A non-lysosomal glucosylceramidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HCG7]
NLGase; This protein enables 5 target(s): This protein is located in 6 target(s): This protein is involved in 12 target(s):
EC 3.2.1.45;
Beta-glucocerebrosidase 2;
Beta-glucosidase 2;
Bile acid beta-glucosidase GBA2;
Bile acid glucosyl transferase GBA2;
Cholesterol glucosyltransferase GBA2;
2.4.1.-;
Cholesteryl-beta-glucosidase GBA2;Research
Bioassay Publications (11)
Timeframe Studies on this Protein(%) All Drugs % pre-1990 0 (0.00) 18.7374 1990's 0 (0.00) 18.2507 2000's 2 (18.18) 29.6817 2010's 9 (81.82) 24.3611 2020's 0 (0.00) 2.80 Compounds (11)
Drugs with Inhibition Measurements
Drug Taxonomy Measurement Average (mM) Bioassay(s) Publication(s) 1-deoxynojirimycin Homo sapiens (human) IC50 24.9500 4 4 miglustat Homo sapiens (human) IC50 25.8906 7 7 castanospermine Homo sapiens (human) IC50 19.0000 1 1 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine Homo sapiens (human) IC50 150.0000 1 1 migalastat Homo sapiens (human) IC50 100.0000 1 1 isofagomine Homo sapiens (human) IC50 0.0200 1 1 1,4-dideoxy-1,4-imino-d-arabinitol Homo sapiens (human) IC50 120.0000 1 1 n-nonyl-1-deoxynojirimycin Homo sapiens (human) IC50 0.0050 2 2 n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin Homo sapiens (human) IC50 0.0015 7 7 ogt2378 Homo sapiens (human) IC50 0.2500 1 1 l-altro-1-deoxynojirimycin Homo sapiens (human) IC50 100.0000 1 1 Enables
Target Category Definition galactosylceramidase activity molecular function Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. [EC:3.2.1.46] glucosylceramidase activity molecular function Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. [EC:3.2.1.45] beta-glucosidase activity molecular function Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. [EC:3.2.1.21, PMID:12594539] glucosyltransferase activity molecular function Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [ISBN:0198506732] steryl-beta-glucosidase activity molecular function Catalysis of the reaction: cholesteryl-beta-D-glucoside + H2O = D-glucose + cholesterol. [EC:3.2.1.104, RHEA:11956] Located In
Target Category Definition Golgi membrane cellular component The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah] endoplasmic reticulum membrane cellular component The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] smooth endoplasmic reticulum cellular component The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. [ISBN:0198506732] cytosol cellular component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] plasma membrane cellular component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] membrane cellular component A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] Involved In
Target Category Definition carbohydrate metabolic process biological process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [GOC:mah, ISBN:0198506732] glucosylceramide catabolic process biological process The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. [GOC:ai] cholesterol metabolic process biological process The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. [ISBN:0198506732] bile acid metabolic process biological process The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. [GOC:go_curators] glycoside catabolic process biological process The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. [GOC:go_curators] central nervous system neuron development biological process The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] lipid glycosylation biological process Covalent attachment of a glycosyl residue to a lipid molecule. [GOC:mah] regulation of actin filament polymerization biological process Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. [GOC:mah] regulation of microtubule polymerization biological process Any process that modulates the frequency, rate or extent of microtubule polymerization. [GOC:mah] glycosphingolipid catabolic process biological process The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. [ISBN:0198506732] regulation of membrane lipid distribution biological process Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane. [GOC:mah, PMID:18441123, PMID:20823909] central nervous system development biological process The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. [GOC:bf, GOC:jid, ISBN:0582227089]