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Histamine H1 receptor
[no definition available]
Synonyms
H1R;
HH1R
Research
Bioassay Publications (35)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (5.71) | 18.7374 |
| 1990's | 12 (34.29) | 18.2507 |
| 2000's | 11 (31.43) | 29.6817 |
| 2010's | 8 (22.86) | 24.3611 |
| 2020's | 2 (5.71) | 2.80 |
Compounds (60)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.Bioorganic & medicinal chemistry letters, , Sep-22, Volume: 8, Issue:18, 1998
Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole.Journal of medicinal chemistry, , Jan-20, Volume: 38, Issue:2, 1995
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity, and oral activity.Journal of medicinal chemistry, , Jul-07, Volume: 38, Issue:14, 1995
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function bJournal of medicinal chemistry, , Apr-09, Volume: 41, Issue:8, 1998
Alkyl derivatives of 1,3,5-triazine as histamine HBioorganic & medicinal chemistry, , 04-01, Volume: 27, Issue:7, 2019
A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.The Journal of pharmacology and experimental therapeutics, , Volume: 309, Issue:1, 2004
Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]Journal of medicinal chemistry, , Nov-21, Volume: 40, Issue:24, 1997
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.Journal of medicinal chemistry, , Aug-12, Volume: 42, Issue:16, 1999
Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]Journal of medicinal chemistry, , Nov-21, Volume: 40, Issue:24, 1997
Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]Journal of medicinal chemistry, , Nov-21, Volume: 40, Issue:24, 1997
N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists.Journal of medicinal chemistry, , Mar-23, Volume: 43, Issue:6, 2000
N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists.Journal of medicinal chemistry, , Dec-04, Volume: 46, Issue:25, 2003
Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists.Journal of medicinal chemistry, , Mar-23, Volume: 43, Issue:6, 2000