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Vasopressin V2 receptor
A vasopressin V2 receptor that is encoded in the genome of rat. [OMA:Q00788, PRO:DNx]
Synonyms
V2R;
AVPR V2;
Antidiuretic hormone receptor;
Renal-type arginine vasopressin receptor
Research
Bioassay Publications (18)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (44.44) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (15)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| l 701324 | Rattus norvegicus (Norway rat) | Kb | 0.0280 | 1 | 1 |
| mdl 104653 | Rattus norvegicus (Norway rat) | Kb | 0.8800 | 1 | 1 |
Oral oxytocin antagonists.Journal of medicinal chemistry, , Sep-23, Volume: 53, Issue:18, 2010
Synthesis and pharmacological evaluation of 5-(4-biphenyl)-3-methyl-4-phenyl-1,2,4-triazole derivatives as a novel class of selective antagonists for the human vasopressin V(1A) receptor.Journal of medicinal chemistry, , Jun-06, Volume: 45, Issue:12, 2002
Orally active, nonpeptide vasopressin V1 antagonists. A novel series of 1-(1-substituted 4-piperidyl)-3,4-dihdyro-2(1H)-quinolinone.Journal of medicinal chemistry, , Jul-09, Volume: 36, Issue:14, 1993
Structure-activity study of novel tricyclic benzazepine arginine vasopressin antagonists.Bioorganic & medicinal chemistry letters, , Jul-07, Volume: 13, Issue:13, 2003
Bridged bicyclic vasopressin receptor antagonists with V(2)-selective or dual V(1a)/V(2) activity.Bioorganic & medicinal chemistry letters, , Nov-04, Volume: 12, Issue:21, 2002
The synthesis and vasopressin (AVP) antagonist activity of a novel series of N-aroyl-2,4,5,6-tetrahydropyrazolo[3,4-d]thieno[3,2-b]azepines.Bioorganic & medicinal chemistry letters, , Apr-17, Volume: 10, Issue:8, 2000
4,10-dihydro-5H-thieno[3,2-c][1]benzazepine derivatives and 9,10-dihydro-4H-thieno[2,3-c][1]benzazepine derivatives as orally active arginine vasopressin receptor antagonists.Bioorganic & medicinal chemistry letters, , Jul-05, Volume: 9, Issue:13, 1999
5-fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-yl carbonyl)-2-pyridinyl]benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor antagonists.Bioorganic & medicinal chemistry letters, , Jul-05, Volume: 9, Issue:13, 1999
5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors.Journal of medicinal chemistry, , Jul-02, Volume: 41, Issue:14, 1998
Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8.Journal of medicinal chemistry, , Feb-22, Volume: 50, Issue:4, 2007
Synthesis of oxytocin antagonists containing conformationally constrained amino acids in position 2.Bioorganic & medicinal chemistry letters, , Mar-08, Volume: 9, Issue:5, 1999
[no title available]Journal of medicinal chemistry, , 05-23, Volume: 62, Issue:10, 2019
Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8.Journal of medicinal chemistry, , Feb-22, Volume: 50, Issue:4, 2007
Carbon-11 N-methyl alkylation of L-368,899 and in vivo PET imaging investigations for neural oxytocin receptors.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 23, Issue:3, 2013
Oral oxytocin antagonists.Journal of medicinal chemistry, , Sep-23, Volume: 53, Issue:18, 2010