Page last updated: 2024-08-07 10:04:27

Pirin

A pirin that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00625]

EC 1.13.11.24;
Probable quercetin 2,3-dioxygenase PIR;
Probable quercetinase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
chir-265	Homo sapiens (human)	IC50	10.0000	1	1
az-628	Homo sapiens (human)	IC50	10.0000	1	1
GDC-0879	Homo sapiens (human)	IC50	10.0000	1	1
plx 4720	Homo sapiens (human)	IC50	0.6700	1	1
plx4032	Homo sapiens (human)	IC50	10.0000	1	1
dabrafenib	Homo sapiens (human)	IC50	10.0000	1	1
tak-632	Homo sapiens (human)	IC50	10.0000	1	1

This protein enables 4 target(s):

Target	Category	Definition
transcription coregulator activity	molecular function	A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
quercetin 2,3-dioxygenase activity	molecular function	Catalysis of the reaction: H+ + O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO. [EC:1.13.11.24, RHEA:15381]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]

This protein is located in 5 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nuclear body	cellular component	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182]

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

This protein is involved in 3 target(s):

Target	Category	Definition
transcription by RNA polymerase II	biological process	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382]
digestion	biological process	The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. [GOC:isa_complete, ISBN:0198506732]
monocyte differentiation	biological process	The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. [GOC:mah]