Proteins > Enoyl-acyl-carrier protein reductase
Page last updated: 2024-08-07 13:41:36
Enoyl-acyl-carrier protein reductase
[no definition available]
Synonyms
Research
Bioassay Publications (12)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (75.00) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (20)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| triclosan | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.0872 | 8 | 8 |
| triclosan | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 0.0554 | 17 | 17 |
| vanillic acid | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 920.0000 | 1 | 1 |
| epigallocatechin gallate | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.2250 | 2 | 2 |
| epigallocatechin gallate | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 0.0910 | 3 | 3 |
| gallocatechol | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 7.0000 | 1 | 1 |
| gallocatechol | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 1.9225 | 3 | 3 |
| epicatechin gallate | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.3500 | 2 | 2 |
| epicatechin gallate | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 0.1363 | 3 | 3 |
| (-)-gallocatechin gallate | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.5000 | 1 | 1 |
| quercetin | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1.8333 | 3 | 3 |
| quercetin | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 0.5283 | 3 | 3 |
| apigenin | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 50.0000 | 1 | 1 |
| luteolin | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 2.0000 | 2 | 2 |
| luteolin | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 2.1000 | 1 | 1 |
| quercetin 3-o-methyl ether | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 35.2000 | 1 | 1 |
| kaempferol | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 20.0000 | 1 | 1 |
| butein | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 12.5000 | 1 | 1 |
| butein | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 2.8280 | 3 | 3 |
| fisetin | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1.0000 | 2 | 2 |
| 3-methylquercetin | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 5.0000 | 1 | 1 |
| morin | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 5.0000 | 1 | 1 |
| myricetin | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.4000 | 1 | 1 |
| corylin | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 58.9500 | 1 | 1 |
| 3,7-dihydroxyflavone | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 10.0000 | 1 | 1 |
| oroidin | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 0.6000 | 2 | 2 |
| (-)-catechin-3-O-gallate | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.3000 | 2 | 2 |
| (-)-catechin-3-O-gallate | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 0.0400 | 1 | 1 |
Methylenebissantin: a rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso.Journal of natural products, , Jun-24, Volume: 74, Issue:6, 2011
Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase.European journal of medicinal chemistry, , Volume: 44, Issue:7, 2009
Mass spectrometry-based systems approach for identification of inhibitors of Plasmodium falciparum fatty acid synthase.Antimicrobial agents and chemotherapy, , Volume: 51, Issue:7, 2007
X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.The Journal of biological chemistry, , Aug-31, Volume: 282, Issue:35, 2007
Discovery of a rhodanine class of compounds as inhibitors of Plasmodium falciparum enoyl-acyl carrier protein reductase.Journal of medicinal chemistry, , May-31, Volume: 50, Issue:11, 2007
Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR).Journal of medicinal chemistry, , Feb-22, Volume: 50, Issue:4, 2007
Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 16, Issue:8, 2006
Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 15, Issue:23, 2005
Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR).Journal of medicinal chemistry, , Feb-22, Volume: 50, Issue:4, 2007
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.Journal of medicinal chemistry, , Jun-01, Volume: 49, Issue:11, 2006
Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR).Journal of medicinal chemistry, , Feb-22, Volume: 50, Issue:4, 2007
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.Journal of medicinal chemistry, , Jun-01, Volume: 49, Issue:11, 2006
Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 20, Issue:16, 2010
Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR).Journal of medicinal chemistry, , Feb-22, Volume: 50, Issue:4, 2007
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.Journal of medicinal chemistry, , Jun-01, Volume: 49, Issue:11, 2006
Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 20, Issue:16, 2010
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.Journal of medicinal chemistry, , Jun-01, Volume: 49, Issue:11, 2006
Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 20, Issue:16, 2010
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.Journal of medicinal chemistry, , Jun-01, Volume: 49, Issue:11, 2006
Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 20, Issue:16, 2010
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.Journal of medicinal chemistry, , Jun-01, Volume: 49, Issue:11, 2006