Chitotriosidase-1

A chitotriosidase-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13231]

EC 3.2.1.14;
Chitinase-1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
theophylline	Homo sapiens (human)	IC50	1,000.0000	1	2
caffeine	Homo sapiens (human)	IC50	363.0000	1	2
pentoxifylline	Homo sapiens (human)	IC50	98.0000	1	1
pentoxifylline	Homo sapiens (human)	Ki	37.0000	1	1
argadin	Homo sapiens (human)	IC50	0.2565	1	2
argadin	Homo sapiens (human)	Ki	0.0200	1	1
argifin	Homo sapiens (human)	IC50	2.5317	2	4
argifin	Homo sapiens (human)	Ki	33.0000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pentoxifylline	Homo sapiens (human)	Kd	52.7000	1	10
argadin	Homo sapiens (human)	Kd	3.6500	1	8
argifin	Homo sapiens (human)	Kd	2.1400	1	7

This protein enables 4 target(s):

Target	Category	Definition
hydrolase activity, hydrolyzing O-glycosyl compounds	molecular function	Catalysis of the hydrolysis of any O-glycosyl bond. [GOC:mah]
chitinase activity	molecular function	Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
chitin binding	molecular function	Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. [GOC:jl, ISBN:0198506732]
endochitinase activity	molecular function	Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain. [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]

This protein is located in 5 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
lysosome	cellular component	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
specific granule lumen	cellular component	The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549]
tertiary granule lumen	cellular component	Any membrane-enclosed lumen that is part of a tertiary granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]

This protein is active in 1 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]

This protein is involved in 5 target(s):

Target	Category	Definition
polysaccharide catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [PMID:33139480]
chitin catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. [GOC:jl, ISBN:0198506732]
immune response	biological process	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]
response to bacterium	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. [GOC:hb]
polysaccharide digestion	biological process	The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism. [GOC:go_curators]