thioguanine-anhydrous has been researched along with Necrosis* in 6 studies
6 other study(ies) available for thioguanine-anhydrous and Necrosis
| Article | Year |
|---|---|
Acute arterial occlusion as the presenting feature in acute promyelocytic leukaemia.
Topics: Amputation, Surgical; Anticoagulants; Antineoplastic Combined Chemotherapy Protocols; Arterial Occlusive Diseases; Cytarabine; Daunorubicin; Female; Foot Diseases; Heparin; Humans; Leukemia, Promyelocytic, Acute; Middle Aged; Necrosis; Popliteal Artery; Thioguanine; Tretinoin | 2001 |
Fulminant hepatic failure after high-dose cytosine arabinoside and mitoxantrone treatment for relapse of acute myelogenous leukaemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Female; Humans; Leukemia, Myeloid, Acute; Liver; Liver Failure, Acute; Mitoxantrone; Necrosis; Recurrence; Thioguanine | 1992 |
Protection against isoproterenol-induced myocardial necrosis in rats by 6-mercaptopurine and 6-thioguanine or by irradiation.
Isoproterenol produces myocardial necrosis in rats. To investigate the possible role of oxygen free radicals generated by xanthine oxidase and neutrophils, we examined the effects of the xanthine oxidase inhibitors, 6-mercaptopurine (6MP) and 6-thioguanine (6TG) combined and allopurinol, or of irradiation (to induce leukopenia) on isoproterenol-induced myocardial necrosis (ISOMN). The incidence and severity of ISOMN was significantly reduced by 6MP + 6TG but not by the specific inhibitor of xanthine oxidase, allopurinol, indicating that the protective effects of 6MP + 6TG may be due to its free radical scavenging activity rather than its xanthine oxidase inhibitory activity. Irradiation provided complete protection against ISOMN in all rats. Marked leukopenia or other radiation-induced protective factors could play a role in the mechanism of the protection. Topics: Allopurinol; Animals; Heart Diseases; Isoproterenol; Leukocytes; Leukopenia; Male; Mercaptopurine; Myocardium; Necrosis; Radiation Injuries, Experimental; Rats; Rats, Inbred Strains; Thioguanine | 1989 |
Necrotizing fasciitis of the vulva during chemotherapy.
A case of necrotizing fasciitis of the vulva arising in a leukemic patient during a chemotherapy nadir is presented. The nature of the process was not recognized initially, and the patient was treated with intravenous antibiotics. After clinically evident necrosis developed, prompt surgical debridement was carried out. Clinical improvement followed and the wound healed well. This case suggests that chemotherapy with its attendant immunosuppression is a predisposing factor in the development of necrotizing fasciitis and warrants a high index of suspicion. Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Fasciitis; Female; Humans; Leukemia, Myeloid, Acute; Necrosis; Thioguanine; Vulva; Vulvar Diseases | 1989 |
Thioguanine-induced adrenocortical necrosis and its prevention by hypophysectomy in the rat. Light and electron microscopic study.
Topics: Adrenal Cortex Diseases; Adrenal Gland Diseases; Animals; Capillary Permeability; Dose-Response Relationship, Drug; Endothelium; Female; Hemorrhage; Horseradish Peroxidase; Hypophysectomy; Microscopy, Electron; Necrosis; Rats; Thioguanine | 1977 |
Cecal necrosis and perforation with systemic chemotherapy.
Topics: Adult; Asparaginase; Breast Neoplasms; Cecal Diseases; Child; Cytarabine; Daunorubicin; Female; Fluorouracil; Humans; Intestinal Perforation; Leukemia; Male; Mercaptopurine; Methotrexate; Middle Aged; Necrosis; Prednisone; Thioguanine; Vincristine | 1973 |