individuals varied in their dose-response pattern."	( Human eosinophils, acidic tetrapeptides (ECF-A) and histamine. Interactions in vitro and in vivo. Evans, DP; Kay, AB; Turnbull, LW, 1977)	0.51
" Complete dose-response relationships were established for the effects of intracarotid infusion of several humoral agents implicated in migraine."	( Internal and external carotid vascular responses to vasoactive agents in the monkey. Duckworth, JW; Lance, JW; Misbach, J; Mylecharane, EJ; Spira, PJ, 1978)	0.26
" Cumulative dose-response curves were obtained in substrate-rich (5."	( Role of glucose in contractility of airway smooth muscle. Loader, J; Souhrada, JF, 1979)	0.26
" In venous and arterial strips, dose-response curves to epinephrine, norepinephrine, serotonin, or histamine were established in the absence and in the presence of corticosteroid."	( Corticosteroid-potentiated vascular responses of the equine digit: a possible pharmacologic basis for laminitis. Elmes, PJ; Eyre, P; Strickland, S, 1979)	0.48
"Postnatal development of histamine receptors in the canine pulmonary circulation was examined utilizing histamine cumulative dose-response curves of pulmonary arteries isolated from neonatal and adult dogs."	( Postnatal changes in response of canine neonatal pulmonary arteries to histamine. Arroyave, CM; Grover, RF; Newman, JH; Reeves, JT; Souhrada, JF, 1979)	0.8
" There was no correlation between reactivity, which reflects the slope of the dose-response curve beyond the threshold dose, and threshold doses, nor between the initial RL (normalized for lung volume) and either threshold or reactivity."	( Variability of airway responses to inhaled histamine in normal subjects. Engel, LA; Habib, MP; Paré, PD, 1979)	0.52
" The aerosol/infusion dosage ratio for comparable reductions of blood pressure were 1 for isoprenaline, and 10 for NP."	( Comparison of sodium nitroprusside and isoprenaline aerosols in histamine-induced bronchial asthma of the guinea pig. Kreye, VA; Marquard, E, 1979)	0.5
" With the use of semilogarithmic dose-response curves they have shown that 80 mg oral propranolol augmented, whereas oral pretreatment with 400 mg W10294A (an experimental bronchodilator) decreased, histamine and methacholine-induced airway constriction."	( Modification of induced airway constriction in healthy subjects. Bouhuys, A; Littner, MR; Schachter, EN, 1979)	0.45
" The lower dosage gave a submaximal increase in LES pressure."	( Modulation of lower esophageal sphincter relaxation in the opossum. Cohen, S; Fournet, J; Snape, WJ, 1979)	0.26
" Two parameters were measured from dose-response curves: rho and pD2."	( Relationship between modulation by estradiol, progesterone and calcium upon the pharmacological reactivity of uteri of dogs. Aucélio, JG; Calixto, JB; Jurkiewicz, A, 1979)	0.26
"We determined the dose-response curve for the effect of histamine on pulmonary fluid and protein exchange when histamine was infused directly into the bronchial artery or pulmonary circulation in anesthetized sheep with a right thoracotomy and an acutely prepared lung lymph fistula."	( Effect of infusing histamine into pulmonary or bronchial artery on sheep pulmonary fluid balance. Nakahara, K; Ohkuda, K; Staub, NC, 1979)	0.83
", pretreatment for 1 hour) produced a dose dependent shift of the histamine wheal dose-response curve to the right in a parallel fashion."	( Cutaneous vascular histamine H1 and H2 receptors in the guinea-pig: the histamine skin wheal as a cutaneous vascular model. Cheng, HC; Munro, NL; Reavis, OK; Woodward, JK, 1979)	0.83
" Dose-response curves were analysed for sensitivity, defined as the minimal histamine dose causing a 20% fall in FEV1 (PC20), and for reactivity, defined as the slope of the dose-response curve once the reaction starts to occur."	( Comparison of histamine bronchial challenges with the Wright nebulizer and the dosimeter. Beaupré, A; Malo, JL, 1979)	0.85
" 2 The effect of histamine on both mitogen and antigen dose-response curves suggests a non-competitive, probably physiological antagonism."	( Inhibition of guinea-pig lymphocyte activation by histamine and histamine analogues. Beets, JL; Dale, MM, 1979)	0.85
" 2 Dose-response curves with ovalbumin as an antigen were obtained for the quick and slow contraction of this anaphylactic reaction."	( Involvement of SRS-A in the Schultz-Dale response of the guinea-pig small intestine. Herman, AG; Laekeman, GM; van Beek, HA, 1979)	0.26
" This dose-response curve could be shifted to the right by administration of dimethylaminoethyl-N-p-methoxybenzyl-N-alpha-aminopyridine (mepyramine; H1-antagonist)."	( [Involvement of both H1- and H2-receptors in the depressor responses of blood pressure to histamine in the rat (author's transl)]. Szelenyi, I; Thiemer, K, 1977)	0.48
" Dose-response experiments with six doses of histamine and two doses of the beta2-agonist showed unchanged calculated maximal response and an increase in D50."	( Effects of beta2-sympathomimetic on histamine-stimulated gastric acid secretion in dogs. Gottrup, F; Ornsholt, J, 1979)	0.79
" Using the prick and intracutaneous methods, dose-response tablets were established for the two preparations showing a good correlation."	( A new well-characterized, purified allergen preparation from timothy pollen. II. Allergenic in vivo and vitro properties. Aas, K; Bolle, R; Frostad, AB; Grimmer, O, 1977)	0.26
"Time-response and dose-response curves for acid output to continuous infusion of histamine (HIST) and pentagastrin (PG) were determined by two techniques in conscious rats provided with chronic gastric fistula."	( Comparison of the step-dose and single-dose acid response to histamine and pentagastrin in chronic gastric fistula rats. Genton, MJ; Pascaud, XB; Roger, AR, 1977)	0.72
" The normalized dose-response relations for histamine with an IMX background and for carbamylcholine were also similar in these two fractions."	( The actions of secretagogues on oxygen uptake by isolated mammalian parietal cells. Soll, AH, 1978)	0.52
" Mepyramine, an H1 receptor antagonist (H1A), inhibited this effect, displacing the histamine dose-response curve to the right."	( Histamine receptors in mesenteric circulation of the cat and rat. Guth, PH; Smith, E, 1978)	1.93
" Pulmonary resistance (RL) was measured and dose-response curves determined in the three conditions."	( Vagal and aerosol histamine interactions on airway responses in dogs. Drazen, JM; Ingram, RH; Loring, SH; Snapper, JR, 1978)	0.59
" Reproduceable responses sufficient for calculating dose-response curves, could be obtained up to 30 h after death."	( Physiological and pharmacological studies on isolated human bronchial preparations. Berlin, E; Boe, J; Thulesius, O, 1978)	0.26
" Differences were observed amongst the agonists in magnitudes of contraction, effective concentration ranges, and slopes of dose-response curves."	( The guinea pig tracheobronchial spiral strip: responses to selected agonists. Hanna, CJ; Roth, SH, 1978)	0.26
" Dose-response curves and time course to MCh challenge differed in CF and asthma."	( Bronchial hyperreactivity in cystic fibrosis and asthma. Corey, M; Krastins, IR; Levison, H; Mitchell, I; Woenne, R, 1978)	0.26
" Waud (Analysis of dose-response curves."	( Developments of computer-based estimation of pA2 values and associated analysis. Angus, JA; Stone, M, 1978)	0.26
"1 Dose-response curves for the positive inotropic and chronotropic responses to isoprenaline were obtained in atria from untreated guinea-pigs and those receiving various reserpine pretreatments."	( Selective reserpine-induced supersensitivity of the positive inotropic and chronotropic responses to isoprenaline and salbutamol in guinea-pig isolated atria. Broadley, KJ; Lumley, P, 1977)	0.26
" The dose-response curves of MPA from guinea pigs to NE and H under this condition were significantly blunted during hypoxia."	( Mechanical response of pulmonary artery under aerobic and hypoxic conditions. Dickey, DW; Souhrada, JF, 1977)	0.26
" A comparison of dose-response curves for PGF2alpha during breathing of two inspired oxygen tensions indicated a decreased sensitivity, but not decreased reactivity, with the higher oxygen tension."	( Oxygen-tension-dependent pulmonary vascular responses to vasoactive agents. Grover, RF; Reeves, JT; Tucker, A; Weir, EK, 1977)	0.26
" Timing sequences and dose-response relations were also completed for prostaglandins by subcutaneous testing in dogs injected with Evans blue (T-1824)."	( Effect of prostaglandins on macromolecular transport from blood to lymph in the dog. Joyner, WL, 1977)	0.26
" The dose-response relationships were not consistently altered by either vagal blockade or vagotomy."	( Canine pulmonary response to aerosol histamine: direct versus vagal effects. Drazen, JM; Ingram, RH; Loring, SH, 1977)	0.53
"3 Bradykinin, 5-hydroxytryptamine (5-HT) and histamine were injected intra-arterially and intra-portally and dose-response curves constructed from these data."	( A comparison of the effects of bradykinin, 5-hydroxytryptamine and histamine on the hepatic arterial and portal venous vascular beds of the dog: histamine H1 and H2-receptor populations. Richardson, PD; Withrington, PG, 1977)	0.75
" The nature of the shifts in the long dose-response curve for PGF2alpha caused by increasing concentration levels of flufenamate indicates a dual competitive/non-competitive type of antagonism."	( The effects of some bronchodilator and anti-inflammatory drugs on prostaglandin F2alpha-induced contraction of guinea-pig isolated trachea. McIntyre, HJ; Temple, DM, )	0.13
" Finally an antrectomy was performed and final dose-response data were collected."	( Gastric acid secretion in gastric fistula dogs after antral denervation and antrectomy. Elashoff, J; Harmon, JW; Trout, HH, 1977)	0.26
" Intravenous infusion of histamine caused marked displacement of the pentagastrin dose-response curve, in a manner suggesting a reduced sensitivity to pentagastrin."	( Suppression of rat stomach histidine decarboxylase activity by histamine: H2-receptor-mediated feed-back. Håkanson, R; Larsson, LI; Liedberg, G; Rehfeld, JF; Sundler, F, 1977)	0.8
"An easy and safe dose-response histamine-inhalation test is described, to measure the level of non-specific bronchial reactivity."	( Bronchial reactivity to inhaled histamine: a method and clinical survey. Cockcroft, DW; Hargreave, FE; Killian, DN; Mellon, JJ, 1977)	0.83
" In three dogs the effect of vagal stimulation was to produce a shift in the dose-response curve to inhaled histamine."	( Bronchial reactivity: interaction between vagal stimulation and inhaled histamine. Benson, MK; Graf, PD, 1977)	0.7
" The therapeutic cycles were standardized, for each drug, in the way of administration, dosage and total duration of the treatment."	( [Therapeutic possibilities in idiopathic headaches. Analysis of about 1000 cases]. Agostoni, A; Brandi, G; Cottino, A; Gai, V; Gastaldi, L; Lisino, F; Nattero, G, 1976)	0.26
" The dose-response curve of stimulated acid output in anemia patients was much flatter than in control patients."	( Gastric acid secretory responses to graded intravenous doses of histamine in hookworm anemia. Aggarwal, KN; Bajaj, SC; Chuttani, HK; Goyal, RK; Naik, SR, 1976)	0.49
" Acetylcholine (ACh) dose-response curves were obtained in both preparations."	( The denervated cremaster muscle of the guinea-pig as a pharmacological preparation. Dale, MM; Evinç, A; Vine, P, 1976)	0.26
" When aerosol dose-response curves were obtained for these agonists immediately following an "allergic asthmatic" episode, the airways were hyporeactive to PGF2alpha, H, and 5-HT, but not to ACh."	( Canine airway responses to acetylcholine, prostaglandin F2alpha, histamine, and serotonin after chronic antigen exposure. Chakrin, LW; Christian, P; Giannone, E; Krell, RD; McCoy, J; Osborn, R, 1976)	0.49
" By utilizing the drugs discussed and titrating the dosage to the needs of the patient, intravenous sedation will last long enough to complete the selected periodontal surgical procedure."	( Intravenous sedation of the periodontal surgical patient. Ruggerio, AC, 1975)	0.25
" Limited dose-response studies showed that 0-25 mug urogastrone kg--1 hr--1 resulted in inhibition of acid output of 80% and was not associated with clinical side-effects."	( Effect of urogastrone on gastric secretion and plasma gastrin levels in normal subjects. Elder, JB; Ganguli, PC; Gerring, EL; Gillespie, IE; Gregory, H, 1975)	0.25
" The dose-response curves for the compound 48/80-induced release of endogenous Hi and for the various amines taken up by the cells were compared."	( Intracellular distribution of amines taken up by rat mast cells. Bergendorff, A, 1975)	0.25
"5 X 10(-6) mol/kg), causes displacement of the histamine dose-response curve."	( Histamine receptors in peripheral vascular beds in the cat. Flynn, SB; Owen, DA, 1975)	1.95
" The dye leakage response to nasal capsaicin challenge was abolished by pretreatment with topical lidocaine, general substance P analogue, topical or general high dosage capsaicin."	( Study on the dye leakage response of nasal mucosa following topical, capsaicin challenge in guinea pigs. Asakura, K; Kataura, A; Kojima, T; Narita, S; Shirasaki, H, 1992)	0.28
" Given orally, RP 58802B (5 mg/kg, 60 min before challenge) produced a greater than three-fold shift to the right of the dose-response curve and depressed the maximum response to histamine by 39 +/- 11%."	( RP 58802B, a long-acting beta 2-adrenoceptor agonist: assessment of antiasthma activity in the guinea-pig in vivo. Lewis, SA; Raeburn, D; Underwood, SL, 1992)	0.48
" The last dosage was repeated every 12 hrs for 4 times more."	( [The epidemiology of adverse reactions to nonsteroidal anti-inflammatory drugs. Nimesulide is tolerated by patients with adverse reactions to NSAIDs and modulates in man the skin response to histamine and codeine]. Altucci, P; Astarita, C; Ferrara, AM; Franzese, A; Raucci, G; Scala, G; Sproviero, S, 1992)	0.47
" The dose-response curves for change in PC20 indicated that the higher doses of the nebulizer solution delivered more drug to beta 2 receptors in the lung than the lower doses from the MDI."	( Relative amount of albuterol delivered to lung receptors from a metered-dose inhaler and nebulizer solution. Bioassay by histamine bronchoprovocation. Blake, KV; Harman, E; Hendeles, L; Hoppe, M, 1992)	0.49
" The dose of agonist that produced a 35% fall in specific airways conductance (PD35 SGaw) was obtained by linear interpolation from the logarithmic dose-response curve."	( Effect of indomethacin on leukotriene4-induced histamine hyperresponsiveness in asthmatic subjects. Christie, PE; Hawksworth, R; Lee, TH; Spur, BW, 1992)	0.54
" In the other 5 dogs, dose-response was obtained with 10(-12) to 10(-7) mol ACh 10 min before and 10 min after administration of 10(-8) mol NKA."	( Airway response by neurokinin A. Kagawa, M; Miura, K; Miura, M; Miura, S; Onodera, A; Shioya, T, 1992)	0.28
"4 micrograms histamine challenge 15 min after oral acrivastine dosing when compared with placebo."	( An evaluation of the antihistamine activity of acrivastine and its onset in human skin. Gibson, JR; Manna, VK; Marks, P, 1992)	0.96
" Lansoprazole (both doses) as well as omeprazole raised the plasma gastrin levels about 11-fold 2 h after dosing and 8-to 10-fold 24 h after dosing, reflecting complete (2 h) and 70-80% (24 h) reductions of gastric acid secretion."	( Lansoprazole and omeprazole have similar effects on plasma gastrin levels, enterochromaffin-like cells, gastrin cells and somatostatin cells in the rat stomach. Håkanson, R; Karlsson, A; Lee, H; Mattsson, H; Sundler, F, 1992)	0.28
" Two of these methods provide different insights, demonstrating different patterns of response to dosage and over time, produced by different agents."	( Patterns of angiogenic response to mast cell granule constituents. Brown, FI; Duncan, JI; Long, WF; McKinnon, A; Thompson, WD; Williamson, FB, 1992)	0.28
" Pretreatment with aerosolized capsaicin (3 micrograms/ml for 15 to 60 s) 30 min before obtaining the dose-response to histamine significantly potentiated percent increase in RL caused by each dose of intravenously administered histamine."	( Pretreatment with aerosolized capsaicin potentiates histamine-induced bronchoconstriction in guinea pigs. Hirose, T; Nishima, S; Umeno, E, 1992)	0.74
", dose-response curves for U46619 and U44069 were shifted to the right in a parallel manner."	( Blockade of thromboxane/endoperoxide receptor-mediated responses in the pulmonary vascular bed of the cat by sulotroban. Babycos, CR; Hood, JS; Ibrahim, IN; Kadowitz, PJ; McMahon, TJ; Nossaman, BD; Ragheb, MS, 1992)	0.28
" There was a marked upward shift in the dose-response curve of histamine (HA; 10(-8) to 10(-3) M) in milk-fed rats, indicating enhanced sensitivity of parietal cell-H2 receptor to exogenous HA."	( Milk-stimulated PGE2 production by isolated gastric cells: a possible role in the inhibition of histamine-induced acid secretion. Brunel-Riveau, B; Ducroc, R; Garzon, B; Geloso, JP; Vilar, J; Wirbel, A, 1992)	0.74
"For describing bronchial responsiveness, it has been suggested that the dose-response slope (DRS), which is the linear slope of the dose-response curve, is a more useful measure of severity than the provoking dose that causes a 20% fall in FEV1 (PD20FEV1)."	( Relation of dose-response slope to respiratory symptoms and lung function in a population study of adults living in Busselton, Western Australia. Berry, G; Peat, JK; Salome, CM; Woolcock, AJ, 1992)	0.28
"We investigated the effects of inhaled beclomethasone dipropionate (BDP) on airway sensitivity (provocative dose producing a 20% fall in forced expiratory volume in one second (FEV1) from baseline (PD20)) and reactivity (slope of the dose-response curve) to inhaled aerosols of hyperosmolar (4."	( Inhaled steroids modify bronchial responses to hyperosmolar saline. Anderson, SD; Rodwell, LT; Seale, JP, 1992)	0.28
" Dose-response curves to aerosolized methacholine or histamine were performed, without and following pretreatment with inhaled gallopamil (10 mg), on 6 different experiment days to determine the cumulative provocative dose (PD50) of each agonist in breath units which caused a 50% decrease in specific airway conductance (SGaw)."	( Modification of histamine- and methacholine-induced bronchoconstriction by calcium antagonist gallopamil in asthmatics. Ahmed, T; Danta, I, 1992)	0.88
" These results demonstrate the specificity and dose-response characteristics of PAF antagonists in cultured human endothelial cells and suggest that a PAF antagonist could be a valuable therapeutic agent in certain human diseases where PAF activation of endothelial cells may have a critical role."	( Antagonism of platelet-activating factor-induced increase in cytosolic free calcium concentration in human endothelial cells. Hirafuji, M; Shinoda, H, 1992)	0.28
" On histamine-stimulated secretion, the differences between the acetylated and the free octapeptides were that the former displayed a dose-response curve parallel to that of oxyntomodulin and a 4-fold higher potency."	( N-acetyl oxyntomodulin30-37: pharmacokinetics and activity on gastric acid secretion. Bataille, D; Carles-Bonnet, C; Jarrousse, C; Martinez, J; Niel, H; Rolland, M, 1992)	0.84
"This study was designed to investigate if two equivalent doses of allergen administered by different dosing regimes--two breaths and 10 breaths of each concentration--would result in the same magnitude of the early and late asthmatic response."	( Bronchial allergen challenge: dose versus concentration. Frølund, L; Heinig, JH; Madsen, F; Scharling, B; Svendsen, UG, 1992)	0.28
" Individual dose-response curves (DRCs) for norepinephrine (NE) and histamine were performed to assess contractile function."	( Regional differences in the effects of septic shock on vascular reactivity in the rabbit. Croce, K; Li, T; Winquist, RJ, 1992)	0.52
" Administration of erythromycin to asthmatic patients in a dosage of 600 mg/d for 10 weeks reduced the bronchial hyperresponsiveness measured by histamine inhalation test."	( Effect of erythromycin on bronchial hyperresponsiveness in patients with bronchial asthma. Miyatake, H; Satake, T; Suzuki, K; Takagi, K; Taki, F, 1991)	0.48
" While pretreatment with inhaled AS-35 (1mg) did not affect the STA2 dose-response curve."	( Interaction of thromboxane A2 and leukotrienes in guinea pig airways in vivo. Bando, T; Fujimura, M; Matsuda, T; Mizuhashi, K, 1991)	0.28
"001) of the mean dose-response relationship."	( Cholinergic mechanisms involved with histamine hyperreactivity in immune rabbit airways challenged with ragweed antigen. Ando, RE; Irvin, CG; Larsen, GL; Tanaka, DT, 1991)	0.55
" Moreover, alpidem, zolpidem, and zopiclone did not modify the 2-chloroadenosine dose-response curves nor the diazepam induced sensitization of adenosine-induced relaxation."	( Influence of diazepam, alpidem, zolpidem and zopiclone, on the response to adenosine of the guinea pig isolated trachea. Advenier, C; Candenas, ML; Devillier, P; Naline, E, 1991)	0.28
" A definite dose-response relationship was demonstrated between the weal and flare areas and the three active treatments."	( Dose-response relationship between objective measures of histamine-induced weals and dose of terfenadine. Lush, M; Marks, R; Newcombe, RG; Shall, L, 1991)	0.53
" A significant dose-response relationship was shown in each of the three regions for all itch variables, except itch latency, and for the flare reactions."	( Perception of histamine-induced itch elicited in three different skin regions. Ekblom, A; Wahlgren, CF, 1991)	0.64
" Dose-response curves for histamine elevation of intracellular Ca2+ (EC50 = 10 microM, maximum at 100 microM) and inositol phosphates (EC50 = 2 microM, maximum at 100 microM) were similar."	( Histamine H1 receptor occupancy triggers inositol phosphates and intracellular calcium mobilization in human non-pigmented ciliary epithelial cells. Bazan, NG; Crook, RB; Polansky, JR, 1991)	2.02
" When compounds were administered intravenously, at a dosage (1 mg/kg) which fully abolished responses to intravenous histamine, the observed rank order for inhibition of PAF-induced hyperreactivity was: ketotifen greater than cetirizine greater than acrivastine greater than KB-2413 greater than oxatomide greater than azelastine greater than terfenadine = astemizole = clemastine = mepyramine = loratadine = saline."	( Histamine(H1) antagonists and airway hyperreactivity in the guinea-pig. Chapman, ID; Hoshiko, K; Morley, J, 1991)	1.93
" Histamine release dose-response curves obtained after histamine measurement by both methods were superimposable."	( Histamine release from human peripheral blood leukocytes analyzed by histamine radioimmunoassay. van Toorenenbergen, AW; Vermeulen, AM, 1990)	2.63
" Histamine increased in a dose-dependent manner cellular cAMP content in L cells permanently transfected with this gene, and preincubation of the cells with the H2-selective antagonist cimetidine shifted the dose-response curve to the right."	( Molecular cloning of a gene encoding the histamine H2 receptor. Campbell, V; DelValle, J; Gantz, I; Logsdon, C; Schäffer, M; Uhler, M; Yamada, T, 1991)	1.46
"7]hCGRP dose-response curve to the right in a parallel fashion."	( Pharmacological characterization of CGRP1 receptor subtype in the vascular system of the rat: studies with hCGRP fragments and analogs. Donoso, MV; Fournier, A; Huidobro-Toro, JP; St-Pierre, S, )	0.13
" Passive sensitization with IgE-rich plasma caused a significant increase in maximal anti-IgE-induced HR in the majority of cord blood samples, and the dose-response curve was similar to that obtained in adult blood."	( Comparison of histamine release in cord blood and adult blood. Bjerke, T; Engberg, TM; Nielsen, BW; Schiøtz, PO, 1991)	0.64
" Significant dose-response relationships were found between histamine concentration and each of ID, Imax, Tii and flare in both patients and controls."	( Patients' perception of itch induced by histamine, compound 48/80 and wool fibres in atopic dermatitis. Bergström, R; Hägermark, O; Wahlgren, CF, 1991)	0.79
" Both the provocative dose to cause a 20 percent decline in the FEV1 (PD20 FEV1) and the slope of the dose-response curve were not significantly different between the standard protocol and either of the two abbreviated protocols."	( Is an abbreviated bronchial challenge with histamine valid? Schmidt, LE; Schwartz, DA; Thorne, PS; Watt, JL, 1992)	0.55
" Also, dose-response functions were obtained for the area of alloknesis produced by intracutaneous injections of histamine."	( Psychophysical studies of the itch sensation and itchy skin ("alloknesis") produced by intracutaneous injection of histamine. Alreja, M; LaMotte, RH; Simone, DA, 1991)	0.7
" Lower concentrations of berberine (less than or equal to 5 x 10(-5) M) induced a parallel rightward shift of the dose-response curve of acetylcholine, suggesting that berberine is antagonizing the actions of acetylcholine at the receptors competitively."	( Pharmacological effects of berberine on the longitudinal muscle of the guinea-pig isolated ileum. Ochillo, RF; Tsai, CS, )	0.13
" The dose-response curves for oxyntomodulin and oxyntomodulin-(19-37) were parallel."	( Oxyntomodulin and its (19-37) and (30-37) fragments inhibit histamine-stimulated gastric acid secretion in the conscious rat. Bataille, D; Carles-Bonnet, C; Jarrousse, C; Martinez, J; Niel, H, 1991)	0.52
" Treatment with centrally acting H1 antagonists (dimethindene and promethazine) in non-sedative dosage diminished the PTZ seizure threshold significantly; no changes were seen after treatment with H2 and H3 antagonists (oxmetidine, ranitidine, zolantidine or thioperamide) and a H3 agonist (R-alpha-methylhistamine)."	( Histamine in brain--its role in regulation of seizure susceptibility. Frey, HH; Hashem, A; Scherkl, R, )	1.75
" However, methylprednisolone should be administered on the basis of ideal body weight, and the dosing interval should be potentially lengthened because of decreased methylprednisolone clearance in obesity."	( Pharmacokinetics and pharmacodynamics of methylprednisolone in obesity. Camara, DS; Dunn, TE; Jusko, WJ; Ludwig, EA; Slaughter, RL, 1991)	0.28
" The measurements derived from the dose-response curve were the PD20 FEV1, which was measured as the provoking dose causing a 20% fall in FEV1, and the dose-response slope (DRS), which was measured as the percentage fall in FEV1 at final dose/total dose administered."	( Repeatability of histamine bronchial challenge and comparability with methacholine bronchial challenge in a population of Australian schoolchildren. Bauman, A; Peat, JK; Salome, CM; Toelle, BG; Wachinger, SL; Woolcock, AJ, 1991)	0.62
" Alteration of airways function was assessed by measuring specific pulmonary conductance (SGL) and dose-response relationships to inhaled histamine, where airways responsiveness was expressed as the effective concentration causing 50% of maximal change in specific airways conductance (EC50SGL)."	( Body temperature modulates the effect of platelet-activating factor (PAF) on airways responsiveness in the rabbit. Hill, M; Irvin, CG; Nieminen, MM, 1991)	0.48
" To determine whether these drugs also protect against excessive airway narrowing, the effect of inhaled salbutamol on the position and shape of the dose-response curves for histamine or methacholine was investigated in 12 patients with asthma and 11 with chronic obstructive lung disease."	( The protective effect of a beta 2 agonist against excessive airway narrowing in response to bronchoconstrictor stimuli in asthma and chronic obstructive lung disease. Bel, EH; Dijkman, JH; Sterk, PJ; Timmers, MC; Zwinderman, AH, 1991)	0.47
" However, after an FMLP dose-response curve in rabbits, tachyphylaxis to a second challenge was seen in some rabbits and airway inflammation was absent."	( Effects of prolonged inhalation of N-formyl-methionyl-leucyl-phenylalanine in rabbits. Berend, N; Breslin, AB; Panaretto, K; Peters, MJ, 1991)	0.28
"To describe bronchial responsiveness in populations, the dose-response slope (DRS), which is the linear slope of the dose-response curve, may be a more useful measure of severity than the provoking dose that causes a 20% fall in FEV1 (PD20 FEV1)."	( Relation of dose-response slope to respiratory symptoms in a population of Australian schoolchildren. Berry, G; Peat, JK; Salome, CM; Woolcock, AJ, 1991)	0.28
" TAME-esterase activity also increased in relation to the dosage of Bk given without significant difference between the various groups."	( Nasal challenge studies with bradykinin: influence upon mediator generation. Baumgarten, CR; Brunnée, T; Kunkel, G; Nigam, S, 1991)	0.28
" Dose-response lines in response to the two agonists, expressed as percent maximal contraction, did not differ among the groups."	( Muscarinic-receptor functioning in tracheas from normal and ovalbumin-sensitive guinea pigs. Biggs, DF; Yang, ZJ, 1991)	0.28
" Regional activity of histamine was studied in various rabbit arteries, including segments of the aorta, aortic branches, branchout regions and arteries to fore and hind limbs by dose-response experiments."	( Regional histaminergic potencies in rabbit systemic circulation. Bökesoy, TA; Gürbüz, H; Onaran, HO, 1991)	1.01
" The dose-response (contraction) relation for histamine was gradual from micromolar to 316 mM (millimolar) histamine."	( Ionic control of the size of the vesicle matrix of beige mouse mast cells. Brodwick, MS; Curran, MJ, 1991)	0.54
" Analysis of individual results demonstrated a shift toward the right of the dose-response curves to histamine with SK&F 104353 compared to that with placebo in three subjects, whereas the active compound did not exhibit any protective effect against histamine in the remaining nine subjects."	( Effects of SK&F 104353, a leukotriene receptor antagonist, on the bronchial responses to histamine in subjects with asthma: a comparative study with terfenadine. Dinh Xuan, AT; Lockhart, A; Marsac, J; Regnard, J; Rey, J; Similowski, T, 1990)	0.72
" Cimetidine (H2 antagonist) and/or diphenhydramine (H1 antagonist) shifted the histamine dose-response curve to the right."	( Fetal pulmonary vasodilation by histamine: response to H1 and H2 stimulation. Accurso, FJ; Truog, RD; Wilkening, RB, 1990)	0.79
" Acrivastine administered 30, 45, 60 or 90 min before challenge produced a right-shift of the histamine dose-response curve of at least 8-fold indicating that a clinically desired degree of H1-antagonism was present within 30 min of ingestion of the recommended therapeutic dose."	( The onset of effect of the H1-antagonist acrivastine ("Semprex") assessed by histamine bronchial challenge in volunteers. Adams, J; Phillips, S; Posner, J; Rolan, PE, 1990)	0.73
" In conclusion, epinastine is one of the most effective peripherally acting H1 antagonist which lacks significant CNS side effects and is suitable as a once daily dosage regimen."	( Antihistaminic activity and side effect profile of epinastine and terfenadine in healthy volunteers. Adamus, WS; Kuthan, H; Schilling, JC, 1990)	0.28
" In neither study were there any significant differences between the acid secretory dose-response curves to histamine in control and test animals."	( Chronic administration of H2-antagonists does not alter gastric secretory responses to histamine, or the antisecretory activity of sufotidine. Humphray, JM; Reeves, JJ; Stables, R, 1990)	0.71
" Dose-response studies showed that sensitized tissues used in the present studies were hyperresponsive to histamine when compared with their nonsensitized control littermates."	( Changes in Schultz-Dale reaction in sensitized canine tracheal smooth muscle. Becker, AB; Kepron, W; Kong, SK; Stephens, NL; Xu, J, 1991)	0.49
" We obtained dose-response curves of peripheral airways challenged with iv histamine or aerosols through the bronchoscope."	( Use of collateral airways to assess airway reactivity. Corddry, DH; Hirshman, CA; Mitzner, W; Sauder, RA; Weinmann, GG, 1991)	0.51
" The provocative concentration causing a 20% fall in FEV1 (logPC20) was calculated by linear interpolation of log dose-response curves."	( Effect of inhaled furosemide and bumetanide on adenosine 5'-monophosphate- and sodium metabisulfite-induced bronchoconstriction in asthmatic subjects. Barnes, PJ; Chen-Worsdell, YM; Chung, KF; Fuller, RW; O'Connor, BJ, 1991)	0.28
" However, a dose-response curve to methacholine is helpful."	( Characteristics of bronchial hyperresponsiveness in chronic obstructive pulmonary disease and in asthma. Anderson, SD; Du Toit, JI; Peat, JK; Salome, CM; Smith, CM; Woolcock, AJ; Zhang, YG, 1991)	0.28
" Dose-response curves to phenylephrine, histamine and 5-hydroxytryptamine were obtained."	( The isolated, perfused bovine ear. A model for pharmacological study of cutaneous vasculature and anaphylaxis. Eghianruwa, KI; Eyre, P, 1991)	0.55
" The distribution of the bronchial responsiveness was described as (1) the provoking concentration that causes a 20% reduction in FEV1 (2) the dose-response slope (DRS), that is, the linear slope of the dose-response curve, and (3) reduction in FEV1 after 6 minutes of exercise on a treadmill."	( The distribution of bronchial responsiveness to histamine and exercise in 527 children and adolescents. Bach-Mortensen, N; Backer, V; Dirksen, A; Hansen, KK; Laursen, EM; Wendelboe, D, 1991)	0.54
"Responsiveness to inhaled histamine and DL propranolol hydrochloride was measured in 31 adult asthmatics and compared with bronchoconstriction provoked by acute oral propranolol dosing (max 160 mg)."	( Bronchoconstriction of the asthmatic airway by inhaled and ingested propranolol. Latimer, KM; Ruffin, RE, 1990)	0.58
" Use of the insert achieved an earlier steady secretory response which allowed cumulative dosing to be performed in each animal."	( Use of a cannula insert in erratic emptying Heidenhain pouch dogs: effect of single and cumulative doses of omeprazole. Ghelani, A; Radziwonik, H, 1990)	0.28
"Bronchial histamine provocation tests were performed in nine patients with nonallergic asthma on four consecutive days 45 minutes after inhalation of placebo or ipratropium bromide in a dose-response manner (40 micrograms, 200 micrograms, and 800 micrograms)."	( Airways responses to ipratropium bromide do not vary with time in asthmatic subjects. Studies of interindividual and intraindividual variation of bronchodilatation and protection against histamine-induced bronchoconstriction. Ihre, E; Larsson, K, 1990)	0.87
" The following methods were used: a) gastric acid hypersecretion induced by histamine and carbachol in the pylorus-ligated rat preparation; b) contractile dose-response curves to histamine and carbachol in the guinea pig ileum; c) dimaprit-stimulated guinea pig atrium in vitro."	( Mechanism of action of doxepin in the treatment of chronic urticaria. Almeida, L; Figueiredo, A; Gonçalo, M; Poiares-Baptista, A; Ribeiro, CA; Teixeira, F, 1990)	0.51
" Neither dose of loratadine had any significant effect on the methacholine dose-response relationship."	( Comparison of the effect of loratadine on the airway and skin responses to histamine, methacholine, and allergen in subjects with asthma. Holgate, ST; Town, GI, 1990)	0.51
" Thioperamide did not alter the dose-response curve to exogenous histamine (0."	( Histamine H3 receptors modulate antigen-induced bronchoconstriction in guinea pigs. Barnes, PJ; Ichinose, M, 1990)	1.96
" Airways responsiveness to each bronchoconstrictor agonist was assessed by constructing cumulative dose-response curves, and the dose that produced a 35% decrease in specific airways conductance (PD35) was obtained by linear interpolation."	( Asthmatic airways have a disproportionate hyperresponsiveness to LTE4, as compared with normal airways, but not to LTC4, LTD4, methacholine, and histamine. Arm, JP; Crea, AE; Fong, CY; Hawksworth, RJ; Lee, TH; O'Hickey, SP; Spur, BW, 1990)	0.48
" On the AMP study day, three AMP dose-response bronchial challenges were performed at 1-hour intervals."	( Repeated exposure of asthmatic airways to inhaled adenosine 5'-monophosphate attenuates bronchoconstriction provoked by exercise. Finnerty, JP; Holgate, ST; Polosa, R, 1990)	0.28
" For measuring non-specific hyperreactivity was used an internationally adopted dose-response technique, where histamine or methacholine is inhaled at doses increasing in two-fold steps."	( [Histamine and methacholine tests in cases of sensitive bronchi--a 10-year experience]. Balder, B; Löwhagen, O, 1990)	1.4
" Dose-response curves to MCh were obtained from bronchial segments before, during, and after incubation with either a subthreshold or a threshold concentration of histamine (10(-10) or 10(-8) M), the stable TxA2 analogue U46619 (10(-11) or 10(-9) M), PGD2 (5 x 10(-9) or 5 x 10(-7) M), PGF2 alpha (10(-9) or 10(-7) M), or LTC4 (10(-11) or 10(-9) M)."	( Effects of inflammatory mediators on the responsiveness of isolated human airways to methacholine. Bonta, IL; de Jongste, JC; Jongejan, RC; Kerrebijn, KF; Raatgeep, RC; Stijnen, T, 1990)	0.47
" Assuming that the binding of carbachol to one site (Site 1) increases [14C]aminopyrine accumulation but its binding to the other site (Site 2) reduces [14C]aminopyrine accumulation, we analysed the dose-response curves for the carbachol effects in the absence and presence of different concentrations of atropine, pirenzepine and AF-DX 116."	( Carbachol-induced potentiation and inhibition of acid secretion by guinea pig gastric gland. Haga, T; Honda, N; Ichiyama, A; Kajimura, M; Kaneko, E, 1990)	0.28
" The amount of dye extracted from the paw showed a clear dose-response relationship to the dose of each agonist injected into the paw."	( Assessment of vascular permeability increase in the mouse by dye leakage during paw edema. Hayashi, M; Oh-ishi, S; Qu, XF; Yamaki, K, 1990)	0.28
" The slopes of the dose-response curves for all three compounds were linear and parallel, with statistically different potencies."	( The effect of platelet-activating factor (PAF), histamine, and ethanol on vascular permeability of the guinea pig conjunctiva. Kim, ED; Roth, SI; Stock, EL; Thamman, R; Walsh, MK, 1990)	0.53
", consistently produced a nearly maximal hypothermic response in non tolerant rats, whereas this dosage induced an elevation of body temperature in tolerant rats."	( Modification of rat thermal responses to morphine by alpha-FMH suggests a role for neural histamine in morphine tolerance. Arrigo-Reina, R; Spadaro, C, 1990)	0.5
" Dose-response curves for pentagastrin pulses show that both the total amount of histamine released and the total amount of acid secreted are saturable processes, paralleling each other."	( Histamine: the sole mediator of pentagastrin-stimulated acid secretion. Ekblad, EB, 1985)	1.94
" A cutaneous vasodilator response was also observed in substance P treated and contralateral ears, but a bell-shaped dose-response relationship was apparent."	( Histamine involvement in the local and systemic microvascular effects produced by intradermal substance P. Ledgard, SE; Owen, DA; Pipkin, MA; Woodward, DF, 1985)	1.71
" The dose-response curve for carbachol was biphasic."	( Stimulation of acid formation by histamine, carbachol and pentagastrin in isolated pig parietal cells. Ljungström, M; Mårdh, S; Norberg, L; Vega, FV, 1986)	0.55
" According to the dose-response curves for isoproterenol and tyramine, left ventricular dP/dtmax was significantly depressed in infarcted hearts, whereas the dose-response curve for the inotropic effect of phenylephrine was markedly enhanced."	( Defibrotide, an antithrombotic substance that preserves postsynaptic alpha- and beta-adrenergic function in post acute infarcted rabbit hearts. Berti, F; Folco, G; Niada, R; Omini, C; Rossoni, G; Tondo, C, )	0.13
" No change in the dose-response curve to histamine between the two preparations was noted."	( Perfused rabbit heart: endothelium-derived relaxing factor in coronary arteries. Bing, RJ; Metz, M; Saeed, M; Schmidli, J, )	0.4
" The dose-response curve of anti-IgE induced histamine release from bronchoalveolar cells of subjects with more than 20% of lymphocytes in the lavage cell population was significantly greater than the dose-response curves of subjects with fewer than 20% of lymphocytes and of controls."	( Bronchoalveolar mast cells in sarcoidosis: increased numbers and accentuation of mediator release. Brostoff, J; Flint, KC; Geraint-James, D; Hudspith, BN; Johnson, NM; Leung, KB; Pearce, FL, 1986)	0.53
") shifted the dopamine dose-response curve to the right in a parallel fashion, indicating competitive antagonism."	( Characterization of vascular dopamine receptors in the gastric circulation of the rabbit. Kullmann, R; Reinsberg, J, )	0.13
" Dose-response curves to TG showed nonparallel increases in both parameters."	( Stimulation of oxyntic and histaminergic cells in gastric mucosa by gastrin C-terminal tetrapeptide. Michelangeli, F; Ruiz, MC, 1986)	0.57
" However, in rings with denuded endothelium, pretreatment with (-)-R202-791 resulted in a rightward shift of the dose-response curve to (+)-S202-791, and a depression of the maximal contraction compared with controls."	( A possible role for the endothelium in porcine coronary smooth muscle responses to dihydropyridine calcium channel modulators. Baik, YH; Koch, WJ; Schwartz, A; Williams, JS, 1987)	0.27
" The tachykinin antagonist (20 microM) produced a shift to the right of the dose-response curves for inositol phosphate accumulation caused by SP and kassinin."	( Effect of the tachykinin antagonist, [D-Pro4, D-Trp7,9,10] substance P-(4-11), on tachykinin- and histamine-induced inositol phosphate generation in intestinal smooth muscle. Bailey, SJ; Holzer, P; Lippe, IT, 1987)	0.49
" It was found that the same individuals responded with histamine release to the same allergens in both histamine release assays, and the dose-response curves were almost identical."	( A new glass microfibre-based histamine analysis for allergy testing in children. Results compared with conventional leukocyte histamine release assay, skin prick test, bronchial provocation test and RAST. Nolte, H; Schiøtz, O; Skov, PS, 1987)	0.81
"On isolated electrically stimulated left and spontaneously beating right guinea-pig atria the interaction between PDE-inhibitors and the positive inotropic and chronotropic action of orciprenaline, forskolin and histamine in dose-response curve was examined."	( Interaction of phosphodiesterase inhibitors triamterene, papaverine, theophylline, IBMX and amrinone with other positive inotropic acting substances on isolated guinea-pig atria. Greeff, K; Schmitt, M, 1987)	0.46
" Removing the epithelium potentiated antigen-induced contraction, as reflected by a 5-fold leftward shift in the antigen dose-response curve, but the maximum response to antigen was not altered."	( Effect of removal of epithelium on antigen-induced smooth muscle contraction and mediator release from guinea pig isolated trachea. Adams, GK; Adkinson, NF; Raible, DG; Undem, BJ, 1988)	0.27
" High voltage stimulation (HVS) was applied simultaneously with the histamine to the vascular bed of the treatment animals in a dosage of 10, 30, or 50 V; the control animals received no electrical stimulation."	( Effect of high voltage pulsed electrical stimulation on microvascular permeability to plasma proteins. A possible mechanism in minimizing edema. Reed, BV, 1988)	0.51
" Airway response was measured as FEV1 and the dose of substance P (using a dose range of 23-736 nmol) producing a 20% decrease in FEV1 (PD20) was calculated from the individual semilogarithmic dose-response curves."	( Effect of nedocromil on bronchospasm induced by inhalation of substance P in asthmatic subjects. Crimi, N; Mistretta, A; Oliveri, R; Palermo, B; Palermo, F; Polosa, R; Vancheri, C, 1988)	0.27
"We performed three consecutive dose-response curves to rapid intravenous infusions of substance P (SP) in anesthetized, mechanically ventilated guinea pigs."	( Enhanced airway responses to substance P after repeated challenge in guinea pigs. Drazen, JM; Shore, SA, 1989)	0.28
"0 nM) on dose-response curves to noradrenaline, histamine, calcium (Ca2+) and potassium (K+) in ring preparations of rabbit basilar artery and central ear artery."	( The selective potentiation of noradrenaline-induced tone by Bay K 8644 in the rabbit basilar artery. Bevan, JA; Dowd, AL; Germann, P; Laher, I, 1989)	0.53
" Dose-response curves with either arecoline or histamine on isolated tracheae from these animals display increased maximal contractions, and decreased EC50 values."	( Endotoxin-induced hyperreactivity of the guinea-pig isolated trachea coincides with decreased prostaglandin E2 production by the epithelial layer. Engels, F; Folkerts, G; Nijkamp, FP, 1989)	0.53
" Dose-response curves were plotted from data obtained following exposure to histamine (10(-7)-10(-3)) and GTN (10(-9)-10(-7)) and compared to responses from age-matched untreated controls, diabetic and diabetic rats treated with insulin (2 U/day)."	( Histamine relaxation of aortic rings from diabetic rats. Chang, KS; Tanz, RD; Weller, TS, 1989)	1.95
" Isocapnic hyperventilation uses a naturally occurring stimulus to provoke bronchoconstriction rather than a chemical stimulus and can be administered in a dose-response fashion."	( Comparison of isocapnic hyperventilation and histamine or methacholine inhalation for the assessment of airway responsiveness. Higgins, D; O'Byrne, PM, )	0.39
"8 mM Ca2+, the rate of glycogen breakdown was increased by theophylline in a dose-dependent manner and the dose-response curve was somewhat similar to that obtained with oxygen uptake."	( Ca2+ requirement for metabolic effects of secretagogues in the amphibian gastric mucosa. Chacín, J; Lobo, P; Subero, O, 1989)	0.28
" The dose-response (D-R) curves for histamine (H) in the HT group shifted leftward and upward as compared with the sham-operated (S) group."	( Effect of histamine on isolated working guinea pig heart with left ventricular hypertrophy produced by pressure overload. Guo, ZG; Luo, WS, 1989)	0.95
" Dose-response studies indicate that the desensitization was associated with a major reduction in the maximal extent of agonist-induced responses."	( Homologous desensitization of muscarinic cholinergic, histaminergic, adrenergic, and serotonergic receptors coupled to phospholipase C in cerebellar granule cells. Chuang, DM; Dillon-Carter, O, 1989)	0.53
" However, the effect of carbamazepine (100 microM) on the respective dose-response curves suggests that the mechanism of inhibition of the carbachol response differs from the inhibition of the histamine and veratrin responses."	( Inhibition of agonist-stimulated inositol lipid metabolism by the anticonvulsant carbamazepine in rat hippocampus. Logan, SD; McDermott, EE, 1989)	0.47
" Labelling muscle slices with [3H]inositol in the presence of carbachol or labelling for longer periods (greater than 6 h) prevented subsequent carbachol-stimulated effects on incorporation without significantly altering the dose-response relationship for carbachol-stimulated [3H]InsP formation and resulted in steady-state labelling conditions confirmed by the ability of atropine to reverse fully the [3H]InsP response to carbachol."	( Characterization of agonist-stimulated incorporation of myo-[3H]inositol into inositol phospholipids and [3H]inositol phosphate formation in tracheal smooth muscle. Barnes, PJ; Chilvers, ER; Nahorski, SR, 1989)	0.28
" During the initial 15-min period, comparison of the dose-response curves revealed that histamine produced a much larger increase in extravascular albumin content than any of the leukotrienes."	( Time-dependent differences in the vasopermeability response to intradermal peptidoleukotrienes. Gary, RK; Hawley, SB; Nieves, AL; Spada, CS; Woodward, DF, )	0.35
" A linear dose-response relationship was shown with random injection order for all subjective variables studied (itch latency and duration, maximal itch intensity, 'total itch index') with the VAS, but only for itch duration and 'total itch index' with the FPNVS."	( Some aspects of the experimental induction and measurement of itch. Ekblom, A; Hägermark, O; Wahlgren, CF, 1989)	0.28
" This was conducted, first as a dose-response study and, second, as a time-course study."	( Inhibition of hypertonic saline-induced bronchoconstriction by terfenadine and flurbiprofen. Evidence for the predominant role of histamine. Finnerty, JP; Holgate, ST; Wilmot, C, 1989)	0.48
" Terfenadine is a widely used nonsedating antihistamine currently approved for use at a dosage of 60 mg every 12 hours."	( Evaluation of inhibition of wheal response to histamine by multiple doses of terfenadine. Ryan, WM, 1989)	0.79
" The dose-response relationships for somatostatin release and inhibition of aminopyrine uptake were similar."	( Inhibition of acid formation and stimulation of somatostatin release by cholecystokinin-related peptides in rabbit gastric glands. Bengtsson, P; Lundqvist, G; Nilsson, G, 1989)	0.28
" Imipramine and nortriptyline also caused a rightward shift in the dose-response curve of histamine-induced cAMP generation."	( Tricyclic antidepressants and acid secretory response of rabbit gastric cells. Batzri, S, 1985)	0.49
" Despite a high mean PUVA dosage (138."	( Phototherapy of urticaria pigmentosa: clinical response and changes of cutaneous reactivity, histamine and chemotactic leukotrienes. Czarnetzki, BM; Frosch, PJ; Kolde, G; Rosenbach, T, 1985)	0.49
" Adenosine also increased the histamine-induced contraction causing a leftward shift of the histamine dose-response curves, an effect that was abolished in the presence of atropine."	( Adenosine potentiates neurally- and histamine-induced contraction of canine airway smooth muscle. Katayama, M; Kobayashi, K; Sakai, N; Takizawa, T; Tamaoki, J, 1989)	0.84
" The slope of the FEV1 dose-response curves showed significant correlation with tobacco consumption."	( A comparison of airway responsiveness in smokers with chronic bronchitis and in asthmatic subjects. Engel, T; Hansen, M; Heinig, JH; Madsen, O; Weeke, ER, 1989)	0.28
" Dose-response relationships were evaluated for SP and NT (10-320 pmols) in AD and healthy controls."	( Skin reactivity to neuropeptides in atopic dermatitis. Giannetti, A; Girolomoni, G, 1989)	0.28
" With increasing doses of histamine, a dose-response relationship was seen in the activity of RAR."	( Action of histamine on the rapidly adapting airway receptors in the dog. Kappagoda, CT; Ravi, K; Teo, KK, 1989)	0.98
" In five dogs, dose-response curves were generated by rapid intra-arterial injection of 10(-10) to 10(-6) mol PAF into the isolated tracheal circulation; tracheal contractile response was measured isometrically in situ."	( PAF-induced contraction of canine trachea mediated by 5-hydroxytryptamine in vivo. Blake, JS; Leff, AR; Mack, MM; Moss, J; Munoz, NM; Murphy, TM, 1989)	0.28
" Dose-response curves for angiotensin II and bradykinin were shown to be double-sigmoidal, with the first EC50 in the nM range; much lower than that for acetylcholine, nicotine or histamine."	( Neuropeptides and other secretagogues in bovine chromaffin cells: their effect on opioid peptide metabolism. Bommer, M; Herz, A, )	0.32
" Previous treatment with 1 microM indomethacin (IND) or 10 microM quinacrine (QUIN) markedly displaced the dose-response curves for Ach on OAS preparations to the left, whereas the EC50 of His was only increased by QUIN."	( Tracheal responsiveness to histamine, PAF-acether and acetylcholine in normal and actively ovalbumin-sensitized guinea pigs. Calixto, JB; Medeiros, YS; Torres, RC, 1989)	0.57
