Proteins > Ornithine decarboxylase
Page last updated: 2024-08-07 12:59:15

Ornithine decarboxylase

An ornithine decarboxylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11926]

Synonyms

ODC;
EC 4.1.1.17

Research

Bioassay Publications (2)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Compounds (4)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
resveratrolHomo sapiens (human)IC5019.000011
zapotinHomo sapiens (human)IC503.400011
genisteinHomo sapiens (human)IC5026.000011
4-hydroxylonchocarpinHomo sapiens (human)IC504.700011

Enables

This protein enables 3 target(s):

TargetCategoryDefinition
ornithine decarboxylase activitymolecular functionCatalysis of the reaction: L-ornithine + H+ = CO2 + putrescine. [EC:4.1.1.17, RHEA:22964]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
protein homodimerization activitymolecular functionBinding to an identical protein to form a homodimer. [GOC:jl]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 2 target(s):

TargetCategoryDefinition
cellular_componentcellular componentA location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). [GOC:pdt]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 7 target(s):

TargetCategoryDefinition
kidney developmentbiological processThe process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544]
polyamine metabolic processbiological processThe chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. [ISBN:0198506732]
cell population proliferationbiological processThe multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb]
positive regulation of cell population proliferationbiological processAny process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
response to virusbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. [GOC:hb]
putrescine biosynthetic process from ornithinebiological processThe chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine. [GOC:mah, MetaCyc:PWY-46]
regulation of protein catabolic processbiological processAny process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:go_curators, GOC:jl]