Proteins > Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Page last updated: 2024-08-07 15:50:51
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
An enoyl-[acyl-carrier-protein] reductase [NADH] FabI that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0AEK4]
Synonyms
ENR;
EC 1.3.1.9;
NADH-dependent enoyl-ACP reductase
Research
Bioassay Publications (9)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
Compounds (12)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| xanthorrhizol | Escherichia coli K-12 | Km | 2.1000 | 2 | 2 |
Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.Journal of natural products, , Jun-28, Volume: 76, Issue:6, 2013
From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK.Bioorganic & medicinal chemistry, , Dec-01, Volume: 15, Issue:23, 2007
Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK.Journal of medicinal chemistry, , Apr-24, Volume: 46, Issue:9, 2003
Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents.Bioorganic & medicinal chemistry letters, , Sep-03, Volume: 11, Issue:17, 2001
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).Bioorganic & medicinal chemistry letters, , Aug-20, Volume: 11, Issue:16, 2001
The food-grade antimicrobial xanthorrhizol targets the enoyl-ACP reductase (FabI) in Escherichia coli.Bioorganic & medicinal chemistry letters, , 12-15, Volume: 30, Issue:24, 2020
Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR).Journal of medicinal chemistry, , Feb-22, Volume: 50, Issue:4, 2007