DNA (cytosine-5)-methyltransferase 3-like

A DNA (cytosine-5)-methyltransferase 3-like that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UJW3]

Synonyms

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (6)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
procainamide	Homo sapiens (human)	IC50	300.0000	1	1
dichlone	Homo sapiens (human)	IC50	0.5000	1	1
5,5'-methylenedisalicylic acid	Homo sapiens (human)	IC50	23.2000	2	2
rg108	Homo sapiens (human)	IC50	315.0000	1	1
genistein	Homo sapiens (human)	IC50	100.0000	1	1
sgi-1027	Homo sapiens (human)	IC50	10.0000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
enzyme activator activity	molecular function	Binds to and increases the activity of an enzyme. [GOC:dph, GOC:mah, GOC:tb]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	molecular function	Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA). [EC:2.1.1.37, PMID:15689527]
DNA binding	molecular function	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
condensed nuclear chromosome	cellular component	A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. [GOC:elh]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 3 target(s):

Target	Category	Definition
ESC/E(Z) complex	cellular component	A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]
catalytic complex	cellular component	A protein complex which is capable of catalytic activity. [GOC:bhm, GOC:TermGenie, PMID:8077207]
heterochromatin	cellular component	A compact and highly condensed form of chromatin that is refractory to transcription. [PMID:32017156]

Involved In

This protein is involved in 14 target(s):

Target	Category	Definition
placenta development	biological process	The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. [GOC:add, ISBN:068340007X]
DNA methylation-dependent heterochromatin formation	biological process	Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. [GOC:mah]
male meiosis I	biological process	A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. [GOC:dph, GOC:mah]
spermatogenesis	biological process	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]
methylation	biological process	The process in which a methyl group is covalently attached to a molecule. [GOC:mah]
epigenetic programing of female pronucleus	biological process	The global programming of epigenetic modifications in the female pronucleus of the newly fertilized zygote. The maternal genome is protected from global DNA demethylation before the first division of the zygote, and instead undergoes passive, replication-dependent demethylation during early embryogenesis, arising from inhibition of the DNA maintenance methyltransferase Dnmt1. [GOC:sp, PMID:22868271]
negative regulation of gene expression, epigenetic	biological process	An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation. [PMID:22243696]
stem cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. [CL:0000034, GOC:isa_complete]
chorionic trophoblast cell differentiation	biological process	The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer. [CL:0011101, GOC:dph, PMID:16983341]
genomic imprinting	biological process	The establishment of epigenetic modifications (imprints) during gametogenesis, and propagation of these imprints during the organism's life. Genomic imprinting leads to an asymmetry between the maternal and paternal alleles and differential expression of the corresponding alleles. This can happen through heterochromatin formation or differential chromatin loop formation. [PMID:24492710, PMID:31896690, PMID:31965998]
negative regulation of DNA methylation-dependent heterochromatin formation	biological process	Any process that decreases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation. [GOC:BHF]
retrotransposon silencing by heterochromatin formation	biological process	A retrotransposon silencing mechanism involving heterochromatin assembly. Heterochromatin is a chromatin conformation that is refractory to transcription. [PMID:25247314, PMID:28951459, PMID:32823517]
autosome genomic imprinting	biological process	The establishment of epigenetic modifications (imprints) in autosomal (non-sexual) chromosomes during gametogenesis, and propagation of these imprints during the organism's life. Genomic imprinting leads to an asymmetry between the maternal and paternal alleles and differential expression of the corresponding alleles. This can happen through heterochromatin formation or differential chromatin loop formation. [PMID:31782494]
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]