Proteins > Histone deacetylase 3
Page last updated: 2024-08-07 15:23:25

Histone deacetylase 3

A histone deacetylase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15379]

Synonyms

HD3;
EC 3.5.1.98;
RPD3-2;
SMAP45

Research

Bioassay Publications (379)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (0.26)18.2507
2000's64 (16.89)29.6817
2010's221 (58.31)24.3611
2020's93 (24.54)2.80

Compounds (91)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gamma-aminobutyric acidHomo sapiens (human)Ki8.190011
butyric acidHomo sapiens (human)IC509.000011
butyric acidHomo sapiens (human)Ki136.000011
celecoxibHomo sapiens (human)IC501.637011
ci 994Homo sapiens (human)IC5020.71651121
ci 994Homo sapiens (human)Ki0.208824
clioquinolHomo sapiens (human)IC5071.0857114
valproic acidHomo sapiens (human)IC501,846.134055
valproic acidHomo sapiens (human)Ki564.000011
fluconazoleHomo sapiens (human)IC5040.000011
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamideHomo sapiens (human)IC500.833022
entinostatHomo sapiens (human)IC503.48385271
entinostatHomo sapiens (human)Ki0.730055
4-phenylbutyric acidHomo sapiens (human)IC50260.000011
4-phenylbutyric acidHomo sapiens (human)Ki2.800011
pomiferinHomo sapiens (human)IC501.050011
pyroxamideHomo sapiens (human)IC505.100022
pyroxamideHomo sapiens (human)Ki0.008011
suberoyl bis-hydroxamic acidHomo sapiens (human)IC5062.600011
suberoyl bis-hydroxamic acidHomo sapiens (human)Ki0.125011
scriptaidHomo sapiens (human)IC500.327455
scriptaidHomo sapiens (human)Ki0.004111
4-phenylbutyric acid, sodium saltHomo sapiens (human)Ki6.340011
fenofibrateHomo sapiens (human)IC5075.000022
fenofibrateHomo sapiens (human)Ki75.000011
vorinostatHomo sapiens (human)IC501.5944327365
vorinostatHomo sapiens (human)Ki0.321888
benzohydroxamic acidHomo sapiens (human)IC5039.701022
acetylcysteineHomo sapiens (human)IC503,160.000011
camptothecinHomo sapiens (human)IC500.050011
bendamustineHomo sapiens (human)IC500.010011
ubenimexHomo sapiens (human)IC50550.000022
osajinHomo sapiens (human)IC506.530011
lapatinibHomo sapiens (human)IC5055.000022
n-hydroxy-2,2-diphenylacetamideHomo sapiens (human)IC5038.650044
bortezomibHomo sapiens (human)IC501.180011
trapoxin aHomo sapiens (human)IC500.004733
e-z cinnamic acidHomo sapiens (human)Ki0.008211
trichostatin aHomo sapiens (human)IC500.33886080
trichostatin aHomo sapiens (human)Ki0.084466
caffeic acidHomo sapiens (human)IC502,540.000011
caffeic acidHomo sapiens (human)Ki10.840011
curcuminHomo sapiens (human)IC50187.000011
chlorogenic acidHomo sapiens (human)IC50258.333333
chlorogenic acidHomo sapiens (human)Ki0.135011
zd 6474Homo sapiens (human)IC5010.000033
desmethylanethol trithioneHomo sapiens (human)IC500.450022
5-chloro-7-[(4-ethyl-1-piperazinyl)-(3-pyridinyl)methyl]-8-quinolinolHomo sapiens (human)IC5025.195018
ex 527Homo sapiens (human)IC50100.000011
sodium butyrateHomo sapiens (human)IC50272.250044
sodium butyrateHomo sapiens (human)Ki365.000011
5'-o-caffeoylquinic acidHomo sapiens (human)IC50185.200022
harmineHomo sapiens (human)IC5010.000033
aureusidinHomo sapiens (human)IC5018.500011
romidepsinHomo sapiens (human)IC500.05891212
romidepsinHomo sapiens (human)Ki0.008433
carboxycinnamic acid bishydroxamideHomo sapiens (human)IC500.070011
3',4'-dihydroxyauroneHomo sapiens (human)IC508.200011
psammaplin aHomo sapiens (human)IC500.022133
trichostatin cHomo sapiens (human)IC5023.630011
laq824Homo sapiens (human)IC500.06071017
laq824Homo sapiens (human)Ki0.004222
indigo carmineHomo sapiens (human)IC50321.620022
tanespimycinHomo sapiens (human)IC501,000.000011
pd 404182Homo sapiens (human)IC5050.000011
tubacinHomo sapiens (human)IC501.190088
