Proteins > Similar to alpha-tubulin isoform 1
Page last updated: 2024-08-07 17:17:31
Similar to alpha-tubulin isoform 1
[no definition available]
Synonyms
Research
Bioassay Publications (60)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (26.67) | 18.2507 |
| 2000's | 9 (15.00) | 29.6817 |
| 2010's | 35 (58.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (33)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| fosbretabulin | Bos taurus (cattle) | Kd | 0.3100 | 1 | 1 |
| npi 2358 | Bos taurus (cattle) | Kd | 8.2000 | 2 | 0 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| nocodazole | Bos taurus (cattle) | INH | 2.2000 | 1 | 1 |
| paclitaxel | Bos taurus (cattle) | Activity | 4.2000 | 1 | 1 |
| paclitaxel | Bos taurus (cattle) | ED50 | 0.7000 | 1 | 1 |
| baccatin iii | Bos taurus (cattle) | ED50 | 10.0000 | 1 | 1 |
| docetaxel | Bos taurus (cattle) | Activity | 2.4000 | 1 | 1 |
| docetaxel | Bos taurus (cattle) | ED50 | 0.8250 | 2 | 2 |
| sb t-1214 | Bos taurus (cattle) | Activity | 0.9000 | 1 | 1 |
1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Optimization of substituted cinnamic acyl sulfonamide derivatives as tubulin polymerization inhibitors with anticancer activity.Bioorganic & medicinal chemistry letters, , 12-15, Volume: 28, Issue:23-24, 2018
Synthesis, biological evaluation and 3D-QSAR studies of novel 5-phenyl-1H-pyrazol cinnamamide derivatives as novel antitubulin agents.European journal of medicinal chemistry, , Mar-26, Volume: 93, 2015
Synthesis and structure-activity relationships of pyridinyl-1H-1,2,3-triazolyldihydroisoxazoles as potent inhibitors of tubulin polymerization.European journal of medicinal chemistry, , Jan-27, Volume: 90, 2015
Design, synthesis and biological evaluation of (E)-3-(3,4-dihydroxyphenyl)acrylylpiperazine derivatives as a new class of tubulin polymerization inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
Antimitotic and vascular disrupting agents: 2-hydroxy-3,4,5-trimethoxybenzophenones.European journal of medicinal chemistry, , Apr-22, Volume: 77, 2014
6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Nov-16, Volume: 43, Issue:23, 2000
The synthesis and evaluation of temperature sensitive tubulin toxins.Bioorganic & medicinal chemistry letters, , Feb-08, Volume: 9, Issue:3, 1999
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.Journal of medicinal chemistry, , Mar-26, Volume: 41, Issue:7, 1998
Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization.Journal of medicinal chemistry, , Dec-03, Volume: 41, Issue:25, 1998
Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
Inhibition of tubulin polymerization by 5,6-dihydroindolo[2,1-alpha]isoquinoline derivatives.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic Journal of medicinal chemistry, , Mar-05, Volume: 36, Issue:5, 1993
[no title available],
Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 24, Issue:15, 2014
Synthesis and biological evaluation of podophyllotoxin congeners as tubulin polymerization inhibitors.Bioorganic & medicinal chemistry, , Oct-01, Volume: 22, Issue:19, 2014
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.Journal of medicinal chemistry, , Jun-29, Volume: 49, Issue:13, 2006
6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Nov-16, Volume: 43, Issue:23, 2000
Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.Journal of medicinal chemistry, , Mar-26, Volume: 41, Issue:7, 1998
Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
Inhibition of tubulin polymerization by 5,6-dihydroindolo[2,1-alpha]isoquinoline derivatives.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
A facile synthesis and microtubule-destabilizing properties of 4-(1H-benzo[d]imidazol-2-yl)-furazan-3-amines.European journal of medicinal chemistry, , Apr-13, Volume: 94, 2015
Inhibition of tubulin polymerization by 5,6-dihydroindolo[2,1-alpha]isoquinoline derivatives.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic Journal of medicinal chemistry, , Mar-05, Volume: 36, Issue:5, 1993
Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.Journal of medicinal chemistry, , Mar-20, Volume: 35, Issue:6, 1992
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.Bioorganic & medicinal chemistry, , Sep-15, Volume: 22, Issue:18, 2014
Synthesis of biologically active taxol analogues with modified phenylisoserine side chains.Journal of medicinal chemistry, , Oct-30, Volume: 35, Issue:22, 1992
The effect of exchanging various substituents at the 2-position of 2-methoxyestradiol on cytotoxicity in human cancer cell cultures and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Oct-10, Volume: 45, Issue:21, 2002
Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth.Journal of medicinal chemistry, , Jul-18, Volume: 40, Issue:15, 1997
Inhibition of tubulin polymerization by 5,6-dihydroindolo[2,1-alpha]isoquinoline derivatives.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.Bioorganic & medicinal chemistry, , Sep-15, Volume: 22, Issue:18, 2014
Novel cytotoxic 3'-(tert-butyl) 3'-dephenyl analogs of paclitaxel and docetaxel.Journal of medicinal chemistry, , Sep-15, Volume: 38, Issue:19, 1995
Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.Journal of medicinal chemistry, , Mar-20, Volume: 35, Issue:6, 1992
1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide.Journal of medicinal chemistry, , Oct-24, Volume: 45, Issue:22, 2002
Evaluating the effects of fluorine on biological properties and metabolic stability of some antitubulin 3-substituted 7-phenyl-pyrroloquinolinones.European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents.European journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors.Journal of medicinal chemistry, , 02-14, Volume: 62, Issue:3, 2019
1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Synthesis and biological evaluation of 7-methoxy-1-(3,4,5-trimethoxyphenyl)-4,5-dihydro-2H-benzo[e]indazoles as new colchicine site inhibitors.Bioorganic & medicinal chemistry letters, , 09-15, Volume: 29, Issue:18, 2019
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors.European journal of medicinal chemistry, , Nov-01, Volume: 181, 2019
1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Triazole tethered C5-curcuminoid-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies.European journal of medicinal chemistry, , Jun-30, Volume: 116, 2016
Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities.Journal of medicinal chemistry, , Jan-14, Volume: 59, Issue:1, 2016
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin.Journal of medicinal chemistry, , Apr-09, Volume: 58, Issue:7, 2015
Synthesis, biological evaluation and 3D-QSAR studies of novel 5-phenyl-1H-pyrazol cinnamamide derivatives as novel antitubulin agents.European journal of medicinal chemistry, , Mar-26, Volume: 93, 2015
Microwave-assisted synthesis and biological evaluation of 3,4-diaryl maleic anhydride/N-substituted maleimide derivatives as combretastatin A-4 analogues.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 25, Issue:3, 2015
Design, synthesis and biological evaluation of novel pyrazoline-containing derivatives as potential tubulin assembling inhibitors.European journal of medicinal chemistry, , Apr-13, Volume: 94, 2015
Quantum chemistry calculation-aided structural optimization of combretastatin A-4-like tubulin polymerization inhibitors: improved stability and biological activity.Journal of medicinal chemistry, , Mar-12, Volume: 58, Issue:5, 2015
Discovery and molecular modeling of novel 1-indolyl acetate--5-nitroimidazole targeting tubulin polymerization as antiproliferative agents.European journal of medicinal chemistry, , Oct-06, Volume: 85, 2014
Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles.Journal of medicinal chemistry, , Aug-14, Volume: 57, Issue:15, 2014
Design, synthesis and biological evaluation of (E)-3-(3,4-dihydroxyphenyl)acrylylpiperazine derivatives as a new class of tubulin polymerization inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
Synthesis, biological evaluation and molecular modeling of 1,3,4-thiadiazol-2-amide derivatives as novel antitubulin agents.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors.Bioorganic & medicinal chemistry, , Jun-15, Volume: 22, Issue:12, 2014
Antimitotic and vascular disrupting agents: 2-hydroxy-3,4,5-trimethoxybenzophenones.European journal of medicinal chemistry, , Apr-22, Volume: 77, 2014
Novel 9'-substituted-noscapines: synthesis with Suzuki cross-coupling, structure elucidation and biological evaluation.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Discovery of biarylaminoquinazolines as novel tubulin polymerization inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 57, Issue:11, 2014
Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential.ACS medicinal chemistry letters, , May-08, Volume: 5, Issue:5, 2014
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.Journal of medicinal chemistry, , Jun-29, Volume: 49, Issue:13, 2006
Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents.Journal of medicinal chemistry, , May-20, Volume: 47, Issue:11, 2004
Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate.Journal of medicinal chemistry, , Jun-06, Volume: 45, Issue:12, 2002
One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization.Journal of medicinal chemistry, , Jun-06, Volume: 45, Issue:12, 2002
6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Nov-16, Volume: 43, Issue:23, 2000
Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Oct-07, Volume: 42, Issue:20, 1999
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.Journal of medicinal chemistry, , Mar-26, Volume: 41, Issue:7, 1998
Antineoplastic agents. 379. Synthesis of phenstatin phosphate.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships.Journal of medicinal chemistry, , Jul-30, Volume: 41, Issue:16, 1998
Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic Journal of medicinal chemistry, , Mar-05, Volume: 36, Issue:5, 1993
Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.Journal of medicinal chemistry, , Mar-20, Volume: 35, Issue:6, 1992
[no title available],
Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents.Journal of medicinal chemistry, , May-20, Volume: 47, Issue:11, 2004
Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships.Journal of medicinal chemistry, , Jul-30, Volume: 41, Issue:16, 1998