borrelidin profile

treponemycin: isolated from Streptomyces albovinaceous; active against Treponema hyodysenteriae [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

borrelidin : A macrolide that is isolated from several Streptomyces species and displays antibiotic, antineoplastic and antimalarial properties. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	6436801
CHEMBL ID	70590
MeSH ID	M0046368
PubMed CID	23724539
CHEMBL ID	4229236
CHEBI ID	78661
MeSH ID	M0046368

Synonym
nsc-216128
borrelidin, from streptomyces sp., >=95% (hplc), lyophilized powder
borrelidin, from streptomyces parvulus, >=98% (hplc)
2-(7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)-cyclopentanecar boxylic acid
brn 0066270
nsc 216128
c28h43no6
borrelidine
bdbm50129555
cid_310900
(1r,2r)-2-((4e,6z)-(2s,8r,9s,11r,13s,15s,16s)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-oxacyclooctadeca-4,6-dien-2-yl)-cyclopentanecarboxylic acid
2-((1s,8r,9s,11r,13s,15s,18r)-7-cyano-16-(s)-hydroxy-8-hydroxy-9,11,13,15-tetramethyl-18-oxo-oxacyclooctadeca-4,6-dien-2-yl)-cyclopentanecarboxylic acid
CHEMBL70590 ,
(1r,2r)-2-[(2s,4e,6z,8r,9s,11r,13s,15s,16s)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl]cyclopentane-1-carboxylic acid
B-3061 ,
5-18-09-00385 (beilstein handbook reference)
unii-pwc22kgm2p
pwc22kgm2p ,
(1r,2r)-2-[(2s,4e,6z,8r,9s,11r,13s,15s,16s)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid
HB3810
AKOS024458302
(-)-borrelidin
OJCKRNPLOZHAOU-UGKRXNSESA-N
(1r,2r)-2-((2s,4e,6z,8r,9s,11r,13s,15s,16s)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)cyclopentanecarboxylic acid
cyclopentanecarboxylic acid, 2-((2s,4e,6z,8r,9s,11r,13s,15s,16s)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)-, (1r,2r)-
borrelidin a
cyclopentanecarboxylic acid, 2-(7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)-, (2s-(2r(1s,2s),4e,6z,8s,9r,11s,13r,15r,16r*))-
CS-0011785
HY-N6742
gtpl11306
BB162712
DTXSID301043878
treponemycin
7184-60-3
borrelidin
quinquangulin k 182
quinquangulin k 031
(1r,2r)-2-[(2r,4e,6z,8r,9s,11r,13s,15s,16s)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid
CHEBI:78661
Q27147895
CHEMBL4229236
(1r,2r)-2-[(2r,4e,6z,8r,9s,11r,13s,15s,16s)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl]cyclopentane-1-carboxylic acid

Excerpt	Reference	Relevance
"Borrelidin (1) is a nitrile-containing bacterially derived polyketide that is a potent inhibitor of bacterial and eukaryotic threonyl-tRNA synthetases. "	( Borrelidin B: isolation, biological activity, and implications for nitrile biosynthesis. Bray, WM; Koehn, FE; Lam, MH; Linington, RG; Loganzo, F; Schulze, CJ; Szal, T; Villalobos, A, 2014)	3.29

Excerpt	Reference	Relevance
"Borrelidin has high and specific antifungal activity against Phytophthora sojae . "	( Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae. An, J; Gao, YM; Jiang, L; Li, M; Liu, CX; Wang, XJ; Xiang, WS; Zhang, J, 2012)	3.26

Excerpt	Reference	Relevance
"Clinically effective anti-cancer drugs have to tread a narrow line between selective cytotoxicity on tumor cells and tolerable adverse effects against healthy tissues."	( Borrelidin has limited anti-cancer effects in bcl-2 overexpressing breast cancer and leukemia cells and reveals toxicity in non-malignant breast epithelial cells. Brüning, A; Gafiuc, D; Mylonas, I; Weiß, M, 2014)	0.4

Role	Description
bacterial metabolite	Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
antimicrobial agent	A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
antifungal agent	An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
antineoplastic agent	A substance that inhibits or prevents the proliferation of neoplasms.
apoptosis inducer	Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
antimalarial	A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
macrolide	A macrocyclic lactone with a ring of twelve or more members derived from a polyketide.
monocarboxylic acid	An oxoacid containing a single carboxy group.
secondary alcohol	A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
diol	A compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols.
aliphatic nitrile	Any nitrile derived from an aliphatic compound.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Threonyl-tRNA synthetase	Phytophthora sojae	IC50 (µMol)	8.0000	8.0000	8.0000	8.0000	AID1083011
Threonyl-tRNA synthetase	Phytophthora sojae	Ki	10.0000	10.0000	10.0000	10.0000	AID1083011
Cyclin-dependent kinase 1	Saccharomyces cerevisiae S288C	IC50 (µMol)	24.0000	0.0800	1.2600	2.5000	AID51559
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
cytosol	L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase	Mycobacterium tuberculosis H37Rv
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (153)

