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arsenazo iii

Description

Arsenazo III: Metallochrome indicator that changes color when complexed to the calcium ion under physiological conditions. It is used to measure local calcium ion concentrations in vivo. [MeSH]

Cross-References

ID SourceID
PubMed CID135445682
SCHEMBL ID1527662
MeSH IDM0001722

Synonyms (37)

Synonym
2,2'-((1,8-dihydroxy-3,6-disulfo-2,7-naphthylene)bis(azo)), dibenzene arsonic acid
nsc-91528
antineoplastic-91528
nsc91528
1668-00-4
arsenazo iii, calcium-sensitive dye
arsenazo iii
2,7-bis(2-arsonophenylazo)-1,8-dihydroxynaphthalene-3,6-disulfonic acid
einecs 216-788-6
2,7-(bis(2-arsonophenylazo))-1,8-dihydroxynaphthalene-3,6-disulphonic acid
ai3-52542
nsc 91528
2,7-naphthalenedisulfonic acid, 3,6-bis((2-arsonophenyl)azo)-4,5-dihydroxy-
arsenazo iii sodium salt
FT-0622479
AKOS015903602
3,6-bis((e)-(2-arsonophenyl)diazenyl)-4,5-dihydroxynaphthalene-2,7-disulfonic acid
SCHEMBL1527662
J-610012
arsenazo iii free acid
arsenazo iii, free acid
FT-0696789
2,2'-(1,8-dihydroxy-3,6-disulfonaphthylene-2,7-bisazo)bisbenzenearsonic acid
mfcd00036695
2,7-bis(2-arsonophenylazo)chromotropic acid
arsenazo(iii)
arsenazo iii, p.a., 85.0%
arsenazo iii, p.a.
2,7-bis(2-arsonophenylazo)-1,8-dihydroxy-3,6-naphthalenedisulfonic acid
Q18651591
D88562
A882299
arsenazoiiisodiumsalt
STARBLD0016539
arsenazo iii,free acid
3,6-bis[(2-arsonophenyl)diazenyl]-4,5-dihydroxynaphthalene-2,7-disulfonic acid
DTXSID201026653

Research

Studies (215)

TimeframeStudies, This Drug (%)All Drugs %
pre-1990149 (69.30)18.7374
1990's30 (13.95)18.2507
2000's19 (8.84)29.6817
2010's13 (6.05)24.3611
2020's4 (1.86)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (0.88%)5.53%
Reviews5 (2.20%)6.00%
Case Studies1 (0.44%)4.05%
Observational0 (0.00%)0.25%
Other219 (96.48%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
gamma-aminobutyric acidamino acid zwitterion;
gamma-amino acid;
monocarboxylic acid
human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
1982198242.0low010000
citric acid, anhydroustricarboxylic acidantimicrobial agent;
chelator;
food acidity regulator;
fundamental metabolite
1982201326.5low010010
chlorinehalide anion;
monoatomic chlorine
cofactor;
Escherichia coli metabolite;
human metabolite
1984198539.5low020000
hydrochloric acidchlorine molecular entity;
gas molecular entity;
hydrogen halide;
mononuclear parent hydride
mouse metabolite2012201411.0low000030
4-nitrophenylphosphatearyl phosphatemouse metabolite2011201113.0low000010
dimethyl sulfoxidesulfoxide;
volatile organic compound
alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
1983198341.0low010000
hydrogenelemental hydrogen;
elemental molecule;
gas molecular entity
antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
1984198539.5low020000
malonic acidalpha,omega-dicarboxylic acidhuman metabolite1991199133.0low001000
phytic acidinositol phosphate202220222.0low000001
nickelmetal allergen;
nickel group element atom
epitope;
micronutrient
1986198638.0low010000
nitratesmonovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species
1984198440.0low020000
phosphoric acidphosphoric acidsalgal metabolite;
fertilizer;
human metabolite;
NMR chemical shift reference compound;
solvent
2014201410.0low000010
spermidinepolyazaalkane;
triamine
autophagy inducer;
fundamental metabolite;
geroprotector
1992199232.0low001000
sperminepolyazaalkane;
tetramine
antioxidant;
fundamental metabolite;
immunosuppressive agent
1992199730.0low003000
succinic acidalpha,omega-dicarboxylic acid;
C4-dicarboxylic acid
anti-ulcer drug;
fundamental metabolite;
micronutrient;
nutraceutical;
radiation protective agent
1996199628.0low001000
1-anilino-8-naphthalenesulfonateaminonaphthalene;
naphthalenesulfonic acid
fluorescent probe1993199331.0low001000
2,4-dinitrophenoldinitrophenolallergen;
antiseptic drug;
bacterial xenobiotic metabolite;
geroprotector;
oxidative phosphorylation inhibitor
1984198440.0low010000
4-aminopyridineaminopyridine;
aromatic amine
avicide;
orphan drug;
potassium channel blocker
1984198440.0low010000
oxyquinolinemonohydroxyquinolineantibacterial agent;
antifungal agrochemical;
antiseptic drug;
iron chelator
1993199331.0low001000
2,5-di-tert-butylhydroquinonehydroquinones1991199133.0low001000
caffeinepurine alkaloid;
trimethylxanthine
adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
1984199337.0low051000
verapamilaromatic ether;
nitrile;
polyether;
tertiary amino compound
1987200329.0low010100
carbonyl cyanide m-chlorophenyl hydrazonehydrazone;
monochlorobenzenes;
nitrile
antibacterial agent;
geroprotector;
ionophore
1997199727.0low001000
cetylpyridiniumpyridinium ion2004200420.0low000100
chloroquineaminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound
anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
1998199826.0low001000
pentetic acidpentacarboxylic acidcopper chelator1995200721.0low001200
erythrosine1991199133.0low001000
carbonyl cyanide p-trifluoromethoxyphenylhydrazonearomatic ether;
hydrazone;
nitrile;
organofluorine compound
ATP synthase inhibitor;
geroprotector;
ionophore
1980199635.5low022000
furosemidechlorobenzoic acid;
furans;
sulfonamide
environmental contaminant;
loop diuretic;
xenobiotic
1984198440.0low010000
nalidixic acid1,8-naphthyridine derivative;
monocarboxylic acid;
quinolone antibiotic
antibacterial drug;
antimicrobial agent;
DNA synthesis inhibitor
2013201311.0low000010
1,2-cyclohexanediamineprimary aliphatic amine202320231.0low000001
phenolsulfonphthalein2,1-benzoxathiole;
arenesulfonate ester;
phenols;
sultone
acid-base indicator;
diagnostic agent;
two-colour indicator
1984198639.0low020000
tetracainebenzoate ester;
tertiary amino compound
local anaesthetic1987198737.0low010000
tetraethylammoniumquaternary ammonium ion1984198638.7low030000
trifluoperazineN-alkylpiperazine;
N-methylpiperazine;
organofluorine compound;
phenothiazines
antiemetic;
calmodulin antagonist;
dopaminergic antagonist;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor;
phenothiazine antipsychotic drug
1984199735.3low021000
amifampridineaminopyridine1984198440.0low010000
dipropylenetriamepolyazaalkanealgal metabolite;
plant metabolite
1992199232.0low001000
carbon tetrachloridechlorocarbon;
chloromethanes
hepatotoxic agent;
refrigerant
1993199331.0low001000
aspartic acidaspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid
Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
1987198737.0low010000
sucroseglycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
1979199039.0low041000
adenosine diphosphateadenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate
fundamental metabolite;
human metabolite
1990199730.5low002000
edetic acidethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid
anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
1979201532.8low021010
egtazic aciddiether;
tertiary amino compound;
tetracarboxylic acid
chelator1980199639.0low0113000
mannitolmannitolallergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent
1990199034.0low001000
tert-butylhydroperoxidealkyl hydroperoxideantibacterial agent;
oxidising agent
1983198341.0low010000
bromthymol blue2,1-benzoxathiole;
arenesulfonate ester;
organobromine compound;
polyphenol;
sultone
acid-base indicator;
dye;
two-colour indicator
1991199133.0low001000
rotenoneorganic heteropentacyclic compound;
rotenones
antineoplastic agent;
metabolite;
mitochondrial NADH:ubiquinone reductase inhibitor;
phytogenic insecticide;
piscicide;
toxin
1984198440.0low010000
quinoxalinesmancude organic heterobicyclic parent;
naphthyridine;
ortho-fused heteroarene
1992199232.0low001000
xanthenesxanthene1998199826.0low001000
bromcresol purple2,1-benzoxathiole;
arenesulfonate ester;
organobromine compound;
polyphenol;
sultone
acid-base indicator;
dye;
two-colour indicator
1992199232.0low001000
framycetinaminoglycosideallergen;
antibacterial drug;
Escherichia coli metabolite
1993199331.0low001000
tetraphenylborate1987198737.0low010000
lithocholic acidbile acid;
C24-steroid;
monohydroxy-5beta-cholanic acid
geroprotector;
human metabolite;
mouse metabolite
1988198836.0low010000
cdtaorganooxygen compound201520235.0low000011
alpha-aminopyridine1984198440.0low010000
methoxyhydroxyphenylglycolmethoxybenzenes;
phenols
1985198539.0low010000
malachite greenorganic chloride saltantibacterial agent;
antifungal drug;
carcinogenic agent;
environmental contaminant;
fluorochrome;
histological dye;
teratogenic agent
2012201212.0low000010
c.i. 425102012201212.0low000010
durapatite202220222.0low000001
stearylamineprimary aliphatic aminefilm-forming compound1994199430.0low001000
2-tert-butylhydroquinonehydroquinonesfood antioxidant1998199826.0low001000
amiloridearomatic amine;
guanidines;
organochlorine compound;
pyrazines
diuretic;
sodium channel blocker
2003200321.0low000100
nile blue1984198539.5low020000
dithiothreitol1,4-dimercaptobutane-2,3-diol;
butanediols;
dithiol;
glycol;
thiol
chelator;
human metabolite;
reducing agent
2000200024.0low001000
cyclic cmp3',5'-cyclic pyrimidine nucleotidehuman metabolite1987198737.0low010000
n-methylaspartateamino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound
neurotransmitter agent1987198737.0low010000
lanthanumf-block element atom;
lanthanoid atom;
scandium group element atom
1984200033.7low021000
manganeseelemental manganese;
manganese group element atom
Escherichia coli metabolite;
micronutrient
1984200231.0low010100
molybdenumchromium group element atommicronutrient2013201311.0low000010
praseodymiumf-block element atom;
lanthanoid atom
1980200034.0low011000
thoriumactinoid atom;
f-block element atom
202020204.0low000010
cadmiumcadmium molecular entity;
zinc group element atom
1986200031.0low011000
gadoliniumf-block element atom;
lanthanoid atom
1995200623.5low001100
uraniumactinoid atom;
f-block element atom;
monoatomic uranium
2006201413.2low000230
vanadiumelemental vanadium;
vanadium group element atom
micronutrient1985200827.5low010100
tricalcium phosphatecalcium phosphate202220222.0low000001
deuteriumdihydrogen1987198737.0low010000
deuterium oxidedeuterated compound;
water
NMR solvent1987198737.0low010000
molybdate iondivalent inorganic anion;
molybdenum oxoanion
