A diacylglycerol lipase-alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y4D2]
DAGL-alpha;
DGL-alpha;
EC 3.1.1.-;
Neural stem cell-derived dendrite regulator;
Sn1-specific diacylglycerol lipase alpha
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| cannabinol | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| 1,6-bis(cyclohexyloximinocarbonyl)hexane | Homo sapiens (human) | IC50 | 23.7977 | 4 | 4 |
| cannabichromene | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| (6ar-trans)-isomer of tetrahydrocannabivarin 9 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| delta(9)-tetrahydrocannabinolic acid | Homo sapiens (human) | IC50 | 27.3000 | 1 | 1 |
| cannabidiolic acid | Homo sapiens (human) | IC50 | 19.4000 | 1 | 1 |
| cannabidiol | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| orlistat | Homo sapiens (human) | IC50 | 0.2678 | 4 | 4 |
| cannabigerol | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cannabigerolic acid | Homo sapiens (human) | IC50 | 30.5000 | 1 | 1 |
| CAY10435 | Homo sapiens (human) | IC50 | 0.0309 | 1 | 1 |
| ly2183240 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| cannabidivarin | Homo sapiens (human) | IC50 | 16.6000 | 2 | 2 |
| omdm 169 | Homo sapiens (human) | IC50 | 2.8000 | 1 | 1 |
| am 6701 | Homo sapiens (human) | IC50 | 0.5100 | 1 | 1 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| acylglycerol lipase activity | molecular function | Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol. [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN] |
| lipoprotein lipase activity | molecular function | Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein. [EC:3.1.1.34, GOC:bf] |
This protein is located in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| early endosome membrane | cellular component | The lipid bilayer surrounding an early endosome. [GOC:pz] |
| dendrite membrane | cellular component | The portion of the plasma membrane surrounding a dendrite. [GOC:mah] |
| dendritic spine membrane | cellular component | The portion of the plasma membrane surrounding a dendritic spine. [GOC:mah] |
| varicosity | cellular component | Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. [GOC:nln] |
| postsynaptic density membrane | cellular component | The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos] |
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| dendrite membrane | cellular component | The portion of the plasma membrane surrounding a dendrite. [GOC:mah] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| postsynaptic membrane | cellular component | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732] |
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| monoacylglycerol biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. [ISBN:0198506732] |
| G protein-coupled glutamate receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, GOC:signaling, PMID:9131252] |
| neuroblast proliferation | biological process | The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. [GOC:ai, GOC:mtg_sensu, GOC:sart] |
| arachidonic acid metabolic process | biological process | The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [ISBN:0198506732] |
| diacylglycerol catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. [PMID:11717312] |
| retrograde trans-synaptic signaling by endocannabinoid | biological process | Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an endocannabinoid ligand. [GOC:dos] |
| regulation of neuroinflammatory response | biological process | Any process that modulates the frequency, rate or extent of neuroinflammatory response. [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423] |
| cannabinoid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of cannabinoid. [GOC:TermGenie] |