Page last updated: 2024-08-07 14:38:43
Neuraminidase
[no definition available]
Synonyms
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| zanamivir | Influenza A virus (A/Turkey/651242/2006(H5N1)) | IC50 | 0.0054 | 4 | 4 |
| zanamivir | Influenza A virus (A/Turkey/651242/2006(H5N1)) | Ki | 0.0010 | 1 | 1 |
| oseltamivir | Influenza A virus (A/Turkey/651242/2006(H5N1)) | IC50 | 0.1104 | 2 | 2 |
| oseltamivir | Influenza A virus (A/Turkey/651242/2006(H5N1)) | Ki | 0.0079 | 1 | 1 |
| bcx 1812 | Influenza A virus (A/Turkey/651242/2006(H5N1)) | IC50 | 0.0094 | 2 | 2 |
| gs 4071 | Influenza A virus (A/Turkey/651242/2006(H5N1)) | IC50 | 1.4208 | 2 | 2 |
Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives.Journal of medicinal chemistry, , 03-08, Volume: 61, Issue:5, 2018
Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.Journal of medicinal chemistry, , 11-21, Volume: 61, Issue:22, 2018
Susceptibility of highly pathogenic H5N1 influenza viruses to the neuraminidase inhibitor oseltamivir differs in vitro and in a mouse model.Antimicrobial agents and chemotherapy, , Volume: 53, Issue:7, 2009
Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.Journal of medicinal chemistry, , 11-21, Volume: 61, Issue:22, 2018
Discovery of N-substituted oseltamivir derivatives as potent and selective inhibitors of H5N1 influenza neuraminidase.Journal of medicinal chemistry, , Oct-23, Volume: 57, Issue:20, 2014