A glutaminyl-peptide cyclotransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16769]
EC 2.3.2.5;
Glutaminyl cyclase;
QC;
sQC;
Glutaminyl-tRNA cyclotransferase;
Glutamyl cyclase;
EC
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| catechol | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| histamine | Homo sapiens (human) | Ki | 850.0000 | 1 | 1 |
| imidazole | Homo sapiens (human) | IC50 | 352.0000 | 1 | 1 |
| imidazole | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| 1-methylimidazole | Homo sapiens (human) | Ki | 30.0000 | 1 | 1 |
| oxyquinoline | Homo sapiens (human) | IC50 | 208.0000 | 1 | 1 |
| benzimidazole | Homo sapiens (human) | Ki | 144.0000 | 2 | 2 |
| histidine | Homo sapiens (human) | Ki | 4,400.0000 | 1 | 1 |
| aminoimidazole carboxamide | Homo sapiens (human) | Ki | 15,500.0000 | 1 | 1 |
| 4-methylimidazole | Homo sapiens (human) | IC50 | 110.0000 | 1 | 1 |
| 2-aminobenzimidazole | Homo sapiens (human) | Ki | 1,800.0000 | 1 | 1 |
| n-acetylimidazole | Homo sapiens (human) | Ki | 107.0000 | 1 | 1 |
| 1-(trimethylsilyl)-1h-imidazole | Homo sapiens (human) | Ki | 167.0000 | 1 | 1 |
| dazoxiben | Homo sapiens (human) | Ki | 2.3000 | 1 | 1 |
| pyromeconic acid | Homo sapiens (human) | IC50 | 232.0000 | 1 | 1 |
| 3-methylhistamine | Homo sapiens (human) | Ki | 120.0000 | 1 | 1 |
| n-acetylhistamine | Homo sapiens (human) | Ki | 10.3615 | 2 | 4 |
| 1-hydroxy-2(1h)-pyridinone | Homo sapiens (human) | IC50 | 353.0000 | 1 | 1 |
| 8-hydroxy-2-quinolinecarboxylic acid | Homo sapiens (human) | IC50 | 203.0000 | 1 | 1 |
| 1-benzylimidazole | Homo sapiens (human) | Ki | 2.6230 | 2 | 3 |
| 1-(3-aminopropyl)imidazole | Homo sapiens (human) | Ki | 410.0000 | 1 | 1 |
| 1-phenylimidazole | Homo sapiens (human) | Ki | 4,600.0000 | 1 | 1 |
| 1-methyl-3-hydroxypyridine-2-one | Homo sapiens (human) | IC50 | 772.0000 | 1 | 1 |
| histidinol | Homo sapiens (human) | Ki | 1,530.0000 | 1 | 1 |
| 2-mercaptobenzimidazole | Homo sapiens (human) | IC50 | 551.0000 | 1 | 1 |
| thiohydantoins | Homo sapiens (human) | IC50 | 390.0000 | 1 | 1 |
| 4',7-dihydroxyflavone | Homo sapiens (human) | IC50 | 45.2000 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| glutaminyl-peptide cyclotransferase activity | molecular function | Catalysis of the reaction: N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4+. [RHEA:23652] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| specific granule lumen | cellular component | The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| tertiary granule lumen | cellular component | Any membrane-enclosed lumen that is part of a tertiary granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620] |
| ficolin-1-rich granule lumen | cellular component | Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620] |
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase | biological process | The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase. [RESID:AA0031] |
| protein modification process | biological process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). [GOC:bf, GOC:jl] |