Page last updated: 2024-08-07 12:50:54
Polymerase acidic protein
An influenza A virus polymerase acidic protein that is encoded in the genome of the H1N1 strain A/Puerto Rico/8/1934. [PMID:11779399, PMID:15163504, PMID:15308710, PMID:18660801, PMID:19194459, PMID:22001919, PMID:7060132, PMID:8113737, PMID:9519825, PR
Synonyms
EC 3.1.-.-;
RNA-directed RNA polymerase subunit P2
Research
Bioassay Publications (12)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
Compounds (20)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| kojic acid | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 12.4446 | 1 | 2 |
| rimantadine | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 11.0000 | 1 | 1 |
| maltol | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 199.7630 | 1 | 2 |
| benzohydroxamic acid | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 500.0000 | 1 | 1 |
| n-hydroxyphthalimide | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 500.0000 | 1 | 1 |
| epigallocatechin gallate | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 5.8600 | 1 | 1 |
| pyromeconic acid | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 23.8094 | 1 | 2 |
| allomaltol | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 16.4744 | 1 | 2 |
| 2-Oxo-4-phenylbutyric acid | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 500.0000 | 2 | 2 |
| benzoylpropionic acid | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 500.0000 | 1 | 1 |
| laudanosoline | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 1.8800 | 1 | 1 |
| 2-hydroxy-4h-isoquinoline-1,3-dione | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 15.0000 | 2 | 2 |
| 2-hydroxy-4h-isoquinoline-1,3-dione | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Ki | 0.8500 | 1 | 1 |
| benzoylacrylic acid | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 500.0000 | 2 | 2 |
| N-(7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)benzamide | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 200.0000 | 1 | 1 |
| flutimide | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 5.2333 | 3 | 3 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| salicylic acid | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | EC50 | 250.0000 | 1 | 1 |
| benzbromarone | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Kd | 48.2000 | 1 | 1 |
| ribavirin | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | EC50 | 21.2667 | 3 | 3 |
| trenbolone acetate | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Kd | 90.7000 | 1 | 1 |
| benzoylpropionic acid | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | EC50 | 250.0000 | 1 | 1 |
| diclazuril | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Kd | 211.0000 | 1 | 1 |
| 2-hydroxy-4h-isoquinoline-1,3-dione | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | EC50 | 3.2200 | 1 | 1 |
| benzoylacrylic acid | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | EC50 | 250.0000 | 1 | 1 |