" The dose-response curve for fall in BP was shifted to the right by one order of magnitude."	( Platelet-activating factor (Paf) antagonist, WEB 2086, protects against Paf-induced hypotension in Macaca fascicularis. Antoniw, JW; Izumi, T; Piper, PJ; Stanton, AW, 1989)	0.28
" The effect of SK&F 104353 was also examined in combination with a pyrilamine-cimetidine dosing regimen sufficient to remove the histaminergic component of cutaneous immediate hypersensitivity."	( Interactive effects of peptidoleukotrienes and histamine on microvascular permeability and their involvement in experimental cutaneous and conjunctival immediate hypersensitivity. Gary, RK; Gleason, JG; Nieves, AL; Wasserman, MA; Williams, LS; Woodward, DF, 1989)	0.74
" The effects of these drugs on the basal tension, on dose-response curves for muscle contraction produced by histamine and on cAMP level were investigated in guinea pig trachea, together with their influence on the resting and histamine-evoked mechanical and membrane activities of dog trachea."	( The effects of methylxanthines, ethymizol, ephedrine and papaverine on guinea pig and dog trachea. Bauer, V; Bilcíková, L; Kolena, J, 1987)	0.49
" The dose-response curve for histamine in each culture was progressively displaced to the right with increasing concentrations of the histamine H2 receptor antagonist cimetidine."	( Demonstration of histamine H2 receptors on human melanoma cells. Evanson, JM; Hart, IR; Taylor, DJ; Whitehead, RJ; Woolley, DE, 1988)	0.91
" Using digitonin-permeabilized cells we showed that adenylate cyclase activity was stimulated by prostaglandin E1 with the same dose-response relationship as was cyclic AMP accumulation in intact cells, but the permeabilized cells showed no response to angiotensin II."	( Angiotensin II potentiates prostaglandin stimulation of cyclic AMP levels in intact bovine adrenal medulla cells but not adenylate cyclase in permeabilized cells. Boarder, MR; Marriott, DB; Plevin, R, 1988)	0.27
" beta-Adrenoceptor antagonists produced a bell-shaped dose-response curve on histamine contractions in cat isolated lung parenchyma strip."	( The response of cat airways to histamine in vivo and in vitro. Blaber, LC; Fryer, AD, 1985)	0.78
" The dose-response curves for CCK8 were shifted in parallel to the right by 10(-6) to 10(-5) M of the three benzodiazepines, although the maximum response to CCK8 was depressed by higher concentrations."	( Cholecystokinin antagonism by benzodiazepines in the contractile response of the isolated guinea-pig gallbladder. Kubota, K; Matsuda, I; Sugaya, K; Sunagane, N; Uruno, T, 1985)	0.27
" Three weeks of pretreatment with 6-OHDA resulted in leftwards shifts of the dose-response curves for the positive chronotropic and inotropic responses of right and left atria to isoprenaline."	( Cardiac postjunctional supersensitivity to beta-agonists after chronic chemical sympathectomy with 6-hydroxydopamine. Broadley, KJ; Chess-Williams, RG; Culling, W; Grassby, PF; Penny, W; Sheridan, DJ, 1985)	0.27
" Dose-response curves were determined for acid output and for mucosal blood flow, which was measured with the neutral red technique."	( Acid secretion and mucosal blood flow in the distal and proximal parts of the canine parietal cell mass in response to cholinergic stimulation. Larsson, JO, 1985)	0.27
" The dose-response curve for stimulation by histamine of adenylate cyclase was shifted to the right in a dose-dependent manner by increasing concentrations of several H2-antagonists."	( A study of the H2-receptor for histamine stimulating adenylate cyclase in homogenates of guinea-pig lung parenchyma. Foreman, JC; Norris, DB; Rising, TJ; Webber, SE, 1986)	0.82
" Amitraz did not significantly shift the dose-response curve to isoprenaline or acetylcholine but antagonized histamine rate responses competitively in the presence of propranolol (2 X 10(-6) M)."	( The cardiac effects of amitraz in the guinea-pig in vivo and in vitro. Pascoe, AL; Reynoldson, JA, 1986)	0.48
" Airway responsiveness was measured by the ability of isoproterenol infusions to shift the histamine dose-response curve for airway constriction."	( Differential recovery of beta adrenoreceptor antagonist and agonist high affinity binding sites in the guinea-pig lung after irreversible blockade. Baker, SP; Muther, TF; Nelson, CA; Pitha, J, 1986)	0.49
"When dose-response curves are replicated, averaging the responses to each dose of drug reduces the slope of the mean curve."	( A method for presenting and comparing dose-response curves. Carpenter, JR, 1986)	0.27
" In anaesthetized guinea-pigs SK&F 93944 displaced histamine bronchoconstriction dose-response curves at doses which had negligible effects on histamine tachycardia."	( Pharmacological studies with SK&F 93944 (temelastine), a novel histamine H1-receptor antagonist with negligible ability to penetrate the central nervous system. Brown, EA; Griffiths, R; Harvey, CA; Owen, DA, 1986)	0.76
" The dose-response analysis showed inhibition of a competitive type."	( Exogenous serotonin and histamine-stimulated gastric acid and pepsin secretion in dogs. Bech, K, 1986)	0.58
" Dose-response effects on microvascular permeability were found with increasing doses of subscrotally injected serotonin or histamine."	( Radioactive colloidal gold as a tool to quantify extravasation of macromolecules in the rat cremaster muscle. Borgers, M; Lauwers, F; Verheyen, A; Vlaminckx, E; Wouters, L, 1987)	0.48
" The dexamethasone action on VIP-stimulated cyclic AMP accumulation takes place within 48 h and is most apparent in the mid-range of the VIP dose-response curve."	( Adrenocortical steroids modify neurotransmitter-stimulated cyclic AMP accumulation in the hippocampus and limbic brain of the rat. Harrelson, AL; McEwen, BS; Rostene, W, 1987)	0.27
" Cimetidine, a specific H2 receptor antagonist, produced parallel shifts in the log dose-response curves for impromidine."	( Presynaptic and postsynaptic effects of histamine and histamine agonists in the superior cervical ganglion of the rat. Snow, RW; Weinreich, D, 1987)	0.54
" Cimetidine produced a parallel displacement of the histamine dose-response curve, suggesting competitive inhibition between this classical H2 receptor antagonist and histamine in the two experimental groups."	( Up- and down-regulation of membrane receptors as possible mechanisms related to the antiulcer actions of milk in rat gastric mucosa. Chastre, E; Emami, S; Gespach, C; Launay, JM; Rosselin, G, 1987)	0.52
" Dose-response curves to acetylcholine (n = 8) and histamine (n = 4) were measured before and after exposure to ozone (3 ppm for 30 min)."	( Role of the parasympathetic nervous system in airway hyperresponsiveness after ozone inhalation. Jones, GL; Lane, CG; Manning, PJ; O'Byrne, PM, 1987)	0.52
" The effectiveness of chronic dosing with temelastine (SK&F 93944) 75 mg twice daily and terfenadine 60 mg twice daily compared with placebo in inhibiting the weal and flare response to intradermal histamine was assessed using non-invasive objective assessment techniques."	( Non-invasive instrumental techniques to detect terfenadine and temelastine induced suppression of histamine weals in man. Marks, R; Shall, L, 1987)	0.68
"In the rabbit isolated aorta, hymenin (10(-6) M), a novel marine alkaloid, caused a parallel rightward shift of the dose-response curve for norepinephrine without affecting that for histamine or KCl, suggesting that hymenin is a competitive antagonist of alpha-adrenoceptors in vascular smooth muscles."	( Alpha-adrenoceptor blocking action of hymenin, a novel marine alkaloid. Kobayashi, J; Nakamura, H; Ohizumi, Y, 1988)	0.47
" With three different doses of oral azelastine, we have performed a dose-response study to determine its protective effect on the airways against histamine-induced bronchoconstriction in 12 patients with mild, atopic asthma."	( The in vivo potency and selectivity of azelastine as an H1 histamine-receptor antagonist in human airways and skin. Aurich, R; Harrison, PJ; Holgate, ST; Rafferty, P, 1988)	0.72
" For all drugs the maximal weal suppression with the dosage chosen was recorded the day after the last dosage, being 29% (for dexchlorfeniramine), 72% (for cyproheptadine), 50% (for astemizole), 62% (for loratadine), and 56% (for terfenadine) of the baseline value."	( Duration of the inhibitory activity on histamine-induced skin weals of sedative and non-sedative antihistamines. Almind, M; Dirksen, A; Nielsen, NH; Svendsen, UG, 1988)	0.54
" Mequitazine at 10(-7) M produced a parallel shift of the dose-response curve to acetylcholine in the rat duodenum, clemizole and the lower doses of mequitazine failed to modify the effect of acetylcholine."	( Antihistaminic and anticholinergic activities of mequitazine in comparison with clemizole. Estañ, L; Martinez-Mir, I; Morales-Olivas, FJ; Rubio, E, 1988)	0.27
" The three dose-response curves were compared by analysis of variance."	( Comparative effects of rilmenidine and clonidine on bronchial responses to histamine in asthmatic subjects. Advenier, C; Dinh Xuan, AT; Lockhart, A; Matran, R; Regnard, J; Vitou, P, 1988)	0.51
" The dose-response characteristics of LTC4 and histamine on oxygen desaturation in asthmatic patients appear to differ significantly and probably are dependent on relative sensitivities of pulmonary vascular and bronchial smooth muscle to these agonists."	( Effect of inhaled leukotriene C4 on cardiopulmonary function. Albazzaz, MK; Dargie, HJ; Patel, KR; Reid, JM; Shakir, S, 1989)	0.53
" None of the differences observed reached statistical significance, in agreement with the similarity of the dose-response curves."	( Analysis of the wheal-and-flare reactions that follow the intradermal injection of histamine and morphine in adults with recurrent, unexplained anaphylaxis and systemic mastocytosis. Bressler, RB; Kaliner, MA; Keffer, JM; Metcalfe, DD; Wright, R, 1989)	0.5
" PC10, PC15, and PC20 were calculated from the dose-response curves."	( The reproducibility and agreement of three indices of airway responsiveness to histamine in asthmatic children. Gerritsen, J; Knol, K; Koëter, GH; Postma, DS; van Aalderen, WM; van der Weele, LT, 1989)	0.5
" H1-agonists (2-methylHi and 2-thiazolylethylamine) also depressed the avoidance response; their dose-response lines run parallel to that of Hi."	( The effects of histamine and some related compounds on conditioned avoidance response in rats. Akahori, H; Kamei, C; Kitazumi, K; Tasaka, K, 1985)	0.62
" In an apparently all-or-none manner, both caused a sinistral shift in dose-response curves for the phasic component of the contractile response to histamine at H1 receptors on the ileum."	( Metronidazole and 5-aminosalicylic acid enhance the contractile activity of histaminergic agonists on the guinea-pig isolated ileum. Barker, LA; Winbery, SL, 1986)	0.7
" Conversely, following potentiation of the response to histamine with DTT, exposure of the tissue to desensitizing concentrations of histamine resulted in a dextral shift of the dose-response curve (dose ratio = 39."	( Selective enhancement of histamine H1-receptor responses in guinea-pig ileal smooth muscle by 1,4-dithiothreitol. Donaldson, J; Hill, SJ, 1986)	0.82
" On a separate day the FMLP dose-response curves were repeated after nebulisation of 500 micrograms of ipratropium bromide."	( Effect of inhaled formyl-methionyl-leucyl-phenylalanine on airway function. Armour, CL; Berend, N; Black, JL; Peters, MJ; Ward, HE, 1988)	0.27
" The selective histamine H1-receptor antagonist chlorpheniramine shifted the dose-response curves of histamine and 2-PEA for inducing vasoconstriction to the right."	( Characteristics of histamine receptors in the isolated and perfused canine coronary arteries. Chiba, S; Nakane, T, 1987)	0.95
" One hour prior to dosing and 1, 2, 3, 4, 6, 8, 12, 16, 24, 28, 32, 36, 40, and 48 hours after dosing, histamine and saline were injected intradermally into opposite arms."	( Effects of loratadine (SCH 29851) in suppression of histamine-induced skin wheals. Dyer, JG; Gural, R; Kassem, N; Robillard, N; Roman, I, 1988)	0.74
" Dose-response and time-course studies revealed that baclofen has little influence on neurotransmitter recognition site affinity, but rather enhances the synthesis or accumulation of second messenger that occurs in response to these agents."	( Characterization of the relationship between gamma-aminobutyric acid B agonists and transmitter-coupled cyclic nucleotide-generating systems in rat brain. Enna, SJ; Karbon, EW, 1985)	0.27
" Dose-response curves were constructed and characterized in terms of the EC50, slope and maximal response attainable relative to histamine."	( Histamine-induced inositol phospholipid breakdown in the longitudinal smooth muscle of guinea-pig ileum. Donaldson, J; Hill, SJ, 1985)	1.92
" With histamine, no significant difference in the dose-response curves between the two muscle layers was found."	( Contraction and cyclic AMP-related relaxation of the intimal and medial smooth muscle layers of pig thoracic aorta. Andersson, RG; Lundholm, L; Wingren, G, 1985)	0.75
" 6-hydroxydopamine (2 X 250 micrograms) there was a small increase in alpha 1-adrenoceptor binding sites but a parallel shift to the left in the noradrenaline [3H]inositol phosphate accumulation dose-response curve."	( Alpha 1-adrenoceptor-mediated inositol phospholipid hydrolysis in rat cerebral cortex: relationship between receptor occupancy and response and effects of denervation. Brown, E; Kendall, DA; Nahorski, SR, 1985)	0.27
" Prazosin produced a parallel shift to the right of the norepinephrine, but not the histamine, dose-response curves indicating the presence of prazosin-sensitive alpha-adrenoceptors in this vessel."	( Evidence for functional alpha-adrenoceptors in rabbit basilar arteries. Bevan, JA; Laher, I, 1985)	0.49
" Calcium-free/EGTA conditions did not, however, alter the dose-response parameters for the response to the H2-agonist, impromidine."	( The role of calcium in the cyclic AMP response to histamine in rabbit cerebral cortical slices. Al-Gadi, M; Hill, SJ, 1987)	0.53
" Dose-response curves revealed that reduction in the response to carbachol was due to a fall in maximal response and not in EC50."	( Acute and chronic lithium treatments influence agonist and depolarization-stimulated inositol phospholipid hydrolysis in rat cerebral cortex. Kendall, DA; Nahorski, SR, 1987)	0.27
" In the two experimental groups, cimetidine produced a parallel displacement of the histamine dose-response curve suggesting competitive inhibition between this classical H2 receptor antagonist and histamine."	( Effect of a milk diet on rat gastric mucosa: receptor activity, histamine metabolism and ultrastructural analyses. Chastre, E; Chatelet, F; Ducroc, R; Emami, S; Garzon, B; Gespach, C; Hervatin, F, 1987)	0.74
" The inhibition was characterized by displacement of the dose-response to histamine to the right, in parallel, without depression of the maximum."	( Actions of nizatidine on the rat uterus, dog stomach and experimentally induced gastric lesions. Evans, DC; Lin, TM; Ruffolo, RR; Warrick, MW, 1986)	0.5
"In normocapnic and deeply hypocapnic guinea-pig heart-lung-preparations (HLPs), dose-response relationships were estimated for the bronchoconstrictor and pulmonary hypertensive responses to histamine (H), 5 hydroxytryptamine (5HT), arachidonic acid (AA) and U-46619, a prostaglandin endoperoxide analogue acting on thromboxane (TXA2) receptors."	( Arachidonic acid and pulmonary function in heart-lung-preparation of guinea-pig: modulation by PCO2. Argiolas, L; Bedetti, C; Carpi, A; Del Basso, P, 1987)	0.46
" A combination of the two drugs both in "standard" and modified dosage resulted in the greatest reduction in the wheal and flare."	( Effect of terfenadine and ranitidine on histamine and suxamethonium wheals. Bödeker, RH; Paul, E; Pfeffer, M, 1988)	0.54
" There was a highly significant correlation between the number of cigarettes the mother smoked in the house and each of these lung function test results, indicating a dose-response relationship."	( Passive smoking and the seasonal difference of severity of asthma in children. Morrison, BJ; Murray, AB, 1988)	0.27
" The threshold provocative dose of histamine needed to cause a 20% fall in starting FEV1 (PD20) was measured by log dose-response curve."	( Increased responsiveness to histamine after propranolol in subjects with asthma nonresponsive to the bronchoconstrictive effect of propranolol. Carpentiere, G; Castello, F; Marino, S, 1988)	0.85
" Protamine produces parallel rightward displacements of the C5a dose-response curves."	( Complement C5a receptor antagonism by protamine and poly-L-Arg on human leukocytes. Kahl, JU; Olsen, UB; Selmer, J, 1988)	0.27
" For these studies, base-line airway dose-response curves to histamine and carbachol were determined on the same day."	( A leukotriene and thromboxane inhibitor (Sch 37224) blocks antigen-induced immediate and late responses and airway hyperresponsiveness in allergic sheep. Abraham, WM; Garrido, R; Stevenson, JS, 1988)	0.52
" Cumulative dose-response curves were constructed to norepinephrine, histamine, serotonin, and potassium chloride, and the protocol was designed such that only one agent and hydrogen ion concentration was studied in each vessel segment."	( Effect of hydrogen ion concentration on in vitro pulmonary vascular reactivity. Bronstein, EH; Porcelli, RJ, 1988)	0.51
"Three consecutive dose-response curves to aerosolized histamine were obtained in 11 anesthetized dogs."	( Characteristics of tachyphylaxis to inhaled histamine in anesthetized dogs. Antol, PJ; Fujita, M; Hyatt, RE, 1988)	0.78
" Three consecutive histamine dose-response curves were obtained in nine dogs pretreated with 5 mg/kg indomethacin; two of these nine were also pretreated with 10 mg/kg indomethacin."	( Histamine tachyphylaxis in canine airways despite prostaglandin synthesis inhibition. Antol, PJ; Gunst, SJ; Hyatt, RE, 1988)	2.05
" In the isolated guinea-pig ileum, domperidone alone did not produce any effect, but produced a right-ward displacement of the contractile dose-response curve to histamine."	( Effect of domperidone on the contractility of isolated guinea-pig atria. Estañ, L; Martinez-Mir, I; Morales-Olivas, FJ; Rubio, E, 1988)	0.47
" EGF (10(-7) M) significantly inhibited the histamine dose-response curve for [14C]AP and IF, but a relatively greater inhibition was observed at higher histamine concentration."	( Epidermal growth factor (EGF) inhibits both intrinsic factor secretion and acid secretion in histamine-stimulated isolated gastric glands. Modlin, IM; Rackoff, PJ; Tyshkov, M; Zdon, MJ, 1988)	0.76
"8 nmol/l) of PGE2 on the mefloquine- and quinine-induced inhibition of the ACh cumulative dose-response curves were also investigated."	( Action of mefloquine on agonist-induced contractions of the guinea-pig isolated ileum. Go, ML; Lee, HS, 1988)	0.27
"In normal subjects in vivo the dose-response curve to inhaled nonsensitizing stimuli reaches a plateau at mild degrees of airway narrowing."	( The combined effects of histamine and methacholine on the maximal degree of airway narrowing in normal humans in vivo. Bel, EH; Dijkman, JH; Sterk, PJ; Timmers, MC, 1988)	0.58
" Airway responsiveness thus appears to be a useful tool for evaluating inhaled beta 2-agonists and designing beta 2-agonist dosing regimens."	( Use of bronchial provocation with histamine to compare the pharmacodynamics of inhaled albuterol and metaproterenol in patients with asthma. Ahrens, RC; Annis, L; Harris, JB; Milavetz, G; Ries, R, 1987)	0.55
"We evaluated the efficacy of an oral dosage form of the investigational smooth muscle relaxant, zindotrine, a novel pyridazine derivative, in counteracting histamine-induced bronchospasm in a group of 12 non-medicated asymptomatic asthmatics."	( The effect of oral zindotrine (MDL-257), a bronchial smooth muscle relaxant, on histamine airways responsiveness in asymptomatic asthmatics. Bangs, SE; Barker, KB; Diamond, L; Gordon, EE; Küng, M, 1987)	0.7
" In a stratified analysis, pulmonary function level appeared to be associated with BR in a dose-response relationship."	( The relationship between airway responsiveness to histamine and pulmonary function level in a random population sample. Rijcken, B; Schouten, JP; Speizer, FE; van der Lende, R; Weiss, ST, 1988)	0.53
"0 micrograms/ml of leukotriene C4, while the pretreatment did not affect the histamine dose-response curve."	( Secondary release of thromboxane A2 in aerosol leukotriene C4-induced bronchoconstriction in guinea pigs. Fujimura, M; Kanamori, K; Matsuda, T; Miyake, Y; Uotani, K, 1988)	0.5
" In both groups a clear dose-response relationship was demonstrated by either reagent."	( Skin reactions to histamine and compound 48/80 in chronic urticaria: a diagnostic tool? Gonzalo Reques, F; Ortega Núñez, A; Pelta-Fernández, R; Rubio Sotes, M, )	0.47
" Histamine dose-response curves were performed in each of two to three separate lobar segments of an individual mongrel dog's lungs."	( Temporal and regional variability of collateral resistance response to histamine. Anderson, K; Drazen, JM; Ludwig, MS; Shore, SA, 1988)	1.42
" The dose-response curves were compared by an analysis of variance."	( Effects of clonidine on bronchial responses to histamine in normal and asthmatic subjects. Advenier, C; Dinh Xuan, AT; Lockhart, A; Mantrand, P; Matran, R; Regnard, J, 1988)	0.53
" Isometric tension studies of control vein and vein bypass grafts treated with histamine resulted in sigmoid dose-response curves."	( Mast cell infiltration: a possible mechanism for vein graft vasospasm. Cross, KS; el-Sanadiki, MN; Hagen, PO; McCann, RL; Mikat, EM; Murray, JJ, 1988)	0.5
"5-2 mg/ml) caused a parallel and concentration-dependent rightward displacement to all three kinins dose-response curves."	( Antagonistic effect of Mandevilla velutina extract on kinin-induced contractions of guinea-pig and cat ileum longitudinal smooth muscle. Calixto, JB; Nicolau, M; Yunes, RA, 1988)	0.27
" Clemastine significantly shifted the histamine dose-response curves to the right in both groups of lung strips."	( Pharmacological analysis of reactivity changes in airways due to acute inflammation in cats. Bánovcin, P; Korpás, J; Visnovský, P, 1987)	0.54
" The dose of histamine producing at 20% change in FEV1 (forced expiratory volume in one second) was calculated from the individual semilogarithmic dose-response curve (PD20)."	( Influence of asthmatic and rhinitic symptomatology duration on bronchial responsiveness to histamine. Crimi, N; Distefano, SM; Mistretta, A; Oliveri, R; Palermo, B; Palermo, F; Polosa, R; Vancheri, C, 1987)	0.86
"Histamine concentration-effect curves were obtained using either an individual or cumulative dosing method."	( Histamine contraction of isolated human airway muscle preparations: role of prostaglandins. Bayol, A; Benveniste, J; Boullet, C; Brink, C; Cerrina, J; Haye-Legrand, I; Labat, C; Raffestin, B, 1986)	3.16
" The effect of a near-threshold dose of PGD2 on histamine dose-response relationships and on the response to a single low dose of histamine were examined."	( The effect of prostaglandin D2 on the response of human skin to histamine. Barr, RM; Greaves, MW; Koro, O; Maurice, PD, 1987)	0.77
"Cumulative dose-response curves for histamine induced responses in mesometrial (ME) and antimesometrial (AME) regions of uterine horns isolated from rats at 7th, 16th and 22nd days of pregnancy, were constructed."	( Is there a prostaglandin involvement in the positive inotropic action of histamine in isolated pregnant rat uterus, apparently mediated via H1-receptors activation? Dveksler, G; Franchi, AM; Gimeno, AL; Gimeno, MF; Viggiano, M, 1987)	0.78
"The release of inflammatory mediators (histamine, PGD2, TxB2, and LTC4) from purified human lung mast cells was characterized by kinetic and anti-IgE dose-response parameters."	( Characterization of inflammatory mediator release from purified human lung mast cells. Adkinson, NF; Lichtenstein, LM; MacGlashan, DW; Peters, SP; Pinckard, RN; Schleimer, RP, 1986)	0.54
" Several methods for summarising the information in the dose-response curve obtained from a histamine challenge test have been compared."	( Estimation and repeatability of the response to inhaled histamine in a community survey. Britton, JR; Burney, PG; Chinn, S; Papacosta, AO; Tattersfield, AE, 1987)	0.74
"To examine the relationship of cigarette smoking, starting airway caliber, and airway pathology to nonspecific airway reactivity, we performed inhalation dose-response curves in 40 patients prior to lung surgery."	( Nonspecific airway reactivity in cigarette smokers. Relationship to airway pathology and baseline lung function. Hogg, JC; Mullen, JB; Paré, PD; Wiggs, BR; Wright, JL, 1986)	0.27
" The dose-response curves to methacholine reached a plateau or maximal effect after a 30 to 50% fall in FEV1 in 14 of the 16 smokers challenged."	( Characteristics of bronchial hyperresponsiveness in smokers with chronic air-flow limitation. Black, JL; Du Toit, JI; Salome, CM; Sundrum, R; Woolcock, AJ, 1986)	0.27
" We investigated whether this limitation is due to a nonspecific inhibitory mechanism (with regard to the agonist) by comparing the maximal response plateaus of histamine and methacholine dose-response curves."	( Maximal airway narrowing in humans in vivo. Histamine compared with methacholine. Dijkman, JH; Sterk, PJ; Timmers, MC, 1986)	0.73
" The released PGI2 significantly altered the dose-response curve to histamine without inhibiting the maximal contractile responses."	( Histamine releases PGI2 from human pulmonary artery. Duff, MJ; Foster, A; Paddon, HB; Schellenberg, RR, 1986)	1.95
" Second, the histamine or methacholine dose-response curve differs in asthmatics with a moderate to severe increase in airway responsiveness from asthmatics with a mild increase in responsiveness or nonasthmatics."	( Airway responsiveness to histamine or methacholine: advances in measurement and interpretation. Adelroth, EC; Hargreave, FE; O'Byrne, PM; Ramsdale, EH; Sterk, P, 1986)	0.94
