Glucose-6-phosphate exchanger SLC37A4

A glucose-6-phosphate exchanger SLC37A4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43826]

Glucose-5-phosphate transporter;
Glucose-6-phosphate translocase;
Solute carrier family 37 member 4;
Transformation-related gene 19 protein;
TRG-19

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
mumbaistatin	Homo sapiens (human)	IC50	0.0050	1	1
s 4048	Homo sapiens (human)	IC50	0.0030	1	1

This protein enables 3 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
glucose-6-phosphate transmembrane transporter activity	molecular function	Enables the transfer of glucose-6-phosphate from one side of a membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
glucose 6-phosphate:phosphate antiporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + phosphate(in) = glucose 6-phosphate(in) + phosphate(out). [GOC:dph, PMID:18337460]

This protein is located in 3 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

This protein is active in 1 target(s):

Target	Category	Definition
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

This protein is involved in 4 target(s):

Target	Category	Definition
glucose metabolic process	biological process	The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. [ISBN:0198506732]
gluconeogenesis	biological process	The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. [MetaCyc:GLUCONEO-PWY]
glucose-6-phosphate transport	biological process	The directed movement of glucose-6-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. [GOC:ai]
phosphate ion transmembrane transport	biological process	The process in which a phosphate is transported across a membrane. [GOC:vw]