N-arachidonyl glycine receptor

An N-arachidonyl glycine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q14330]

Synonyms

NAGly receptor;
G-protein coupled receptor 18

Research

Bioassay Publications (4)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (75.00)	24.3611
2020's	1 (25.00)	2.80

Compounds (6)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
abnormal cannabidiol	Homo sapiens (human)	IC50	10.0000	1	1
sr141716	Homo sapiens (human)	IC50	10.1000	1	1
cp-55,940	Homo sapiens (human)	IC50	5.9900	1	1
n-arachidonylglycine	Homo sapiens (human)	IC50	10.0000	1	1
emindole SB	Homo sapiens (human)	IC50	10.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
dronabinol	Homo sapiens (human)	EC50	4.6100	1	1
abnormal cannabidiol	Homo sapiens (human)	EC50	10.0000	1	1
n-arachidonylglycine	Homo sapiens (human)	EC50	3.3547	3	3

Enables

This protein enables 1 target(s):

Target	Category	Definition
G protein-coupled receptor activity	molecular function	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
cytoplasmic vesicle membrane	cellular component	The lipid bilayer surrounding a cytoplasmic vesicle. [GOC:mah]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 7 target(s):

Target	Category	Definition
CD8-positive, alpha-beta intraepithelial T cell differentiation	biological process	The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. [GOC:add, ISBN:0781735149]
CD8-positive, gamma-delta intraepithelial T cell differentiation	biological process	The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. [GOC:add, ISBN:0781735149]
negative regulation of leukocyte chemotaxis	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. [GOC:add]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
negative regulation of tumor necrosis factor production	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production. [GOC:mah, PMID:10891884, PMID:15560120]
positive regulation of Rho protein signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. [GOC:bf]
phospholipase C-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]