2-5A-dependent ribonuclease

A 2-5A-dependent ribonuclease that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05823]

Synonyms

2-5A-dependent RNase;
EC 3.1.26.-;
Ribonuclease 4;
Ribonuclease L;
RNase L

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (100.00)	2.80

Compounds (4)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
butylparaben	Homo sapiens (human)	IC50	2,400.0000	1	1
vitexin	Homo sapiens (human)	IC50	190.0000	1	1
hyperoside	Homo sapiens (human)	IC50	1.4325	4	4
myricetin	Homo sapiens (human)	IC50	264.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
myricetin	Homo sapiens (human)	Activity	30.0000	1	1

Enables

This protein enables 9 target(s):

Target	Category	Definition
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
RNA endonuclease activity	molecular function	Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. [GOC:mah, ISBN:0198547684]
RNA nuclease activity	molecular function	Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. [GOC:mah, ISBN:0198547684]
protein kinase activity	molecular function	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
rRNA binding	molecular function	Binding to a ribosomal RNA. [GOC:jl]
ribonucleoprotein complex binding	molecular function	Binding to a complex of RNA and protein. [GOC:bf, GOC:go_curators, GOC:vk]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
mitochondrial matrix	cellular component	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nuclear matrix	cellular component	The dense fibrillar network lying on the inner side of the nuclear membrane. [ISBN:0582227089]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cellular_component	cellular component	A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). [GOC:pdt]

Involved In

This protein is involved in 10 target(s):

Target	Category	Definition
rRNA processing	biological process	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. [GOC:curators]
mRNA processing	biological process	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. [GOC:mah]
protein phosphorylation	biological process	The process of introducing a phosphate group on to a protein. [GOC:hb]
regulation of mRNA stability	biological process	Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. [GOC:jl]
negative regulation of viral genome replication	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication. [GOC:go_curators]
fat cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. [CL:0000136, GOC:go_curators]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
positive regulation of glucose import	biological process	Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. [GOC:ai, GOC:dph, GOC:tb]
defense response to virus	biological process	Reactions triggered in response to the presence of a virus that act to protect the cell or organism. [GOC:ai]
RNA processing	biological process	Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. [GOC:mah]