Compounds > royleanone
Page last updated: 2024-12-08

royleanone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

royleanone: from root of Salvia officinalis; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
SalviagenusA genus in the mint family (LAMIACEAE).[MeSH]LamiaceaeThe mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]

Cross-References

ID SourceID
PubMed CID442084
CHEMBL ID1813341
CHEBI ID8904
SCHEMBL ID21291506
MeSH IDM0270359

Synonyms (25)

Synonym
nsc-122417
royleanone
C09182
6812-87-9
AC1L9C85 ,
AKOS004901865 ,
chebi:8904 ,
CHEMBL1813341 ,
nsc753735
nsc-753735
1377-96-4
901618Q8AX ,
1,4-phenanthrenedione, 4b,5,6,7,8,8a,9,10-octahydro-3-hydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bs,8as)-
podocarpa-8,12-diene-11,14-dione, 12-hydroxy-13-isopropyl-
1,4-phenanthrenedione, 4b,5,6,7,8,8a,9,10-octahydro-3-hydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bs-trans)-
12-hydroxy-8,12-abietadiene-11,14-dione
unii-901618q8ax
(4bs,8as)-3-hydroxy-2-isopropyl-4b,8,8-trimethyl- 4b,5,6,7,8,8a,9,10-octahydrophenanthrene-1,4-dione
AKOS032948936
FS-8601
Q27108179
SCHEMBL21291506
(+)-royleanone
CS-0016746
HY-N1338
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1058382Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID1058386Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID769609Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Antiproliferative activity of abietane diterpenoids against human tumor cells.
AID1058388Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID769611Cytotoxicity against human U937 cells after 72 hrs by MTT assay2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Antiproliferative activity of abietane diterpenoids against human tumor cells.
AID1058385Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID769610Cytotoxicity against human MOLT3 cells after 72 hrs by MTT assay2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Antiproliferative activity of abietane diterpenoids against human tumor cells.
AID1058384Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID612372Cytotoxicity against human MV-3 cells after 24 hrs by MTT assay2011Bioorganic & medicinal chemistry, Aug-15, Volume: 19, Issue:16
In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica.
AID1304621Antileishmanial activity against Leishmania donovani LV82 promastigotes expressing red fluorescent protein after 72 hrs by flow cytometric analysis2016Journal of natural products, Mar-25, Volume: 79, Issue:3
Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum.
AID1058387Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID1304623Antileishmanial activity against transgenic Leishmania amazonensis amastigotes infected in CD-1 mouse peritoneal macrophages assessed as beta-lactamase activity after 72 hrs by nitrocefin dye-based spectrophotometric analysis2016Journal of natural products, Mar-25, Volume: 79, Issue:3
Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum.
AID612371Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay2011Bioorganic & medicinal chemistry, Aug-15, Volume: 19, Issue:16
In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica.
AID769612Cytotoxicity against human HL60 cells after 72 hrs by MTT assay2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Antiproliferative activity of abietane diterpenoids against human tumor cells.
AID769608Cytotoxicity against human SK-MEL-1 cells after 72 hrs by MTT assay2013Journal of natural products, Aug-23, Volume: 76, Issue:8
Antiproliferative activity of abietane diterpenoids against human tumor cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (5.88)18.2507
2000's4 (23.53)29.6817
2010's10 (58.82)24.3611
2020's2 (11.76)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.56%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (94.44%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
miltefosine
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.		2.1310phosphocholines;
phospholipid		anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor
4-(4-nitrobenzyl)pyridine
[no description available]		2.0710
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.4720delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
etoposide
[no description available]		2.0810beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
taxodione
taxodione: structure		2.7830diterpenoid
sugiol
sugiol: diterpene with anti-inflammatory activity from Calocedrus formosana bark; structure in first source. sugiol : An abietane diterpenoid that is ferruginol in which the methylene group para to the phenolic hydroxy group has been substituted by an oxo group.		340abietane diterpenoid;
carbotricyclic compound;
cyclic terpene ketone;
meroterpenoid;
phenols		antineoplastic agent;
antioxidant;
antiviral agent;
plant metabolite;
radical scavenger
tanshinone
tanshinone: from root of Salvia miltiorrhiza Bunge; RN given refers to tanshinone I; cardioprotective agent and neuroprotective agent		2.0610abietane diterpenoidanticoronaviral agent
miltirone
miltirone: from Salvis miltiorrhiza Bunge; central benzodiazepine receptor ligand; structure given in first source		2.0610abietane diterpenoid
cryptotanshinone
cryptotanshinone: from Salvia miltiorrhiza		2.0610abietane diterpenoidanticoronaviral agent
tanshinone ii a
tashinone IIA: a cardiovascular agent with antineoplastic activity; isolated from Salvia miltiorrhiza; structure in first source		2.0610abietane diterpenoid
ferruginol
ferruginol: structure in first source. ferruginol : An abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12.		2.7830abietane diterpenoid;
carbotricyclic compound;
meroterpenoid;
phenols		antibacterial agent;
antineoplastic agent;
plant metabolite;
protective agent
6,7-dehydroroyleanone
6,7-dehydroroyleanone: diterpene abietane quinone isolated from Salvia moorcraftiana or Lepechinia bullata (both Lamiaceae); Rn given from CA Index Guide; RN not in Chemline 12/84; structure given in first source		2.0810
horminone
horminone: RN refers to (4bS-(4balpha,8abeta,10beta))-isomer; from root of Salvia officinalis; structure given in second source. horminone : An abietane diterpenoid that is abieta-8,12-diene substituted by hydroxy groups at positions 7 and 12 and oxo groups at positions 11 and 14 (the 7alpha stereoisomer) .		3.1450
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.1310antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
1-oxomiltirone
1-oxomiltirone: from roots of the Iranian medicinal plant Perovskia abrotanoides; structure in first source		2.4820
11-hydroxysugiol
11-hydroxysugiol : An abietane diterpenoid that is sugiol in which the hydrogen ortho to the phenolic hydroxy group has been replaced by a hydroxy group.		2.0810abietane diterpenoid;
carbotricyclic compound;
catechols;
cyclic terpene ketone;
meroterpenoid		EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant metabolite
levomepromazine maleate
6-hydroxysalvinolone: from Salvia chorassanica; structure in first source		2.5120
7-methoxyrosmanol
7-methoxyrosmanol: from Salvia dorrii; structure in first source		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Necrosis
The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.		07.2510
Cancer of Pancreas
[description not available]		02.0710
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		02.0710