Assay ID	Title	Year	Journal	Article
AID1082768	Antifungal activity against Phytophthora sojae race 9 assessed as growth inhibition at 28 degC after 7 days (beneficial crop soybean)	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1271287	Inhibition of ThRS in human UMSCC1 cells assessed as increase in caspase-3/7 level at 5 uM after 4 hrs by luminescent assay	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID276481	Antiproliferative activity against 251L cell line at 10 uM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID1585333	Selectivity index, ratio of IC50 for HEK293T cells to MIC for Candida albicans ATCC MYA-2876	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and antifungal evaluation of borrelidin derivatives.
AID1271292	Inhibition of ThRS in human UMSCC23 cells assessed as increase in CHOP mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1082767	Antifungal activity against Phytophthora sojae race 5 assessed as growth inhibition at 28 degC after 7 days (beneficial crop soybean)	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1082765	Antifungal activity against Phytophthora sojae race 3 assessed as growth inhibition at 28 degC after 7 days (beneficial crop soybean)	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1082773	Antifungal activity against Phytophthora sojae race 1 in germinated soybean seeds assessed as root length at 5 mg/L after 48 hr (untreated control = 4.15 +/- 0.71 cm)	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1271320	Inhibition of ThRs in mouse MEF cells expressing Gcn2 (-/-) assessed as effect on Noxa mRNA level at 5 uM by RT-PCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271336	Inhibition of ThRS in human UMSCC14A cells assessed as increase in TRB3 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271305	Inhibition of ThRS in human UMSCC14A cells assessed as increase in cleaved caspase 9 level at 5 uM after 8 to 36 hrs by immunoblot analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1082766	Antifungal activity against Phytophthora sojae race 4 assessed as growth inhibition at 28 degC after 7 days (beneficial crop soybean)	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1271335	Inhibition of ThRS in human UMSCC1 cells assessed as increase in TRB3 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271285	Inhibition of cell proliferation in human UMSCC23 cells for 24 hrs by Celltiter Glo assay	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271297	Inhibition of ThRS in human UMSCC14A cells assessed as increase in ATF3 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID276486	Antiproliferative activity against 394NL cell line at 10 uM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID1271286	Cytotoxicity against HEK cells after 24 hrs by CelltiterGlo assay	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271328	Inhibition of cell proliferation in mouse MEF cells expressing Atf4(-/-) after 16 hrs CelltiterGlo assay	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1082779	Antifungal activity against Phytophthora sojae race 1 in germinated soybean seeds assessed as disease control efficacy at 5 mg/L after 48 hr relative to control	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1271294	Inhibition of ThRS in human UMSCC14A cells assessed as increase in XBP1 splicing by RT-PCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271325	Inhibition of ThRs in mouse MEF cells expressing Altf4 (-/-) assessed as effect on cell death-related gene expression by RT-PCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1082769	Antifungal activity against Phytophthora sojae race 13 assessed as growth inhibition at 28 degC after 7 days (beneficial crop soybean)	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1271330	Inhibition of cell proliferation in mouse MEF cells expressing Pkr(-/-) after 16 hrs CelltiterGlo assay	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271293	Inhibition of ThRS in human A253 cells assessed as increase in CHOP mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271332	Inhibition of ThRS in human UMSCC14A cells assessed as increase in NOXA mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1082780	Antifungal activity against Phytophthora sojae race 1 in germinated soybean seeds assessed as disease control efficacy at 10 mg/L after 48 hr relative to control	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1271317	Inhibition of ThRs in mouse MEF cells expressing Gcn2 (-/-) assessed as effect on phosphorylated eIF2alpha level at 5 uM by immunoblot analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271278	Inhibition of cell proliferation in human UMSCC1 cells for 24 hrs by Celltiter Glo assay	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID276482	Antiproliferative activity against H460 cell line at 10 uM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID202692	Ability to inhibit cell proliferation of Saccharomyces cerevisiae strain BY4741	2003	Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13	Borrelidin induces the transcription of amino acid biosynthetic enzymes via a GCN4-dependent pathway.
AID1271339	Inhibition of ThRS in human UMSCC1 cells assessed as increase in PUMA mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271338	Inhibition of ThRS in human A253 cells assessed as increase in TRB3 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID740870	Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by lactate dehydrogenase assay	2013	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8	Borrelidin analogues with antimalarial activity: design, synthesis and biological evaluation against Plasmodium falciparum parasites.
AID276509	Inhibition of HUVEC tubule formation assessed as length of branches at 100 nM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID1271288	Inhibition of ThRS in human UMSCC1 cells assessed as increase in UPR-related gene expression at 10 uM by RT-PCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271290	Inhibition of ThRS in human UMSCC1 cells assessed as increase in apoptosis-related gene expression at 10 uM by RT-PCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID590639	Inhibition of Mycobacterium tuberculosis recombinant MBP-tagged MshC assessed as formation of fluorescently labeled Cys-GlcN-Ins by HPLC	2011	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 21, Issue:8	Susceptibility and mode of binding of the Mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to tRNA synthetase inhibitors.
