Page last updated: 2024-08-07 18:43:45
Dihydroorotate dehydrogenase
[no definition available]
Synonyms
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (12)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| dsm 74 | Plasmodium falciparum (malaria parasite P. falciparum) | Kd | 0.1700 | 1 | 1 |
On dihydroorotate dehydrogenases and their inhibitors and uses.Journal of medicinal chemistry, , Apr-25, Volume: 56, Issue:8, 2013
Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors.Journal of medicinal chemistry, , Jun-26, Volume: 57, Issue:12, 2014
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.Journal of medicinal chemistry, , Apr-09, Volume: 52, Issue:7, 2009
Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors.Journal of medicinal chemistry, , Jun-26, Volume: 57, Issue:12, 2014
Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening.Journal of medicinal chemistry, , Oct-11, Volume: 55, Issue:19, 2012
Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.Journal of medicinal chemistry, , May-14, Volume: 52, Issue:9, 2009
Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007