tubacinHomo sapiens (human)Ki0.409622
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetroneHomo sapiens (human)IC500.01511515
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetroneHomo sapiens (human)Ki0.000922
belinostatHomo sapiens (human)IC500.19421215
belinostatHomo sapiens (human)Ki0.007333
sk-7041Homo sapiens (human)IC500.172011
panobinostatHomo sapiens (human)IC500.20312533
panobinostatHomo sapiens (human)Ki0.001744
hdac-42Homo sapiens (human)IC500.158022
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideHomo sapiens (human)IC508.53431031
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideHomo sapiens (human)Ki0.250424
n1-(2-aminophenyl)-n7-phenylheptanediamideHomo sapiens (human)IC5026.046033
bml 210Homo sapiens (human)IC5044.99861010
n-(2-amino-5-fluorobenzyl)-4-(n-(pyridine-3-acrylyl)aminomethyl)benzamideHomo sapiens (human)IC5030.580266
givinostatHomo sapiens (human)IC500.136011
givinostatHomo sapiens (human)Ki0.003022
mocetinostatHomo sapiens (human)IC503.41801121
mocetinostatHomo sapiens (human)Ki0.265011
methyl 3,5-di-o-caffeoyl quinateHomo sapiens (human)IC506.290022
r 306465Homo sapiens (human)IC500.007522
quisinostatHomo sapiens (human)IC500.003966
quisinostatHomo sapiens (human)Ki0.003222
abexinostatHomo sapiens (human)IC500.148011
abexinostatHomo sapiens (human)Ki0.046738
chidamideHomo sapiens (human)IC501.612454
hc toxinHomo sapiens (human)IC500.430011
hc toxinHomo sapiens (human)Ki1.350011
azumamide eHomo sapiens (human)IC500.080011
azumamide eHomo sapiens (human)Ki0.025011
cnf 2024Homo sapiens (human)IC501.000022
N-(2-aminophenyl)-2-pyrazinecarboxamideHomo sapiens (human)IC500.381333
pci 34051Homo sapiens (human)IC5040.149588
cudc 101Homo sapiens (human)IC500.156174
largazoleHomo sapiens (human)IC500.724988
N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl esterHomo sapiens (human)IC500.250144
trichostatin rkHomo sapiens (human)IC50100.000011
jq1 compoundHomo sapiens (human)IC500.291011
tubastatin aHomo sapiens (human)IC5016.62382433
pracinostatHomo sapiens (human)IC500.098022
pracinostatHomo sapiens (human)Ki0.019011
acy-1215Homo sapiens (human)IC500.06301717
acy-1215Homo sapiens (human)Ki0.123011
cudc-907Homo sapiens (human)IC500.002966
rgfp966Homo sapiens (human)IC500.140044
rg2833Homo sapiens (human)IC500.061522
rg2833Homo sapiens (human)Ki0.005011
mi-192Homo sapiens (human)IC500.084033
acy-738Homo sapiens (human)IC500.218022
2-((1-(3-fluorophenyl)cyclohexyl)amino)-n-hydroxypyrimidine-5-carboxamideHomo sapiens (human)IC5011.223011
4-((1-butyl-3-phenylureido)methyl)-n-hydroxybenzamideHomo sapiens (human)IC504.219655
osimertinibHomo sapiens (human)IC501.000011
santacruzamate aHomo sapiens (human)IC505.000011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
bufexamacHomo sapiens (human)Kd341.000011
ci 994Homo sapiens (human)EC503.810011
entinostatHomo sapiens (human)EC501.000011
imatinibHomo sapiens (human)EC50100.000011
vorinostatHomo sapiens (human)EC502.819788
belinostatHomo sapiens (human)EC500.030022
panobinostatHomo sapiens (human)EC500.169511
kd 5170Homo sapiens (human)EC500.045011
cudc-907Homo sapiens (human)EC500.126211

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamideHomo sapiens (human)AC502.100011
pyroxamideHomo sapiens (human)AC507.900011
vorinostatHomo sapiens (human)AC503.100011
vorinostatHomo sapiens (human)INH0.188522
vorinostatHomo sapiens (human)Inhibition0.080011
trapoxin aHomo sapiens (human)AC500.010011
trichostatin aHomo sapiens (human)AC500.400011
trichostatin aHomo sapiens (human)Inhibition0.003511
romidepsinHomo sapiens (human)INH0.024411
largazoleHomo sapiens (human)INH0.572011