AID1082790	Phytotoxicity against germinated Glycine max (soybean) seeds at 10 mg/L	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1271312	Inhibition of ThRS in human UMSCC14A cells assessed as increase in DNA cleavage at 5 uM after 16 and 36 hrs by electrophoresis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID276505	Growth inhibition in HUVEC	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID1271323	Inhibition of ThRs in mouse MEF cells expressing Gcn2 (-/-) assessed as effect on Trb3 mRNA level at 5 uM by RT-PCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID740871	Antimalarial activity against Plasmodium falciparum FCR-3 infected in human erythrocytes after 72 hrs by lactate dehydrogenase assay	2013	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8	Borrelidin analogues with antimalarial activity: design, synthesis and biological evaluation against Plasmodium falciparum parasites.
AID1083022	Binding affinity to C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as static fluorescence quenching by FRET analysis	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1271342	Inhibition of ThRS in human A253 cells assessed as increase in PUMA mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1083011	Inhibition of C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as reduction in initial velocity at the step of threonine activation preincubated for 10 min with 4 uM enzyme befo	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1271346	Inhibition of ThRS in human A253 cells assessed as increase in DR5 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271283	Inhibition of ThRS in human UMSCC1 cells assessed as increase in XBP1 splicing by RT-PCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1083009	Binding affinity to C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as Stern-Volmer quenching constant at 27 degC by fluorescence spectroscopy	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1271304	Inhibition of ThRS in human A253 cells assessed as increase in caspase-3/7 level at 5 uM after 4 hrs by luminescent assay	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271322	Inhibition of ThRs in mouse MEF cells expressing Gcn2 (-/-) assessed as effect on Gadd45beta mRNA level at 5 uM by RT-PCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1171073	Growth inhibition of human HT-29 cells	2014	Journal of natural products, Nov-26, Volume: 77, Issue:11	Borrelidin B: isolation, biological activity, and implications for nitrile biosynthesis.
AID1082772	Antifungal activity against Phytophthora sojae race 1 in germinated soybean seeds assessed as root length at 1 mg/L after 48 hr (untreated control = 4.15 +/- 0.71 cm)	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1082770	Antifungal activity against Phytophthora sojae race 44 assessed as growth inhibition at 28 degC after 7 days (beneficial crop soybean)	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID276488	Antiproliferative activity against DU145 cell line at 10 uM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID1271324	Inhibition of ThRs in mouse MEF cells expressing Gcn2 (-/-) assessed as effect on Dr5 mRNA level at 5 uM by RT-PCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271345	Inhibition of ThRS in human UMSCC23 cells assessed as increase in DR5 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1083020	Binding affinity to C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as increase in alpha helicity of the protein at protein to compound ratio of 1:5 by CD spectroscopy (Rvb = 1	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1271341	Inhibition of ThRS in human UMSCC23 cells assessed as increase in PUMA mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271343	Inhibition of ThRS in human UMSCC1 cells assessed as increase in DR5 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271327	Inhibition of cell proliferation in mouse MEF cells expressing Chop(-/-) after 16 hrs Celltiter Glo assay	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID276504	Antiproliferative activity against NCI60 cell line	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID276508	Inhibition of HUVEC tubule formation assessed as length of branches at 10 nM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID1271311	Inhibition of ThRS in human UMSCC1 cells assessed as increase in DNA cleavage at 5 uM after 16 and 36 hrs by electrophoresis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1171071	Growth inhibition of human NCI-N87 cells	2014	Journal of natural products, Nov-26, Volume: 77, Issue:11	Borrelidin B: isolation, biological activity, and implications for nitrile biosynthesis.
AID1082771	Antifungal activity against Phytophthora sojae race 54 assessed as growth inhibition at 28 degC after 7 days (beneficial crop soybean)	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1082777	Antifungal activity against Phytophthora sojae race 1 in germinated soybean seeds assessed as lesion length at 10 mg/L after 48 hr (untreated control = 3.34 +/- 0.64 cm)	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1271289	Inhibition of ThRS in human UMSCC1 cells assessed as increase in DNA damaging-related gene expression at 10 uM by RT-PCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID276480	Antiproliferative activity against SF268 cell line at 10 uM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID276483	Antiproliferative activity against MCF7 cell line at 10 uM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID1585335	Selectivity index, ratio of IC50 for HEK293T cells to MIC for Aspergillus fumigatus CCTCC AF 93048	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and antifungal evaluation of borrelidin derivatives.
