4-aminopyridine has been researched along with Necrosis in 4 studies
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Morphological aspects of the formation and fate of neurons that underwent dramatic ultrastructural compaction ("dark" neurons) induced by 4-aminopyridine epilepsy were compared in an excitotoxic and a neighboring normal-looking area of the rat brain cortex." | 3.74 | The mode of death of epilepsy-induced "dark" neurons is neither necrosis nor apoptosis: an electron-microscopic study. ( Baracskay, P; Czurkó, A; Gallyas, F; Juhász, G; Kiglics, V, 2008) |
| " There is a great controversy around the use of this drug because of its narrow safety index and because a large number of adverse effects have been reported." | 1.40 | Liver and kidney damage induced by 4-aminopyridine in a repeated dose (28 days) oral toxicity study in rats: gene expression profile of hybrid cell death. ( Capo, MA; Del Pino, J; Díaz, MJ; Frejo, MT; García, J; Lobo, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Frejo, MT | 1 |
| Del Pino, J | 1 |
| Lobo, M | 1 |
| García, J | 1 |
| Capo, MA | 1 |
| Díaz, MJ | 1 |
| Díaz, P | 1 |
| Sibley, CP | 1 |
| Greenwood, SL | 1 |
| Gallyas, F | 1 |
| Kiglics, V | 1 |
| Baracskay, P | 1 |
| Juhász, G | 1 |
| Czurkó, A | 1 |
| Inoue, H | 1 |
| Okada, Y | 1 |
4 other studies available for 4-aminopyridine and Necrosis
| Article | Year |
|---|---|
Liver and kidney damage induced by 4-aminopyridine in a repeated dose (28 days) oral toxicity study in rats: gene expression profile of hybrid cell death.
Topics: 4-Aminopyridine; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Apoptosi | 2014 |
Oxygen-Sensitive K+ Channels Modulate Human Chorionic Gonadotropin Secretion from Human Placental Trophoblast.
Topics: 4-Aminopyridine; Chorionic Gonadotropin; Chorionic Villi; Female; Humans; Hydrogen Peroxide; L-Lacta | 2016 |
The mode of death of epilepsy-induced "dark" neurons is neither necrosis nor apoptosis: an electron-microscopic study.
Topics: 4-Aminopyridine; Animals; Apoptosis; Brain; Cell Death; Cell Survival; Cerebral Cortex; Epilepsy; Ma | 2008 |
Roles of volume-sensitive chloride channel in excitotoxic neuronal injury.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Apoptosis; Benzothiadiazines; Bicuculline; Bu | 2007 |