Enables

This protein enables 15 target(s):

TargetCategoryDefinition
transcription corepressor bindingmolecular functionBinding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. [GOC:krc]
chromatin bindingmolecular functionBinding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
transcription corepressor activitymolecular functionA transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
histone deacetylase activitymolecular functionCatalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. [PMID:9893272, RHEA:58196]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
enzyme bindingmolecular functionBinding to an enzyme, a protein with catalytic activity. [GOC:jl]
cyclin bindingmolecular functionBinding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. [GOC:ai]
chromatin DNA bindingmolecular functionBinding to DNA that is assembled into chromatin. [GOC:mah]
protein lysine deacetylase activitymolecular functionCatalysis of the reaction: H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]. [PMID:27296530, RHEA:58108]
histone deacetylase bindingmolecular functionBinding to histone deacetylase. [GOC:jl]
NF-kappaB bindingmolecular functionBinding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. [GOC:ai]
DNA-binding transcription factor bindingmolecular functionBinding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. [GOC:txnOH-2018]
protein decrotonylase activitymolecular functionCatalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]. [PMID:28497810, PMID:30279482, PMID:34608293]
histone decrotonylase activitymolecular functionCatalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] = (2E)-2-butenoate + L-lysyl-[histone]. [PMID:28497810]
protein de-2-hydroxyisobutyrylase activitymolecular functionCatalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]. [PMID:29192674]

Located In

This protein is located in 7 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
Golgi apparatuscellular componentA membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
mitotic spindlecellular componentA spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 2 target(s):

TargetCategoryDefinition
histone deacetylase complexcellular componentA protein complex that possesses histone deacetylase activity. [GOC:mah]
transcription repressor complexcellular componentA protein complex that possesses activity that prevents or downregulates transcription. [GOC:mah]

Involved In

This protein is involved in 27 target(s):

TargetCategoryDefinition
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
establishment of mitotic spindle orientationbiological processA cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. [GOC:ems]
in utero embryonic developmentbiological processThe process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. [GOC:go_curators, GOC:mtg_sensu]
positive regulation of protein phosphorylationbiological processAny process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
chromatin organizationbiological processThe assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. [PMID:20404130]
transcription by RNA polymerase IIbiological processThe synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382]
protein deacetylationbiological processThe removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. [GOC:ai]
regulation of mitotic cell cyclebiological processAny process that modulates the rate or extent of progress through the mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]
positive regulation of protein ubiquitinationbiological processAny process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah]
regulation of protein stabilitybiological processAny process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. [GOC:dph, GOC:mah, GOC:tb]
positive regulation of TOR signalingbiological processAny process that activates or increases the frequency, rate or extent of TOR signaling. [GOC:mah]
circadian regulation of gene expressionbiological processAny process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. [GOC:mah]
regulation of multicellular organism growthbiological processAny process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. [GOC:dph, GOC:ems, GOC:tb]
positive regulation of protein import into nucleusbiological processAny process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus. [GOC:jl]
regulation of circadian rhythmbiological processAny process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:dph, GOC:jl, GOC:tb]
negative regulation of apoptotic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of DNA-templated transcriptionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
negative regulation of JNK cascadebiological processAny process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]
spindle assemblybiological processThe aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]
establishment of skin barrierbiological processEstablishment of the epithelial barrier, the functional barrier in the skin that limits its permeability. [GOC:dph]
cellular response to fluid shear stressbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. [GOC:mah]
positive regulation of cold-induced thermogenesisbiological processAny process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809]
DNA repair-dependent chromatin remodelingbiological processA chromatin remodeling process that allows DNA repair enzyme to access genomic DNA and repair DNA lesions. [PMID:15528408, PMID:28053344, PMID:29095668, PMID:35689883]
cornified envelope assemblybiological processThe aggregation, arrangement and bonding together of a set of components to form a cornified envelope. [GO_REF:0000079, GOC:pm, GOC:TermGenie, PMID:22226963, PMID:24794495]
negative regulation of cardiac muscle cell differentiationbiological processAny process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation. [GOC:BHF]
epigenetic regulation of gene expressionbiological processA process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal. [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474]