AID1083027	Binding affinity to C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as quenching rate constant at 27 degC by fluorescence spectroscopy	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1271303	Inhibition of ThRS in human UMSCC14A cells assessed as increase in caspase-3/7 level at 5 uM after 4 hrs by luminescent assay	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1083016	Antifungal activity against Phytophthora sojae race 1 assessed as radial growth inhibition at 0.006 ug/ml incubated at 28 degC in the dark for 6 to 8 days in presence of 0.6 mM threonine	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID276507	Inhibition of HUVEC tubule formation assessed as number of branches at 100 nM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID1083014	Antifungal activity against Phytophthora sojae race 1 assessed as radial growth inhibition at 0.008 ug/ml incubated at 28 degC in the dark for 6 to 8 days in presence of 0.2 to 0.6 mM glutamine	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1271337	Inhibition of ThRS in human UMSCC23 cells assessed as increase in TRB3 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271277	Inhibition of ThRs in mouse MEF cells expressing Perk (-/-) assessed as effect on phosphorylated eIF2alpha level at 5 uM by immunoblot analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1083026	Binding affinity to C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as quenching rate constant at 37 degC by fluorescence spectroscopy	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1271281	Inhibition of ThRS in human UMSCC1 cells assessed as increase in ATF4 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID276491	Antiproliferative activity against 1138L cell line at 10 uM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID276485	Antiproliferative activity against MDA467 cell line at 10 uM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID276484	Antiproliferative activity against MDA231 cell line at 10 uM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID1271344	Inhibition of ThRS in human UMSCC14A cells assessed as increase in DR5 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271308	Inhibition of ThRS in human UMSCC23 cells assessed as increase in cleaved caspase 9 level at 5 uM after 8 to 36 hrs by immunoblot analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271329	Inhibition of cell proliferation in mouse MEF cells expressing Hri(-/-) after 16 hrs CelltiterGlo assay	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271307	Inhibition of ThRS in human UMSCC14A cells assessed as increase in cleaved PARP level at 5 uM after 8 to 36 hrs by immunoblot analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271299	Inhibition of ThRS in human A253 cells assessed as increase in ATF3 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1083015	Antifungal activity against Phytophthora sojae race 1 assessed as radial growth inhibition at 0.008 ug/ml incubated at 28 degC in the dark for 6 to 8 days in presence of 0.2 to 0.6 mM alanine	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1083010	Binding affinity to C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) at 20 to 200 uM at 27 to 47 degC after 30 min by fluorescence quenching assay	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1083017	Antifungal activity against Pythium species	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1271316	Inhibition of ThRs in mouse MEF cells expressing Perk (-/-) assessed as effect on Chop level at 5 uM by immunoblot analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID740869	Cytotoxicity against human MCR5 cells after 7 days by MTT assay	2013	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8	Borrelidin analogues with antimalarial activity: design, synthesis and biological evaluation against Plasmodium falciparum parasites.
AID1171072	Growth inhibition of human MDA-MB-361 cells	2014	Journal of natural products, Nov-26, Volume: 77, Issue:11	Borrelidin B: isolation, biological activity, and implications for nitrile biosynthesis.
AID1271300	Inhibition of ThRS in human UMSCC14A cells assessed as increase in ATF4 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1082775	Antifungal activity against Phytophthora sojae race 1 in germinated soybean seeds assessed as lesion length at 1 mg/L after 48 hr (untreated control = 3.34 +/- 0.64 cm)	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1271282	Effect on Bip/GRP78 mRNA level in human UMSCC1 cells at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271298	Inhibition of ThRS in human UMSCC23 cells assessed as increase in ATF3 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271291	Inhibition of ThRS in human UMSCC14A cells assessed as increase in CHOP mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1083018	Binding affinity to C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as decrease in beta sheet content of the protein at protein to compound ratio of 1:5 by CD spectroscopy (Rvb	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1271306	Inhibition of ThRS in human UMSCC14A cells assessed as increase in cleaved caspase 3 level at 5 uM after 8 to 36 hrs by immunoblot analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1585334	Selectivity index, ratio of IC50 for HEK293T cells to MIC for Candida parapsilosis ATCC 22019	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and antifungal evaluation of borrelidin derivatives.
AID1271321	Inhibition of ThRs in mouse MEF cells expressing Gcn2 (-/-) assessed as effect on Puma mRNA level at 5 uM by RT-PCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1082776	Antifungal activity against Phytophthora sojae race 1 in germinated soybean seeds assessed as lesion length at 5 mg/L after 48 hr (untreated control = 3.34 +/- 0.64 cm)	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1271295	Inhibition of ThRS in human UMSCC23 cells assessed as increase in XBP1 splicing by RT-PCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1083025	Binding affinity to C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as quenching rate constant at 47 degC by fluorescence spectroscopy	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1585331	Antifungal activity against Aspergillus fumigatus CCTCC AF 93048 at 100 ug/ml after 48 hrs by micro broth dilution method	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and antifungal evaluation of borrelidin derivatives.
AID1083023	Binding affinity to C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as positive entropy and enthalpy changes by themodynamic analysis	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1271326	Inhibition of cell proliferation in mouse MEF cells expressing eIF2alpha Ser51Ala mutant after 16 hrs Celltiter Glo assay	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1082774	Antifungal activity against Phytophthora sojae race 1 in germinated soybean seeds assessed as root length at 10 mg/L after 48 hr (untreated control = 4.15 +/- 0.71 cm)	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1271296	Inhibition of ThRS in human A253 cells assessed as increase in XBP1 splicing by RT-PCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271313	Inhibition of ThRS in human UMSCC23 cells assessed as increase in DNA cleavage at 5 uM after 16 and 36 hrs by electrophoresis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271318	Inhibition of ThRs in mouse MEF cells expressing Gcn2 (-/-) assessed as effect on Chop level at 5 uM by immunoblot analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID740867	Selectivity index, ratio of IC50 for human MCR5 cells to IC50 for Plasmodium falciparum FCR-3	2013	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8	Borrelidin analogues with antimalarial activity: design, synthesis and biological evaluation against Plasmodium falciparum parasites.
