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Lysosomal alpha-glucosidase
A lysosomal alpha-glucosidase that is encoded in the genome of rat. [OMA:Q6P7A9, PRO:DNx]
Synonyms
EC 3.2.1.20;
Acid maltase
Research
Bioassay Publications (27)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (14.81) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 17 (62.96) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
Compounds (26)
Drugs with Inhibition Measurements
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica.Journal of natural products, , Volume: 65, Issue:12, 2002
N-Butyl-l-deoxynojirimycin (l-NBDNJ): Synthesis of an Allosteric Enhancer of α-Glucosidase Activity for the Treatment of Pompe Disease.Journal of medicinal chemistry, , 12-14, Volume: 60, Issue:23, 2017
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Design, synthesis and glycosidase inhibition of C-4 branched LAB and DAB derivatives.European journal of medicinal chemistry, , Apr-05, Volume: 233, 2022
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Revised structure of a homonojirimycin isomer from Aglaonema treubii: first example of a naturally occurring alpha-homoallonojirimycin.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 9, Issue:21, 1999
Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases.Journal of medicinal chemistry, , Jul-02, Volume: 41, Issue:14, 1998
Synthesis and biological evaluation of α-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class of α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Synthesis and biological evaluation of α-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class of α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Biological evaluation of 3'-O-alkylated analogs of salacinol, the role of hydrophobic alkyl group at 3' position in the side chain on the α-glucosidase inhibitory activity.Bioorganic & medicinal chemistry letters, , May-15, Volume: 21, Issue:10, 2011
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
New arylalkanones from Horsfieldia macrobotrys, effective antidiabetic agents concomitantly inhibiting α-glucosidase and free radicals.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 25, Issue:20, 2015
Polyketides with α-Glucosidase Inhibitory Activity from a Mangrove Endophytic Fungus, Penicillium sp. HN29-3B1.Journal of natural products, , Aug-28, Volume: 78, Issue:8, 2015
Synthesis and biological evaluation of α-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class of α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
Synthesis and α-glucosidase inhibitory activity evaluation of N-substituted aminomethyl-β-d-glucopyranosides.Bioorganic & medicinal chemistry, , Sep-01, Volume: 21, Issue:17, 2013
Quercitylcinnamates, a new series of antidiabetic bioconjugates possessing α-glucosidase inhibition and antioxidant.European journal of medicinal chemistry, , Volume: 66, 2013
A new series of N2-substituted-5-(p-toluenesulfonylamino)phthalimide analogues as α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 23, Issue:7, 2013
Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii.Bioorganic & medicinal chemistry, , Jan-15, Volume: 20, Issue:2, 2012
Concise synthesis of (+)-conduritol F and inositol analogues from naturally available (+)-proto-quercitol and their glucosidase inhibitory activity.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 22, Issue:4, 2012
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of α-glucosidase inhibitors.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 21, Issue:2, 2011
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Biological evaluation of 3'-O-alkylated analogs of salacinol, the role of hydrophobic alkyl group at 3' position in the side chain on the α-glucosidase inhibitory activity.Bioorganic & medicinal chemistry letters, , May-15, Volume: 21, Issue:10, 2011
Selective α-glucosidase substrates and inhibitors containing short aromatic peptidyl moieties.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 21, Issue:8, 2011
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease.European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
Design, synthesis and glycosidase inhibition of C-4 branched LAB and DAB derivatives.European journal of medicinal chemistry, , Apr-05, Volume: 233, 2022
New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii.Journal of natural products, , Volume: 65, Issue:2, 2002
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor. Part 2.Bioorganic & medicinal chemistry, , Nov-01, Volume: 20, Issue:21, 2012
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Biological evaluation of 3'-O-alkylated analogs of salacinol, the role of hydrophobic alkyl group at 3' position in the side chain on the α-glucosidase inhibitory activity.Bioorganic & medicinal chemistry letters, , May-15, Volume: 21, Issue:10, 2011
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata WIGHT).Journal of natural products, , Volume: 71, Issue:6, 2008
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor. Part 2.Bioorganic & medicinal chemistry, , Nov-01, Volume: 20, Issue:21, 2012
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor.Bioorganic & medicinal chemistry, , Apr-01, Volume: 19, Issue:7, 2011
Alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata WIGHT).Journal of natural products, , Volume: 71, Issue:6, 2008
Biological evaluation of 3'-O-alkylated analogs of salacinol, the role of hydrophobic alkyl group at 3' position in the side chain on the α-glucosidase inhibitory activity.Bioorganic & medicinal chemistry letters, , May-15, Volume: 21, Issue:10, 2011
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011