" The dose-response relation of the coronary diameter to histamine was not influenced by pretreatment with the nerve transmitter blockers guanethidine (3 X 10(-6) M), atropine (10(-6) M), and tetrodotoxin (3 X 10(-7) M)."	( Pathogenesis of coronary artery spasm in miniature swine with regional intimal thickening after balloon denudation. Egashira, K; Kawasaki, T; Kobayashi, T; Nakamura, M; Tomoike, H; Yamamoto, Y, 1987)	0.52
" steeper dose-response curve of histamine than manifest allergics."	( Quantitative skin prick testing. Dose-response of histamine- and allergen-induced wheal reactions. Malling, HJ, 1987)	0.81
" Histamine dose-response curves were performed before and 4 h after PAF administration."	( Effect of platelet-activating factor on aerosol histamine responsiveness in awake sheep. Christman, BW; Lefferts, PL; Snapper, JR, 1987)	1.44
" The cimetidine dose-response curves and the calculated ED50 values were similar in the different experimental situations."	( Effects of cimetidine, atropine and pirenzepine on basal and stimulated gastric acid secretion in the rat. Ekelund, M; Håkanson, R; Vallgren, S, 1987)	0.27
" Epinephrine stimulation of AC was affected by reserpine and was characterized by an upward shift of the epinephrine dose-response curve with no change in the epinephrine EC50."	( Reserpine-induced supersensitivity in adenylate cyclase preparations from guinea-pig heart. Cros, GH; McNeill, JH, 1987)	0.27
" Human bronchi were obtained from thoracotomy and dose-response relationships for each agonist were obtained for bronchial rings suspended in isotonic Krebs-Henseleit solution (290 mOsm)."	( The effect of non-isotonic solutions on human isolated airway smooth muscle. Anderson, SD; Black, JL; Finney, MJ, 1987)	0.27
"The histamine H2-receptor on the human parietal cell has been characterized by using dose-response curves and the negative logarithm of the molar concentration of an antagonist (pA2) analyses of cimetidine antagonism of betazole, histamine, and impromidine stimulation in isolated human and rabbit gastric glands."	( Histamine H2-receptor of human and rabbit parietal cells. Elander, B; Fellenius, E; Haglund, U; Leth, R; Olbe, L, 1987)	2.27
" All dose-response curves were linear and parallel."	( Skin test reactivity to histamine from infancy to old age. Bousquet, J; Manderscheid, JC; Michel, FB; Skassa-Brociek, W, 1987)	0.58
" A PC20 was determined by interpolation on the log dose-response curve."	( Fixed ventilation during tidal volume breathing bronchial challenge may improve repeatability. Frølund, L; Madsen, F; Nielsen, NH; Svendsen, UG; Weeke, B, 1987)	0.27
" Odds ratios increased with decreasing threshold values in a dose-response relationship for all symptoms, except for bronchitis periods."	( The association of airways responsiveness to respiratory symptom prevalence and to pulmonary function in a random population sample. Rijcken, B; Schouten, JP; Speizer, FE; van der Lende, R; Weiss, ST, )	0.13
" Vascular reactivity (maximum response) and drug sensitivity (ED50) were compared using cumulative dose-response data for each pharmacological agent."	( Pregnancy- and gender-related changes in pulmonary vascular reactivity. Cutaia, M; Friedrich, P; Grimson, R; Porcelli, RJ, 1987)	0.27
" The dose-response relationships following vagotomy were assessed during spontaneous ventilation and during muscular paralysis and mechanical ventilation with tidal volume (VT) similar to each animal's VT prior to vagotomy."	( Effect of tidal volume and anesthetic agent on airway responsiveness to histamine. Davidson, AB; Drazen, JM; Ingram, RH; Seltzer, J, 1986)	0.5
" Group B (n = 10), H24 (n = 5), and H72 (n = 5) were anesthetized with sodium thiamylal (B) or halothane and N2O (H24, H72) for 3 h, during which a dose-response curve to histamine was obtained."	( Prolonged hyporesponsiveness of airway smooth muscle to histamine following general anesthesia. Amyot, R; Chapleau, D; Couture, J; Michoud, MC; St-Jean, S, 1986)	0.71
" Therefore, we obtained dose-response curves to aerosols of histamine and ouabain in guinea pigs to determine whether an in vivo relationship existed between the excitatory effects of histamine and the enzyme-inhibiting effect of ouabain."	( Airway responses to inhaled ouabain and histamine in conscious guinea pigs. Agrawal, KP; Hyatt, RE, 1986)	0.78
" To investigate this phenomenon further, dose-response curves to agonists under different oxygen concentrations were examined."	( Substrate dependence and oxygen sensitivity of tone and of spontaneous and evoked contractions of the distal colonic muscularis mucosae of opossum. Christensen, J; Mason, JB; Percy, WH; Roberts, RL, 1986)	0.27
"To determine if clinical concentrations of halothane have direct relaxant effects on airway smooth muscle, the authors compared dose-response curves to histamine in the control state (thiopental) and during halothane anesthesia (1."	( Mode of action of halothane on histamine-induced airway constriction in dogs with reactive airways. Hirshman, CA; Shah, MV, 1986)	0.76
" The H1-antagonist clemizole antagonized competitively the effect of histamine but the H2-antagonist ranitidine did not modify the dose-response curve to histamine in the guinea-pig colon."	( Pharmacological investigation into the effects of histamine and histamine analogues on guinea-pig and rat colon in vitro. Aguilar, MJ; Morales-Olivas, FJ; Rubio, E, 1986)	0.76
"05) shifts to the right of the histamine dose-response curve in normal physiological salt solution (PSS)."	( Differential effects of adenosine and verapamil on histamine vascular contractions. Merrill, GF; Tozzi, CA, 1986)	0.81
" The PD20 (dose of histamine which causes a 20% fall of FEV1) was determined on a semi-log dose-response curve."	( [Relation between respiratory function, bronchial reactivity and symptoms in heavy smokers]. Vincent, A; Woolcock, AJ, 1986)	0.6
" The slopes of log dose-response curves (SLDRC) to H and SLDRC to ACH were of similar magnitude both in N and AST and linearly related; however, for either agonist, bronchial sensitivity (PD40) and reactivity (SLDRC) failed to correlate."	( The relationship between acetylcholine- and histamine-induced constriction of large airways in normal subjects and subjects with asthma: a possible role for postreceptor mechanisms. Popa, V, 1986)	0.53
" Cimetidine shifted the dose-response curve for histamine to the right, but chlorpheniramine did not alter the response."	( Mechanisms of histamine-induced relaxation in isolated monkey and dog coronary arteries. Toda, N, 1986)	0.89
" The dose of histamine that doubled SRaw (PC200His) was determined by interpolation from histamine dose-response curves."	( Bronchial reactivity increases soon after the immediate response in dual-responding asthmatic subjects. Bernstein, IL; Murlas, CG; Steinberg, D; Thorpe, JE, 1987)	0.64
" Using this device, we were able to obtain the direct-writing dose-response curve of respiratory resistance measured during quiet breathing."	( Effect of nifedipine on dose-response curves to acetylcholine and histamine measured during quiet breathing. Arai, M; Fueki, R; Kobayashi, S; Kuroiwa, H; Tomioka, S, 1986)	0.51
"4 microM or dithiothreitol (DTT) 1 microM, dose-response curves to histamine were moved to the left in both control and rubbed tissues, and the maximum response was increased."	( The influence of epithelium on the responsiveness of guinea-pig isolated trachea. Holroyde, MC, 1986)	0.51
" Aerosol pretreatment with the cyclooxygenase inhibitor indomethacin had no significant effect on either LTC4 or LTD4 dose-response curves; however, at the highest doses of these agonists a notable, nonsignificant inhibition of effects on both Rp and Cdyn was seen."	( Pharmacology of aerosol leukotriene C4- and D4-induced alteration of pulmonary mechanics in anesthetized cynomolgus monkeys. Giles, RE; Krell, RD; Williams, JC, 1986)	0.27
" Dose-response contraction curves for histamine, carbachol, and norepinephrine were obtained in the ileal, parenchymal, and aortic strips, respectively."	( Smooth muscle inhibition by an extract of Sesbania drummondii. Flory, W; Marceau-Day, ML; O'Malley, NA; Venugopalan, CS, 1987)	0.54
" On the other hand, the dose-response curve for tyramine shifted to the right in a parallel manner, and histamine-induced vasoconstriction was markedly potentiated by prolonged cold storage in a maximal increase in perfusion pressure."	( Effects of prolonged cold storage on the responsiveness of isolated and perfused canine intermediate auricular artery. Chiba, S; Ito, T, 1985)	0.48
" Dose-response studies performed with either prostaglandin E2 or histamine alone revealed that each agent increased microvascular permeability in a dose-related fashion."	( Potentiation of histamine-induced microvascular permeability by prostaglandin E2 in rat mesentery. Guth, PH; Ohya, Y, 1985)	0.85
" In each dog, dose-response curves to inhaled aerosolized histamine were obtained in both lungs separately but synchronously."	( Central and local cholinergic components of histamine-induced bronchoconstriction in dogs. Bai, TR; Martin, JG; Shore, SA; Wang, CG, 1985)	0.77
"This study was designed to assess the acute effect of 1 mg of orally administered ketotifen on the dose-response curve to both histamine and methacholine, in 15 patients with bronchial asthma."	( Acute effect of ketotifen on the dose-response curve of histamine and methacholine in asthma. Barja, S; Cruz, E; Ferretti, R; Lisboa, C; Moran, J; Moreno, R; Sanchez, I, 1985)	0.72
"Slopes of the dose-response curves to inhaled histamine or methacholine and PC20 were compared in 14 subjects with symptoms of bronchial hyperexcitability and in 10 normal subjects."	( Slope of the dose-response curve to inhaled histamine and methacholine and PC20 in subjects with symptoms of airway hyperexcitability and in normal subjects. Cartier, A; Gagnon, G; Malo, JL; Martin, RR; Pineau, L, 1985)	0.79
" Dose-response curves for agonists and the effects of antagonists are often undetermined."	( The pharmacology of fever. Dascombe, MJ, 1985)	0.27
" Only the ketotifen and clemastine groups differed significantly from the placebo group on shifting log dose-response curves of inhaled histamine."	( Long-term modification on histamine-induced bronchoconstriction by disodium cromoglycate and ketotifen versus placebo. Colas Sanz, C; de Barrio Fernandez, M; Gozalo Reques, F; Herrero Lopez, T; Rubio Sotes, M; Senent Sanchez, C, 1985)	0.77
" In the single dosage range of 50-200 micrograms, misoprostol inhibits gastric acid secretion in a dose-related manner both in the basal state and after stimuli such as histamine and standard test meals."	( Misoprostol clinical pharmacology. Establishment of activity in man. Steiner, JA, 1985)	0.46
" The IAR showed a very good reproducibility and significant dose-response relationship (P less than ."	( The immediate asthmatic response to allergen challenge. Berger, MP; Kruis, M; Pelikan, M; Pelikan, Z, 1986)	0.27
" The dose-response characteristics for the 5-HT-mediated steady-state current differ, however, from those of the 5-HT-induced ACh response facilitation."	( Serotonin enhances the excitatory acetylcholine response in the RB cell cluster of Aplysia californica. Koester, J; Simmons, LK, 1986)	0.27
" Histamine dose-response characteristics in the presence of mepyramine and clemastine suggest the H1 antagonism to be competitive in nature."	( H1-histaminergic activation stimulates inositol-1-phosphate accumulation in chromaffin cells. Bommer, M; Costa, T; Herz, A; Noble, EP; Sincini, E, 1986)	1.8
" Dose-response studies were performed using intravenous histamine or tetragastrin."	( Stimulation of gastric acid secretion in the rhesus monkey. Harmon, JW; Trout, HH; Zinner, M, 1985)	0.52
"Histamine dose-response curves were performed on anesthetized tracheostomized guinea pigs that were paralyzed and mechanically ventilated at a constant tidal volume and breathing frequency."	( Histamine dose-response curves in guinea pigs. Hogg, JC; Hulbert, WC; McLean, T; Paré, PD; Wiggs, B, 1985)	3.15
" The result, obtained from the cumulative dose-response curve, was expressed as the provocative dose (PD20) of histamine producing a 20% fall in forced expiratory volume in one second (FEV1)."	( Damage of the airway epithelium and bronchial reactivity in patients with asthma. Haahtela, T; Heino, M; Kava, T; Laitinen, A; Laitinen, LA, 1985)	0.48
"Submaximal histamine dose-response curves were obtained on 34 dogs divided into six groups."	( Interaction of verapamil hydrochloride and atropine sulphate on histamine-induced bronchoconstriction. Brandt, HD; Bunn, AE; Krivoy, N, 1985)	0.9
"5 mg/l; 20 min), when administered to guinea pigs 1 h before exposure to acetylcholine (Ach), induced potentiation of cumulative dose-response curve of this agonist on isolated tracheal strips as well as a decrease of the lethal doses of Ach."	( Kerosene aerosol induces guinea-pig airway hyperreactivity to acetylcholine. Arruzazabala, L; Casacó, A; de la Vega, AR; García, M; González, R, 1985)	0.27
" Pretreatment with propranolol or the combination of propranolol and atropine prior to the histamine dose-response curve did not affect the increased response seen after cigarette smoke exposure, but pretreatment with atropine abolished it."	( The effect of acute airway inflammation on bronchial reactivity in guinea pigs. Hogg, JC; Hulbert, WM; McLean, T, 1985)	0.49
" We studied bronchial responsiveness to histamine in 30 patients with acute or chronic bronchitis, 28 patients with bronchial asthma and in 42 more patients with other lung diseases, using a new device--the Astograph--which yielded graphically a continuous dose-response curve of the respiratory resistance by the oscillation method during the inhalation of histamine diphosphate."	( Measurement of the non-specific threshold stimulus for the bronchial tree by continuous monitoring of respiratory resistance using the oscillation method. Jansen, LP; Maesen, FP; Smeets, JJ; Tjwa, MK, 1985)	0.54
" The double reciprocal plot of the dose-response relationship between the peak ACh current and the amount of ACh applied suggested that histamine (100 microM) depressed the ACh-induced current in a competitive manner."	( Histamine is an antagonist of the acetylcholine receptor at the frog endplate. Ariyoshi, M; Hasuo, H; Koketsu, K; Ohta, Y; Tokimasa, T, 1985)	1.91
" Dose-response curves were constructed for five agents."	( The effectiveness of local injections of vasodilating agents to produce vasodilation in subcutaneous tissue in rabbits. DeYoung, NJ; Duncan, HJ; Faris, IB, 1985)	0.27
" Dose-response studies revealed that the inhibition of mast cell-mediated wealing required a certain cumulative threshold dose of UVR (about 35 J/cm2 UVA + 20 mJ/cm2 UVB)."	( UV suppression of mast cell-mediated wealing in human skin. Gollhausen, R; Kaidbey, K; Schechter, N, 1985)	0.27
" Increasing doses of histamine were given in order to obtain the dose-response characteristics of the changes in Cdyn, G and P-V curves."	( [Effects of histamine on the pressure-volume curve of the respiratory system in the guinea pig]. Atlan, G; Clerici, C; Harf, A; Lhoste, F; Macquin, I, )	0.83
" Analysis of the dose-response curves for the enzyme-activating effect of pentagastrin and cholecystokinin-octapeptide indicated that the D50 values for these two stimulants were not altered by shunting but that the maximal enzyme activation was greatly elevated."	( Effects of portacaval shunt on the rat stomach. Ekelund, M; Håkanson, R; Holmin, T; Oscarson, J; Rehfeld, JF; Sundler, F; Westrin, P, 1985)	0.27
" The compounds are competitive and specific CCK-antagonists, causing a parallel right shift of the cumulative dose-response curve of the agonist."	( New glutaramic acid derivatives with potent competitive and specific cholecystokinin-antagonistic activity. Bani, M; Chistè, R; Makovec, F; Pacini, MA; Rovati, LA; Setnikar, I, 1985)	0.27
"Three consecutive dose-response curves to inhaled aerosolized histamine, separated by 1-h intervals, were obtained in 20 anesthetized mongrel dogs."	( Tachyphylaxis to inhaled aerosolized histamine in anesthetized dogs. Martin, JG; Shore, S, 1985)	0.78
" Histamine-content, anaphylactic histamine-release and the anaphylactic dose-response curve of the full-thickness ileum and of the longitudinal muscle strip have been measured and compared."	( The Schultz-Dale response of the longitudinal muscle strip preparation of guinea-pig ileum. Dale, MM; Zilletti, L, 1970)	1.16
" Conscious gastric-cannulated rats were given [(3)H]histidine and aminoguanidine by dosage procedures intended to build up fast-turnover and slow-turnover pools of tissue [(3)H]histamine."	( The release of histamine during gastric acid secretion in conscious rats. el-Munshid, HA; Lake, HJ, 1974)	0.8
" Histamine at the peak of its dose-response curve, 3 x 10(-4)moles/liter, produced approximately a 300% increase in cyclic 3',5'-AMP accumulation in the guinea pig, 60% in the cat, and 90% in the human heart particles."	( Activation of myocardial adenyl cyclase by histamine in guinea pig, cat, and human heart. Klein, I; Levey, GS, 1971)	1.42
" The difference in sensitivity was greater in the lower than the upper parts of the dose-response curves."	( Differences in sensitivity to vasoconstrictor drugs within the wall of the sheep carotid artery. Graham, JM; Keatinge, WR, 1972)	0.25
" Dose-response curves were obtained for intravenous infusions of adrenaline, noradrenaline, angiotensin, vasopressin and histamine."	( Effects of infusions of catecholamines, angiotensin, vasopressin and histamine on hepatic blood volume in the anaesthetized cat. Greenway, CV; Lautt, WW, 1972)	0.69
" The rise in brain histamine after dosage with histidine persisted for several hours, depending on the dose; with 500 mg/kg, the rise was virtually unchanged after 16 hours."	( Concentration of histamine in different parts of the brain and hypophysis of rabbit: effect of treatment with histidine, certain other amino acids and histamine. Abou, YZ; Adam, HM; Stephen, WR, 1973)	0.92
" A plateau secretion of acid evoked by infusing histamine in a near maximal dosage was inhibited by atropine to the same extent as the gastrin-induced secretion in the Pavlov pouch."	( Inhibition of gastric secretion by atropine in conscious rats. Johansson, I; Lundell, L; Svensson, SE, 1971)	0.51
" The magnitude of the supersensitivity was inversely correlated with the slope of the dose-response curves to the four agonists."	( Nonspecific supersensitivity of the guinea-pig vas deferens produced by decentralization and reserpine treatment. Westfall, DP, 1970)	0.25
" In contrast, with pertussis protective fraction as inducer, there was clear dose-response regression, with 100% mortality possible."	( Endotoxin-induced hypersensitivity to histamine in mice. I. Contrasting effects of bacterial lipopolysaccharides and the classical histamine-sensitizing factor of Bordetella pertussis. Broderick, EJ; Levine, L; Pieroni, RE, 1966)	0.52
" Dose-response studies indicate that bradykinin is more potent than serotonin or histamine in respect of wealing."	( Responses of skin blood vessels to bradykinin, histamine and 5-hydroxytryptamine. Greaves, M; Shuster, S, 1967)	0.73
" The dose-response curves of terbutaline on isolated tracheae of actively sensitized guinea pigs were significantly shifted to the right in comparison with control trachea (ED50 11."	( Mechanical and biochemical alterations in guinea-pig tracheae caused by sensitisation. Beier, W; Feddersen, C; Kaukel, E; Koppermann, G; Schrum, C, 1984)	0.27
" Dose-response studies were performed with increasing concentrations of histamine both in the absence and presence of H1 receptor blockade using 10(-5) M diphenhydramine."	( Temporal relationship of cyclic nucleotide levels and calcium exchange to histamine-induced tension development. Kolbeck, RC; Speir, WA, 1984)	0.73
"Neuromuscular blocking agents can be evaluated in anesthetized cats, dogs, or rhesus monkeys using dose-response relationships to assess the degree of separation between neuromuscular blocking activity and effects on cardiovascular and autonomic systems."	( Experimental and clinical evaluation of neuromuscular blocking agents. Hughes, R, 1984)	0.27
" Dose-response curves were performed to aerosol histamine in 11 dogs both before and 1 hr after H2 receptor blockade with cimetidine (1 mg/kg as a rapid intravenous infusion)."	( In vivo effect of cimetidine on canine pulmonary responsiveness to aerosol histamine. Braasch, PS; Drazen, JM; Ingram, RH; Loring, SH; Snapper, JR, 1980)	0.75
" Dose-response curves to intra-arterial administration of arachidonic acid (12 to 200 microgram kg-1), bradykinin (0."	( Responses to arachidonic acid and other dilator agonists and their modification by inhibition of prostaglandin synthesis in the canine hindlimb. Morcillo, E, 1980)	0.26
" Dose-response experiments with five doses of pentagastrin or histamine (single-dose studies) and two doses of beta 2-agonist suggested a change after vagotomy in the mechanisms of inhibition of gastric acid secretion: for pentagastrin, from a non-competitive type to an uncompetitive type, and for histamine, from a competitive type to a non-significant inhibition."	( Effect of beta 2-sympathomimetic on pentagastrin- and histamine-stimulated gastric acid secretion in vagotomized gastric fistula dogs. Andersen, D; Gottrup, F; Ornsholt, J, 1980)	0.75
" In each airway segment, cumulative dose-response effects of ovalbumin were obtained in the absence and presence of a maximally effective concentration of a beta adrenergic receptor agonist, sulfonterol."	( Parainfluenza 3 infection blocks the ability of a beta adrenergic receptor agonist to inhibit antigen-induced contraction of guinea pig isolated airway smooth muscle. Ain-Shoka, AA; Buckner, CK; Busse, WW; Clayton, DE; Dick, EC; Shult, P, 1981)	0.26
"To examine whether either the degree of existing beta adrenergic tone or the magnitude of beta adrenergic response during bronchoconstriction might account for the differences that exist between dogs in their pulmonary responsiveness to aerosol challenge with bronchoconstrictor agents, dose-response curves were performed in a group of dogs to either histamine or prostaglandin-F2 alpha, both before beta blockade with propranolol."	( Effects of beta adrenergic blockade on histamine and prostaglandin-F2 alpha responsiveness in the dog. Braasch, PS; Drazen, JM; Ingram, RH; Loring, SH; Snapper, JR, 1981)	0.7
" Mepyramine alone displaced the histamine dose-response curve to the right."	( Antagonism of vasodepressor and gastric secretory responses to histamine by the H2-receptor antagonists, ranitidine and cimetidine, in the anaesthetized dog. Daly, MJ; Humphray, JM; Stables, R, 1981)	0.79
"The H2-receptor antagonists ranitidine and cimetidine were tested against gastric secretory dose-response curves to histamine, pentagastrin and bethanechol in the Heidenhain-pouch dog."	( The effect of ranitidine on gastric acid secretory response curves to histamine, pentagastrin or bethanechol in the dog with a Heidenhain pouch. Bunce, KT; Daly, MJ; Humphray, JM; Stables, R, 1981)	0.71
"To investigate the nature of the variable response to inhaled histamine in monkeys, we performed dose-response curves in a group of 10 anesthetized Macaca mulatta monkeys before and after administration of propranolol and atropine in inhaled doses sufficient to produce significant beta-adrenergic and cholinergic blockade of airway smooth muscle."	( Bronchial response to histamine after inhaled propranolol and atropine in monkeys. Nicholls, I; Pare, PD, 1982)	0.82
" Blocking the direct actions of histamine with concentrations of pyrilamine greater than 10(-7) M resulted in a biphasic histamine dose-response curve: lower histamine concentrations produced a dose-dependent decrease of the twitch response; higher concentrations produced a potentiation."	( Histamine receptors in the myenteric plexus-longitudinal muscle of the guinea-pig ileum: H1- and H2-receptor-mediated potentiation of the contractile response to electrical stimulation. Yellin, TO; Zavecz, JH, 1982)	1.99
" The present work investigates in vitro the inhibitory dose-response curves to histamine, 4-methyl-histamine and 2-pyridylethylamine in depolarized (KCl 37 mM) uterus from estrogenous sensitized rats."	( [Inhibitory action of histamine on the isolated rat uterus]. Esplugues, J; Marti-Bonmati, E; Morales-Olivas, FJ; Morcillo, E; Rubio, E, )	0.67
" Using quantitative cytochemistry of CA activity in guinea-pig oxyntic cells, we compared the dose-response relationships (1."	( Evidence for histamine H1 and H2 receptors in guinea-pig oxyntic cells. Heldsinger, AA; Skoglund, ML; Vinik, AI, 1983)	0.64
" Cumulative dose-response effects of ovalbumin were obtained on paired parenchymal strips, one used as control and the other drug treated."	( Pharmacological alteration of antigen-induced contraction of lung parenchymal strips isolated from the actively sensitized guinea pig. Buckner, CK; Busse, WW; Songsiridej, V, 1983)	0.27
"The effect of astemizole on the weal and flare response to intradermal histamine has been studied in normal volunteers after single dosing, and in patients with urticaria and pruritus after chronic dosing with the drug."	( The effects of astemizole on histamine-induced weal and flare. Bateman, DN; Chapman, PH; Rawlins, MD, 1983)	0.79
" However, the pressor effect of adrenaline and noradrenaline (NA) were significantly reduced in dogs, and the dose-response curves to NA in aortic strips and to the alpha-agonist, phenylephrine in rats was shifted to the right in a parallel manner by quinidine."	( Vascular alpha-adrenergic blocking properties of quinidine. Caldwell, RW; Elam, JT; Mecca, TE; Nash, CB, 1983)	0.27
