Page last updated: 2024-08-07 21:13:40
Aldehyde oxidase
An aldehyde oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q06278]
Synonyms
EC 1.2.3.1;
Aldehyde oxidase 1;
Azaheterocycle hydroxylase;
1.17.3.-
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
Compounds (18)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| benzamidine | Homo sapiens (human) | Kii | 1,620.0000 | 1 | 1 |
| benzamidine | Homo sapiens (human) | Kis | 1,240.0000 | 1 | 1 |
| raloxifene | Homo sapiens (human) | Kii | 0.0070 | 1 | 1 |
| thioridazine | Homo sapiens (human) | Kii | 1.3000 | 1 | 1 |
| thioridazine | Homo sapiens (human) | Kis | 1.3000 | 1 | 1 |
Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case.Journal of medicinal chemistry, , 09-09, Volume: 64, Issue:17, 2021
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.Journal of agricultural and food chemistry, , May-11, Volume: 59, Issue:9, 2011
Aldehyde oxidase: an enzyme of emerging importance in drug discovery.Journal of medicinal chemistry, , Dec-23, Volume: 53, Issue:24, 2010
Enables
This protein enables 9 target(s):
| Target | Category | Definition |
|---|
| aldehyde oxidase activity | molecular function | Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide. [EC:1.2.3.1] |
| iron ion binding | molecular function | Binding to an iron (Fe) ion. [GOC:ai] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| molybdopterin cofactor binding | molecular function | Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. [ISSN:09498257] |
| flavin adenine dinucleotide binding | molecular function | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732] |
| NAD binding | molecular function | Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. [GOC:ai] |
| 2 iron, 2 sulfur cluster binding | molecular function | Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] |
| FAD binding | molecular function | Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:mah] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Involved In
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|
| lipid metabolic process | biological process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma] |
| xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |