Proteins > DNA topoisomerase 4 subunit B
Page last updated: 2024-08-07 21:08:03
DNA topoisomerase 4 subunit B
A protein that is a translation product of the parE gene in Staphylococcus aureus. [PRO:DNx, UniProtKB:P0C1S7]
Synonyms
EC 5.6.2.2;
Topoisomerase IV subunit B
Research
Bioassay Publications (12)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 7 (58.33) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ciprofloxacin | Staphylococcus aureus | IC50 | 6.4850 | 6 | 6 |
| novobiocin | Staphylococcus aureus | IC50 | 22.6500 | 6 | 6 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ciprofloxacin | Staphylococcus aureus | CC50 | 0.4000 | 1 | 1 |
| gatifloxacin | Staphylococcus aureus | CC50 | 0.2000 | 1 | 1 |
Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 57, 2022
1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum.ACS medicinal chemistry letters, , Jun-09, Volume: 13, Issue:6, 2022
Design and synthesis of ciprofloxacin-sulfonamide hybrids to manipulate ciprofloxacin pharmacological qualities: Potency and side effects.European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with Journal of medicinal chemistry, , 10-28, Volume: 64, Issue:20, 2021
Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive ACS medicinal chemistry letters, , Dec-10, Volume: 11, Issue:12, 2020
Development of a Dual-Acting Antibacterial Agent (TNP-2092) for the Treatment of Persistent Bacterial Infections.Journal of medicinal chemistry, , 07-28, Volume: 59, Issue:14, 2016
Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.Journal of medicinal chemistry, , Sep-26, Volume: 56, Issue:18, 2013
N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification.European journal of medicinal chemistry, , Feb-15, Volume: 188, 2020
Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors.ACS medicinal chemistry letters, , Dec-10, Volume: 11, Issue:12, 2020
An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
New MedChemComm, , Jun-01, Volume: 10, Issue:6, 2019
Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site.Journal of medicinal chemistry, , Jul-23, Volume: 58, Issue:14, 2015