"In the rabbit isolated aorta and renal artery, aaptamine (3 X 10(-5)M), a novel heteroaromatic substance isolated from a sea sponge Aaptos aaptos produced a parallel, rightward shift of the dose-response curve for noradrenaline, whereas that for histamine or KCl was not affected."	( Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle. Kajiwara, A; Kobayashi, J; Nakamura, H; Ohizumi, Y, 1984)	0.45
" A monoexponential dose-response relationship was found between the specific diamine oxidase inhibitor aminoguanidine and reduced survival time."	( Intestinal diamine oxidase and histamine release in rabbit mesenteric ischemia. Hesterberg, R; Hinterlang, E; Kusche, J; Lorenz, W; Ohmann, C; Richter, H; Schmal, A; Stahlknecht, CD; Weber, D, 1981)	0.55
" Within a limited dose range, linear/log dose-response curves can be obtained after application of histamine or bradykinin."	( Use of 125I-labeled human serum albumin for quantitation of microvascular permeability in rat skin: reevaluation of an old method for studies on substances with an enhancing effect on microvascular permeability. Gerdin, B, 1981)	0.48
" The S-shaped dose-response relationship with D2O was shifted to the left in the patients with BR to exercise compared to patients without (P less than 0 X 025)."	( Release of histamine from leucocytes and its determinants in vitro in relation to bronchial responsiveness to inhaled histamine and exercise in vivo. Degenhart, HJ; Kerrebijn, KF; Neijens, HJ; Raatgeep, HC, 1982)	0.65
" Both substance P and histamine produced sigmoid dose-response curves for the following parameters: 1 min and 5 min planimetrically measured areas of erythema, and mean diameter of weal."	( Vascular responses of human skin to injection of substance P and mechanism of action. Coutts, AA; Eady, RA; Greaves, MW; Jorizzo, JL, 1983)	0.58
"Sprague-Dawley male albino rats showed in a dose-response study a maximal drinking response to a 5 U/kg dose of SC insulin in a 2-hr test."	( Histaminergic mechanism for drinking elicited by insulin in the rat. Hecht, ES; Kraly, FS; Miller, LA, 1983)	1.71
" Atropine (100 microM) produced a rightward shift of the dose-response curve, indicating the presence of a muscarinic receptor."	( Regulation of pepsinogen release from canine chief cells in primary monolayer culture. Amirian, DA; Ayalon, A; Sanders, MJ; Soll, AH, 1983)	0.27
" Substance P was shown to produce rapid, small contractions of trhe lung strip at doses from 10(-9) to 10(-5) M, and there was no apparent dose-response relationship."	( The effect of substance P and related peptides on the guinea-pig lung strip. Foreman, JC; Webber, SE, 1984)	0.27
" The H1-antagonist chlorpheniramine shifted to the right the dose-response curves to histamine and to 2-aminoethylthiazole with the kinetics of the competitive antagonism."	( Histamine receptors in the human ureter. Bertaccini, G; Bezzi, E; Potenzoni, D; Zappia, L, 1983)	1.93
"In order to determine the shape of the dose-response curves of the human airways to bronchial challenge, changes in forced expiratory volume in one second (FEV1) after inhaled histamine were measured in 8 current asthmatic, 2 mildly asthmatic, and 10 normal subjects."	( The shape of the dose-response curve to histamine in asthmatic and normal subjects. Salome, CM; Woolcock, AJ; Yan, K, 1984)	0.73
" The dose-response curves of inhibition of mitogen-induced lymphocyte activation for chloroquine and methylamine are very steep and are similar to the dose-response curves obtained with dimaprit and nordimaprit, but very different from the flat dose-response curves previously described for histamine."	( A comparison of dimaprit, nordimaprit, methylamine and chloroquine as inhibitors of mitogen-induced lymphocyte activation. Dale, MM; Ladd, R, 1984)	0.44
" All parameters were examined for agonist and antagonist potency using dose-response curves, ED50 and pA2 values."	( Histamine responsiveness of isolated gastric glands. Berglindh, T; Chew, CS; Hersey, SJ; Sachs, G, 1980)	1.7
" The dose-response curve was monophasic for both peptides, the production of cyclic AMP being sensitive to 10(-10) M secretin and to 5 ."	( Evidence for a cyclic AMP system highly sensitive to secretin in gastric glands isolated from the rat fundus and antrum. Bataille, D; Dupont, C; Gespach, C; Jaeger, E; Rosselin, G; Wünsch, E, 1980)	0.26
" Dose-response studies were performed for individual agonists and then with agonists administered together for the same animal."	( Cholinergic and alpha adrenergic augmentation of histamine-induced contraction of canine airway smooth muscle. Leff, AR; Munoz, NM, 1981)	0.52
"To investigate the mechanism of intracellular transmission of three representative stimuli for gastric acid secretion, the dose-response relations of cyclic nucleotides accompanied by acid secretion stimulated by histamine, pentagastrin and bethanechol were comparatively studied using an in vitro preparation of guinea pig gastric mucosa surviving with a constant potential difference and acid secretion sensitive to amytal."	( Cyclic nucleotide response to acid-secreting stimuli in guinea pig gastric mucosa in vitro. Matsumoto, H; Miyoshi, A; Ohe, K; Shirakawa, T, 1981)	0.45
" Complete dose-response curves of H+ secretion as a function of K+ concentration could now be obtained."	( Cation effects on acid secretion in rabbit gastric glands. Berglindh, T; Koelz, HR; Sachs, G, 1981)	0.26
" The dose-response curve of the adenylate cyclase activity was not shifted to the left."	( Adenylate cyclase activity in gastric mucosal biopsies and cAMP in gastric juice before and after cimetidine treatment in healthy subjects. Aadland, E; Berstad, A; Ruoff, HJ; Torjesen, P, 1981)	0.26
" Dose-response curves were constructed for the 6 most active compounds and characterized in terms of the IC50, the slope and the maximum response attainable relative to that of histamine."	( Histamine H1-agonist potentiation of adenosine-stimulated cyclic AMP accumulation in slices of guinea-pig cerebral cortex: comparison of response and binding parameters. Daum, PR; Hill, SJ; Young, JM, 1982)	1.9
" dosing of SCH 28080, 1 mg/kg, indicating that the antisecretory action of SCH 28080 was not secondary to changes in gastric blood flow."	( Studies on the mechanisms of the antisecretory and cytoprotective actions of SCH 28080. Barnett, A; Casciano, C; Chiu, PJ; Long, JF; Tetzloff, G, 1983)	0.27
"The dose-response curve of histamine-induced cyclic AMP elevation in monolayer cultures of primary foetal-bovine articular chondrocytes was displaced to the right by cimetidine."	( Histamine H2 receptors on foetal-bovine articular chondrocytes. Taylor, DJ; Woolley, DE; Yoffe, JR, 1983)	2.01
" Very low concentrations of atropine shifted the carbachol dose-response curve to the right and allowed inhibition constants for the antagonist to be easily calculated."	( Inositol phospholipid hydrolysis in rat cerebral cortical slices: I. Receptor characterisation. Brown, E; Kendall, DA; Nahorski, SR, 1984)	0.27
" The position of the dose-response curve for histamine in cerebral cortical slices was similar to that of the curve for the receptor binding of histamine deduced from histamine inhibition of [3H]mepyramine binding."	( Histamine stimulation of inositol 1-phosphate accumulation in lithium-treated slices from regions of guinea pig brain. Daum, PR; Downes, CP; Young, JM, 1984)	1.97
" In 8 asthmatic subjects, dose-response curves were determined to isocapnic hyperventilation of cold air 30 min after inhalation of chlorpheniramine maleate (18 mg nebulized during tidal breathing), 2 doses of atropine sulphate (3 mg and 18 mg nebulized), or placebo."	( The protective effect of inhaled chlorpheniramine and atropine on bronchoconstriction stimulated by airway cooling. Daniel, EE; Hargreave, FE; Morris, M; O'Byrne, PM; Roberts, RS; Thomson, NC, 1983)	0.27
" Aerosols were generated by Wright's nebulizer and dose-response curves to histamine and methacholine constructed following preadministration of saline, prostaglandin F2 alpha or citric acid."	( The influence of pretreatment with prostaglandin F2 alpha on bronchial sensitivity to inhaled histamine and methacholine in normal subjects. Costello, JF; Dunlop, LS; Heaton, RW; Henderson, AF, 1984)	0.72
" The ability of commercial porcine heparin glycosaminoglycan as well as native rat heparin proteoglycan to inhibit lectin-induced blastogenesis in a dose-response fashion confirmed the previous data with the use of fractionated DWG."	( Analysis of the effect of mast cell granules on lymphocyte blastogenesis in the absence and presence of mitogens: identification of heparin as a granule-associated suppressor factor. Frieri, M; Metcalfe, DD, 1983)	0.27
" In light of the relative ineffectiveness of the above calcium antagonists on the LTD4 dose-response curves, it is suggested that airways contraction is dependent on mobilization of intracellular calcium and that the action of nitrendipine and verapamil as inhibitors of antigen- and A23187-induced contractions is at the point of blocking mediator (i."	( Effects of calcium channel blockers and a calmodulin antagonist on contractions of guinea pig airways. Burka, JF, 1984)	0.27
" DSCG attenuated the acetylcholine-induced contractile responses and shifted the dose-response curve of acetylcholine downward."	( Effect of disodium cromoglycate on the action of bronchoactive agents in guinea-pig tracheal strips. Ishihara, Y; Kitamura, S; Takaku, F, 1984)	0.27
" To better histamine stimulation of pepsin, histamine was used at doses at the lower end of the dose-response scale in five dogs with gastric fistula."	( Histamine H-2 receptor stimulation and inhibition of pepsin secretion in the dog. Hirschowitz, BI; Molina, E; Rentz, J, 1981)	2.1
" The dose-response curves for respective components of the salivary and vasodilator responses to PEA were parallel with the corresponding curves for histamine and in producing these responses PEA was about 40 times less potent than histamine on a molar basis."	( Characterization of neuronal and vascular histamine receptors mediating the salivary and vasodilator responses to histamine of the dog submandibular gland. Nunoki, K; Shimizu, T; Taira, N, 1981)	0.73
" If the mice were dosed daily (i."	( Effect of histamine agonists and antagonists on the production of murine reaginic antibodies. Baker, AP; Chakrin, LW; Holden, DA; Smith, WJ; Sung, CP, 1981)	0.67
"The mechanism of an inhibitory effect of histamine on the sensitivity of frog skeletal muscle endplate was analyzed by studying the dose-response relation between the quantity of ACh applied iontophoretically and the ACh-induced postsynaptic current (ACh current), and also the interaction between histamine and erabutoxin-b (ETX-b)."	( Histamine as an endogenous antagonist of nicotinic ACh-receptor. Ariyoshi, M; Koketsu, K; Ohta, Y, 1984)	1.98
"To determine (1) whether changes in plasma histamine occurred during provoked bronchospasm and (2) if so, whether such changes could be related to variations in plasma catecholamines, venous plasma histamine and catecholamines were measured during a dose-response carbachol challenge in eight healthy volunteers."	( Plasma histamine and catecholamines during carbachol-induced bronchoconstriction in normal subjects. Harf, A; Lhoste, F; Macquin, I; Sabatier, C; Zerah, F, 1984)	0.99
"Inhalation histamine dose-response curves were constructed 15 minutes after inhalation of saline placebo or verapamil (4 mg) for eight patients with mild atopic asthma in a double blind, random manner."	( Effects of calcium channel blockade on histamine induced bronchoconstriction in mild asthma. Banks, J; Davies, BH; Fennerty, A; Walters, EH, 1984)	0.93
" With increase of the concentration of a synthetic LPC for pretreatment of the ileum, the slope of the dose-response curve of histamine or acetylcholine added cumulatively became more gentle, the maximal contraction was suppressed apparently, and which were associated with the shift of the curve to the higher concentration of the stimulants."	( Comparison of antispasmodic effect of synthetic lysolecithins with various fatty acid moieties on guinea pig ileum. Hayakawa, T; Nakanishi, K; Takauchi, K; Tokumura, A; Tsukatani, H; Yamada, S; Yoshida, J, 1984)	0.47
" Simultaneous application of Hi and 10 micrograms of diphenhydramine, pyrilamine or promethazine, apparently causing no analgesic effect from a single administration, caused a parallel shift of the dose-response curve of Hi to the right."	( Analgesic effect of histamine induced by intracerebral injection into mice. Chung, YH; Kamei, C; Miyake, H; Tasaka, K, 1984)	0.59
" These data indicate that the intraarterial infusion of Venoruton at this dosage does not inhibit the ability of simultaneously infused histamine or bradykinin to increase transvascular fluid and macromolecular efflux in the canine forelimb perfused at constant arterial inflow."	( O-(beta-hydroxyethyl)-rutoside (Venoruton) fails to block histamine or bradykinin-induced edema formation in the canine forelimb perfused at constant arterial inflow. Dabney, JM; Dobbins, DE; Soika, CY, 1984)	0.71
" In dose-response studies in normal subjects, prostaglandin D2 caused a significant (20 +/- 6 per cent) fall in specific airway conductance after the two highest concentrations (250 and 500 micrograms per milliliter), whereas prostaglandin F2 alpha had no effect."	( The bronchoconstrictor effect of inhaled prostaglandin D2 in normal and asthmatic men. Hardy, CC; Holgate, ST; Robinson, C; Tattersfield, AE, 1984)	0.27
" Cumulative dose-response curves for H, in strips isolated from proestrous rats, showed that the agonist inhibited, at all the concentrations tested, spontaneous myometrial contractions, evoking a maximum effect (100% inhibition) at 10(-5)M."	( Prostaglandins and ovarian factors as modulators of the negative inotropic action of histamine in the isolated rat uterus. Dveksler, G; Franchi, AM; Gimeno, AL; Gimeno, MF; Viggiano, M, 1984)	0.49
" Dose-response curves were analysed for (1) provocative concentration (PC) of histamine causing a 20% fall in FEV1 and a 40% change in the other measurements; (2) threshold concentration (TC)--the concentration at which changes in the measurement exceed 2 SD from control values; (3) reactivity (R)--the slope of the dose-response curve beyond TC."	( Histamine dose-response curves in asthma: reproducibility and sensitivity of different indices to assess response. Dehaut, P; Malo, JL; Martin, RR; Rachiele, A, 1983)	1.94
"Two methods of interpreting histamine inhalation dose-response curves were compared in 27 normal and 41 asthmatic subjects."	( Measurement of responsiveness to inhaled histamine using FEV1: comparison of PC20 and threshold. Berscheid, BA; Cockcroft, DW; Murdock, KY, 1983)	0.83
" To assess responsiveness we anesthetized the dogs and obtained dose-response curves of increasing concentrations of acetylcholine or histamine aerosols delivered to the airways vs."	( Time course of airway hyperresponsiveness induced by ozone in dogs. Aizawa, H; Fabbri, LM; Holtzman, MJ; Nadel, JA; O'Byrne, PM; Skoogh, BE; Walters, EH, 1983)	0.47
"25-20 mg/kg) in a dose-response study."	( A probe for a histaminergic component of drinking in the rat. Kraly, FS, 1983)	0.63
" Thus a bell-shaped dose-response curve resulted for the inhibition of isoprenaline by Mn2+."	( Antagonism by manganese of isoprenaline dilatation of the guinea-pig isolated trachea. Jamieson, DD; le Coutier, A; Quinn, RJ, )	0.13
" The H1-histamine antagonists, (+)-chloropheniramine and diphenhydramine, caused a parallel shift to the right of the splenic extract dose-response curve without suppression of the maximum response."	( H1-histamine receptors may mediate the contractile response of guinea-pig ileum to 'histamine-free' splenic extracts. Ainz, LF; Casis, E; de Gandarias, JM; Gil-Rodrigo, CE; Goiriena de Gandarias, JJ, 1983)	1.32
"The present study investigated the effects of repetitive exposure to a select group of biogenic amines (epinephrine, norepinephrine, histamine, and serotonin) on pulmonary vascular reactivity by constructing and analyzing a set of four sequential cumulative dose-response curves to one biogenic amine in the isolated blood-perfused left lower lobe of the cat lung in vivo."	( Pulmonary vascular reactivity after repetitive exposure to selected biogenic amines. Cutaia, M; Porcelli, RJ, 1983)	0.47
" The slopes of the individual dose-response curves were not significantly different which suggested a common mechanism of action."	( Central and peripheral anti-inflammatory actions by clonidine and a structurally related imidazoline analog. Holsapple, MP; Lowy, MT; Malave, A; Yim, GK, 1984)	0.27
"To examine for a relationship between in vivo nonspecific bronchial reactivity to histamine and in vitro smooth muscle response to histamine, we performed inhalation dose-response curves prior to lung surgery in 12 patients and compared this with their bronchial smooth muscle response in vitro."	( A comparison of in vivo and in vitro human airway reactivity to histamine. Armour, CL; Chan, N; Hogg, JC; Lazar, NM; Paré, PD; Schellenberg, RR; Taylor, SM, 1984)	0.73
" In aortic ring segments, precontracted by norepinephrine, three types of dose-response curves were found: relaxation (rat), contraction (guinea-pig, cat, mouse) and relaxation followed by contraction at higher doses (rabbit)."	( Effect of histamine on aorta preparations of different species. Leusen, I; Van de Voorde, J, 1984)	0.67
" Similar effects were observed on guinea-pig "in vitro" stomach preparation where PM2 and Papaverine were ineffective in modifying Histamine dose-response curves and PM3 reduced significantly maximal peak effects of Histamine, behaving as a non-competitive antagonist."	( [Pharmacological actions of alkylaminoalkyl-phenylbenzisothazole compounds on the gastrointestinal tract]. Barocelli, E; Bordi, F; Chiavarini, M; Impicciatore, M; Morini, G; Plazzi, P, 1984)	0.47
"Dose-response studies in vitro and in vivo revealed four types of alterations of dose-response curves along with changes in the baseline, two of them in accordance and two in disagreement with Wilder's law of initial value (LIV)."	( The underlying bases of pharmacological results in agreement or disagreement with the law of initial value. Brunner, F; Pöch, G, 1984)	0.27
" It was predominantly sensitivity to these agents that was increased, with a parallel shift of the dose-response curves towards increased bronchoconstriction."	( Time-dependent effect of prostaglandin E2 inhalation on airway responses to bronchoconstrictor agents in normal subjects. Bevan, C; Davies, BH; Parrish, RW; Smith, AP; Walters, EH, 1982)	0.26
" readiness for asthma in general (the crucial dosage of histamine able to induce asthma increases)."	( Pharmacology of disodium cromoglycate. Altounyan, RE, 1980)	0.51
"The present work investigates (a) the modification by pretreatment with selective H1- and H2-receptor antagonists on the dose-response curves (DRC) to histamine for heart rate, blood pressure, renal arterial blood flow and renal vascular resistance in anesthetized dogs, and (b) the characteristics of the DRC to histamine in canine isolated renal artery."	( Histamine H1- and H2-receptors in canine renal artery in vivo and in vitro. Bedate, H; Esplugues, J; Moragues, A; Morcillo, E, 1981)	1.9
" Repetitive cumulative dose-response curves demonstrated a progressive decline in the response of the pulmonary circulation to histamine."	( Role of histamine in regulating pulmonary vascular tone and reactivity. Bergofsky, EH; Mahoney, WA; Porcelli, RJ; Ventura, DF, 1981)	0.9
" In normal calcium Krebs solution, dose-response curves to histamine were markedly reduced by verapamil while acetylcholine responses were relatively unaffected."	( The effect of prostaglandin E2 on histamine-stimulated calcium mobilization as a possible explanation for histamine tachyphylaxis in canine tracheal smooth muscle. Anderson, WH; Krzanowski, JJ; Polson, JB; Szentivanyi, A, 1983)	0.79
" Cumulative dose-response curves point to a non-competitive antagonism."	( Spasmolytic activity of the flavonoids from Thymus vulgaris. Lemli, JA; Van Den Broucke, CO, 1983)	0.27
"The value of determining the slope of the histamine dose-response curve, in addition to the histamine provocation concentration producing a 20% reduction in FEV1 (PC20-FEV1), was assessed by analysis of histamine dose-response curves in 40 patients selected as having a wide range of increased non-specific bronchial responsiveness to inhaled histamine."	( Slope of the dose-response curve: usefulness in assessing bronchial responses to inhaled histamine. Berscheid, BA; Cockcroft, DW, 1983)	0.75
" On each occasion a regression line for the descending part of the log-cumulative dose-response curve was computed."	( Prostaglandins and the control of airways responses to histamine in normal and asthmatic subjects. Walters, EH, 1983)	0.51
"5-10 mM, sodium ascorbate shifted the dose-response curve for DMPP to the left and enhanced the maximum contraction."	( Effect of ascorbate on the contractile response induced by DMPP in guinea-pig ileal longitudinal muscle strip. Hayashi, E; Maeda, T; Shinozuka, K; Takeda, M, 1983)	0.27
" Under nonlethal conditions of dosage and exposure time, all compounds blocked carbachol-induced paralysis, indicating a possible action at schistosome cholinergic sites."	( Schistosoma mansoni: species-selective response to N-chloroethyl-acetylcholine derivatives. Ahmed, AE; Hillman, GR; Willcockson, WS, 1983)	0.27
"1 mg/kg iv) was given after the second aerosol histamine challenge, and a third dose-response curve was performed."	( Effect of endotoxin on airway responsiveness to aerosol histamine in sheep. Brigham, KL; Hinson, JM; Hutchison, AA; Snapper, JR, 1983)	0.77
" Dose-response curves were determined for acid output and mucosal blood flow, which was measured with the Neutral Red technique."	( Difference in kinetics between the distal and proximal parts of the canine parietal cell mass in response to histamine. Larsson, JO, 1983)	0.48
"We studied the effects of atropine (10(-10) to 10(-6) M), tetrodotoxin (TTX) (10(-6) g/ml), and neostigmine (10(-7) M) on the histamine dose-response curve of canine tracheal smooth muscle (TSM) in vitro."	( Mechanisms of histamine-induced contraction of canine airway smooth muscle. Irvin, CG; Martin, JG; Shenkier, T; Shore, S, 1983)	0.83
" They conclude that, as already suggested for others kinds of neoplasms of the lung and gastroenteric tract, also in the neoplastic pathology of the breast, the haematic hystamine dosage is a useful parameter for the monitoring the course of the illness."	( [Hyperhistaminemia in neoplasms of the breast]. Faverio, F; Guzzetti, A; Jemoli, R; Mereghetti, A, 1982)	0.75
" It is necessary to collect sufficient background factors and to use proper dose-response studies."	( Clinical implications of bronchial hyperreactivity. Simonsson, BG, 1980)	0.26
" Inhalation dose-response curves to histamine diphosphate were constructed on two separate occasions using the same standardised technique."	( Induction of bronchial hypersensitivity: evidence for a role for prostaglandins. Bevan, C; Parrish, RW; Smith, AP; Walters, EH, 1981)	0.54
" Bronchoconstriction was produced by close intraarterial injection of histamine, acetylcholine, serotonin, or PGF2 alpha at a dosage of 10 microgram each."	( [Role of vagus nerves in bronchoconstriction induced by chemical mediators]. Goto, K; Hayakawa, H; Hosokawa, T; Kitagawa, H; Kobayashi, N; Misawa, M; Yanaura, S, 1982)	0.5
" The dose-response curve for rats with gastric vagotomy was shifted to the right."	( Histamine-elicited drinking is dependent upon gastric vagal afferents and peripheral angiotensin II in the rat. Kraly, FS; Miller, LA, 1982)	1.71
" In the rabbit ear artery, denervation resulted in a significant leftward shift of dose-response curves for norepinephrine (8."	( Effect of superior cervical ganglionectomy on the sensitivity of rabbit ear artery and cerebral arteries of rabbit and cat to vasoactive agents. Araki, H; Lee, TJ; Su, C, 1982)	0.26
" We have compared 13 volunteer controls and 16 paranoid schizophrenics; each subject was injected intradermally with histamine, 10, 20, and 50 microgram, doses predetermined in volunteers to give a dose-response curve."	( The histamine-induced skin reaction in schizophrenic and normal subjects. Kazimierczak, W; Maslinski, C; Pilc, A; Schayer, RW; Zaborwski, A, 1982)	1.03
" When isolated longitudinal muscle strips from this preparation were tested with E-2-P before and after blockade with 2-haloalkylamines, it was found that these agents produced an irreversible shift to the right in the dose-response curve without significant depression of the maximum response even at very high antagonist concentrations."	( Irreversible blockade of responses to a partial agonist acting at the histamine H1-receptor. Cook, D; Iwanow, D; Kenakin, T; Krueger, C, 1982)	0.5
" The dose-response curve of egg albumin on the trachea was shifted to the right."	( Decreased Schultz-Dale reaction in airways from sensitized guinea pigs treated with threshold concentrations of egg albumin in vivo. Andersson, RG; Hedman, SE, 1982)	0.26
" However, neither gastric nor duodenal ulcer was observed within 2 months with the dosage of 10 mg/day."	( Significance of sustained gastric hypersecretion by the emulsified histamine solution. Sekine, T; Woodward, ER, 1982)	0.5
" In the first group, dose-response relationships of inhaled histamine and the provocation dose defined as the threshold (PD) were calculated by various methods, using different techniques of analysis of the dose-response relationship."	( Bronchial responsiveness as a function of inhaled histamine and the methods of measurement. Degenhart, HJ; Hofkamp, M; Kerrebijn, KF; Neijens, HJ, )	0.63
