Proteins > Prostaglandin E2 receptor EP4 subtype
Page last updated: 2024-08-07 18:35:22
Prostaglandin E2 receptor EP4 subtype
A prostaglandin E2 receptor EP4 subtype that is encoded in the genome of rat. [OMA:P43114, PRO:DNx]
Synonyms
PGE receptor EP4 subtype;
PGE2 receptor EP4 subtype;
Prostanoid EP4 receptor
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| dinoprostone | Rattus norvegicus (Norway rat) | IC50 | 0.0021 | 1 | 1 |
| cp533536 | Rattus norvegicus (Norway rat) | IC50 | 3.2000 | 1 | 1 |
| cj-023,423 | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| dinoprostone | Rattus norvegicus (Norway rat) | EC50 | 0.0021 | 2 | 2 |
| cj-023,423 | Rattus norvegicus (Norway rat) | Kd | 0.0065 | 1 | 1 |
Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists.Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 19, Issue:7, 2009