silicon and Necrosis

We conducted this study to investigate the efficacy of the silicon gel application on the nares in prevention of nasal injury in preterm infants ventilated with nasal continuous positive airway pressure (NCPAP). Patients (n=179) were randomized into two groups: Group 1 (n=87) had no silicon gel applied to nares, and in Group 2 (n=92), the silicon gel sheeting was used on the surface of nares during ventilation with NCPAP. Nasal injury developed in 13 (14.9%) neonates in Group 1 and 4 (4.3%) newborns in Group 2 (OR:3.43; 95% CI: 1.1-10.1; P<0.05). The incidence of columella necrosis was also significantly higher in the Group 1 (OR: 6.34; 95% CI: 0.78-51.6; P<0.05). We conclude that the silicon gel application may reduce the incidence and the severity of nasal injury in preterm infants on nasal CPAP.

Topics: Administration, Topical; Continuous Positive Airway Pressure; Gels; Humans; Infant, Newborn; Infant, Premature; Necrosis; Nose; Prospective Studies; Silicon; Wounds and Injuries

Morphological changes in the skin of animals were studied after application of concentrated hydrofluoric and hexafluorosilicic acid. The intact skin was not generally affected by these acids. Areas injured before application of the acid showed, however, a continuous spreading of necrosis in the deeper regions. The first histological changes were noticed 1 h after the application. Such early histological findings could be seen long before any macroscopic reaction. The main characteristic findings were the hypocellular necrosis and edema reaching as far as the subcutis. The necrosis showed sharp leukocyte demarcations.

Topics: Animals; Epidermis; Fluorides; Forensic Medicine; Guinea Pigs; Hydrofluoric Acid; Necrosis; Rats; Rats, Inbred Lew; Silicic Acid; Silicon; Skin; Swine

Topics: Animals; Aorta; Aorta, Abdominal; Aorta, Thoracic; Aortic Diseases; Aortography; Dogs; Female; Male; Necrosis; Rubber; Silicon; Time Factors