Escherichia coli metabolite2013201311.0low000010
fluorideshalide anion;
monoatomic fluorine
2013201311.0low100020
calcium oxalateorganic calcium salt201220227.0low000011
glutamic acidglutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid
Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
1985198539.0low010000
nigericinpolycyclic etherantibacterial agent;
antimicrobial agent;
bacterial metabolite;
potassium ionophore
1988199831.0low011000
diltiazem5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetateantihypertensive agent;
calcium channel blocker;
vasodilator agent
1987198737.0low010000
fomesafenaromatic ether;
C-nitro compound;
monochlorobenzenes;
N-sulfonylcarboxamide;
organofluorine compound;
phenols
agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide
1984198440.0low010000
fura-21991199232.7low003000
vanadatestrivalent inorganic anion;
vanadium oxoanion
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor
1985198539.0low010000
25-hydroxycholesterol25-hydroxy steroid;
oxysterol
human metabolite1984198440.0low010000
2-cresolphthalexon1991199133.0low001000
bromatesbromine oxoanion;
monovalent inorganic anion
2008200816.0low000100
3,4-dihydroxyphenylglycolcatechols;
tetrol
metabolite;
mouse metabolite
1985198539.0low010000
cobaltcobalt group element atom;
metal allergen
micronutrient1980200234.7low020100
1,2-bis(2-aminophenoxy)ethane-n,n,n',n'-tetraacetic acidpolyamino carboxylic acid;
tetracarboxylic acid
chelator1993199331.0low001000
quin21986198638.0low010000
fluo-3xanthene dyefluorochrome1998199826.0low001000
1,2-dimyristoylphosphatidylethanolamine2007200717.0low000100
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidazamacrocyclechelator;
copper chelator
2009200915.0low000100
prisma-fil2014201410.0low000010
dodecyloctaethyleneglycol monoetherhydroxypolyether1983198341.0low010000
fenton's reagent2014201410.0low000010
n-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-n,n',n',n'',n''-pentaacetic acid2007200717.0low000100
tetraphenylphosphoniumheteroorganic entity;
phosphorus molecular entity;
polyatomic cation
2000200024.0low001000
inositol 1,4,5-trisphosphatemyo-inositol trisphosphatemouse metabolite1993199828.5low002000
quinidinecinchona alkaloidalpha-adrenergic antagonist;
anti-arrhythmia drug;
antimalarial;
drug allergen;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
muscarinic antagonist;
P450 inhibitor;
potassium channel blocker;
sodium channel blocker
1984198539.7low030000
ryanodine1999199925.0low001000
alpha-cyclodextrincyclodextrin1993199331.0low001000
thapsigarginbutyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone
calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
1998199826.0low001000
arginine vasopressinvasopressincardiovascular drug;
hematologic agent;
mitogen
1991199133.0low001000
oxazolone1986198638.0low010000
safranine torganic chloride saltfluorochrome;
histological dye
1997199727.0low001000
sodium taurodeoxycholatebile acid taurine conjugatehuman metabolite1988198836.0low010000
nadp1984198440.0low010000
valinomycincyclodepsipeptide;
macrocycle
antimicrobial agent;
antiviral agent;
bacterial metabolite;
potassium ionophore
1984198837.7low030000
cobaltous chloridecobalt salt;
inorganic chloride
allergen;
calcium channel blocker;
sensitiser;
two-colour indicator
1986198638.0low010000
6-cyano-7-nitroquinoxaline-2,3-dionequinoxaline derivative1992199232.0low001000
alizarin red sorganic sodium salt;
organosulfonate salt
histological dye2004201116.5low000110
osteoprotegerinlong-chain fatty acid2011201113.0low000010
bilirubinbiladienes;
dicarboxylic acid
antioxidant;
human metabolite;
mouse metabolite
1991199232.5low002000
11-cis-retinalretinalchromophore;
human metabolite;
mouse metabolite
1979198243.3low030000
leukotriene b4dihydroxy monocarboxylic acid;
hydroxy polyunsaturated fatty acid;
leukotriene;
long-chain fatty acid
human metabolite;
mouse metabolite;
plant metabolite;
vasoconstrictor agent
1982198341.5low020000
1,2-oleoylphosphatidylcholinephosphatidylcholine(1+)1985198738.0low020000
bariumalkaline earth metal atom;
elemental barium
1984198440.0low020000
rubidiumalkali metal atom1988198836.0low010000
aluminumboron group element atom;
elemental aluminium;
metal atom
2001200123.0low000100
strontiumalkaline earth metal atom1984199136.5low011000
lasalocidbeta-hydroxy ketone;
monocarboxylic acid;
