Page last updated: 2024-12-06

neptunium

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Neptunium is a synthetic actinide element with the symbol Np and atomic number 93. It was first produced in 1940 at the University of California, Berkeley by Edwin McMillan and Philip Abelson. It is not found naturally on Earth, but is produced in nuclear reactors as a byproduct of uranium fission. Neptunium is a silvery-white radioactive metal with a high density. It has several isotopes, the most common being neptunium-237, which has a half-life of 2.14 million years. Neptunium is used in nuclear weapons and in the production of plutonium-238, which is used in radioisotope thermoelectric generators. Neptunium is also being studied for its potential use in nuclear medicine and in the treatment of cancer. Because neptunium is a transuranic element, its radioactivity and chemical properties make it an important subject of study in nuclear chemistry and physics. The study of neptunium provides valuable insights into the behavior of heavy elements and the nature of radioactivity.'

Neptunium: A radioactive element of the actinide metals family. It has the atomic symbol Np, and atomic number 93. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID23933
CHEBI ID33387
MeSH IDM0014640

Synonyms (22)

Synonym
neptunium
NP ,
CHEBI:33387
93np
7439-99-8
neptunio
neptunium atom
NP6 ,
neptunium ion(5 )
neptunium(5+)
neptunium, ion(np5 )
6200k977bq ,
unii-6200k977bq
einecs 231-108-8
neptunium, ion(np6 )
neptunium ion(6 )
neptunium, ion (np4+)
neptunium [mi]
neptunium, elemental
neptunium [hsdb]
DTXSID5074840
Q1105

Research Excerpts

Overview

Neptunium-237 is a radionuclide of great interest owing to its long half-life. Neptunium is a transuranium element, produced in tonne quantities in nuclear reactors.

ExcerptReferenceRelevance
"Neptunium-237 is a radionuclide of great interest owing to its long half-life (2.14 × 10(6) years) and relative mobility as the neptunyl ion (NpO2(+)) under many surface and groundwater conditions. "( Effects of Titanium Doping in Titanomagnetite on Neptunium Sorption and Speciation.
Olive, DT; Powell, BA; Wylie, EM, 2016
)
2.13
"Neptunium is a transuranium element, produced in tonne quantities in nuclear reactors. "( An X-ray absorption spectroscopy study of neptunium(V) reactions with Mackinawite (FeS).
Charnock, JM; Hennig, C; Jones, MJ; Livens, FR; Mosselmans, JF; Moyes, LN; Pattrick, RA; Reed, WA; Vaughan, DJ, 2002
)
2.02

Bioavailability

ExcerptReferenceRelevance
" These results are consistent with the hypothesis that Np(V), when given in small mass quantities to fed animals, is reduced in the gastrointestinal tract to Np(IV), which is less well absorbed than Np(V)."( Effects of fasting and/or oxidizing and reducing agents on absorption of neptunium from the gastrointestinal tract of mice and adult or neonatal rats.
Ruemmler, PS; Ryan, JL; Sullivan, MF, 1984
)
0.5
" The most important ones were related to the bioavailability and mobility of radionuclides in the environment, for example soil-to-plant transfer factors, the bioaccumulation factors for marine biota and the gut uptake fraction for terrestrial mammals."( Study of the uncertainty in estimation of the exposure of non-human biota to ionising radiation.
Agüero, A; Avila, R; Beresford, NA; Broed, R; Brown, J; Iospje, M; Robles, B; Suañez, A, 2004
)
0.32

Dosage Studied

ExcerptRelevanceReference
" The ligands were injected intravenously at a dosage of 30 mumol kg-1 and the animals killed 24 h later."( Evaluation of the efficiency of DTPA and other new chelating agents for removing neptunium from target organs.
Bailly, T; Burgada, R; Metivier, H; Paquet, F; Poncy, JL, 1997
)
0.52
"The data obtained after simultaneous injections showed that the ligand dosage effectiveness was not linear and depended on the tissues being considered."( Efficacy of 3,4,3-LIHOPO for reducing neptunium retention in the rat after simulated wound contamination.
Ansoborlo, E; Durbin, PW; Hengé-Napoli, MH; Houpert, P; Montègue, B; Paquet, F; Raymond, KN, 2000
)
0.58
"To examine dose-response relationships between internal uranium exposures and select outcomes among a cohort of uranium enrichment workers."( Dose-response relationships between internally-deposited uranium and select health outcomes in gaseous diffusion plant workers, 1948-2011.
Anderson, JL; Bertke, SJ; Tollerud, DJ; Yiin, JH, 2018
)
0.48
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
actinoid atom
f-block element atom
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (251)

TimeframeStudies, This Drug (%)All Drugs %
pre-1990109 (43.43)18.7374
1990's28 (11.16)18.2507
2000's47 (18.73)29.6817
2010's60 (23.90)24.3611
2020's7 (2.79)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 80.07

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index80.07 (24.57)
Research Supply Index5.58 (2.92)
Research Growth Index4.55 (4.65)
Search Engine Demand Index140.43 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (80.07)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews9 (3.41%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other255 (96.59%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]