AID1271284	Inhibition of cell proliferation in human UMSCC14A cells for 24 hrs by Celltiter Glo assay	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271314	Inhibition of ThRS in human A253 cells assessed as increase in DNA cleavage at 5 uM after 16 and 36 hrs by electrophoresis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1083007	Binding affinity to C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as Stern-Volmer quenching constant at 47 degC by fluorescence spectroscopy	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1083012	Antifungal activity against Phytophthora sojae race 1 assessed as radial growth inhibition at 0.008 ug/ml incubated at 28 degC in the dark for 6 to 8 days in presence of 0.2 to 0.6 mM L-aspargine	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1585327	Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by micro broth dilution method	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and antifungal evaluation of borrelidin derivatives.
AID276490	Antiproliferative activity against A498 cell line at 10 uM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID1082764	Antifungal activity against Phytophthora sojae race 1 assessed as growth inhibition at 28 degC after 7 days (beneficial crop soybean)	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1271279	Inhibition of ThRS in human UMSCC1 cells assessed as increase in CHOP mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271315	Inhibition of cell proliferation in human A549 cells expressing BAX/BAK (-/-) after 24 hrs by CelltiterGlo assay	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271334	Inhibition of ThRS in human A253 cells assessed as increase in NOXA mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID276487	Antiproliferative activity against OVCAR-3 cell line at 10 uM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID51559	Inhibition of cyclin-dependent kinase activity of Cdc28p/CDK2p in Saccharomyces cerevisiae	2003	Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13	Borrelidin induces the transcription of amino acid biosynthetic enzymes via a GCN4-dependent pathway.
AID1271340	Inhibition of ThRS in human UMSCC14A cells assessed as increase in PUMA mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1083021	Binding affinity to C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as increase in alpha helicity of the protein at protein to compound ratio of 1:1 by CD spectroscopy (Rvb = 1	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1271331	Inhibition of ThRS in human UMSCC1 cells assessed as increase in NOXA mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271309	Inhibition of ThRS in human UMSCC23 cells assessed as increase in cleaved caspase 3 level at 5 uM after 8 to 36 hrs by immunoblot analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1585329	Antifungal activity against Candida albicans ATCC MYA-2876 at 100 ug/ml after 48 hrs by micro broth dilution method	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and antifungal evaluation of borrelidin derivatives.
AID1083019	Binding affinity to C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as decrease in beta sheet content of the protein at protein to compound ratio of 1:1 by CD spectroscopy (Rvb	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1083013	Antifungal activity against Phytophthora sojae race 1 assessed as radial growth inhibition at 0.008 ug/ml incubated at 28 degC in the dark for 6 to 8 days in presence of 0.2 to 0.6 mM tyrosine	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1585332	Cytotoxicity against HEK293T cells assessed as growth inhibition after 48 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and antifungal evaluation of borrelidin derivatives.
AID1083024	Binding affinity to C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as equilibrium binding constant by fluorescence spectroscopy	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1271310	Inhibition of ThRS in human UMSCC23 cells assessed as increase in cleaved PARP level at 5 uM after 8 to 36 hrs by immunoblot analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID202698	Global transcription profiling experiment to examine the changes in the mRNA levels in the wt laboratory strain treated with the concentration of borrelidin (100 mM) that inhibitedcontinued growth of wt yeast	2003	Bioorganic & medicinal chemistry letters, Jul-07, Volume: 13, Issue:13	Borrelidin induces the transcription of amino acid biosynthetic enzymes via a GCN4-dependent pathway.
AID1271319	Inhibition of ThRs in mouse MEF cells expressing Perk (-/-) assessed as increase in Noxa mRNA level at 5 uM by RT-PCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID740868	Selectivity index, ratio of IC50 for human MCR5 cells to IC50 for Plasmodium falciparum K1	2013	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8	Borrelidin analogues with antimalarial activity: design, synthesis and biological evaluation against Plasmodium falciparum parasites.
AID276489	Antiproliferative activity against LNCAP cell line at 10 uM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID1083008	Binding affinity to C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as Stern-Volmer quenching constant at 37 degC by fluorescence spectroscopy	2012	Journal of agricultural and food chemistry, Oct-03, Volume: 60, Issue:39	Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
AID1271301	Inhibition of ThRS in human UMSCC23 cells assessed as increase in ATF4 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1271302	Inhibition of ThRS in human A253 cells assessed as increase in ATF4 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID276506	Inhibition of HUVEC tubule formation assessed as number of branches at 10 nM	2006	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue:22	Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
