A sodium channel protein type 1 subunit alpha that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35498]
Sodium channel protein brain I subunit alpha;
Sodium channel protein type I subunit alpha;
Voltage-gated sodium channel subunit alpha Nav1.1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| phenytoin | Homo sapiens (human) | IC50 | 18.5000 | 1 | 1 |
| amiodarone | Homo sapiens (human) | IC50 | 4.8000 | 1 | 1 |
| amitriptyline | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| chlorpromazine | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| cifenline | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| haloperidol | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| imipramine | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| mexiletine | Homo sapiens (human) | IC50 | 43.0000 | 1 | 1 |
| nifedipine | Homo sapiens (human) | IC50 | 37.0000 | 1 | 1 |
| nitrendipine | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| phenobarbital | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| naphthazarin | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| pimozide | Homo sapiens (human) | IC50 | 0.0540 | 1 | 1 |
| mexiletine hydrochloride | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| diltiazem | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| sertindole | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| mibefradil | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| tedisamil | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| uk 68798 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| n-methylpiperidin-4-yl propionate | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| cns 5161 | Homo sapiens (human) | IC50 | 1.7500 | 1 | 1 |
| senicapoc | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| ica-121431 | Homo sapiens (human) | IC50 | 0.0260 | 2 | 2 |
| 2-ethyl-5-methoxy-n,n-dimethyltryptamine | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| 5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole | Homo sapiens (human) | IC50 | 0.6600 | 1 | 1 |
| tetrodotoxin | Homo sapiens (human) | IC50 | 0.0170 | 2 | 2 |
| cnv1014802 | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |
| saxitoxin | Homo sapiens (human) | IC50 | 0.0023 | 1 | 1 |
| gs-458967 | Homo sapiens (human) | IC50 | 5.2000 | 2 | 2 |
| ajmaline | Homo sapiens (human) | IC50 | 8.2000 | 1 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated sodium channel activity | molecular function | Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729] |
| voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | molecular function | Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse. [GOC:dos] |
This protein is located in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| intercalated disc | cellular component | A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. [GOC:mtg_muscle, PMID:11732910] |
| nuclear body | cellular component | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182] |
| Z disc | cellular component | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. [GOC:mtg_muscle, ISBN:0815316194] |
| T-tubule | cellular component | Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. [GOC:mtg_muscle, ISBN:0815316194] |
| node of Ranvier | cellular component | An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. [GOC:mh] |
| neuronal cell body | cellular component | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators] |
| axon initial segment | cellular component | Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. [GOC:nln, GOC:sl, PMID:1754851, PMID:21551097] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated sodium channel complex | cellular component | A sodium channel in a cell membrane whose opening is governed by the membrane potential. [ISBN:0198506732] |
This protein is involved in 13 target(s):
| Target | Category | Definition |
|---|---|---|
| sodium ion transport | biological process | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| adult walking behavior | biological process | The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. [GOC:jid, GOC:pr, ISBN:0198606907] |
| determination of adult lifespan | biological process | The pathways that regulate the duration of the adult phase of the life-cycle of an animal. [PMID:25561524, PMID:273723695, PMID:3424805] |
| neuronal action potential propagation | biological process | The propagation of an action potential along an axon, away from the soma. [GOC:isa_complete] |
| neuronal action potential | biological process | An action potential that occurs in a neuron. [GOC:dph, GOC:isa_complete, GOC:tb] |
| nerve development | biological process | The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] |
| neuromuscular process controlling posture | biological process | Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts. [GOC:dph, GOC:tb] |
| detection of mechanical stimulus involved in sensory perception of pain | biological process | The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal. [GOC:ai, GOC:dos] |
| establishment of localization in cell | biological process | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. [GOC:ai, GOC:dos, GOC:dph, GOC:tb] |
| cardiac muscle cell action potential involved in contraction | biological process | An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| membrane depolarization during action potential | biological process | The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| regulation of presynaptic membrane potential | biological process | Any process that modulates the potential difference across a presynaptic membrane. [GOC:dph, GOC:ef] |
| sodium ion transmembrane transport | biological process | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:vw] |