ketoconazole has been researched along with Necrosis in 12 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Preincubation of cells with an anti-MDR1 monoclonal antibody prior to the drug treatment, coincubation of cells with a potent CYP3A4 inhibitor--ketoconazole--or with both compounds increased Taxol toxicity and proapoptotic activity, indicating that the P-glycoprotein system has a major role in Taxol disposition in hepatoblastoma cells." | 3.72 | Threshold for antiproliferative and proapoptotic activity of ttaxol in HepG2 cells expressing human CYP3A4: effect of P-glycoprotein transporters. ( Cederbaum, AI; Holownia, A, 2003) |
| "Blastomycosis is an unusual but significant pathogen which occasionally presents with genitourinary tract involvement." | 2.40 | Blastomycosis of the epididymis and prostate. ( Oyasu, R; Schaeffer, A; Seo, R, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Periasamy, S | 1 |
| Liu, CT | 1 |
| Chien, SP | 1 |
| Chen, YC | 1 |
| Liu, MY | 1 |
| Ly, VT | 1 |
| Brock, B | 1 |
| Holownia, A | 1 |
| Cederbaum, AI | 1 |
| Chien, RN | 1 |
| Sheen, IS | 1 |
| Liaw, YF | 1 |
| Kolts, BE | 1 |
| Langfitt, M | 1 |
| Seo, R | 1 |
| Oyasu, R | 1 |
| Schaeffer, A | 1 |
| Findor, JA | 1 |
| Sorda, JA | 1 |
| Igartua, EB | 1 |
| Avagnina, A | 1 |
| Van Puijenbroek, EP | 1 |
| Metselaar, HJ | 1 |
| Berghuis, PH | 1 |
| Zondervan, PE | 1 |
| Stricker, BH | 1 |
| Niimi, T | 1 |
| Kajita, M | 1 |
| Saito, H | 1 |
| De Beule, K | 1 |
| De Doncker, P | 1 |
| Cauwenbergh, G | 1 |
| Koster, M | 1 |
| Legendre, R | 1 |
| Blatchford, N | 1 |
| Daunas, J | 1 |
| Chwetzoff, E | 1 |
| Kendrey, G | 1 |
| Kovács, M | 1 |
| Krivoy, N | 1 |
| Bassan, L | 1 |
1 review available for ketoconazole and Necrosis
| Article | Year |
|---|---|
Blastomycosis of the epididymis and prostate.
Topics: Adult; Antifungal Agents; Blastomycosis; Epididymis; Humans; Ketoconazole; Male; Necrosis; Prostate; | 1997 |
1 trial available for ketoconazole and Necrosis
| Article | Year |
|---|---|
The treatment of aspergillosis and aspergilloma with itraconazole, clinical results of an open international study (1982-1987).
Topics: Aspergillosis; Aspergillosis, Allergic Bronchopulmonary; Chronic Disease; Clinical Trials as Topic; | 1988 |
10 other studies available for ketoconazole and Necrosis
| Article | Year |
|---|---|
Daily sesame oil supplementation mitigates ketoconazole-induced oxidative stress-mediated apoptosis and hepatic injury.
Topics: Animals; Antifungal Agents; Antioxidants; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Inj | 2016 |
Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices.
Topics: Adenosine Triphosphate; Animals; Aspartate Aminotransferases; Benzopyrans; Chromatography, High Pres | 2011 |
Threshold for antiproliferative and proapoptotic activity of ttaxol in HepG2 cells expressing human CYP3A4: effect of P-glycoprotein transporters.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member | 2003 |
Unintentional rechallenge resulting in a causative relationship between ketoconazole and acute liver injury.
Topics: Acute Disease; Antifungal Agents; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Female; Hu | 2003 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
Ketoconazole-induced liver damage.
Topics: Adult; Aged; Antifungal Agents; Chemical and Drug Induced Liver Injury; Fatal Outcome; Female; Human | 1998 |
[Acute hepatocytic necrosis during ketoconazole therapy for treatment of onychomycosis. National Foundation for Registry and Evaluation of Adverse Effects].
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Antifungal Agents; Chemical and Dr | 1998 |
Necrotizing bronchial aspergillosis in a patient receiving neoadjuvant chemotherapy for non-small cell lung carcinoma.
Topics: Aged; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Aspergillosis; Aspergillus | 1991 |
[Histopathologic observations on acute liver lesions in patients taking Nizoralt (ketokonazol)].
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole; Liver; Liver Cirrhosis; | 1988 |
[Ketoconazole-induced acute liver necrosis].
Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole; Liver; Middle Aged; Necrosis | 1986 |