Proteins > Sodium/potassium-transporting ATPase subunit beta-2
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Sodium/potassium-transporting ATPase subunit beta-2
A sodium/potassium-transporting ATPase subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14415]
Synonyms
Adhesion molecule in glia;
AMOG;
Sodium/potassium-dependent ATPase subunit beta-2
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (12)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ouabain | Homo sapiens (human) | LC50 | 9.4000 | 1 | 1 |
Gombamide A, a cyclic thiopeptide from the sponge Clathria gombawuiensis.Journal of natural products, , Jul-26, Volume: 76, Issue:7, 2013
Sesterterpenes from the tropical sponge Coscinoderma sp.Journal of natural products, , Aug-26, Volume: 74, Issue:8, 2011
Synthesis and evaluation of panaxatriol derivatives as NaBioorganic & medicinal chemistry letters, , 09-15, Volume: 28, Issue:17, 2018
Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds.Journal of medicinal chemistry, , Aug-14, Volume: 46, Issue:17, 2003
Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds.Journal of medicinal chemistry, , Aug-14, Volume: 46, Issue:17, 2003
Synthesis and inotropic activity of 1-(O-aminoalkyloximes) of perhydroindene derivatives as simplified digitalis-like compounds acting on the Na(+),K(+)-ATPase.Journal of medicinal chemistry, , Jan-03, Volume: 45, Issue:1, 2002
17 alpha-O-(aminoalkyl)oxime derivatives of 3 beta,14 beta-dihydroxy-5 beta-androstane and 3 beta-hydroxy-14-oxoseco-D-5 beta-androstane as inhibitors of Na(+),K(+)-ATPase at the digitalis receptor.Journal of medicinal chemistry, , Nov-08, Volume: 44, Issue:23, 2001
Synthesis of 20-hydroxy-, 20-amino-, and 20-nitro-14-hydroxy-21-nor-5 beta,14 beta-pregnane C-3 glycosides and related derivatives: structure-activity relationships of pregnanes that bind to the digitalis receptor.Journal of medicinal chemistry, , Jan-08, Volume: 36, Issue:1, 1993
Cardiac glycosides. 7. Sugar stereochemistry and cardiac glycoside activity.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|
| ATPase activator activity | molecular function | Binds to and increases the activity of an ATP hydrolysis activity. [GOC:ajp] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| protein-macromolecule adaptor activity | molecular function | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. [GOC:bf, GOC:mah, GOC:vw] |
| protein heterodimerization activity | molecular function | Binding to a nonidentical protein to form a heterodimer. [GOC:ai] |
| ATPase binding | molecular function | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. [GOC:ai] |
Located In
This protein is located in 13 target(s):
| Target | Category | Definition |
|---|
| photoreceptor inner segment | cellular component | The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. [GOC:add, PMID:12019563] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| external side of plasma membrane | cellular component | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
| lateral plasma membrane | cellular component | The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. [GOC:hb, GOC:mah, GOC:pr] |
| cell projection membrane | cellular component | The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. [GOC:krc, GOC:mah] |
| cell body membrane | cellular component | The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections. [GOC:ecd] |
| cell periphery | cellular component | The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. [GOC:pdt] |
| astrocyte projection | cellular component | A prolongation or process extending from the soma of an astrocyte and wrapping around neurons. [NIF_Subcellular:sao1630537580] |
| astrocyte end-foot | cellular component | Terminal process of astrocyte abutting non-neuronal surfaces in the brain. [NIF_Subcellular:sao388182739] |
| neuron to neuron synapse | cellular component | A synapse in which pre and post-synaptic cells are neurons. [GOC:dos] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| sodium:potassium-exchanging ATPase complex | cellular component | Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. [ISBN:0198506732] |
Involved In
This protein is involved in 15 target(s):
| Target | Category | Definition |
|---|
| intracellular sodium ion homeostasis | biological process | A homeostatic process involved in the maintenance of a steady state level of sodium ions within a cell. [GOC:ai, GOC:mah] |
| positive regulation of neuron projection development | biological process | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:dph, GOC:tb] |
| intracellular potassium ion homeostasis | biological process | A homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell. [GOC:mah] |
| cell-substrate adhesion | biological process | The attachment of a cell to the underlying substrate via adhesion molecules. [GOC:mah, GOC:pf] |
| positive regulation of ATP-dependent activity | biological process | Any process that activates or increases the rate of an ATP-dependent activity. [GOC:mah] |
| sodium ion export across plasma membrane | biological process | The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:14674689] |
| protein stabilization | biological process | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai] |
| membrane repolarization | biological process | The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| cell communication by electrical coupling involved in cardiac conduction | biological process | The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| transport across blood-brain barrier | biological process | The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008] |
| positive regulation of potassium ion transmembrane transporter activity | biological process | Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity. [GOC:BHF, GOC:TermGenie] |
| positive regulation of sodium ion export across plasma membrane | biological process | Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720] |
| positive regulation of potassium ion import across plasma membrane | biological process | Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900] |
| negative regulation of glial cell migration | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] |
| potassium ion import across plasma membrane | biological process | The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. [PMID:9139127] |