AID1271333	Inhibition of ThRS in human UMSCC23 cells assessed as increase in NOXA mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1082778	Antifungal activity against Phytophthora sojae race 1 in germinated soybean seeds assessed as disease control efficacy at 1 mg/L after 48 hr relative to control	2012	Journal of agricultural and food chemistry, Feb-08, Volume: 60, Issue:5	Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.
AID1271280	Inhibition of ThRS in human UMSCC1 cells assessed as increase in ATF3 mRNA level at 5 uM after 6 hrs by RT-qPCR analysis	2015	ACS medicinal chemistry letters, Nov-12, Volume: 6, Issue:11	Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.
AID1389355	Cytotoxicity against human L02 cells by CCK8 assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89.
AID1389353	Cytotoxicity against human HepG2 cells by CCK8 assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89.
AID1389356	Cytotoxicity against HUVEC12 cells by CCK8 assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89.
AID1389350	Cytotoxicity against human A549 cells by CCK8 assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89.
AID1389352	Cytotoxicity against human HeLa cells by CCK8 assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89.
AID1389354	Cytotoxicity against human MCF7 cells by CCK8 assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89.
AID1389351	Cytotoxicity against human CNE2 cells by CCK8 assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	13 (16.88)	18.7374
1990's	2 (2.60)	18.2507
2000's	20 (25.97)	29.6817
2010's	38 (49.35)	24.3611
2020's	4 (5.19)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Reviews	5 (6.67%)	6.00%
Case Studies	0 (0.00%)	4.05%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
Other	70 (93.33%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chloroquine chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.. Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.	2.08	1	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
metalaxyl metalaxyl : A racemate comprising equal amounts of (R)- and (S)-metalaxyl. A systemic fungicide, it is active against phytopathogens of the order Peronosporales and is used to conrtrol Pythium in a number of vegetable crops.. methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate : An alanine derivative that is methyl alaninate in which one of the hydrogens attached to the nitrogen is substituted by a methoxyacetyl group, while the other is substituted by a 2,6-dimethylphenyl group.. metalaxyl: RN given refers to (DL-Ala)-isomer	2.07	1	alanine derivative; aromatic amide; carboxamide; ether; methyl ester
fr 109615 cispentacin: structure given in first source; isolated from Bacillus cereus	2.06	1
ochratoxin a ochratoxin A: structure in first source & in Merck, 9th ed, #6549. ochratoxin A : A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.	2.06	1	isochromanes; monocarboxylic acid amide; N-acyl-L-phenylalanine; organochlorine compound; phenylalanine derivative	Aspergillus metabolite; calcium channel blocker; carcinogenic agent; mycotoxin; nephrotoxin; Penicillium metabolite; teratogenic agent
mupirocin mupirocin : An alpha,beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium Pseudomonas fluorescens, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections.. Mupirocin: A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.	2.06	1	alpha,beta-unsaturated carboxylic ester; epoxide; monocarboxylic acid; oxanes; secondary alcohol; triol	antibacterial drug; bacterial metabolite; protein synthesis inhibitor
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	2.17	1	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
niacin Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.. vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).. nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.	6.92	1	pyridine alkaloid; pyridinemonocarboxylic acid; vitamin B3	antidote; antilipemic drug; EC 3.5.1.19 (nicotinamidase) inhibitor; Escherichia coli metabolite; human urinary metabolite; metabolite; mouse metabolite; plant metabolite; vasodilator agent
propionic acid propionic acid : A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.	2.01	1	saturated fatty acid; short-chain fatty acid	antifungal drug
oxyquinoline Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.	2.06	1	monohydroxyquinoline	antibacterial agent; antifungal agrochemical; antiseptic drug; iron chelator
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	2.06	1	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
juglone juglone: structure. juglone : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogen at position 5 has been replaced by a hydroxy group. A plant-derived 1,4-naphthoquinone with confirmed antibacterial and antitumor activities.	2.06	1	hydroxy-1,4-naphthoquinone	geroprotector; herbicide; reactive oxygen species generator
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source	3.13	1	chromones; morpholines; organochlorine compound	autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector
pd 98059 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source. 2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.	3.13	1	aromatic amine; monomethoxyflavone	EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector
threonine Threonine: An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.. threonine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 1-hydroxyethyl group.	8.09	5	amino acid zwitterion; aspartate family amino acid; L-alpha-amino acid; proteinogenic amino acid; threonine	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
tryptophan Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	6.92	1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
styrene Styrene: A colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.. styrene : A vinylarene that is benzene carrying a vinyl group. It has been isolated from the benzoin resin produced by Styrax species.	2.02	1	styrenes; vinylarene; volatile organic compound	mouse metabolite; mutagen; plant metabolite
cyclopentane Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.	2.67	3	cycloalkane; cyclopentanes; volatile organic compound	non-polar solvent
thiazoles [no description available]	2.1	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	2.25	1	dialdehyde	biomarker
homoserine homoserine : An alpha-amino acid that is glycine substituted at the alpha-position by a 2-hydroxyethyl group.. L-homoserine : The L-enantiomer of homoserine.	6.96	1	amino acid zwitterion; homoserine	algal metabolite; Escherichia coli metabolite; human metabolite; Saccharomyces cerevisiae metabolite
