A sarcoplasmic/endoplasmic reticulum calcium ATPase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14983]
SERCA1;
SR Ca(2+)-ATPase 1;
EC 7.2.2.10;
Calcium pump 1;
Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform;
Endoplasmic reticulum class 1/2 Ca(2+) ATPase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| chelerythrine | Homo sapiens (human) | IC50 | 27.0000 | 1 | 1 |
| thapsigargin | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| biselyngbyaside | Homo sapiens (human) | Ki | 0.0190 | 1 | 1 |
| alpha-cyclopiazonic acid | Homo sapiens (human) | Ki | 1.8000 | 1 | 1 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| P-type calcium transporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out). [RHEA:18105] |
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| ATP hydrolysis activity | molecular function | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065] |
| calcium-dependent ATPase activity | molecular function | Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+). [GOC:mah] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| sarcoplasmic reticulum | cellular component | A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage. [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684] |
| platelet dense tubular network membrane | cellular component | The lipid bilayer surrounding the platelet dense tubular network. [GOC:mah, PMID:1322202] |
| sarcoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the sarcoplasmic reticulum. [GOC:rph] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| calcium channel complex | cellular component | An ion channel complex through which calcium ions pass. [GOC:mah] |
This protein is involved in 19 target(s):
| Target | Category | Definition |
|---|---|---|
| calcium ion transport | biological process | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| apoptotic mitochondrial changes | biological process | The morphological and physiological alterations undergone by mitochondria during apoptosis. [GOC:mah, GOC:mtg_apoptosis] |
| positive regulation of fast-twitch skeletal muscle fiber contraction | biological process | Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction. [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] |
| positive regulation of endoplasmic reticulum calcium ion concentration | biological process | Any process that increases the concentration of calcium ions in the endoplasmic reticulum. [GOC:mah] |
| negative regulation of endoplasmic reticulum calcium ion concentration | biological process | Any process that decreases the concentration of calcium ions in the endoplasmic reticulum. [GOC:mah] |
| monoatomic ion transmembrane transport | biological process | A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:mah] |
| response to endoplasmic reticulum stress | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. [GOC:cjm, GOC:mah] |
| positive regulation of mitochondrial calcium ion concentration | biological process | Any process that increases the concentration of calcium ions in mitochondria. [GOC:ai] |
| maintenance of mitochondrion location | biological process | Any process in which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere. [GOC:ai, GOC:dph, GOC:tb] |
| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | biological process | The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. [GOC:mah, GOC:mtg_apoptosis, PMID:18701708] |
| calcium ion import | biological process | The directed movement of calcium ions into a cell or organelle. [GOC:mah] |
| relaxation of skeletal muscle | biological process | A process in which the extent of skeletal muscle tissue contraction is reduced. Muscle relaxation involves the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. [GOC:BHF, GOC:rl] |
| positive regulation of cardiac muscle cell contraction | biological process | Any process that activates or increases the frequency, rate or extent of cardiac muscle cell contraction. [PMID:19525381] |
| positive regulation of ATPase-coupled calcium transmembrane transporter activity | biological process | Any process that activates or increases the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671] |
| positive regulation of calcium ion import into sarcoplasmic reticulum | biological process | Any process that activates or increases the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590] |
| regulation of cardiac conduction | biological process | Any process that modulates the frequency, rate or extent of cardiac conduction. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] |
| calcium ion import into sarcoplasmic reticulum | biological process | The directed movement of calcium ions into a sarcoplasmic reticulum. [GOC:BHF, PMID:17286271] |
| calcium ion transmembrane transport | biological process | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah] |
| intracellular calcium ion homeostasis | biological process | A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell. [GOC:ceb, GOC:mah] |