Fatty acid-binding protein, adipocyte

A fatty acid-binding protein, adipocyte that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15090]

Synonyms

Adipocyte lipid-binding protein;
ALBP;
Adipocyte-type fatty acid-binding protein;
A-FABP;
AFABP;
Fatty acid-binding protein 4

Research

Bioassay Publications (13)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (30.77)	29.6817
2010's	6 (46.15)	24.3611
2020's	3 (23.08)	2.80

Compounds (11)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
palmitic acid	Homo sapiens (human)	IC50	0.9300	1	1
palmitic acid	Homo sapiens (human)	Ki	0.3360	1	1
1-anilino-8-naphthalenesulfonate	Homo sapiens (human)	Ki	1.0000	1	1
fenamic acid	Homo sapiens (human)	IC50	51.0000	1	1
fenamic acid	Homo sapiens (human)	Ki	50.6903	1	1
2-phenoxybenzoic acid	Homo sapiens (human)	Ki	500.0000	1	1
arachidonic acid	Homo sapiens (human)	IC50	2.7500	1	1
oleic acid	Homo sapiens (human)	IC50	26.1000	1	1
oleic acid	Homo sapiens (human)	Ki	0.8425	2	2
linoleic acid	Homo sapiens (human)	IC50	10.7667	3	3
linoleic acid	Homo sapiens (human)	Ki	6.8000	1	1
HTS 01037	Homo sapiens (human)	Ki	0.6700	1	1
bms 309403	Homo sapiens (human)	IC50	0.2210	1	1
bms 309403	Homo sapiens (human)	Ki	0.1096	6	6

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
palmitic acid	Homo sapiens (human)	Kd	83.0000	1	1
1-anilino-8-naphthalenesulfonate	Homo sapiens (human)	Kd	0.1500	1	1
stearic acid	Homo sapiens (human)	Kd	80.0000	1	1
arachidonic acid	Homo sapiens (human)	Kd	0.1800	1	1
elaidic acid	Homo sapiens (human)	Kd	58.0000	1	1
bms 309403	Homo sapiens (human)	Kd	1.1513	2	2

Enables

This protein enables 4 target(s):

Target	Category	Definition
long-chain fatty acid transmembrane transporter activity	molecular function	Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [ISBN:0198506732]
long-chain fatty acid binding	molecular function	Binding to a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:pm, PMID:12641450]
hormone receptor binding	molecular function	Binding to a receptor for a hormone. [GOC:ai]
fatty acid binding	molecular function	Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198506732]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
lipid droplet	cellular component	An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. [GOC:mah, GOC:tb]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Involved In

This protein is involved in 11 target(s):

Target	Category	Definition
response to bacterium	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. [GOC:hb]
long-chain fatty acid transport	biological process	The directed movement of a long-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:ai]
cholesterol homeostasis	biological process	Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators]
negative regulation of DNA-templated transcription	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of inflammatory response	biological process	Any process that activates or increases the frequency, rate or extent of the inflammatory response. [GOC:ai]
white fat cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. [PMID:12508945]
brown fat cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. [PMID:12588810]
cellular response to lithium ion	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. [GOC:mah]
cellular response to tumor necrosis factor	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. [GOC:mah]
positive regulation of cold-induced thermogenesis	biological process	Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809]
fatty acid transport	biological process	The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [GOC:ai]

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