" An additional study was conducted in which six subjects took 0 (placebo), 1, 2, and 4 gm/day of AA to determine the dose-response effect of AA on histamine skin tests."	( The effect of ascorbic acid on cutaneous and nasal response to histamine and allergen. Danziger, RE; Fortner, BR; Nelson, HS; Rabinowitz, PS, 1982)	0.7
"The dose-response relationship of histamine (Hi) and N tau-methylhistamine (MeHi) was analysed in isolated ileum and the right auricle of the guinea pig, in isolated mouse stomach and in the blood flow through the submandibular gland of the cat."	( Analysis of the dose-response relationship of histamine and N tau-methylhistamine. Erjavec, F; Stanovnik, L, 1982)	0.8
" Phentolamine competitively antagonized ADR and PE-induced contractile responses of arteries while on veins, ISOP and PE dose-response curves (DRCs) were shifted to the right in the presence of propranolol."	( Autonomic and autacoid activity in antigen-sensitized and control ovine pulmonary vein and artery. Eyre, P; Mirbahar, KB, 1982)	0.26
" The development of resistance was assessed from salbutamol dose-response studies in which the airway response was measured as specific airway conductance (sGaw)."	( Airway response to salbutamol: effect of regular salbutamol inhalations in normal, atopic, and asthmatic subjects. Harvey, JE; Tattersfield, AE, 1982)	0.26
" In vitro, both pulmonary arterial and venous strips showed a contractile dose-response to histamine, which was blocked by the H1-antagonist pyrilamine (mepyramine)."	( Characterization of H1- and H2-receptor function in pulmonary and systemic circulations of sheep. Ahmed, T; Eyre, P; Mirbahar, KB; Oliver, W; Wanner, A, 1982)	0.48
" After cholinergic blockade with atropine, dose-response curves to intra-arterial (ia) histamine (10(-10)-10(-6) mol) were performed in 11 adrenal-intact (ADi) and 5 adrenalectomized (ADx) dogs receiving steady-state sympathetic stimulation from continuous intravenous infusion (62."	( Sympathetic inhibition of histamine-induced contraction of canine trachealis in vivo. Hendrix, SG; Leff, AR; Munoz, NM, 1982)	0.79
" We constructed cumulative log dose-response curves and determined the steepest slope and the provocative dose of histamine (PD35) needed to cause a 35% fall in specific airway conductance (SGaw)."	( Histamine dose-response relationships in normal and asthmatic subjects. The importance of starting airway caliber. Chung, KF; Keyes, SJ; Morgan, B; Snashall, PD, 1982)	1.92
" Histamine doses causing a decrease in Cdyn of 50% and 75% and an increase in RL of 300% and 600% (ED50Cdyn, ED75Cdyn, ED300RL and ED600RL, respectively) were interpolated from the histamine dose-response curves."	( Pulmonary effects of intravenous histamine in the conscious pony: dose-response relationships and reproducibility. Derksen, FJ; Robinson, NE; Slocombe, RF, 1982)	1.46
" The results suggest that cumulative dose-response curves for drugs potentially affecting the airways or antagonizing histamine can be constructed within 1 day using histamine inhalation tests."	( Repeated histamine inhalation tests in asthmatic patients. Alpers, JH; Crockett, AJ; Hamilton, R; Ruffin, RE, 1981)	0.89
" SK & F 91581 (10(-4) M) had no effect upon these responses and amodiaquine (10(-5) M) depressed the maxima of the rate response dose-response curves."	( Uptake and metabolism of histamine in guinea-pig isolated atria and their relationship to the pharmacological responses. Broadley, KJ; Owen, DA; Smith, IR; Wilson, C, 1980)	0.56
" The dose-response relationship for histamine was measured in all subjects, using inhalations of progressively more concentrated histamine solutions."	( Airway reactivity in cotton bract-induced bronchospasm. Bouhuys, A; Brown, S; Buck, M; Kolack, B; Schachter, EN; Zuskin, E, 1981)	0.54
" A dose-response study for histamine stimulation is presented."	( Vagally innervated and denervated gastric pouch in one and the same dog--a new model. Guldvog, I, 1980)	0.56
" Heparin Na attenuated histamine-, prostaglandin F2 alpha-, acetylcholine-, serotonin-induced contractile responses dose-dependently, and shifted the dose-response curves of histamine, prostaglandin F2 alpha, acetylcholine, serotonin and bradykinin downward."	( Effect of heparin Na on the action of various bronchoconstrictors in guinea pig tracheal strips. Ishihara, Y; Kitamura, S, 1981)	0.57
" The efflux of paraquat from lung slices prepared from rats dosed intravenously with paraquat was biphasic, having a very fast component and a slow component."	( Factors affecting the efflux of paraquat from rat lung slices. Rose, MS; Smith, LL; Wyatt, I, 1981)	0.26
" Pulmonary resistance (RL) was measured, and dose-response curves were constructed in the four conditions."	( Direct and reflex bronchoconstriction induced by histamine aerosol inhalation in dogs. Drazen, JM; Ingram, RH; Loring, SH; Yanta, MA, 1981)	0.52
"Pulmonary artery and vein from an ovalbumin sensitized canine model of allergic asthma showed hypersensitivity (leftward shift of dose-response curve) and hyper-reactivity (upward shift) to histamine when compared to those from a littermate control in vitro."	( Pharmacological studies of sensitized canine pulmonary blood vessels. Kong, SK; Stephens, NL, 1981)	0.45
" The presence of specific H1 histamine receptors was further supported by shifts in the dose-response curve to histamine by four different concentrations of diphenhydramine."	( Mechanisms of histamine stimulated secretion in rabbit ileal mucosa. Higgs, NB; Linaker, BD; McKay, JS; Turnberg, LA, 1981)	0.91
" Attempts to define dose-response relationships and effects on sensitive subject populations are described."	( Effects of ozone exposure on lung function in man: a review. Folinsbee, LJ, 1981)	0.26
"The aim of the present study was to determine if the measurement of the slope of teh histamine dose-response curve (bronchial reactivity) could provide useful information on the clinical state of asthma."	( Histamine dose-response curves in asthma: relevance of the distinction between PC20 and reactivity in characterising clinical state. Beaupré, A; Malo, JL, 1981)	1.93
" These findings differ from earlier reports that for maximal gastric secretion Asians required a higher dosage of histamine compared with Caucasian subjects."	( Histamine dosage for maximal gastric secretion in Asians - a reappraisal. Ti, TK, 1981)	1.92
" Cimetidine caused parallel displacement of the dose-response curve to histamine, but failed to alter the response to carbachol or gastrin."	( Secretagogue stimulation of [14C]aminopyrine accumulation by isolated canine parietal cells. Soll, AH, 1980)	0.49
" A limit to the shift of cumulative dose-response curves for the inotropic response suggested an H1 receptor resistant component."	( A positive inotropic response of guinea pig isolated atria to histamine not mediated via H1 or H2 receptors. Broadley, KJ; Wilson, C, 1980)	0.5
" Linear transformation of the dose-response curve indicated mixed inhibition."	( Importance of the kidneys for gastrin elimination and gastric function. El Munshid, HA; Håkanson, R; Liedberg, G; Rehfeld, JF; Sundler, F, 1980)	0.26
"125 mg/kg histamine were the optimum time interval and dose, respectively, as determined by appropriate time-response and dose-response studies."	( Effect of ozone on respiratory response of guinea pigs to histamine. Amdur, MO; Gordon, T, 1980)	0.91
" (5) The left artial tension dose-response curves to histamine were not potentiated."	( The effect of phosphodiesterase inhibitors on guinea-pig cardiac responses to histamine and isoprenaline. Broadley, KJ; Wilson, C, 1980)	0.74
" Dose-response curves were constructed and analysed in the presence of H1- and H2-antagonists."	( The effect of histamine and histamine antagonists on gastric acid secretion and mucosal blood flow in man. Knight, SE; McIsaac, RL; Rennie, CD, 1980)	0.62
" This postulate was confirmed by observed activity changes in released beta-glucuronidase in mucosal tissue, as well as by dose-response in vitro data on isolated hepatic lysosomes exposed to zinc."	( Studies of zinc and histamine on lysosomal fragility: possible role in stress ulceration. Cheema, A; Cho, CH; Pfeiffer, CJ, 1980)	0.58
" To establish an optimal dosage schedule, 15 healthy male volunteers entered a two-phased study to determine (1) the single dose of prednisone required to produce maximal suppression of histamine and basophil levels and (2) the effects of repeated prednisone doses."	( Dose-response studies of the suppression of whole blood histamine and basophil counts by prednisone. Kay, DR; Mathews, KP; Muilenberg, ML; Pan, PM; Saavedra-Delgado, AM, 1980)	0.7
" Dose-response curves were drawn on a scale which made the dosage equivalent in molecular weight."	( Comparison of bronchial reactivity to histamine and methacholine in asthmatics. Salome, CM; Schoeffel, RE; Woolcock, AJ, 1980)	0.53
" Cumulative dose-response contraction curves were constructed."	( A dual action of histamine on isolated human pulmonary arteries. Boe, J; Boe, MA; Simonsson, BG, 1980)	0.6
" At a dosage of 100 mg/kg (+/-)-alpha-FMH did not alter histamine-N-methyltransferase, DOPA decarboxylase, and glutamate decarboxylase activities."	( Inhibition of histamine synthesis in brain by alpha-fluoromethylhistidine, a new irreversible inhibitor: in vitro and in vivo studies. Barbin, G; Garbarg, M; Rodergas, E; Schwartz, JC, 1980)	0.87
" Individual histamine dose-response curves were shifted to the right by increasing ranitidine and cimetidine concentrations (0."	( Secretagogue-induced [14C]aminopyrine uptake in isolated equine parietal cells. Campbell-Thompson, M, 1994)	0.67
" Dexamethasone (Dex) never suppressed histamine paw edema of mice before 1 hr after its dosing as new protein(s) synthesis is required."	( Nitric oxide- and hydrogen peroxide-mediated gene expression by glucocorticoids and FK506 in histamine paw edema of mice. Oyanagui, Y, 1994)	0.78
"The effect of theophylline (a non-selective phosphodiesterase (PDE) inhibitor), dosed intratracheally (it) as a dry powder, on histamine- and platelet activating factor (Paf)-induced bronchospasm and antigen (ovalbumin, OA)-, histamine- and Paf-induced microvascular leakage (MVL) in the airways, was studied in the anaesthetized guinea-pig."	( Effect of theophylline administered intratracheally as a dry powder formulation on bronchospasm and airway microvascular leakage in the anesthetized guinea-pig. Raeburn, D; Woodman, VR, 1994)	0.49
" Baseline respiratory values and dose-response slope of the subsample were also not significantly different."	( Chronic respiratory symptoms, bronchial responsiveness and dietary sodium and potassium: a population-based study. Basso, O; Bruschi, C; Casali, L; Cerveri, I; De Marco, R; Fanfulla, F; Zoia, MC, 1995)	0.29
" A histamine challenge test was done 12 h after the last dose of each treatment period, and dose-response curves to inhaled salbutamol (200-3200 micrograms) were constructed 36 h after the last dose."	( Bronchodilator subsensitivity to salbutamol after twice daily salmeterol in asthmatic patients. Grove, A; Lipworth, BJ, 1995)	0.91
"Full dose-response curves to histamine were constructed in 16 healthy volunteers (mean age, 47 +/- 20 years; age range, 21 to 80 years) by infusing histamine (2 to 136 ng/min) into dorsal hand veins preconstricted with the alpha-adrenergic selective agonist phenylephrine."	( H1- and H2-histamine receptor-mediated vasodilation varies with aging in humans. Bedarida, G; Blaschke, TF; Bushell, E; Hoffman, BB, 1995)	0.97
" Dose-response curves to histamine were repeated after infusion of the H2-selective antagonist cimetidine at a dose sufficient to completely block the H2-mediated response (49 micrograms/min)."	( H1- and H2-histamine receptor-mediated vasodilation varies with aging in humans. Bedarida, G; Blaschke, TF; Bushell, E; Hoffman, BB, 1995)	0.98
"1 microM of histamine (n = 7 each) as 15 min infusions were employed in a dose-response study, and compared to control perfused hearts (n = 7)."	( The effects of exogenous histamine in isolated rat hearts. Skjelbakken, T; Vaage, J; Valen, G, 1995)	0.97
" No differences in ELGV dose-response curves to LTD4 were seen in A23187- and vehicle-exposed animals."	( Inhaled A23187 produces a preferential sensitization to substance P. Bendele, AM; Cockerham, SL; Silbaugh, SA; Stengel, PW, 1993)	0.29
" Histamine responsiveness was analyzed by means of the dose-response slope (DRS)."	( Bronchial responsiveness to inhaled histamine in both adults with intrinsic and extrinsic asthma: the importance of prechallenge forced expiratory volume in 1 second. Ulrik, CS, 1993)	1.47
" However, the dose-response curve for pentagastrin in the presence of ranitidine plus IBMX was similar to that obtained in the absence of IBMX."	( Gastrin action on aminopyrine accumulation in isolated pig parietal cells requires cAMP. Cabero, JL; Li, ZQ; Mårdh, S, 1993)	0.29
" Comparisons of relative potency 30 min post dosing between emedastine and other anti-histamines demonstrated that emedastine is equipotent to ketotifen, and 7, 7, 10, 10, 100, 357, 3333, and 5813 times more potent than brompheniramine, chlorpheniramine, clemastine, pyrilamine, levocabastine, pheniramine, diphenhydramine, and antazoline, respectively."	( Preclinical efficacy of emedastine, a potent, selective histamine H1 antagonist for topical ocular use. Parnell, DW; Spellman, JM; Stephens, DJ; Yanni, JM, 1994)	0.76
" The test consists in the inhalation during 2 minutes, every 5 minutes of a double dosage of drug followed by measurement of MEVS after each step."	( [Nonspecific bronchial provocation with histamine and methacholine]. Gliga, M; Moldovan, D, )	0.4
" In each subject, dose-response curves for the effects on forced expiratory volume in one second (FEV1) of serially doubling doses of inhaled histamine were obtained on three different days, 15 min after pretreatment with either methoxamine (10 mg) or duplicated placebo."	( Effects of pretreatment with inhaled methoxamine on bronchial responses to histamine in asthmatic subjects. Dall'Ava-Santucci, J; Dinh-Xuan, AT; Lockhart, A; Monchi, M; Phan-Puibaraud, TT; Regnard, J, 1995)	0.72
" Since PAF has unusual dose-response characteristics in vitro, this study investigated the effects of different doses or concentrations of PAF given by intravenous and aerosol administration in anesthetized rabbits."	( Bimodal effect of platelet-activating factor (PAF) on airways responsiveness in the rabbit. Henson, PM; Irvin, CG; Nieminen, MM, )	0.13
" However, sorocein A antagonized in a non-competitive manner BK-induced contraction in GPI, characterized by a graded displacement to the right of the dose-response curve, and progressive depression of the maximal contraction."	( Pharmacological analysis of the methanolic extract and sorocein A, a new Diels-Alder compound isolated from the roots of Sorocea bonplandii Bailon in the isolated rat uterus and guinea pig ileum. Bisognin, T; Calixto, JB; Della Monache, F; Ferrari, F; Messana, I; Yunes, RA, 1993)	0.29
" Clemizole and reserpine treatment did not produce any modification of the dose-response curve to histamine."	( Effect of histamine on the longitudinal and circular muscle of the oestrogen dominated rat uterus. Estañ, L; Herrero, J; Martínez-Mir, I; Morales-Olivas, FJ; Rubio, E, 1993)	0.91
" Moreover, the inhibitory effect of YM-14471 was more prolonged than those of famotidine and cimetidine by either route, and it was as long as that of omeprazole dosed orally."	( Antisecretory effects of a novel and long-lasting histamine H2-receptor antagonist, YM-14471, in rats and dogs. Fujihara, A; Kamato, T; Miyata, K; Nishida, A; Takeda, M; Yuki, H, 1993)	0.54
" ml-1 is useful; this low concentration would reduce total dosage and unwanted side effects."	( Dose-response relation of ornipressin with regard to vasoconstriction in human skin. Fruhstorfer, H; Heisler, M, 1994)	0.29
" In the PAG/DR, the HA dose-response curve had an inverted U-shape, showing that HA can induce both antinociceptive (0."	( Histamine-induced modulation of nociceptive responses. Hough, LB; Mischler, SA; Nalwalk, JW; Thoburn, KK, 1994)	1.73
"1 mumol/site) appeared to produce greater shifts of the dose-response curve to BK (0."	( Cutaneous permeability responses to bradykinin and histamine in the guinea-pig: possible differences in their mechanism of action. Douglas, GJ; Khawaja, AM; Lawrence, L; Page, CP; Paul, W; Perez, AC; Schachter, M, 1994)	0.54
" To explain the differing discriminant ability of the six provocation doses (PD20 = PD15 > PD10T = PD40 > PD20C > PD10), this study analyzed the role of % delta/variability, log dose-response curve, airway hysteresis and the test itself in the original group of 20 normal and 20 asthmatic subjects."	( Physiologic factors affecting the discriminant ability of provocation doses to histamine. Popa, V, 1994)	0.52
" In general, we found a dose-response relationship in grouped data, with a greater fall in VO4 with increasing dose of histamine, but there was no correlation between percent fall in VO4 and VmaxFRC."	( Nasal response to inhaled histamine measured by acoustic rhinometry in infants. Kano, S; Pedersen, OF; Sly, PD, 1994)	0.8
" However, the dosage of SEPS capable of inducing HDC and ODC was much higher (100 to 1,000 times) than that of LPS."	( Stimulation of the synthesis of histamine and putrescine in mice by a peptidoglycan of gram-positive bacteria. Abe, M; Ando, T; Endo, Y; Kumagai, K, 1994)	0.57
" Interpolating from the dose-response curve taken before desensitization, this is equivalent to an average 23% reduction in the number of muscarinic receptors."	( Measurement of changes in functional muscarinic acetylcholine receptor density in single neuroblastoma cells using calcium release kinetics. Thompson, SH; Wang, SS, 1994)	0.29
" The dose-response curves for histamine in the control group pretreated with cimetidine were shifted to the left and responses reached almost the same level as those of the atherosclerotic group."	( Mechanisms of augmented vascular responses to histamine in atherosclerotic rabbit common carotid arteries. Chiba, S; Fujiwara, T, 1994)	0.84
" These changes were more pronounced by increasing the dosage of histamine."	( Effects of calcium channel and H1-receptor blockers on the responses of slowly adapting pulmonary stretch receptors to histamine in vagotomized rabbits. Kanno, T; Matsumoto, S; Nagayama, T; Shimizu, T; Yamasaki, M, 1993)	0.73
" Dose-response curves of calcium-induced contractions in depolarized preparations were shifted to the right but maximum responses were not changed by AR."	( Inhibition of drug-induced contractions of guinea-pig ileum by Annona crassiflora seed extract. De Oliveira, AB; Pires, V; Weinberg, J; Weinberg, Mde L, 1993)	0.29
" Cimetidine decreased IK in the presence of histamine, by shifting the dose-response curve to histamine to the right."	( Modulation by histamine of the delayed outward potassium current in guinea-pig ventricular myocytes. Abiko, Y; Yazawa, K, 1993)	0.91
" The PD20 (dose of histamine causing a 20% fall in FEV1) was measured before and 11, 35, and 59 h after cessation of treatment and a bronchodilator dose-response study before and 83 h after cessation of treatment."	( Asthma control during and after cessation of regular beta 2-agonist treatment. Pavord, ID; Tattersfield, AE; Wahedna, I; Wisniewski, AF; Wong, CS, 1993)	0.61
" Time-response (three experiments) and dose-response (six experiments) curves showed that the maximal effect was obtained after an incubation time of 24 h and a dose of 1 microM of histamine."	( Activation by histamine of bronchial epithelial cells from nonasthmatic subjects. Bousquet, J; Campbell, AM; Chanez, P; Godard, P; Lacoste, P; Michel, FB; Vignola, AM, 1993)	0.84
" In healthy volunteers full dose-response curves were constructed by infusing histamine, before and after administration of an H1 or H2 antagonist or both antagonists, into dorsal hand veins preconstricted with the alpha-adrenergic agonist phenylephrine."	( Histamine-induced venodilation in human beings involves both H1 and H2 receptor subtypes. Bedarida, G; Blaschke, TF; Dachman, WD; Hoffman, BB, 1994)	1.96
" The most currently used bronchial provocation tests are those with nebulisation of histamine or methacholine either a tidal volume or from a dosimeter, a dose-response curve being obtained in measuring expiratory flows or airway resistance."	( [Non-allergenic bronchial hyperreactivity. Measurement methods and reproducibility]. Boulet, LP; Denjean, A, 1994)	0.51
"1 mg/kg to determine the dose-response relationship."	( Safety and potency of ANQ 9040 in male volunteers. Damask, MC; Donati, F; Jones, RM; Mant, TG; Munday, IT, 1994)	0.29
" The provocative dose causing a 50% increase in the Rrs (PD50Rrs) was interpolated from the log dose-response curve."	( Respiratory resistance and transcutaneous PO2 during histamine provocation in children with bronchial asthma. Aberg, N; Bjure, J; Engström, I; Holmgren, D; Sixt, R, 1993)	0.54
" Ultrasonically nebulized hypertonic saline challenge was given in a dose-response manner to determine the provocative dose of hypertonic saline-laden air required to produce a fall in forced expiratory volume in 1 second (FEV1) of 20% or greater (PD20HS)."	( The contribution of neurogenic reflexes to hypertonic saline-induced bronchoconstriction in asthma. Holgate, ST; Makker, HK, 1993)	0.29
" The possibility of creating dose-response curves and posterior regression line, allow a comparison of these lines by means of an analysis of covariance."	( A study of the immediate cutaneous response. Influencing factors. García Vadillo, C; Lobatón Sánchez de Medina, P; Millán Nnez-Cortés, J; Moreno Benítez, F, )	0.13
" After a stable baseline was obtained, dose-response curves to histamine (50, 100, or 200 micrograms intravenous bolus) or hypocapnia (0% CO2 for 2 min with 100, 200, or 400 ml/min collateral flow) were constructed."	( Effects of halothane, propofol, and thiopental on peripheral airway reactivity. Lindeman, KS; Mehr, EH, 1993)	0.53
" Since the dose-response relationship is not typical of a drug-receptor interaction, it appears unlikely that the leukotoxin is a direct agonist of H1 receptors."	( Effects of Pasteurella haemolytica culture supernate on bovine tracheal smooth muscle. Bélanger, A; Harris, WH; Yamashiro, S, 1993)	0.29
"14 microM Ro 31-8220) and shifted the dose-response curve for the effect of carbachol concentration of aminopyrine accumulation downwards and to the right."	( Inhibition by Ro 31-8220 of acid secretory activity induced by carbachol indicates a stimulatory role for protein kinase C in the action of muscarinic agonists on isolated rat parietal cells. Hanson, PJ; McKenna, JP, 1993)	0.29
" Histamine was found to induce a dose-response related increase, whereas blood flow volume tended to decrease in each concentration range in the series of PAF administration."	( Regional blood flow volume in the eustachian tube. Kubo, N; Kumazawa, T; Minami, T; Tomoda, K; Yamashita, T, 1993)	1.2
" In some individual dose-response curves, the scores obtained by HRM were shifted to higher allergen and anti-IgE concentrations."	( Comparison of fiberglass-based histamine assay with a conventional automated fluorometric histamine assay, case history, skin prick test, and specific serum IgE in patients with milk and egg allergic reactions. Kleine-Tebbe, J; Kunkel, G; Nolte, H; Roedsgaard, D; Skov, PS; Wahn, U; Werfel, S, 1993)	0.57
" Addition of antihistamines (mepyramine and metiamide) to the organ bath abolished the response to exogenous histamine, but failed to alter the dose-response relationship of the reaction to cumulative challenge with rising titres of anti-IgE."	( Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects. Björck, T; Dahlén, SE, 1993)	0.97
" The hypertonic responsiveness was determined in a dose-response manner to a maximum dose of 310 1 and the exercise induced asthma symptom severity was scored on a scale of 0-5."	( Relation of the hypertonic saline responsiveness of the airways to exercise induced asthma symptom severity and to histamine or methacholine reactivity. Holgate, ST; Makker, HK, 1993)	0.5
") dosing to rats."	( Pharmacological characterization of FK1052, a dihydropyridoindole derivative, as a new serotonin 3 and 4 dual receptor antagonist. Kadowaki, M; Kohsaka, M; Mori, J; Nagakura, Y; Tokoro, K; Tomoi, M, 1993)	0.29
" The analyses were repeated using the dose-response slope as a continuous measure of responsiveness and by applying a method to adjust for censoring the responsiveness data."	( Factors associated with bronchial responsiveness to histamine in a population sample of adults. De Vries, K; Mensinga, TT; Rijcken, B; Schouten, JP; Van der Lende, R; Weiss, ST, 1993)	0.54
" Normality and separation of symptom groups of the early dose-response slope with provocative dose producing a 20% fall in FEV1 (PD20)."	( Comparison of PD20 with two alternative measures of response to histamine challenge in epidemiological studies. Britton, JR; Burney, PG; Chinn, S; Higgins, BG; Tattersfield, AE, 1993)	0.52
" The aim of this study was to investigate the wheal and flare dose-response to intradermal injection of alpha-human ANP in normal humans."	( Effects of intradermal injection of atrial natriuretic peptide. Higham, MA; Ind, PW; Sharara, AM; Spanevello, A, 1995)	0.29
"Pretreatment with SKF 91488 shifted, in a dose-dependent fashion, the dose-response curves of the leakage of dye to histamine to lower concentrations in the trachea, main bronchi, and nasal mucosa."	( Histamine N-methyltransferase inhibitor potentiates histamine- and antigen-induced airway microvascular leakage in guinea pigs. Maeyama, K; Morikawa, M; Nakazawa, H; Sasaki, H; Sekizawa, K; Watanabe, T; Yamauchi, K, 1995)	1.94
