Excitatory amino acid transporter 1

An excitatory amino acid transporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43003]

Synonyms

Sodium-dependent glutamate/aspartate transporter 1;
GLAST-1;
Solute carrier family 1 member 3

Research

Bioassay Publications (13)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (46.15)	29.6817
2010's	5 (38.46)	24.3611
2020's	2 (15.38)	2.80

Compounds (15)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid	Homo sapiens (human)	IC50	1,000.0000	1	1
cysteine	Homo sapiens (human)	IC50	376.0000	1	0
aspartic acid	Homo sapiens (human)	IC50	90.1265	4	2
d-glutamate	Homo sapiens (human)	IC50	1,000.0000	1	0
glutamic acid	Homo sapiens (human)	IC50	76.4503	4	4
glutamic acid	Homo sapiens (human)	Ki	33.3114	1	2
d-aspartic acid	Homo sapiens (human)	IC50	398.0000	1	0
dihydrokainate	Homo sapiens (human)	IC50	3,081.1400	1	2
serine o-sulfate	Homo sapiens (human)	IC50	100.0000	1	1
hinokinin	Homo sapiens (human)	IC50	500.0000	1	1
3-hydroxyaspartic acid, (threo-l)-isomer	Homo sapiens (human)	IC50	3.8952	1	2
2-amino-3-phenylmethoxybutanedioic acid	Homo sapiens (human)	IC50	11.2874	3	5
dl-threo-beta-benzyloxyaspartate	Homo sapiens (human)	IC50	310.5514	3	8
l-beta-threo-benzyl-aspartate	Homo sapiens (human)	IC50	36.9954	2	3
ucph 101	Homo sapiens (human)	IC50	1.1672	6	8

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
glutamic acid	Homo sapiens (human)	Km	8.5500	2	2
sym 2081	Homo sapiens (human)	Km	13.0000	1	1

Enables

This protein enables 7 target(s):

Target	Category	Definition
L-glutamate transmembrane transporter activity	molecular function	Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
high-affinity L-glutamate transmembrane transporter activity	molecular function	Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. [TC:2.A.3.10.5]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
glutamate:sodium symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). [TC:2.A.27.1.1]
glutamate binding	molecular function	Binding to glutamate, the anion of 2-aminopentanedioic acid. [GOC:ai]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
neutral L-amino acid transmembrane transporter activity	molecular function	Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]

Located In

This protein is located in 9 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
basal plasma membrane	cellular component	The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
cytoplasmic vesicle	cellular component	A vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles]
neuron projection	cellular component	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
synapse	cellular component	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
membrane protein complex	cellular component	Any protein complex that is part of a membrane. [GOC:dos]

Involved In

This protein is involved in 27 target(s):

Target	Category	Definition
neurotransmitter uptake	biological process	The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. [ISBN:0123668387]
monoatomic ion transport	biological process	The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai]
neurotransmitter transport	biological process	The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai]
intracellular sodium ion homeostasis	biological process	A homeostatic process involved in the maintenance of a steady state level of sodium ions within a cell. [GOC:ai, GOC:mah]
chemical synaptic transmission	biological process	The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]
sensory perception of sound	biological process	The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. [GOC:ai]
response to xenobiotic stimulus	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
response to light stimulus	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. [GOC:go_curators, ISBN:0582227089]
gamma-aminobutyric acid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. [GOC:ai]
response to wounding	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. [GOC:go_curators]
neutral amino acid transport	biological process	The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
L-glutamate transmembrane transport	biological process	The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore. [PMID:21307582]
cranial nerve development	biological process	The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
auditory behavior	biological process	The behavior of an organism in response to a sound. [GOC:pr, GOC:rc]
response to antibiotic	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. [GOC:ai, GOC:ef]
cell morphogenesis involved in neuron differentiation	biological process	The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. [GOC:dph, GOC:tb]
positive regulation of synaptic transmission	biological process	Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. [GOC:ai]
neuromuscular process controlling balance	biological process	Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. [GOC:ai, GOC:dph]
L-glutamate import	biological process	The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle. [GOC:ai, GOC:jsg, GOC:mah]
transepithelial transport	biological process	The directed movement of a substance from one side of an epithelium to the other. [GOC:mah, GOC:yaf, ISBN:0716731363]
D-aspartate import across plasma membrane	biological process	The directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol. [PMID:7914198]
cellular response to cocaine	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. [GOC:mah]
potassium ion transmembrane transport	biological process	A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah]
L-glutamate import across plasma membrane	biological process	The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]
L-aspartate import across plasma membrane	biological process	The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol. [GO_REF:0000069, PMID:7914198]
transport across blood-brain barrier	biological process	The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008]
chloride transmembrane transport	biological process	The process in which chloride is transported across a membrane. [GOC:TermGenie, GOC:vw]