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gallopamil and Necrosis

gallopamil has been researched along with Necrosis in 8 studies

Gallopamil: Coronary vasodilator that is an analog of iproveratril (VERAPAMIL) with one more methoxy group on the benzene ring.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"To determine whether gallopamil (D600), a methoxy derivative of verapamil, administered immediately before coronary artery reperfusion reduces the extent of myocardial hemorrhage and necrosis, the left anterior descending coronary artery was occluded for 3 h and reperfused for 3 h in anesthetized, open-chest dogs."7.68Reduction in myocardial hemorrhage and the extent of necrosis by gallopamil (D600) in dogs with coronary artery reperfusion. ( Endo, T; Hayakawa, H; Maroko, PR; Sato, N, 1991)
"To examine whether gallopamil (D600), a methoxy derivative of verapamil, has sustained beneficial effects on the ischemic myocardium, its effects on the size of myocardial infarction determined 6 hours (protocol 1) and 24 hours (protocol 2) after left anterior descending coronary artery occlusion were compared in anesthetized, open-chest dogs."7.68Sustained beneficial effects of gallopamil (D600) on size of myocardial infarction 24 hours after coronary artery occlusion in dogs. ( Endo, T; Hayakawa, H; Kiuchi, K; Maroko, PR; Sato, N, 1990)
"To determine whether gallopamil (D600), a methoxy derivative of verapamil, administered immediately before coronary artery reperfusion reduces the extent of myocardial hemorrhage and necrosis, the left anterior descending coronary artery was occluded for 3 h and reperfused for 3 h in anesthetized, open-chest dogs."3.68Reduction in myocardial hemorrhage and the extent of necrosis by gallopamil (D600) in dogs with coronary artery reperfusion. ( Endo, T; Hayakawa, H; Maroko, PR; Sato, N, 1991)
"To examine whether gallopamil (D600), a methoxy derivative of verapamil, has sustained beneficial effects on the ischemic myocardium, its effects on the size of myocardial infarction determined 6 hours (protocol 1) and 24 hours (protocol 2) after left anterior descending coronary artery occlusion were compared in anesthetized, open-chest dogs."3.68Sustained beneficial effects of gallopamil (D600) on size of myocardial infarction 24 hours after coronary artery occlusion in dogs. ( Endo, T; Hayakawa, H; Kiuchi, K; Maroko, PR; Sato, N, 1990)
"Perfusion of the isolated rat heart with Krebs-Henseleit solution containing adrenochrome (25 or 50 mg/l), and oxidation product of catechalmines, resulted in contractile failure and myocardial necrosis."3.66Protection against adrenochrome-induced myocardial damage by various pharmacological interventions. ( Beamish, RE; Dhalla, NS; Singal, PK; Taam, GM; Yates, JC, 1980)
"The effect of inhibiting isoprenaline-induced intracellular calcium accumulation on the degree of damage produced in the rat myocardium by this amine has been investigated by simultaneously dosing rats with the calcium antagonistic drug D600."1.26The effect of a calcium antagonist (D600) on isoprenaline-induced myocardial necrosis in the rat. ( Powell, T; Rowles, PM; Steen, E; Woolf, N, 1979)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19905 (62.50)18.7374
1990's3 (37.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yates, JC1
Taam, GM1
Singal, PK1
Beamish, RE1
Dhalla, NS1
Steen, E1
Woolf, N1
Powell, T1
Rowles, PM1
Leder, O1
Strubelt, O1
Hoffmann, A1
Siegers, CP1
Sierra-Callejas, JL1
Sigel, H1
Janke, J1
Fleckenstein, A1
Endo, T2
Sato, N2
Hayakawa, H2
Maroko, PR3
Kiuchi, K1
Faria, DB1
Goncalves, FR1

Other Studies

8 other studies available for gallopamil and Necrosis

ArticleYear
Protection against adrenochrome-induced myocardial damage by various pharmacological interventions.
    British journal of experimental pathology, 1980, Volume: 61, Issue:3

    Topics: Adrenochrome; Animals; Antihypertensive Agents; Cardiomyopathies; Gallopamil; Heart; In Vitro Techni

1980
The effect of a calcium antagonist (D600) on isoprenaline-induced myocardial necrosis in the rat.
    British journal of experimental pathology, 1979, Volume: 60, Issue:3

    Topics: Animals; Calcium; Cardiomyopathies; Gallopamil; Isoproterenol; Male; Myocardium; Necrosis; Rats; Ver

1979
[Microscopic quantification of myocardial necroses in experimental cardiology].
    Acta histochemica. Supplementband, 1976, Volume: 16

    Topics: Animals; Calcitonin; Dose-Response Relationship, Drug; Gallopamil; Histological Techniques; Isoprote

1976
On the pathogenesis of cardiac necroses induced by theophylline and caffeine.
    Acta pharmacologica et toxicologica, 1976, Volume: 39, Issue:3

    Topics: Animals; Blood Pressure; Caffeine; Calcium; Gallopamil; Heart; Heart Rate; Isoproterenol; Male; Myoc

1976
Restriction of isoproterenol-induced myocardial Ca uptake and necrotization in rats by a new Ca-antagonistic compound (ethyl-4-(3,4,5-trimethoxycinnamoyl) piperazinyl acetate (Vascordil)).
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 6

    Topics: Animals; Biological Transport; Calcium; Cardiomyopathies; Cinnamates; Dose-Response Relationship, Dr

1975
Reduction in myocardial hemorrhage and the extent of necrosis by gallopamil (D600) in dogs with coronary artery reperfusion.
    Journal of cardiovascular pharmacology, 1991, Volume: 18, Issue:5

    Topics: Animals; Autoradiography; Blood Pressure; Coronary Vessels; Dogs; Female; Gallopamil; Heart Diseases

1991
Sustained beneficial effects of gallopamil (D600) on size of myocardial infarction 24 hours after coronary artery occlusion in dogs.
    American heart journal, 1990, Volume: 119, Issue:5

    Topics: Animals; Autoradiography; Dogs; Female; Gallopamil; Hemodynamics; Male; Myocardial Infarction; Myoca

1990
Three-dimensional analysis of infarct size reduction after administration of gallopamil in dogs.
    Arzneimittel-Forschung, 1990, Volume: 40, Issue:1

    Topics: Animals; Autoradiography; Coronary Disease; Dogs; Female; Gallopamil; Hemodynamics; Male; Models, Bi

1990
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