A protein that is a translation product of the CPK1 gene in Plasmodium falciparum 3D7. [PRO:DNx, UniProtKB:P62344]
EC 2.7.11.1;
PfCDPK1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| cytidine | Plasmodium falciparum 3D7 | IC50 | 1.0000 | 1 | 0 |
| c 137 | Plasmodium falciparum 3D7 | IC50 | 1.0000 | 1 | 0 |
| imidocarb | Plasmodium falciparum 3D7 | IC50 | 1.0000 | 1 | 0 |
| 1,1-Dichloro-2,2-bis(4-hydroxyphenyl)ethylene | Plasmodium falciparum 3D7 | IC50 | 1.0000 | 1 | 0 |
| mmv665852 | Plasmodium falciparum 3D7 | IC50 | 1.0000 | 1 | 0 |
| 1,3,4,10-Tetrahydro-9(2H)-acridinone | Plasmodium falciparum 3D7 | IC50 | 1.0000 | 1 | 0 |
| jp-1302 | Plasmodium falciparum 3D7 | IC50 | 1.0000 | 1 | 0 |
| 1,4,8-trimethyl-12-quinolino[2,3-b]quinolinamine | Plasmodium falciparum 3D7 | IC50 | 1.0000 | 1 | 0 |
| polysulfide rubber | Plasmodium falciparum 3D7 | IC50 | 1.0000 | 1 | 0 |
| 2-[2-methoxyethyl-(1-oxo-2-thiophen-2-ylethyl)amino]-N-[(4-methoxyphenyl)methyl]-2-(4-propan-2-ylphenyl)acetamide | Plasmodium falciparum 3D7 | IC50 | 1.0000 | 1 | 0 |
| purfalcamine | Plasmodium falciparum 3D7 | IC50 | 0.0076 | 2 | 2 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| imatinib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| staurosporine | Plasmodium falciparum 3D7 | Kd | 0.0002 | 1 | 1 |
| gefitinib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| lestaurtinib | Plasmodium falciparum 3D7 | Kd | 0.0056 | 1 | 1 |
| vatalanib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| ruboxistaurin | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| canertinib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| birb 796 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| sb 203580 | Plasmodium falciparum 3D7 | Kd | 0.8500 | 1 | 1 |
| enzastaurin | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| erlotinib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| lapatinib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| sorafenib | Plasmodium falciparum 3D7 | Kd | 0.2200 | 1 | 1 |
| pd 173955 | Plasmodium falciparum 3D7 | Kd | 3.3000 | 1 | 1 |
| s 1033 | Plasmodium falciparum 3D7 | Kd | 0.7900 | 1 | 1 |
| bms 387032 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| tandutinib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| vx-745 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| dasatinib | Plasmodium falciparum 3D7 | Kd | 0.6400 | 1 | 1 |
| zd 6474 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| alvocidib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| bosutinib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| su 11248 | Plasmodium falciparum 3D7 | Kd | 1.3000 | 1 | 1 |
| vx680 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| axitinib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| pd 184352 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| bms345541 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| midostaurin | Plasmodium falciparum 3D7 | Kd | 0.9500 | 1 | 1 |
| ki 20227 | Plasmodium falciparum 3D7 | Kd | 1.8000 | 1 | 1 |
| pi103 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| hki 272 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| tofacitinib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| cediranib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| masitinib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| pazopanib | Plasmodium falciparum 3D7 | Kd | 0.3700 | 1 | 1 |
| azd 6244 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| su 14813 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| bibw 2992 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| tg100-115 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| pha 665752 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| brivanib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| at 7519 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| bi 2536 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| nvp-ast487 | Plasmodium falciparum 3D7 | Kd | 0.0085 | 1 | 1 |
| kw 2449 | Plasmodium falciparum 3D7 | Kd | 2.4000 | 1 | 1 |
| abt 869 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| gw 2580 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| crizotinib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| chir-265 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| motesanib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| mln8054 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| GDC-0879 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| gsk 461364 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| azd 1152-hqpa | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| nvp-tae684 | Plasmodium falciparum 3D7 | Kd | 0.7100 | 1 | 1 |
| fedratinib | Plasmodium falciparum 3D7 | Kd | 1.2000 | 1 | 1 |
| gsk690693 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| gdc 0941 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| plx 4720 | Plasmodium falciparum 3D7 | Kd | 0.0017 | 1 | 1 |
| sgx 523 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| quizartinib | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| incb-018424 | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| gsk 1838705a | Plasmodium falciparum 3D7 | Kd | 10.0000 | 1 | 1 |
| gsk 1363089 | Plasmodium falciparum 3D7 | Kd | 0.2300 | 1 | 1 |
| chir 258 | Plasmodium falciparum 3D7 | Kd | 0.6100 | 1 | 1 |
| nintedanib | Plasmodium falciparum 3D7 | Kd | 1.2000 | 1 | 1 |
| pp242 | Plasmodium falciparum 3D7 | Kd | 0.4900 | 1 | 1 |