Page last updated: 2024-08-07 16:55:47
Cathepsin D
[no definition available]
Synonyms
EC 3.4.23.5
Research
Bioassay Publications (10)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 6 (60.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| thioridazine | Bos taurus (cattle) | IC50 | 0.0600 | 1 | 1 |
| enalkiren | Bos taurus (cattle) | IC50 | 50.5000 | 2 | 2 |
| terlakiren | Bos taurus (cattle) | IC50 | 0.0240 | 1 | 1 |
| h 142 | Bos taurus (cattle) | IC50 | 0.0070 | 1 | 1 |
| cgp 38560a | Bos taurus (cattle) | IC50 | 1.3400 | 2 | 2 |
| ditekiren | Bos taurus (cattle) | IC50 | 6.3000 | 1 | 1 |
| pepstatin | Bos taurus (cattle) | IC50 | 0.0235 | 4 | 4 |
| pepstatin | Bos taurus (cattle) | Ki | 0.0005 | 1 | 1 |
| aliskiren | Bos taurus (cattle) | IC50 | 100.0000 | 1 | 1 |
Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction.Journal of medicinal chemistry, , Volume: 33, Issue:10, 1990
Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo.Journal of medicinal chemistry, , Volume: 29, Issue:10, 1986
Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin.Journal of medicinal chemistry, , Volume: 29, Issue:12, 1986
Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors.Journal of medicinal chemistry, , Volume: 28, Issue:11, 1985