monohydroxybenzoic acid;
oxanes;
oxolanes;
polyether antibiotic;
secondary alcohol;
tertiary alcohol
bacterial metabolite;
coccidiostat;
ionophore
1982198441.0low020000
phosphorusmonoatomic phosphorus;
nonmetal atom;
pnictogen
macronutrient2012201212.0low000010
carbocyaninescyanine dye;
organic iodide salt
fluorochrome1985198539.0low010000
tetrodotoxinazatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid
animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
1983198739.2low050000
antimycin aamidobenzoic acid1991199133.0low001000
beta-escin1987198737.0low010000
gadolinium dtpagadolinium coordination entityMRI contrast agent1995200723.0low001100
sq-23377cyclic ether;
enol;
polyunsaturated fatty acid;
very long-chain fatty acid
calcium ionophore;
metabolite
1982198540.5low020000
dioleoylphosphatidic acid1,2-bis(octadec-9-enoyl)phosphatidic acid1985198638.5low020000
veratridine1982198640.0low040000
calcimycinbenzoxazole1980199439.3low0203000
murexide1980199239.8low031000
nadorganophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
1984198539.5low020000
gramicidin a1985198638.5low020000
phosphatidylcholines1,2-diacyl-sn-glycero-3-phosphocholine1984199436.6low061000
atractyloside1997199727.0low001000
lucifer yelloworganic lithium saltfluorochrome1986198638.0low010000
potassium bromatebromate salt;
potassium salt
flour treatment agent2008200816.0low000100
ascorbic acidascorbic acid;
vitamin C
coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
2013201311.0low000010
chlortetracycline1982198341.5low040000
oligomycins1984199733.5low011000
nitrophenols2011201113.0low000010
carboxyatractyloside1997199727.0low001000
cyclosporine1997200025.5low002000
digitonin1986199832.0low011000
apyrase1985198539.0low010000
cyclic gmp3',5'-cyclic purine nucleotide;
guanyl ribonucleotide
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
1983198838.0low040000
guanosine triphosphateguanosine 5'-phosphate;
purine ribonucleoside 5'-triphosphate
Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor
1987198737.0low010000
hypoxanthinenucleobase analogue;
oxopurine;
purine nucleobase
fundamental metabolite1985198539.0low010000
allopurinolnucleobase analogue;
organic heterobicyclic compound
antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
1985198539.0low010000
antipyrylazo iii1980198640.4high0130000
stilbazochrome-p1958198055.0high020000
2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein1991199133.0low001000
nk 23671986198638.0low010000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Abrasion, Dental02014201410.0low000010
Asialia02012201212.0low000010
Benign Neoplasms, Brain02006200618.0low000100
Brain Neoplasms02006200618.0low000100
Cancer of Pituitary01982198242.0low010000
Carbon Tetrachloride Poisoning01993199331.0low001000
Carcinoma, Ehrlich Tumor01985198539.0low010000
Cardiac Failure01999199925.0low001000
Caries, Dental02013201311.0low000010
Catatonic Rigidity01985198539.0low010000
Dental Caries02013201311.0low000010
Dental Plaque02013201311.0low100010
Experimental Neoplasms01982198242.0low010000
Extravascular Hemolysis01984199236.0low011000
Gammapathy, Monoclonal01997199727.0low001000
Glioblastoma with Sarcomatous Component02006200618.0low000100
Gliosarcoma02006200618.0low000100
Heart Failure01999199925.0low001000
Hemolysis01984199236.0low011000
Hypercalcemia01997199727.0low001000
Hyperparathyroidism01991199133.0low001000
Injury, Myocardial Reperfusion01990199034.0low001000
Libman-Sacks Disease01983198341.0low110000
Lupus Erythematosus, Systemic01983198341.0low110000
Milk-Alkali Syndrome01997199727.0low001000
Muscle Contraction01979198740.5high0170000
Muscle Relaxation01984198440.0low010000
Muscle Rigidity01985198539.0low010000
Necrosis01993199331.0low001000
Neuroblastoma01986198638.0low010000
Paraproteinemias01997199727.0low001000
Pituitary Neoplasms01982198242.0low010000
Sensitivity and Specificity01991200625.0medium003300
Tooth Erosion02012201411.0low000030
Xerostomia02012201212.0low000010

Safety/Toxicity (1)

ArticleYear
Cadmium hepatotoxicity and alterations of the mitochondrial function.
Journal of toxicology. Clinical toxicology, , Volume: 38, Issue:4
2000

Pharmacokinetics (1)

ArticleYear
Volume regulation by Amphiuma red blood cells: cytosolic free Ca and alkali metal-H exchange.
The American journal of physiology, , Volume: 250, Issue:3 Pt 1
1986