cobamamide and Necrosis

cobamamide has been researched along with Necrosis* in 1 studies

Other Studies

1 other study(ies) available for cobamamide and Necrosis

Article	Year
[The modifying influence of adenosylcobalamin on the transplacental carcinogenic effect of N-nitroso-N-ethylurea in organ cultures of the kidneys of DBA/2 mice]. Eksperimental'naia onkologiia, 1989, Volume: 11, Issue:3 Transplacental effect of cobalamin coenzyme, adenosylcobalamin (Adocbl), on the carcinogenic action of N-nitroso-N-ethylurea (ENU) was studied in culture of the mouse embryonic kidney tissue by histoautoradiography. Coenzyme methylmalonyl-CoA-mutase, Adocbl, injected into DBA/2 mice in the prenatal period did not stimulate the proliferative activity of epithelial cells of the embryonic kidney. The treatment with Adocbl did not intensify hyperplastic changes common for the early stages of carcinogenesis. The frequency of hyperplastic changes mainly of focal proliferation in kidney explants with the combined administration was considerably lower than with the isolated action of the carcinogen and amounted to 8.7% and 21.5%, respectively (P less than 0.001). Topics: Animals; Autoradiography; Cobamides; Drug Interactions; Embryo, Mammalian; Ethylnitrosourea; Female; Hyperplasia; Kidney; Kidney Neoplasms; Mice; Mice, Inbred DBA; Necrosis; Organ Culture Techniques; Placenta; Pregnancy	1989

Article

Year

[The modifying influence of adenosylcobalamin on the transplacental carcinogenic effect of N-nitroso-N-ethylurea in organ cultures of the kidneys of DBA/2 mice].

Eksperimental'naia onkologiia, 1989, Volume: 11, Issue:3

Transplacental effect of cobalamin coenzyme, adenosylcobalamin (Adocbl), on the carcinogenic action of N-nitroso-N-ethylurea (ENU) was studied in culture of the mouse embryonic kidney tissue by histoautoradiography. Coenzyme methylmalonyl-CoA-mutase, Adocbl, injected into DBA/2 mice in the prenatal period did not stimulate the proliferative activity of epithelial cells of the embryonic kidney. The treatment with Adocbl did not intensify hyperplastic changes common for the early stages of carcinogenesis. The frequency of hyperplastic changes mainly of focal proliferation in kidney explants with the combined administration was considerably lower than with the isolated action of the carcinogen and amounted to 8.7% and 21.5%, respectively (P less than 0.001).

Topics: Animals; Autoradiography; Cobamides; Drug Interactions; Embryo, Mammalian; Ethylnitrosourea; Female; Hyperplasia; Kidney; Kidney Neoplasms; Mice; Mice, Inbred DBA; Necrosis; Organ Culture Techniques; Placenta; Pregnancy

1989