Proteins > G1/S-specific cyclin-D3
Page last updated: 2024-08-07 16:24:36

G1/S-specific cyclin-D3

A G1/S-specific cyclin-D3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30281]

Synonyms

Research

Bioassay Publications (32)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (28.13)29.6817
2010's15 (46.88)24.3611
2020's8 (25.00)2.80

Compounds (13)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
olomoucineHomo sapiens (human)IC50250.000011
staurosporineHomo sapiens (human)IC500.055066
cyc 202Homo sapiens (human)IC5010.000011
cgp 74514aHomo sapiens (human)IC500.786522
bms 387032Homo sapiens (human)IC500.925011
alvocidibHomo sapiens (human)IC500.198333
pd 0183812Homo sapiens (human)IC500.008011
palbociclibHomo sapiens (human)IC500.019488
palbociclibHomo sapiens (human)Ki0.027011
rgb 286638Homo sapiens (human)IC500.002011
at 7519Homo sapiens (human)IC500.153044
azd5438Homo sapiens (human)IC500.021011
ribociclibHomo sapiens (human)IC500.035266
abemaciclibHomo sapiens (human)IC500.011299
abemaciclibHomo sapiens (human)Ki0.008211

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
alvocidibHomo sapiens (human)ID500.400011

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
cyclin-dependent protein serine/threonine kinase activitymolecular functionCyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
protein kinase bindingmolecular functionBinding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
cyclin-dependent protein serine/threonine kinase activator activitymolecular functionBinds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. [GOC:dph, PMID:2569363, PMID:3322810]
cyclin-dependent protein serine/threonine kinase regulator activitymolecular functionModulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 3 target(s):

TargetCategoryDefinition
centrosomecellular componentA structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684]
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 3 target(s):

TargetCategoryDefinition
cyclin D3-CDK4 complexcellular componentA protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]
cyclin D3-CDK6 complexcellular componentA protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. [GOC:so, PMID:15935619]
cyclin-dependent protein kinase holoenzyme complexcellular componentCyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. [GOC:krc, PMID:11602261]

Involved In

This protein is involved in 10 target(s):

TargetCategoryDefinition
G1/S transition of mitotic cell cyclebiological processThe mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. [GOC:mtg_cell_cycle]
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
positive regulation of protein phosphorylationbiological processAny process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
signal transductionbiological processThe cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
T cell proliferationbiological processThe expansion of a T cell population by cell division. Follows T cell activation. [GOC:jl]
regulation of cell population proliferationbiological processAny process that modulates the frequency, rate or extent of cell proliferation. [GOC:jl]
positive regulation of cyclin-dependent protein serine/threonine kinase activitybiological processAny process that activates or increases the frequency, rate or extent of CDK activity. [GOC:go_curators, GOC:pr]
cell divisionbiological processThe process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr]
positive regulation of G1/S transition of mitotic cell cyclebiological processAny signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]
regulation of cyclin-dependent protein serine/threonine kinase activitybiological processAny process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. [GOC:go_curators, GOC:pr]