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Dihydrofolate reductase
A dihydrofolate reductase that is encoded in the genome of chicken. [PRO:DAN]
Synonyms
EC 1.5.1.3
Research
Bioassay Publications (10)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 7 (70.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (14)
Drugs with Inhibition Measurements
On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 12. 1,2-Dihydroquinolylmethyl analogues with high activity and specificity for bacterial dihydrofolate reductase.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 8. The 3,4,5-triethyl isostere of trimethoprim. A study of specificity.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 8. The 3,4,5-triethyl isostere of trimethoprim. A study of specificity.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
Quantitative structure-activity relationships of 2, 4-diamino-5-(2-X-benzyl)pyrimidines versus bacterial and avian dihydrofolate reductase.Journal of medicinal chemistry, , Oct-22, Volume: 41, Issue:22, 1998
On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships.Journal of medicinal chemistry, , Volume: 32, Issue:8, 1989