A tyrosine-protein phosphatase non-receptor type 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17706]
EC 3.1.3.48;
T-cell protein-tyrosine phosphatase;
TCPTP
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (12.90) | 29.6817 |
| 2010's | 23 (74.19) | 24.3611 |
| 2020's | 4 (12.90) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 5-iodo-2-(oxaloamino)benzoic acid | Homo sapiens (human) | Ki | 14.0000 | 1 | 1 |
| lithocholic acid | Homo sapiens (human) | IC50 | 13.2850 | 2 | 2 |
| glycyrrhetinic acid | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| oleanolic acid | Homo sapiens (human) | IC50 | 10.7900 | 18 | 19 |
| vanadates | Homo sapiens (human) | IC50 | 22.5633 | 1 | 3 |
| ursolic acid | Homo sapiens (human) | IC50 | 4.1433 | 3 | 3 |
| madecassic acid | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| maslinic acid | Homo sapiens (human) | IC50 | 19.4700 | 1 | 1 |
| geniposide | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| asiatic acid | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| celastrol | Homo sapiens (human) | IC50 | 20.9000 | 2 | 2 |
| cryptotanshinone | Homo sapiens (human) | IC50 | 55.7000 | 1 | 1 |
| boswellic acid | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| procurcumenol | Homo sapiens (human) | IC50 | 26.8000 | 1 | 1 |
| pinocembrin | Homo sapiens (human) | IC50 | 36.7300 | 1 | 1 |
| genipin | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| 2-(oxaloamino)benzoic acid | Homo sapiens (human) | Ki | 23.0000 | 1 | 1 |
| chlorogenic acid | Homo sapiens (human) | IC50 | 77.9000 | 1 | 1 |
| tocopherylquinone | Homo sapiens (human) | IC50 | 35.0900 | 1 | 1 |
| illudalic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| eupatoriopicrine | Homo sapiens (human) | IC50 | 28.0000 | 1 | 1 |
| 2-amino-6-chloropurine | Homo sapiens (human) | IC50 | 75.9400 | 1 | 5 |
| corosolic acid | Homo sapiens (human) | IC50 | 11.3100 | 1 | 1 |
| 11-keto-boswellic acid | Homo sapiens (human) | IC50 | 9.4500 | 1 | 1 |
| 3-epioleanolic acid | Homo sapiens (human) | IC50 | 5.1000 | 1 | 1 |
| oleanonic acid | Homo sapiens (human) | IC50 | 5.6300 | 1 | 1 |
| zedoarondiol | Homo sapiens (human) | IC50 | 15.7000 | 1 | 1 |
| formylchromone | Homo sapiens (human) | Ki | 27.6500 | 2 | 2 |
| rk 682 | Homo sapiens (human) | IC50 | 5.1000 | 1 | 1 |
| variabilin | Homo sapiens (human) | IC50 | 0.8000 | 1 | 1 |
This protein enables 8 target(s):
| Target | Category | Definition |
|---|---|---|
| protein tyrosine phosphatase activity | molecular function | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48] |
| integrin binding | molecular function | Binding to an integrin. [GOC:ceb] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| protein kinase binding | molecular function | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl] |
| syntaxin binding | molecular function | Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. [ISBN:0198506732] |
| receptor tyrosine kinase binding | molecular function | Binding to a receptor that possesses protein tyrosine kinase activity. [GOC:mah] |
| STAT family protein binding | molecular function | Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses. [GOC:mr, InterPro:IPR001217, PMID:21447371, PMID:24470978] |
| non-membrane spanning protein tyrosine phosphatase activity | molecular function | Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. [EC:3.1.3.48] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| endoplasmic reticulum-Golgi intermediate compartment | cellular component | A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. [GOC:pr, PMID:16723730] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| endosome lumen | cellular component | The volume enclosed by the membrane of an endosome. [GOC:mah] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
This protein is involved in 33 target(s):
| Target | Category | Definition |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |
| negative regulation of cell population proliferation | biological process | Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators] |
| insulin receptor signaling pathway | biological process | The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. [GOC:ceb] |
| negative regulation of tumor necrosis factor-mediated signaling pathway | biological process | Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. [GOC:dph, GOC:tb] |
| negative regulation of lipid storage | biological process | Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:BHF, GOC:dph, GOC:tb] |
| B cell differentiation | biological process | The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. [GO_REF:0000022, GOC:mah] |
| T cell differentiation | biological process | The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. [GO_REF:0000022, GOC:jid, GOC:mah] |
| erythrocyte differentiation | biological process | The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. [GOC:mah] |
| peptidyl-tyrosine dephosphorylation | biological process | The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. [GOC:bf] |
| insulin receptor recycling | biological process | The process that results in the return of an insulin receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive an insulin signal. Internalized insulin receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation. [GOC:bf, GOC:signaling, PMID:3907718] |
| negative regulation of epidermal growth factor receptor signaling pathway | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. [GOC:go_curators] |
| negative regulation of tyrosine phosphorylation of STAT protein | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. [GOC:jl, PMID:11426647] |
| glucose homeostasis | biological process | Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators] |
| negative regulation of macrophage differentiation | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation. [GOC:go_curators] |
| positive regulation of gluconeogenesis | biological process | Any process that activates or increases the frequency, rate or extent of gluconeogenesis. [GOC:go_curators] |
| negative regulation of insulin receptor signaling pathway | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling. [GOC:bf] |
| negative regulation of inflammatory response | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. [GOC:ai] |
| negative regulation of T cell receptor signaling pathway | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. [GOC:ai] |
| negative regulation of chemotaxis | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. [GOC:ai] |
| regulation of type II interferon-mediated signaling pathway | biological process | Any process that modulates the rate, frequency or extent of an interferon-gamma-mediated signaling pathway. [GOC:dph] |
| negative regulation of type II interferon-mediated signaling pathway | biological process | Any process that decreases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway. [GOC:dph] |
| negative regulation of type I interferon-mediated signaling pathway | biological process | Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. [GOC:dph] |
| negative regulation of interleukin-6-mediated signaling pathway | biological process | Any process that decreases the rate, frequency or extent of an interleukin-6-mediated signaling pathway. [GOC:BHF, GOC:mah] |
| negative regulation of ERK1 and ERK2 cascade | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986] |
| regulation of hepatocyte growth factor receptor signaling pathway | biological process | Any process that modulates the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway. [GOC:TermGenie, PMID:18819921] |
| negative regulation of interleukin-2-mediated signaling pathway | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2-mediated signaling pathway. [GOC:TermGenie, PMID:11909529] |
| negative regulation of interleukin-4-mediated signaling pathway | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-4-mediated signaling pathway. [GOC:TermGenie, PMID:17210636] |
| negative regulation of macrophage colony-stimulating factor signaling pathway | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway. [GOC:TermGenie, PMID:16705167] |
| negative regulation of positive thymic T cell selection | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of positive thymic T cell selection. [GOC:TermGenie, PMID:22080863] |
| positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | biological process | Any process that activates or increases the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352] |
| positive regulation of PERK-mediated unfolded protein response | biological process | Any process that activates or increases the frequency, rate or extent of the PERK-mediated unfolded protein response. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] |
| negative regulation of platelet-derived growth factor receptor-beta signaling pathway | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway. [GOC:obol] |
| negative regulation of receptor signaling pathway via JAK-STAT | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT. [GOC:bf] |