A programmed cell death protein 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q15116]
Protein PD-1;
hPD-1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (100.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| sesamin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| pomalidomide | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| apiin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| fosbretabulin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| signaling receptor activity | molecular function | Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| external side of plasma membrane | cellular component | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
This protein is involved in 12 target(s):
| Target | Category | Definition |
|---|---|---|
| B cell apoptotic process | biological process | Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. [CL:0000236, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149] |
| adaptive immune response | biological process | An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149] |
| negative regulation of tolerance induction | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction. [GOC:add] |
| negative regulation of T cell mediated immune response to tumor cell | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell. [GOC:add] |
| negative regulation of B cell apoptotic process | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process. [GOC:add, GOC:mtg_apoptosis] |
| apoptotic process | biological process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] |
| humoral immune response | biological process | An immune response mediated through a body fluid. [GOC:hb, ISBN:0198506732] |
| negative regulation of immune response | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. [GOC:ai] |
| negative regulation of T cell activation | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation. [GOC:ai] |
| regulatory T cell apoptotic process | biological process | Any apoptotic process in a regulatory T cell. [GOC:nhn, GOC:TermGenie, PMID:20471291] |
| regulation of immune response | biological process | Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. [GOC:ai] |
| positive regulation of T cell apoptotic process | biological process | Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] |