deoxyuridine [no description available]	3.13	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.02	1	metal allergen; nickel group element atom; platinum group metal atom
zirconium Zirconium: A rather rare metallic element with atomic number 40, atomic weight 91.224, and symbol Zr.	2.02	1	titanium group element atom
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	3.13	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
etoposide [no description available]	2.15	1	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
ribavirin Rebetron: Rebetron is tradename	3.13	1	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide	anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
halofuginone [no description available]	3.27	1	quinazolines
thiazolyl blue thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.	2.1	1	organic bromide salt	colorimetric reagent; dye
glutathione disulfide Glutathione Disulfide: A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.	2.25	1	glutathione derivative; organic disulfide	Escherichia coli metabolite; mouse metabolite
steffimycin steffimycin: see also record for steffimycin B; structure	3.16	1
sb 203580 [no description available]	3.13	1	imidazoles; monofluorobenzenes; pyridines; sulfoxide	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector; Hsp90 inhibitor; neuroprotective agent
thaxtomine a thaxtomine A: a phytotoxin produced by Streptomyces scabies; RN given for (3R-trans)-isomer; structure in first source	3.19	1
mupirocin mupirocin : An alpha,beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium Pseudomonas fluorescens, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections.. Mupirocin: A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.	4.1	4	alpha,beta-unsaturated carboxylic ester; epoxide; monocarboxylic acid; oxanes; secondary alcohol; triol	antibacterial drug; bacterial metabolite; protein synthesis inhibitor
malonyl coenzyme a Malonyl Coenzyme A: A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems.. omega-carboxyacyl-CoA : An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of any alpha,omega-dicarboxylic acid.	2.17	1	malonyl-CoAs	EC 2.3.1.21 (carnitine O-palmitoyltransferase) inhibitor; Escherichia coli metabolite; metabolite; mouse metabolite
naphthoquinones Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.	2.06	1
menaquinone 6 menaquinone 6: RN given refers to (all-E)-isomer	2.08	1
sirolimus Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.. sirolimus : A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.	4.04	2	antibiotic antifungal drug; cyclic acetal; cyclic ketone; ether; macrolide lactam; organic heterotricyclic compound; secondary alcohol	antibacterial drug; anticoronaviral agent; antineoplastic agent; bacterial metabolite; geroprotector; immunosuppressive agent; mTOR inhibitor
concanamycin b concanamycin B: from Streptomyces diastatochromogenes S-45; structure given in first source	3.19	1
ammonium sulfate Ammonium Sulfate: Sulfuric acid diammonium salt. It is used in CHEMICAL FRACTIONATION of proteins.. ammonium sulfate : An inorganic sulfate salt obtained by reaction of sulfuric acid with two equivalents of ammonia. A high-melting (decomposes above 280degreeC) white solid which is very soluble in water (70.6 g/100 g water at 0degreeC; 103.8 g/100 g water at 100degreeC), it is widely used as a fertilizer for alkaline soils.	1.95	1	ammonium salt; inorganic sulfate salt	fertilizer
concanamycin a concanamycin A: from Streptomyces diastatochromogenes S-45; inhibits vacuolar H+ ATPase. concanamycin A : A concanamycin in which the lactone ring contains 4 double bonds and is substituted by 4 methyl groups, 2 hydroxy groups, 2 methoxy groups and an ethyl group.	3.19	1	carbamate ester; concanamycin	antifungal agent; EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor; metabolite
fd 891 FD 891: an 18-membered macrolide with an epoxide ring at C8 and C9; the epoxide may play an important role in its cytocidal activity; structure given in first source	3.19	1
sq-23377 Ionomycin: A divalent calcium ionophore that is widely used as a tool to investigate the role of intracellular calcium in cellular processes.. ionomycin : A very long-chain fatty acid that is docosa-10,16-dienoic acid which is substituted by methyl groups at positions 4, 6, 8, 12, 14, 18 and 20, by hydroxy groups at positions 11, 19 and 21, and by a (2',5-dimethyloctahydro-2,2'-bifuran-5-yl)ethanol group at position 21. An ionophore produced by Streptomyces conglobatus, it is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes.	2.02	1	cyclic ether; enol; polyunsaturated fatty acid; very long-chain fatty acid	calcium ionophore; metabolite
staurosporine staurosporinium : Conjugate acid of staurosporine.	2.15	1	ammonium ion derivative
agrocin 84 agrocin 84: contains glucose, deoxy arabinose & other yet unidentified sugars. agrocin 84 : A nucleotide conjugate that is produced by Agrobacterium radiobacter strain K-84. A 'Trojan horse' antibiotic used to control crown gall.	2.6	1	purines
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.15	1
piperidines Piperidines: A family of hexahydropyridines.	3.27	1
methylmalonyl-coenzyme a [no description available]	2.02	1
4-epianhydrotetracycline 4-epianhydrotetracycline: impurity in pahrmaceutical preparations of tetracycline; RN refers to (4S-(4alpha,4aalpha,12aalpha))-isomer	2.06	1
streptolydigin streptolydigin: antibiotic isolated from culture filtrates of Streptomyces lydicus; active against gram-postive bacteria except micrococci; minor descriptor (75-87); on line & INDEX MEDICUS search ANTIBIOTICS (75-87). streptolydigin : A monocarboxylic acid amide that is a broad-spectrum antibiotic produced by Streptomyces lydicus.	3.16	1	bridged compound; cyclic ketal; enol; monocarboxylic acid amide; N-glycosyl compound; organic heterobicyclic compound; pyrrolidinone; spiro-epoxide	antimicrobial agent; bacterial metabolite; EC 2.7.7.6 (RNA polymerase) inhibitor
indolmycin indolmycin: produced by a strain of Streptomyces griseus; RN given refers to cpd without isomeric designation; structure. indolmycin : A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted at the 2 and 5-pro-S positions by methylamino and [(1R)-1-(1H-indol-3-yl)ethyl] groups, respectively.	2.06	1	1,3-oxazoles; indoles; secondary amino compound	antibacterial agent; antimicrobial agent; bacterial metabolite; EC 6.1.1.2 (tryptophan--tRNA ligase) inhibitor