" In contrast, it was found that 13-HODE itself induced a decrease in diastolic arterial blood pressure when it was injected intravenously after either a single dose of histamine (10, 100 or 1000 micrograms kg-1) or after a dose-response curve of histamine (0."	( Hypotensive effect of 13-hydroxylinoleic acid in the rat: mediation via the release of a CGRP-like mediator from capsaicin-sensitive nerves. Buckley, TL; Engels, F; Henricks, PA; Muis, T; Nijkamp, FP; van Heuven-Nolsen, D, 1995)	0.49
" We report the results of analyzing bronchial dose-response curves by measuring percent fall in vital capacity (delta FVC%) as the response rather than the PC20."	( Detection of excessive bronchoconstriction in asthma. Gibbons, WJ; Lougheed, D; Macklem, PT; Sharma, A, 1996)	0.29
" Self-reported symptoms of asthma were graded on a scale from 0 to 5, where 0 = no symptoms within the preceding 12 months and 5 = daily including nocturnal symptoms, and histamine responsiveness was analysed by means of the dose-response slope (DRS)."	( Peripheral eosinophil counts as a marker of disease activity in intrinsic and extrinsic asthma. Ulrik, CS, 1995)	0.49
" Histamine and bradykinin had similar dose-response relations, and a maximal effect was observed between 20 and 50 microM."	( Effect of inflammatory agents on electrical resistance across the blood-brain barrier in pial microvessels of anaesthetized rats. Butt, AM, 1995)	1.2
"We wished to determine why in vitro agonist dose-response curves show reduced leftward shift (1/2-1 log dose units) in sensitized canine airway smooth muscle compared to curves elicited in vivo (2-3 log dose unit)."	( The Schultz-Dale response of sensitized canine bronchial smooth muscle. Chitano, P; Sigurdsson, SB; Stephens, NL, 1995)	0.29
" With the dosing regimes used, both rolipram and theophylline inhibited eosinophil recruitment, whilst only rolipram prevented the development of airway hyperresponsiveness."	( Effects of theophylline and rolipram on antigen-induced airway responses in neonatally immunized rabbits. Blake, SM; Gozzard, N; Herd, CM; Higgs, GA; Holbrook, M; Hughes, B; Page, CP, 1996)	0.29
" The octapeptide may be simplified by deleting the two C-terminal amino acids while keeping its efficacy and the slope of the dose-response curve."	( H-Lys-Arg-Asn-Lys-Asn-Asn-OH is the minimal active structure of oxyntomodulin. Aumelas, A; Bataille, D; Carles-Bonnet, C; Jarrousse, C; Martinez, J; Niel, H, 1996)	0.29
" Histamine decreased lymphocyte proliferation while (in order of potency) cimetidine, the hydroxy metabolite of metronidazole, imidazole and metronidazole, increased the mitogenic response to PHA in a dose-response fashion."	( Effects of metronidazole and its metabolites on histamine immunosuppression activity. Elizondo, G; Ostrosky-Wegman, P, 1996)	1.46
" While trypan blue potentiated the effect of histamine and shifted its dose-response curve to the left, it did not affect the contractile effects of acetylcholine."	( Effect of trypan blue on the action of acetylcholine, histamine and salbutamol in the isolated guinea-pig ileum. Damankeshideh, M; Mahmoudian, M, 1996)	0.8
" The same general protocol was used for all studies, except that the dosage and time of TYB-2285 treatment was varied."	( Effect of TYB-2285 on antigen-induced airway responses in sheep. Abraham, WM; Ahmed, A; Cortes, A; Sielczak, M; Wantanabe, A, 1996)	0.29
" The YM022 dosage required to inhibit basal acid secretion is consistent with that required to suppress pentagastrin-induced acid secretion."	( Comparative evaluation of the role of endogenous gastrin in basal acid secretion in conscious rats provided with chronic fistula and pylorus ligation. Akuzawa, S; Miyata, K; Nishida, A; Takemoto, Y; Uchida-Kobayashi, A, 1996)	0.29
" Changes in [Ca2+]i and inositol phosphate production exhibit a similar dose-response relationship for histamine (maximal effect at 10(-4) M), with both phenomena being blocked by the H1 antagonist mepyramine and being insensitive to pertussis toxin treatment."	( Histamine activates phospholipase C in human airway epithelial cells via a phorbol ester-sensitive pathway. Barzanti, F; Gruenert, DC; Hrelia, S; Rugolo, M, 1996)	1.95
" When selecting a 15-min pretreatment interval with equieffective anti-WFR doses from the first dose-response experiments (i."	( Effects of local treatment with salmeterol and terbutaline on anti-IgE-induced wheal, flare, and late induration in human skin. Grönneberg, R; Raud, J, 1996)	0.29
" Function testing of bronchial responsiveness consists of 2 major parts : 1) standard method of acetylcholine or histamine inhalation test 2) direct-writing recorder of the dose-response curves of the airway to methacholine test (Astograph)."	( [Function testing of bronchial responsiveness]. Fukuoka, M; Kubo, H; Nakajima, S; Tohda, Y, 1996)	0.5
"Ouabain-sensitive [86Rb] uptake and degranulation increased in parallel and in a dose-response fashion with increasing Fc receptor cross-linking."	( A role for the sodium, potassium adenosine triphosphatase (Na+,K+ ATPase) enzyme in degranulation of rat basophilic leukaemia cells. Gentile, DA; Skoner, DP, 1996)	0.29
" Serotonin but not histamine was found to significantly inhibit in a dose-response fashion the induction and expression of MHC class II molecules."	( Differing regulation of major histocompatibility class II and adhesion molecules on human umbilical vein endothelial cells by serotonin. Joshua, IG; Justus, DE; Li, F; Lian, R, 1997)	0.63
"1 mL CA in mg x mL(-1)) was calculated from dose-response curves."	( Persistence of airway hyperresponsiveness and viral antigen following respiratory syncytial virus bronchiolitis in young guinea-pigs. Krusat, T; Marek, W; Oberdieck, B; Philippou, S; Riedel, F; Streckert, HJ, 1997)	0.3
" This was shown by a parallel shift of the agonist dose-response curves to the right."	( In vivo effect of alpha 1-acid glycoprotein on experimentally enhanced capillary permeability in guinea-pig skin. Linnau, Y; Muchitsch, EM; Pichler, L; Teschner, W, )	0.13
"5 hours after dosing compared with placebo."	( Effect of pranlukast, an oral leukotriene receptor antagonist, on leukotriene D4 (LTD4) challenge in normal volunteers. Barnes, NC; Compton, CH; Dennis, M; Georgiou, P; Howland, K; O'Shaughnessy, TC, 1997)	0.3
" FK224 (10(-6) M and 10(-5) M, respectively) significantly inhibited NKA-induced contraction and 10(-5) M FK224 shifted the dose-response curve to more than one log unit higher concentration."	( Tachykinin antagonist FK224 inhibits neurokinin A-, substance P- and capsaicin-induced human bronchial contraction. Ando, M; Fujii, K; Goto, E; Hamamoto, J; Hirata, N; Honda, I; Iwagoe, H; Kohrogi, H; Yamaguchi, T, 1997)	0.3
"The dose-response effects of intravenous infusion of prostacyclin on capillary permeability (the capillary filtration coefficient technique), hydrostatic capillary pressure, transcapillary filtration, and vascular tone were analyzed in vivo on cat skeletal muscle from a normal and an increased permeability level."	( Low-dose prostacyclin has potent capillary permeability-reducing effect in cat skeletal muscle in vivo. Grände, PO; Möller, AD, 1997)	0.3
" Dose-response curves to (+)-WIN 55212 and CP 55940 were shifted to the right, with no reduction of maximal response, by pretreatment with SR141716A (31."	( Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus. Coutts, AA; Pertwee, RG, 1997)	0.3
" Both were dosed at 10 mg/day."	( Loratadine treatment of rhinitis due to pollen allergy reduces epithelial ICAM-1 expression. Canonica, GW; Ciprandi, G; Danzig, M; Passalacqua, G; Pronzato, C; Ricca, V, 1997)	0.3
"25 x 10(-5) M RANTES produced a dose-response stimulation of HDC mRNA in the tissues of skin injection sites."	( RANTES is a pro-inflammatory chemokine and chemoattracts basophil cells to extravascular sites. Barbacane, RC; Boucher, W; Conti, P; Letourneau, R; Pang, X; Reale, M; Theoharides, TC; Thibault, J, 1997)	0.3
" Results are most usefully expressed as the provocative dose producing a 20% fall in FEV1 (PD20FEV1) or the dose-response slope (DRS)."	( Testing airway responsiveness using inhaled methacholine or histamine. James, A; Ryan, G, 1997)	0.54
"Our study shows clearly that the efficacy of a single therapeutic dosage of cetirizine is consistently good for suppression of cutaneous reactivity to histamine in healthy volunteers."	( Consistency of the efficacy of cetirizine and ebastine on skin reactivity. Benabdesselam, O; Frossard, N; Melac, M; Pauli, G, 1998)	0.5
" The authors conclude that studies with NED in nonatopic asthmatics should be continued, but the dosage of the drug ought to be bigger and the time of treatment ought to be longer."	( [The effect of nedocromil sodium on the clinical course, ventilatory parameters and nonspecific bronchial hyperreactivity in patients with nonatopic bronchial asthma treated with beclomethasone dipropionate]. Grabski, W; Grzelewska-Rzymowska, I; Kroczyńska-Bednarek, J; Tymińska, K, 1997)	0.3
" Changes in RRS (1 Hz) during histamine challenge were used to generate histamine dose-response curves, from which the provocative concentrations that evoked a 75 or 100% increase in baseline RRS (PCRRS75 and PCRRS 100, respectively) were determined."	( Association between bronchoalveolar lavage cytologic features and airway reactivity in horses with a history of exercise intolerance. Ellenberg, S; Hoffman, AM; Mazan, MR, 1998)	0.59
" Bronchoconstrictor and bronchodilator responsiveness were assessed with cumulative dose-response curves, using histamine and terbutaline, respectively."	( Lack of correlation between bronchoconstrictor response and bronchodilator response in a population-based study. de Gooijer, A; Douma, WR; Koëter, GH; Postma, DS; Rijcken, B; Schouten, JP; Weiss, ST, 1997)	0.51
" Histamine dose-response curves showed that concentrations between 5 nm and 5 microM increased permeability, while concentrations from 50 microM to 5 mM reduced it."	( Regulation of cerebral microvascular permeability by histamine in the anaesthetized rat. Easton, AS; Fraser, PA; Sarker, MH, 1998)	1.46
" Dose-response relationships to histamine were done in rings of canine pulmonary artery from heartworm and control dogs, in the presence and absence of endothelial cells, the H1 receptor blocker tripelennamine, or the H2 receptor blocker cimetidine."	( Dirofilaria immitis: heartworm infection converts histamine-induced constriction to endothelium-dependent relaxation in canine pulmonary artery. Kaiser, L; Williams, JF, 1998)	0.84
"001); and similarly a decline in histamine dose-response slope was observed."	( Longitudinal determinants of bronchial responsiveness to inhaled histamine. Backer, V; Ulrik, CS, 1998)	0.82
" A rightward shift in the dose-response curve for InsP3-induced Ca2+ release was observed in permeabilized monolayers of vasopressin-pretreated A7r5 cells (EC50 630 nM and 400 nM for pretreated and non-pretreated cells, respectively)."	( Agonist-induced down-regulation of type 1 and type 3 inositol 1,4,5-trisphosphate receptors in A7r5 and DDT1 MF-2 smooth muscle cells. Casteels, R; Deelman, L; Henning, RH; Missiaen, L; Parys, JB; Sipma, H; Smedt, HD; Vanlingen, S, 1998)	0.3
" Dose-response curves to acetylcholine (ACh), substance P (SP), and histamine were constructed in lungs isolated from rabbits immediately or 48 h after air or O3 exposure O3 induced a significant increase in the baseline value of deltaPt, more markedly 48 h after the exposure."	( Comparison of ozone-induced effects on lung mechanics and hemodynamics in the rabbit. Ansay, M; Delaunois, A; Gustin, P; Montaño, LM; Segura, P; Vargas, MH, 1998)	0.54
" Both AA and BB at 10(-6) g/ml caused a slight shift to the right of the dose-response curve for Ca2+ in isolated guinea pig ileum, and a concentration up to 3 x 10(-6) g/ml displayed noncompetitive antagonistic effects."	( Pharmacological activities of khellactones, compounds isolated from Peucedanum japonicum THUNB. and Peucedanum praeruptorium DUNN. Aida, Y; Chiba, M; Kasama, T; Takeuchi, N; Tobinaga, S, 1998)	0.3
" Whole EN activity was not stimulated even by the highest dose (1 x 10(-1) M) of histamine when the nose was pretreated with saline, but was substantially stimulated by histamine in a dose-response fashion (1 x 10(-2) M) after pretreatment with HCI or H2SO4."	( Does histamine stimulate trigeminal nasal afferents? Kuwahara, M; Sekizawa, S; Sugano, S; Tsubone, H, 1998)	1.04
" The dose-response relationship and possible tachyphylaxis were tested for each chemical."	( Activation of neurons in rat trigeminal subnucleus caudalis by different irritant chemicals applied to oral or ocular mucosa. Carstens, E; Handwerker, HO; Kuenzler, N, 1998)	0.3
" The quantitative traits assessed included serum levels of total IgE and specific IgE to house dust mite and mixed grass, blood eosinophil counts, and the dose-response slope (DRS) of FEV1 to histamine provocation."	( Linkage of chromosome 5q and 11q gene markers to asthma-associated quantitative traits in Australian children. Burton, PR; Cookson, WO; Daniels, SE; Gibson, NA; Goldblatt, J; LeSöuef, PN; Palmer, LJ; Rye, PJ; Tay, GK, 1998)	0.49
"), which facilitates histamine release, significantly shifted the methamphetamine dose-response curve to the left when tested together with different doses of methamphetamine and markedly extended the time-course of methamphetamine's discriminative-stimulus effects."	( Potentiation of the discriminative-stimulus effects of methamphetamine by the histamine H3 receptor antagonist thioperamide in rats. Goldberg, SR; Munzar, P; Nosál, R, 1998)	0.85
" The dose-response function was extremely steep, however, since other doses showed either no effect or behavioral toxicity."	( Antinociceptive activity of impentamine, a histamine congener, after CNS administration. Hough, LB; Leurs, R; Menge, WM; Nalwalk, JW; Timmerman, H, 1999)	0.57
" It remains unclear whether there is a dose-response relationship between inhaled corticosteroids and effect on bronchial hyperresponsiveness."	( Effect of inhaled corticosteroids on bronchial responsiveness in patients with "corticosteroid naive" mild asthma: a meta-analysis. Akkermans, RP; Molema, J; van Grunsven, PM; van Schayck, CP; van Weel, C, 1999)	0.3
" Comparison of the dose-response curves between TPA-induced hydrogen (H+) secretion, as measured by aminopyrine (AP) uptake, and the membrane-associated PKC-alpha suggests that translocation of PKC-alpha is not involved in the H+ secretory process in PC."	( Expression and characterization of protein kinase C in isolated rabbit parietal cells. Kim, SW; Levine, RA; Loo, A; Nandi, J, 1999)	0.3
" However, comparison of normal subjects, atopics without dermatitis and patients with atopic dermatitis, showed the differences in dose-response effects of PAF and histamine on weal volume and flare area to be nonsignificant."	( Comparison of weal and flare responses to platelet activating factor (PAF) and histamine, and the ultrastructural effects of PAF in the skin of atopic and normal subjects. Archer, CB; Bradfield, JW; Brooks, J; Jenks, PJ; Kavanagh, GM, 1999)	0.73
" There were no differences in normalized dose-response curves to KCl among three groups."	( Different contractile properties between intralobar and extralobar pulmonary arteries of the rabbit. Earm, YE; Ho, WK; Kang, TM; Lee, SH; Lee, SJ; Park, MK; Uhm, DY, 1999)	0.3
" However, high concentrations of these cations produce significant toxicity, so dosage will be an important concern in development of these agents."	( Relaxant effect of magnesium and zinc on histamine-induced bronchoconstriction in dogs. Hashimoto, Y; Hirota, K; Ishihara, H; Matsuki, A; Ohtomo, N; Sato, T; Yoshioka, H, 1999)	0.57
" An increase in airway sensitivity was defined as a significant leftward shift of the dose-response curve when compared with saline-challenged control sensitized animals."	( Airway hyperresponsiveness in anaesthetised guinea-pigs 18-24 hours after antigen inhalation does not occur with all intravenously administered spasmogens. Broadley, KJ; Johnson, A, 1999)	0.3
" Histamine challenge was performed until a 50% fall in forced expiratory volume in one second (FEV(1)) occurred and the response was expressed as the provocative concentration causing a 20% fall in FEV(1) (PC(20)) and as the dose-response slope (maximal % fall in FEV(1)/cumulative dose (micromol))."	( Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. de Gouw, HW; Sterk, PJ; Twiss, IM; Verbruggen, MB, 1999)	1.46
"Oral L-arginine does not influence airway hyperresponsiveness to histamine as reflected by PC(20), although the dose-response slope is slightly reduced in patients with asthma."	( Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. de Gouw, HW; Sterk, PJ; Twiss, IM; Verbruggen, MB, 1999)	0.78
"6 microgram/kg) and aminophylline (25 mg/kg), which were determined by the dose-response curves for inhibition of histamine-induced bronchoconstriction, were intravenously administered 5 minutes before the propranolol inhalation."	( Difference in bronchoprotective effects of bronchodilators on postallergic propranolol-induced bronchoconstriction. Fujimura, M; Ishiura, Y; Matsuda, T; Mizuhashi, K; Myou, S, 1999)	0.51
"At this dosage the histamine-induced flare was at least 80% inhibited at the start of the second administration Thereafter, on successive administrations, the inhibition was even more pronounced and the response control was nearly total."	( A pharmacokinetic-pharmacodynamic modelling of the antihistaminic (H1) effects of cetirizine. Ganem, B; Kuch, MD; Tillement, JP; Urien, S, 1999)	0.63
"1-235 nmol site(-1)) injected intradermally into the rostral back elicited scratching of the injected site, with bell-shaped dose-response relationship."	( Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice. Kuraishi, Y; Nagasawa, T; Satoh, M; Yamaguchi, T, 1999)	0.3
" Female Fischer rats were dosed with ciprofibrate (50 mg/kg body weight per day) alone or combined with octreotide LAR (10 mg/30 days) for 60 days."	( Octreotide inhibits the enterochromaffin-like cell but not peroxisome proliferator-induced hypergastrinemia. Bakke, I; Sandvik, AK; Waldum, HL, 2000)	0.31
" Phentolamine (10(-7) M) produced a parallel rightward shift of the NE dose-response curve."	( Agonist-induced isometric contraction of smooth muscle cell-populated collagen gel fiber. Isshiki, Y; Itoh, Y; Kai, C; Oishi, K; Takano-Ohmuro, H; Takeda, Y; Uchida, MK; Yamaura, K, 2000)	0.31
" Dose-response curves were investigated in response to the endothelium-dependent agonists histamine, serotonin, and acetylcholine (for pigs, substance P) and to the endothelium-independent agonist sodium nitroprusside (SNP) under control conditions and before and after incubation of the vessels with sepiapterin (substrate for BH4 synthesis)."	( Endothelial dysfunction of coronary resistance arteries is improved by tetrahydrobiopterin in atherosclerosis. Amann, K; Bleeke, T; Kübler, W; Tiefenbacher, CP; Vahl, C; Vogt, A, 2000)	0.53
" Inhibition of the wheal response observed for cetirizine and levocetirizine was apparent by 1 h after dosage and lasted for mean durations of 24."	( A randomized, double-blind, crossover comparison among cetirizine, levocetirizine, and ucb 28557 on histamine-induced cutaneous responses in healthy adult volunteers. Baltes, E; De Vos, C; Devalia, JL; Hanotte, F, 2001)	0.53
"Information on the dose-response relationship is a prerequisite to defining the non-response threshold of exposure."	( Lipopolysaccharide-induced nasal cytokine response: a dose-response evaluation. Danuser, B; Krueger, H; Rebsamen, H; Weber, C, 2000)	0.31
"To assess the itch-associated response of primary afferents innervating the murine skin in vivo, dose-response curves and time-courses for itch-scratching and cutaneous nerve firing responses to intradermal injections of pruritogens (histamine and serotonin) were compared in ICR and ddY mice."	( Itch-associated responses of afferent nerve innervating the murine skin: different effects of histamine and serotonin in ICR and ddY mice. Kuraishi, Y; Maekawa, T; Nojima, H, 2000)	0.71
" The dose-response curves for three histamine concentrations (0."	( Changes over 13 years in skin reactivity to histamine in cohorts of children aged 9-13 years. Barreto, M; Ciofetta, G; Falasca, C; Martella, S; Pia Villa, M; Ronchetti, R, 2001)	0.85
" In SCWL, body temperature was not affected by HA until 165 min postinjection when HA decreased temperature in a quadratic dose-response with maximum hypothermia being achieved at a dose of 25 microg."	( Feeding, drinking, and temperature responses of chickens to intracerebroventricular histamine. Denbow, DM; Meade, S, 2001)	0.54
"We report here that the dose-response curve of the histamine-stimulated phosphoinositide hydrolysis in the guinea pig cerebellar slices was shifted to the left when the slices were pretreated with SKF 91488 (100 microM), a specific inhibitor of histamine N-methyltransferase (HMT)."	( Histamine N-methyltransferase regulates histamine-induced phosphoinositide hydrolysis in guinea pig cerebellum. Kitanaka, J; Kitanaka, N; Takemura, M; Terada, N; Tsujimura, T, 2001)	2.01
" A possible explanation for the inhibitory effects of histamine at 10-mM dosage was apparently found in that the effects of the high concentration may be supraphysiological; and furthermore, there is a difference in the mechanism by which histamine exerts its effects mediated by the histamine receptors on the cochlea."	( The effects of histamine and its antagonists on the cochlear microphonic and the compound action potential of the guinea pig. Masuyama, K; Minoda, R; Toriya, T; Yumoto, E, 2001)	0.91
" In HLPs perfused with homologous blood, dose-response curves for the haemodynamic and bronchial effects of PAF (1 - 32 ng) were carried out in the absence or presence of L-NNA (200 microM)."	( Nitric oxide (NO) modulation of PAF-induced cardiopulmonary action: interaction between NO synthase and cyclo-oxygenase-2 pathways. Calabrese, R; del Basso, P; Fabi, F; Stati, T, 2001)	0.31
" Pretreatment of the rats with an ip bolus injection of alpha-fluoromethylhistidine, a suicide inhibitor of a histidine decarboxylase (HDC), at a dosage of 224 micromol/kg blocked the conversion of histidine into histamine and attenuated the suppressive effect of histidine on food intake from 64."	( Histidine suppresses food intake through its conversion into neuronal histamine. Akehi, Y; Chiba, S; Sakata, T; Tajima, D; Yoshimatsu, H, 2002)	0.73
" In contrast, the dose-response curve for substance P recorded 1 h after antigen challenge was not modified by pretreatment with silymarin."	( Protective effect of silymarin in antigen challenge- and histamine-induced bronchoconstriction in in vivo guinea-pigs. Apostoliti, F; Breschi, MC; Martinotti, E; Nieri, P, 2002)	0.56
" Histamine dose-dependently induced the contraction of sections of the guinea-pig small intestine, and the pretreatment of the tissue section with aminoguanidine (100 microM), a diamine oxidase inhibitor, but not with S-[4-(N,N-dimethylamino)butyl]isothiourea (100 microM), an inhibitor of histamine N-methyltransferase, shifted the dose-response curve of histamine-induced contraction to lower concentrations."	( Expression of diamine oxidase (histaminase) in guinea-pig tissues. Kitanaka, J; Kitanaka, N; Takemura, M; Terada, N; Tsujimura, T, 2002)	1.22
" The dose-response curve for orexin B suggested an effect mediated by type II (OX2) receptors."	( Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline). Brown, RE; Eriksson, KS; Haas, HL; Sergeeva, OA, 2002)	0.53
" Findings suggest that there may be a role for second-generation antihistamines in treating asthma, with patient selection as well as dosing both important therapeutic considerations."	( Role of histamine in the pathophysiology of asthma: immunomodulatory and anti-inflammatory activities of H1-receptor antagonists. Gelfand, EW, 2002)	0.98
" By modeling the histamine-induced baseline response simultaneously with active treatment, predictions of the response are possible not only following different dosing regimens of omeprazole, but also following different degrees of histamine stimulation."	( Gastric acid secretion in the dog: a mechanism-based pharmacodynamic model for histamine stimulation and irreversible inhibition by omeprazole. Abelö, A; Eriksson, UG; Gabrielsson, J; Holstein, B; Karlsson, MO, 2002)	0.88
" Dose-response curves for adrenaline were carried out as standard protocol."	( Characteristics of histamine tachyphylaxis in rat uterine smooth muscle. Gil Marqués, M; Martínez-Mir, I; Morales-Olivas, FJ; Rubio-Gomis, E, 2002)	0.64
" During hypothermic extracorporeal circulation and postperfusion period, the dosage of the myorelaxant substantially decreased."	( [Rocuronium (esmerone) in anesthesia during surgery under extracorporeal circulation]. Chernov, VA; Ermolenko, AE; Il'nitskiĭ, VV; Kozlov, IA; Vershuta, DV, )	0.13
" The animals were killed 60 min after dosing and their duodena were removed."	( Changes in duodenal mast cells in response to dehydroleucodine. Fogal, T; Penissi, A; Piezzi, R; Rudolph, I, 2003)	0.32
" In conclusion, this study shows that, at the end of the conventional dosing interval, ebastine 10 mg and cetirizine 10 mg once daily in repeated doses suppressed the histamine wheal more effectively than did loratadine 10 mg once daily or fexofenadine 60 mg twice daily."	( Inhibition of the histamine wheal by ebastine compared with cetirizine, fexofenadine and loratadine at steady state. Boyce, M; Carey, W; Luria, X; Warrington, S, 2002)	0.84
" In addition, the dose-response curve for histamine-induced elevations in intracellular calcium was shifted following IL-4 stimulation."	( IL-4 primes human endothelial cells for secondary responses to histamine. Awong, G; Cuvelier, SL; Iqbal, SM; Patel, KD; Tibbles, LA; Wierzbicki, T, 2003)	0.82
