Peptidyl-prolyl cis-trans isomerase FKBP1B

A peptidyl-prolyl cis-trans isomerase FKBP1B that is encoded in the genome of human. [PRO:DNx, UniProtKB:P68106]

Synonyms

PPIase FKBP1B;
EC 5.2.1.8;
12.6 kDa FK506-binding protein;
12.6 kDa FKBP;
FKBP-12.6;
FK506-binding protein 1B;
FKBP-1B;
Immunophilin FKBP12.6;
Rotamase;
h-FKBP-12

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (3)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cyclosporine	Homo sapiens (human)	Ki	0.0060	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tacrolimus	Homo sapiens (human)	Kd	0.0004	1	1
sirolimus	Homo sapiens (human)	Kd	0.0002	1	1

Enables

This protein enables 8 target(s):

Target	Category	Definition
peptidyl-prolyl cis-trans isomerase activity	molecular function	Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). [EC:5.2.1.8]
signaling receptor binding	molecular function	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
FK506 binding	molecular function	Binding to a 23-membered macrolide lactone FK506. [GOC:jl]
channel regulator activity	molecular function	Binds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. [GOC:mah]
calcium channel inhibitor activity	molecular function	Binds to and stops, prevents, or reduces the activity of a calcium channel. [GOC:mah]
cyclic nucleotide binding	molecular function	Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. [GOC:ai]
transmembrane transporter binding	molecular function	Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
Z disc	cellular component	Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. [GOC:mtg_muscle, ISBN:0815316194]
sarcoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the sarcoplasmic reticulum. [GOC:rph]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
sarcoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the sarcoplasmic reticulum. [GOC:rph]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
calcium channel complex	cellular component	An ion channel complex through which calcium ions pass. [GOC:mah]

Involved In

This protein is involved in 23 target(s):

Target	Category	Definition
'de novo' protein folding	biological process	The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. [GOC:mb]
smooth muscle contraction	biological process	A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
negative regulation of heart rate	biological process	Any process that stops, prevents or reduces the frequency or rate of heart contraction. [GOC:dph, GOC:tb]
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. [GOC:BHF, GOC:dph, GOC:tb]
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	biological process	Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. [GOC:BHF, GOC:dph, GOC:tb]
neuronal action potential propagation	biological process	The propagation of an action potential along an axon, away from the soma. [GOC:isa_complete]
calcium-mediated signaling	biological process	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling]
protein maturation by protein folding	biological process	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein. [GOC:isa_complete]
response to vitamin E	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus. [GOC:sl]
insulin secretion involved in cellular response to glucose stimulus	biological process	The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus. [GOC:bf, GOC:yaf, PMID:8492079]
protein refolding	biological process	The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. [GOC:mb]
T cell proliferation	biological process	The expansion of a T cell population by cell division. Follows T cell activation. [GOC:jl]
response to hydrogen peroxide	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. [GOC:jl]
positive regulation of axon regeneration	biological process	Any process that activates, maintains or increases the rate of axon regeneration. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
negative regulation of calcium-mediated signaling	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling. [GOC:ai, PMID:11696592]
release of sequestered calcium ion into cytosol	biological process	The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment. [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]
negative regulation of release of sequestered calcium ion into cytosol	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. [GOC:ai]
positive regulation of sequestering of calcium ion	biological process	Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. [GOC:ai]
regulation of cytosolic calcium ion concentration	biological process	Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. [GOC:ai, GOC:mah, GOC:rph]
response to redox state	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. [GOC:mah, PMID:15131240, PMID:16987039]
negative regulation of insulin secretion involved in cellular response to glucose stimulus	biological process	Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. [GOC:BHF, GOC:dph]
protein peptidyl-prolyl isomerization	biological process	The modification of a protein by cis-trans isomerization of a proline residue. [GOC:krc, PMID:16959570]