Condition	Relationship Strength	Studies
E coli Infections [description not available]	2.6	1
Escherichia coli Infections Infections with bacteria of the species ESCHERICHIA COLI.	2.6	1
Disseminated Fungal Infection [description not available]	2.25	1
Candida Infection [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.59	2
Candidiasis Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)	2.25	1
Autoimmune Disease [description not available]	2.15	1
Sterility, Male [description not available]	2.15	1
Autoimmune Diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.	2.15	1
Infertility, Male The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.	2.15	1
Orchitis Inflammation of a TESTIS. It has many features of EPIDIDYMITIS, such as swollen SCROTUM; PAIN; PYURIA; and FEVER. It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS and then the TESTIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD.	2.15	1
Cancer of Pancreas [description not available]	2.17	1
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	2.17	1
Black Fever [description not available]	2.17	1
Leishmaniasis, Visceral A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African.	2.17	1
Breast Cancer [description not available]	2.53	2
Cancer of Lung [description not available]	2.17	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.53	2
Lung Neoplasms Tumors or cancer of the LUNG.	2.17	1
Parasitemia The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)	2.08	1
Infections, Plasmodium [description not available]	2.08	1
Malaria A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.	7.08	1
Leucocythaemia [description not available]	2.1	1
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	7.1	1
Acute Lymphoid Leukemia [description not available]	2.07	1
Precursor Cell Lymphoblastic Leukemia-Lymphoma A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.	2.07	1
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	2.07	1
Benign Neoplasms [description not available]	2.03	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.03	1
Metastase [description not available]	2.94	1
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.94	1
Angiogenesis, Pathologic [description not available]	1.99	1

borrelidin

Description

Cross-References

Synonyms (42)

Research Excerpts

Overview

Effects

Toxicity

Roles (6)

Drug Classes (5)

Protein Targets (3)

Inhibition Measurements

Ceullar Components (1)

Bioassays (153)

Research

Studies (77)

Market Indicators

Research Demand Index: 29.88

Study Types

borrelidin

Description

Cross-References

Synonyms (42)

Research Excerpts

Overview

Effects

Toxicity

Roles (6)

Drug Classes (5)

Protein Targets (3)

Inhibition Measurements

Ceullar Components (1)

Bioassays (153)

Research

Studies (77)

Market Indicators

Research Demand Index: 29.88

Study Types

Related Drugs (50)

Related Conditions (32)