"1 microM), or the cyclooxygenase enzyme (COX) inhibitor diclofenac (10 microM) each caused a parallel and rightward shift in the dose-response relation for OVA, providing evidence for contributions of histamine, cysteinyl-leukotrienes, and COX products to the OVA-induced bronchoconstriction in the IPL."	( Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. Dahlén, SE; Låstbom, L; Ryrfeldt, A; Sundström, E, 2003)	0.51
" Sensitivity was high, results reproducible and linear log dose-response relationships obtained over a wide dosage range."	( A method for the quantitative estimation of drugs on the isolated intact trachea. JAMIESON, D, 1962)	0.24
" The dose-response curve is shown to be linear, and the precision of the method is good (lambda =0."	( Assay of oxytocin by rat mammary gland in vitro. RYDEN, G; SJOHOLM, I, 1962)	0.24
" dosage exerted a small but measurable anti-whealing effect five hours after ingestion."	( Studies of the "antihistaminic" effect of pyribenzamine administered by various routes. LeVAN, P; PERRY, DJ; STERNBERG, TH, 1951)	0.23
" Dose-response curves were characterized by their sensitivity (PD20) and reactivity."	( Relationship between exhaled carbon monoxide and airway hyperresponsiveness in asthmatic patients. García-Río, F; Pino, JM; Prados, C; Ramirez, M; Villamor, J; Viñas, A, 2004)	0.32
" Percentage predicted forced expiratory volume in one second (FEV(1)), the concentration of histamine inducing a 20% fall in FEV(1) (PD(20)), and the dose-response slope (DRS) were similar between groups at follow-up."	( Randomized controlled trial of unflued gas heater replacement on respiratory health of asthmatic schoolchildren. Hiller, JE; Martin, J; McElroy, HJ; Nitschke, M; Pilotto, LS; Pisaniello, D; Ruffin, RE; Smith, BJ, 2004)	0.54
" These data were then used to guide bolus dosing in multiples of ED95 in six dogs instrumented for hemodynamic measurements as well as inspiratory pressure and pulmonary compliance."	( Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs. Hashim, M; Heerdt, PM; Kang, R; Mook, RJ; Savarese, JJ; The', A, 2004)	0.32
" Bolus dosing produced no cardiopulmonary change until a decrease in mean arterial pressure was elicited in four of six dogs at 25 x ED95."	( Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs. Hashim, M; Heerdt, PM; Kang, R; Mook, RJ; Savarese, JJ; The', A, 2004)	0.32
" The data show that most dosage regimens suggested in the literature for the oral administration of clemastine to dogs are likely to give too low a systemic exposure of the drug to allow effective therapy."	( Clinical pharmacology of clemastine in healthy dogs. Bergvall, K; Bondesson, U; Hansson, H; Hedeland, M; Törneke, K, 2004)	0.32
" Additionally, a dose-response relationship was determined in dogs using the histamine releaser compound 48/80."	( Classification of perioperative histamine-related reactions. Duda, D; Sattler, J; Sitter, H; Torossian, A, 2004)	0.84
" A dose-response curve of plasma histamine release was created."	( Classification of perioperative histamine-related reactions. Duda, D; Sattler, J; Sitter, H; Torossian, A, 2004)	0.89
" Isolated mesenteric arterial bed from normotensive rats was preconstricted with phenylephrine, and dose-response curves for histamine, acetylcholine (ACh), sodium nitroprusside (SNP), and pinacidil were performed before and after incubation with nocodazole or colchicine."	( Disruption of microtubular network attenuates histamine-induced dilation in rat mesenteric vessels. Brum, Cde A; Duarte, ID; Leite, R; Webb, RC, 2005)	0.79
" This study was performed to investigate the effect of EGF dosage forms on the histamine content of the experimentally induced wound and some wound healing criters in the mice."	( The effect of EGF application in gel form on histamine content of experimentally induced wound in mice. Babül, A; Dinçer, S; Erdoğan, D; Gönül, B; Ozoğul, C, 2004)	0.81
"To compare the activity of antihistamines by the index of area under dose-response curve (AUDRC) obtained from histamine-induced wheal and flare reactions."	( [Comparative activity of antihistamines on area under dose-response curve from histamine-induced wheal and flare responses in human skin]. Wang, RQ; Zhang, HY, 2004)	0.9
"7 mmol/L) were performed for each one before dosing and 2, 4, and 24 hours after dosing."	( [Comparative activity of antihistamines on area under dose-response curve from histamine-induced wheal and flare responses in human skin]. Wang, RQ; Zhang, HY, 2004)	0.61
"9 ln (mmol/L) x mm2 at each time (before dosing and 2, 4, 24 hours after dosing) respectively."	( [Comparative activity of antihistamines on area under dose-response curve from histamine-induced wheal and flare responses in human skin]. Wang, RQ; Zhang, HY, 2004)	0.61
" In BALB/c mice the effect of histamine and carbachol was reduced by PGE(2), whereas in C57BL/6 mice dose-response curves to these secretagogues were not affected."	( Host-specific differences in the physiology of acid secretion related to prostaglandins may play a role in gastric inflammation and injury. Hunt, RH; Padol, IT, 2005)	0.62
" The results were used to simulate a 320-mg twice-daily dosing regimen."	( A pharmacokinetic/pharmacodynamic model for a platelet activating factor antagonist based on data arising from Phase I studies. Aarons, L; Brearley, C; Evans, L, 2005)	0.33
" In a longitudinal study, data were collected on atopy and lower respiratory tract illness (LRTI) in infancy, and AR (expressed as dose-response slope (DRS)), atopy, tobacco-smoke exposure and PDA in childhood."	( Determinants of airway responsiveness to histamine in children. Gibson, NA; Goldblatt, J; Landau, LI; Le Souëf, PN; Palmer, LJ; Rye, PJ; Turner, SW; Young, S, 2005)	0.59
") produced a 12-fold shift in the histamine bronchoconstrictor dose-response curve."	( Airway closure after antigen challenge in cynomolgus monkeys: effect of the histamine H1 receptor antagonist, chlorpheniramine maleate. Celly, CS; Chapman, RW; Hey, JA; House, A; Lamca, JE; Skeans, S, 2005)	0.84
" A significant dose-response relationship was shown for the itch duration and itch intensity as rated with both scales."	( Children's rating of itch: an experimental study. Wahlgren, CF, )	0.13
" A rat model of MODS was established 24 h after intraperitoneal injection of zymosan at dosage of 75 mg/kg."	( Amelioration of the development of multiple organ dysfunction syndrome by somatostatin via suppression of intestinal mucosal mast cells. Lan, C; Liu, R; Tang, C; Wang, C, 2005)	0.33
"BALB/c mice were dosed by intraperitoneally with Ovalbumin, Beef serum albumin, Trypsin inhibitor and Potato acid phosphatase respectively (0."	( [Assessment of the BALB/c mice as a suitable animal model for the investigation of food allergy]. Guo, YC; Liu, XM; Lü, XZ; Yang, XG, 2005)	0.33
" Histidine at a specific dosage range might serve as a beneficial adjuvant for the clinical treatment of epilepsy, especially when accompanied by impaired spatial memory."	( Histidine enhances carbamazepine action against seizures and improves spatial memory deficits induced by chronic transauricular kindling in rats. Chen, Z; Jin, CL; Li, Q; Liu, LY; Xu, LS; Yang, LX; Zhu-Ge, ZB, 2005)	0.33
" The lowest dose (2 mg/kg) given the longest time (3 months) was close to the dosage for vestibular defective patients."	( Dose- and duration-dependent effects of betahistine dihydrochloride treatment on histamine turnover in the cat. Lacour, M; Tighilet, B; Trottier, S, 2005)	0.55
" First, we constructed a dose-response curve."	( Acute bacterial rhinosinusitis causes hyperresponsiveness to histamine challenge in mice. Kirtsreesakul, V; Klemens, JJ; Luxameechanporn, T; Naclerio, RM, 2005)	0.57
" Multiple chloroquine drug doses were used, revealing the existence of inverted-U dose-response relationships in every strain, allowing us to determine strain-dependent peak scratching behavior over the entire dose range."	( Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse. Green, AD; Lehto, SG; Mogil, JS; Smith, SB; Young, KK, 2006)	0.33
" At higher concentrations, 3 x 10(-5) and 10(-4) m, of the antagonist, the agonist dose-response curve was shifted to the right with a decrease in the maximum effect."	( Antagonism by imidazoline-type drugs of muscarinic and other receptors in the guinea-pig ileum. Miller, DD; Patil, PN; Salazar-Bookaman, MM, 2006)	0.33
" The influence of histamine dosage on free radicals was investigated in both lung cancer and healthy subjects."	( Histamine and selenium in lung cancer. Cimino, F; Della Rovere, F; Familiari, D; Granata, A; Tomaino, A; Zirilli, A, )	1.91
"Thirty-two Wistar rats were randomly divided into the normal group, model group, low dosage group, (treated with Astragalus membranacaus injection, 10 g crude medication/kg) and high dosage group (treated with Astragalus membranacaus injection, 20 g crude medication/kg)."	( Effect of Astragalus membranaceus injection on the activity of the intestinal mucosal mast cells after hemorrhagic shock-reperfusion in rats. Cai, J; Chen, LX; Gan, XL; Hei, ZQ; Huang, HQ; Li, SR, 2006)	0.33
" Dose-response curves were constructed for each candidate messenger that significantly (p<0."	( Secretion of ghrelin from rat stomach ghrelin cells in response to local microinfusion of candidate messenger compounds: a microdialysis study. de la Cour, CD; Håkanson, R; Norlén, P, 2007)	0.34
"Thirty-two Sprague-Dawley (SD) rats were randomly divided into four groups: sham group (group S), model group (group M), high and low dosage of CS groups, (treated with CS 50 mg/kg or 25 mg/kg, group C1 and C2)."	( Pretreatment of cromolyn sodium prior to reperfusion attenuates early reperfusion injury after the small intestine ischemia in rats. Cai, J; Gan, XL; Hei, ZQ; Li, SR; Luo, GJ, 2007)	0.34
" The dose-response curve for histamine is shifted to the left by approximately two orders of magnitude following 45 s pre-treatment with 1 microM PGE2."	( Prostaglandin E2 sensitizes primary sensory neurons to histamine. Bevan, S; Foster, AF; Nicolson, TA; Richards, CD, 2007)	0.88
" The dose-response curves of serotonin were shifted to the right approx."	( Advantages of human umbilical vein scaffolds derived from cesarean section vs. vaginal delivery for vascular tissue engineering. Birnbaum, DE; Hoenicka, M; Huber, G; Jacobs, VR; Schmid, FX, 2008)	0.35
" The effects of various histamine H(1) receptor antagonists on the dose-response curve for histamine were evaluated."	( The noncompetitive antagonism of histamine H1 receptors expressed in Chinese hamster ovary cells by olopatadine hydrochloride: its potency and molecular mechanism. Funahashi, J; Hayashi, K; Matsumoto, Y; Mori, K; Yano, H, 2008)	0.93
"Due to missing information on appropriate dosing of aminophylline in meconium aspiration syndrome (MAS), this study compared effects of high-dose and low-dose aminophylline on lung function of animals with MAS."	( Comparison of the effects of low-dose vs. high-dose aminophylline on lung function in experimental meconium aspiration syndrome. Calkovska, A; Drgova, A; Mokra, D; Mokry, J; Petraskova, M; Pullmann, R; Redfors, B, 2008)	0.35
"Standardized green tea extract was evaluated for exposure and toxicity in Beagle dogs following oral dosing by capsules."	( Exposure and toxicity of green tea polyphenols in fasted and non-fasted dogs. Crowell, JA; Kapetanovic, IM; Krishnaraj, R; Lindeblad, M; Lyubimov, A; Zakharov, A, 2009)	0.35
"Histamine may be present in biological fluids and in pharmaceutical dosage forms such as antiallergenic agents; when in excess, it causes a disorder called histaminosis."	( Histamine interaction with Zn2+ and Cu2+ porphyrins. Bernad-Bernad, MJ; Gracia-Mora, J; Recillas-Mota, JJ, 2009)	3.24
" The antihistamine response after ebastine dosing would be decreased following rifampin pretreatments."	( Itraconazole and rifampin alter significantly the disposition and antihistamine effect of ebastine and its metabolites in healthy participants. Cha, IJ; Lee, SS; Liu, KH; Shin, JG; Shon, JH; Yeo, CW, 2010)	1.01
" The four diterpene acids dosed at 25 approximately 100 mg/kg had dose-dependently anti-asthmatic effects: 7-oxo-sandaracopimaric acid > 17-hydroxy-ent-kaur-15-en-19-oic acid > kaurenoic acid > hederagenin."	( Inhibitory effects of diterpene acids from root of Aralia cordata on IgE-mediated asthma in guinea pigs. Cho, JH; Kim, CJ; Lee, JY; Sim, SS; Whang, WK, 2010)	0.36
" Deviations from the expected dose-response have led to the advancement of various possible mechanisms of toxicity, none of them proven."	( Scombroid poisoning: a review. Hungerford, JM, 2010)	0.36
" The antiinflammatory dose-response curve of loratadine was shifted to the left when studied in combination with montelukast (0."	( Concomitant activity of histamine and cysteinyl leukotrienes on porcine nasal mucosal vessels and nasal inflammation in the rat. Hunter, JC; Jia, Y; Jimenez, J; Lieber, G; McLeod, RL, 2010)	0.67
" Flares were induced before dosing and up to 96 h afterwards by intradermal PAF and histamine."	( Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males. Church, MK, 2010)	0.81
" This is delayed by lower dosage at early stages, made possible by additional treatment with histamine antagonists."	( L-Dopa activates histaminergic neurons. Blandina, P; Haas, HL; Klyuch, BP; Li, S; Lin, JS; Passani, MB; Sergeeva, OA; Yanovsky, Y; Yao, Q, 2011)	0.93
" Its inhibitory effect was dependent on the dosage and administration period."	( Anti-scratching behavioral effect of Lactobacillus plantarum PM008 isolated from kimchi in mice. Han, MJ; Hyun, YJ; Jang, SE; Kim, DH; Trinh, HT, 2011)	0.37
" Three injections all caused anaphylactoid symptoms in guinea pigs in different doses or injection speed and the response intensity was found to be dosage and injection speed dependant."	( [Effect of traditional Chinese medicine injections on type I allergy]. Huang, C; Li, H; Liu, J; Luo, X; Mei, X; Xu, J, 2011)	0.37
" Certain patient populations, such as children and pregnant or lactating women, require special consideration regarding antihistamine choice and dosing as part of rhinitis therapy."	( Antihistamine therapy in allergic rhinitis. Hoyte, FC; Katial, RK, 2011)	1.13
" Results included the provocative dose inducing a decrease in FEV1 by 15% (PD15 FEV1 ) and the dose-response slope."	( Bronchial hyperresponsiveness in an adult population in Helsinki: decreased FEV1 , the main determinant. Juusela, M; Lundbäck, B; Pallasaho, P; Piirilä, P; Sarna, S; Sovijärvi, A, 2013)	0.39
" First, the dose-response was investigated by assessing FBF throughout a dose-escalating histamine infusion."	( Histamine-induced vasodilatation in the human forearm vasculature. Bateman, DN; Crowe, J; Cuthbert, H; Eddleston, M; Jenkins, PJ; Johnston, NR; Sandilands, EA; Webb, DJ, 2013)	2.05
" In presence of 10 mM histamine the glycine dose-response curve was shifted, increasing the EC50 for glycine from 25."	( New insights in endogenous modulation of ligand-gated ion channels: histamine is an inverse agonist at strychnine sensitive glycine receptors. Gisselmann, G; Hatt, H; Kletke, O; Lorenz, P; Meier, JC; Oberland, S; Sergeeva, OA, 2013)	0.94
" These results suggest that double-dosed levocetirizine treatment suppresses histamine-induced skin symptoms more rapidly, profoundly and sustainably than conventionally dosed levocetirizine treatment."	( A double dose of levocetirizine leads to better control of histamine-induced flare, wheal and itch in healthy donors. Kabashima, K; Miyachi, Y; Nakahigashi, K; Nakamizo, S; Tanizaki, H, 2013)	0.86
"This work investigated the binding behavior of phenanthrene by humic acids (HA-2 and HA-5), proteins (bovine serum albumin (BSA)), lysozyme and pepsin), and their complexes using a passive dosing technique."	( Phenanthrene binding by humic acid-protein complexes as studied by passive dosing technique. Ghosh, S; Wang, Z; Xing, B; Zhao, J, 2014)	0.4
" In Experiment 2, histamine decreased cocaine's potency and effectiveness as a reinforcer in a dose-dependent manner as indicated by rightward and downward shifts, respectively, in the dose-response functions."	( Assessment of the effects of contingent histamine injections on the reinforcing effectiveness of cocaine using behavioral economic and progressive-ratio designs. Freeman, KB; McMaster, BC; Roma, PG; Woolverton, WL, 2014)	1
" The dose-response curve for ACh (0."	( In vitro study of acetylcholine and histamine induced contractions in colon and rectum of adult and neonate rats. Mandal, MB; Singh, S, )	0.41
" In addition, QKLI-induced histamine, VEGF, TNF-alpha release was measured after ICR mice received the single dosing of QKLI iv."	( [Experimental study on pseudoallergic reaction of Qingkailing injection]. Cui, HY; Li, CY; Li, GQ; Liang, AH; Wang, YT; Yi, Y; Zhang, YS; Zhao, Y, 2014)	0.7
" Extrapolation of the log dose-response curve was undertaken to calculate the concentration (provocation concentration, PC) causing an increase airways resistance of 20, 40, 60, 80, 100, 120, 140 and 160% (RInt PC1."	( Airways resistance in bronchial challenge testing. Baxter, MA; Coates, D; Wilson, AM, 2015)	0.42
"The pediatric dosage form of Egroferon--a drug indicated for the treatment of influenza and acute respiratory infections (ARIs)--is developed taking in account the broad range of pathogens (most of which are viruses), and age-dependent features of immune system reactions (absence of specific immunity and immunological memory, relative "immaturity" of immune reactions, reduced interferon production by immunocompetent cells, etc."	( [Ergoferon liquid dosage form--efficacious and safe treatment for childhood acute respiratory infections. Interim outcomes of a multi-center, randomized, double-blind, placebo-controlled clinical trial]. Bal'tserovich, NB; Galustian, AN; Geppe, NA; Kamaev, AV; Kondiurina, EG; Laléko, SL; Lazareva, SG; Mel'nikova, IM; Pak, TE; Perminova, OA; Sabitov, AU; Zhiglinskaia, OV, 2014)	0.4
" A dose-dependent relation between parasite liver load and histamine dosage was observed."	( Addition of histamine to subcutaneously injected Plasmodium berghei sporozoites increases the parasite liver load and could facilitate whole-parasite vaccination. Heine, JF; Mueller, AK; Pfeil, J, 2015)	1.04
" Indeed, histamine elicited a sigmoid dose-response curve for IP3 production, shifted to the right by chlorpheniramine maleate, and elicited a double bell-shaped curve for cAMP production, partially suppressed by the selective H2R, H3R and H4R antagonists when each added alone, and completely ablated when combined together."	( Histamine receptor expression in human renal tubules: a comparative pharmacological evaluation. Camussi, G; Chazot, PL; Grange, C; Lanzi, C; Moggio, A; Pini, A; Rosa, AC; Veglia, E, 2015)	2.28
"The allergen dose-response curve is flat; thus, small changes in wheal size reflect large differences in skin sensitivity."	( Evaluation of methods for the estimation of threshold concentrations by the skin prick test. Dreborg, S; Holgersson, M, 2015)	0.42
" Significant release of histamine was detected in blood samples taken 2min after dosing at the highest concentrations tested."	( Nonclinical evaluation of the potential for mast cell activation by an erythropoietin analog. Boyne, M; Chimalakonda, K; Howard, KE; Pang, E; Weaver, JL, 2015)	0.72
" We demonstrated that histaminergic activity was regulated by group II metabotropic glutamate receptors (mGluR 2 and 3) using systemic dosing with mGluR 2/3 agonist and antagonists and an mGluR 2 positive allosteric modulator."	( Glutamatergic regulation of brain histamine neurons: In vivo microdialysis and electrophysiology studies in the rat. Dijkman, U; Fell, MJ; Flik, G; Folgering, JH; Johnson, BJ; Perry, KW; Svensson, KA; Westerink, BH, 2015)	1.01
"To study the reservoir effect of topical steroids in a steroid-responsive condition which may enable a decrease in the dosing frequency of topical steroids."	( The reservoir effect of topical steroids in vitiliginous skin: A cross-sectional study. Nasir, F; Singh, SK, )	0.13
"Airway responsiveness to histamine, assessed as a dose-response slope (DRS), and a respiratory questionnaire were completed at 1, 6 and 12 months and 6, 11 and 18 years of age."	( Longitudinal assessment of airway responsiveness from 1 month to 18 years in the PIAF birth cohort. Cox, DW; Goldblatt, J; Hayden, CM; Landau, LI; Le Souëf, PN; Mullane, D; Turner, SW; Zhang, GC, 2015)	0.72
" Our work provides a delineation of molecular mechanisms underlying the widespread clinical association of antihistamines and GR agonists, which may contribute to future dosage optimization and reduction of well-described side effects associated with glucocorticoid administration."	( Effects of histamine H1 receptor signaling on glucocorticoid receptor activity. Role of canonical and non-canonical pathways. Davio, C; Fernández, N; Fitzsimons, CP; Granja-Galeano, G; Monczor, F; Shayo, C; Zappia, CD, 2015)	1.02
" The dosage of anti-histamines to control the symptoms was onefold the recommended dose in 51·6% of patients (16 patients), twofold in 32% (10 patients) and three-fourfold in 16·1% (five patients)."	( Idiopathic histaminergic angioedema without wheals: a case series of 31 patients. Boccon-Gibod, I; Bouillet, L; Chatain, C; Deroux, A; Dumestre Perard, C; Faisant, C; Mansard, C; Pralong, P, 2016)	1.15
"Adverse reactions of injectable drugs usually occur at first administration and are closely associated with the dosage and speed of injection."	( A Reliable Method for the Evaluation of the Anaphylactoid Reaction Caused by Injectable Drugs. Li, C; Peng, G; Wang, F; Weng, Z, 2016)	0.43
" In dose-response and time-course experiments, primary cultures of mast cells (bone marrow-derived mast cells and peritoneal cell-derived mast cells) generated from Plscr1-/- mice exhibited a reduced release of β-hexosaminidase upon FcεRI engagement as compared to their wild-type counterparts."	( Phospholipid scramblase 1 amplifies anaphylactic reactions in vivo. Benhamou, M; Blank, U; Charles, N; Coudrat, J; Kassas-Guediri, A; Launay, P; Monteiro, RC; Pacreau, E, 2017)	0.46
" However, the mechanisms and dose-response relationships are poorly understood."	( Effects of nebulised magnesium sulphate on inflammation and function of the guinea-pig airway. Broadley, KJ; Ford, WR; Kidd, EJ; Powell, C; Turner, DL, 2017)	0.46
" Using an in vitro experimental approach, the physiological role of the airway epithelium on smooth muscle relaxation has been investigated by analyzing the dose-response curves for carbachol- or histamine-induced contractions on epithelium intact versus denuded tracheal tissue."	( Relaxant effect of ghrelin on guinea pig isolated tracheal smooth muscle: role of epithelial NO and PGE Al-Ayed, MSZ, 2018)	0.67
", dose-response studies for various different ligands), the cost for the disposable electrode arrays as well as the available time resolution for sequential well-by-well recordings may become limiting."	( Stepwise Dosing Protocol for Increased Throughput in Label-Free Impedance-Based GPCR Assays. Bernhardt, G; Buschauer, A; Gmeiner, P; Huebner, H; Kade, C; Mildner, AK; Skiba, M; Stolwijk, JA; Wegener, J, 2020)	0.56
" The dose-response curves show an analytical range between 5 and 200 nM of histamine, corresponding to physiologically normal conditions while higher concentrations correlate with disease."	( Towards a catheter-based impedimetric sensor for the assessment of intestinal histamine levels in IBS patients. Cornelis, P; Doll, T; Peeters, M; Putzeys, T; Tack, J; Troost, F; Van de Cauter, L; Verhaert, N; Wackers, G; Wagner, P; Wübbenhorst, M, 2020)	1.02
" The patient was weaned off vasopressors, dosed famotidine and discharged 43 hours after fish ingestion with no symptoms and normal ECG."	( Severe scombroid poisoning and life-threatening hypotension. Carter, AC; Desai, S; Katugaha, SB; Soto, P, 2021)	0.62
" Recent advances in nanotechnology may be pivotal to generating muco-adhesive nanosystems, which is desirable to prolong local retention, reduce dosing frequency and relieve mucosal irritation."	( Chitosan-centered nanosystems as sustained therapeutics for allergic rhinitis intervention: Inhibition of histamine-induced cascades. Chen, X; Fan, P; Liu, Y; Qin, D; Sun, M, 2021)	0.83
" Food intolerance is an abnormal non-immunological response of the organism to the ingestion of food or its components in a dosage normally tolerated."	( Histamine Intolerance-The More We Know the Less We Know. A Review. Danis, R; Hrubisko, M; Huorka, M; Wawruch, M, 2021)	2.06
" The dose-response curves showed that the anticonvulsant activity of pitolisant changed in a dose-dependent manner."	( Anticonvulsant activity of the histamine H3 receptor inverse agonist pitolisant in an electrical kindling model of epilepsy. Beheshti, S; Wesal, MW, 2022)	1.01
" The significance for the out-patient clinic HS group, but not the population HS group may reflect a dose-response relationship."	( Decreased Arterial Vascular Tone in Small Arteries in Severe Hidradenitis Suppurativa - A Study Using Finger Photopulseplethysmography. Ahlehoff, O; E Jemec, GB; Ellervik, C; Miller, IM; Mogensen, UB; Rytgaard, H; Zarchi, K, 2022)	0.72
" All rats received the treatments orally for 14 days as follows; (1): distilled water, (2) HIS at a dosage level of 250 mg/kg BWT daily and (3) HIS at a dosage level of 1750 mg/kg BWT weekly."	( The potential mechanism of histamine-inducing cardiopulmonary inflammation and apoptosis in a novel oral model of rat intoxication. Hassanen, EI; Kamel, S; Mahmoud, MA; Mansour, HA; Mohamed, WA, 2023)	1.21
" These findings might help in the translation from animals to humans and in the selection of the optimal dosing of rhDAO_mHBM during human histamine challenge studies."	( Recombinant human diamine oxidase prevents hemodynamic effects of continuous histamine infusion in guinea pigs. Boehm, T; Gludovacz, E; Jilma, B; Rager-Resch, M; Reiter, B; Weiss-Tessbach, M, 2023)	1.34